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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21047

FusionGeneSummary for MAPKBP1_STX6

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPKBP1_STX6
Fusion gene ID: 21047
HgeneTgene
Gene symbol

MAPKBP1

STX6

Gene ID

23005

10228

Gene namemitogen-activated protein kinase binding protein 1syntaxin 6
SynonymsJNKBP-1|JNKBP1|NPHP20-
Cytomap

15q15.1

1q25.3

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase-binding protein 1JNK-binding protein 1syntaxin-6
Modification date2018051920180523
UniProtAcc

O60336

O43752

Ensembl transtripts involved in fusion geneENST00000221214, ENST00000457542, 
ENST00000260357, ENST00000456763, 
ENST00000514566, ENST00000507762, 
ENST00000258301, ENST00000469135, 
ENST00000542060, 
Fusion gene scores* DoF score7 X 4 X 3=841 X 1 X 1=1
# samples 61
** MAII scorelog2(6/84*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: MAPKBP1 [Title/Abstract] AND STX6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA324569MAPKBP1chr15

42066809

+STX6chr1

180962562

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000221214ENST00000258301MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-intronENST00000221214ENST00000469135MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-5UTRENST00000221214ENST00000542060MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-3CDSENST00000457542ENST00000258301MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-intronENST00000457542ENST00000469135MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-5UTRENST00000457542ENST00000542060MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-3CDSENST00000260357ENST00000258301MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-intronENST00000260357ENST00000469135MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-5UTRENST00000260357ENST00000542060MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-3CDSENST00000456763ENST00000258301MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-intronENST00000456763ENST00000469135MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-5UTRENST00000456763ENST00000542060MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-3CDSENST00000514566ENST00000258301MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-intronENST00000514566ENST00000469135MAPKBP1chr15

42066809

+STX6chr1

180962562

-
5UTR-5UTRENST00000514566ENST00000542060MAPKBP1chr15

42066809

+STX6chr1

180962562

-
intron-3CDSENST00000507762ENST00000258301MAPKBP1chr15

42066809

+STX6chr1

180962562

-
intron-intronENST00000507762ENST00000469135MAPKBP1chr15

42066809

+STX6chr1

180962562

-
intron-5UTRENST00000507762ENST00000542060MAPKBP1chr15

42066809

+STX6chr1

180962562

-

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FusionProtFeatures for MAPKBP1_STX6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPKBP1

O60336

STX6

O43752

Negative regulator of NOD2 function. It down-regulatesNOD2-induced processes such as activation of NF-kappa-B signaling,IL8 secretion and antibacterial response (PubMed:22700971).Involved in JNK signaling pathway (By similarity).{ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. Involved in intracellular vesicle trafficking.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAPKBP1_STX6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAPKBP1_STX6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAPKBP1APTX, KRTAP5-9, KRT31, MDFI, MEOX2, TRIM27, SIAH1, TCF4, TCF12, TRIP6, RGS20, KEAP1, SPRY2, GLRX3, ADAMTSL4, TEX11, ALG13, KRTAP4-12, KRTAP3-2, KRTAP9-2, KRTAP9-4, KRT40, KRTAP10-7, KRTAP10-9, KRTAP10-1, KRTAP10-8, KRTAP10-3, NOTCH2NL, WDR62STX6VAMP4, VAMP3, VAMP8, STX7, SNAP23, NSF, VPS53, VPS52, VPS51, VPS54, CSGALNACT1, MARCH2, PSMA3, STX4, GOSR2, NAPB, ENO1, MOV10, NXF1, VAMP7, VTI1B, VPS45, NAPA, STX18, GOSR1, GTF3C2, CUX1, STX5, GTF3C1, B3GAT3, STX12, BNIP1, SCFD1, UGT8, SNAP29, STX8, NAPG, GTF3C3, VTI1A, NBAS, STX3, STX10, STXBP5, TSPAN3, CLEC12A, TMEM17, TMEM216, TMEM200A, STX11, MRAP2, FAM171B, STXBP6, SEC22B, TPCN2, COG6, HAUS1, TRIM25, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAPKBP1_STX6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAPKBP1_STX6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSTX6C0038868Progressive supranuclear palsy1CTD_human
TgeneSTX6C1866282CEROID LIPOFUSCINOSIS, NEURONAL, 61CTD_human