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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21038

FusionGeneSummary for MAPKAPK5_PAWR

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPKAPK5_PAWR
Fusion gene ID: 21038
HgeneTgene
Gene symbol

MAPKAPK5

PAWR

Gene ID

8550

5074

Gene namemitogen-activated protein kinase-activated protein kinase 5pro-apoptotic WT1 regulator
SynonymsMAPKAP-K5|MK-5|MK5|PRAKPAR4|Par-4
Cytomap

12q24.12-q24.13

12q21.2

Type of geneprotein-codingprotein-coding
DescriptionMAP kinase-activated protein kinase 5MAPK-activated protein kinase 5MAPKAP kinase 5MAPKAPK-5p38-regulated/activated protein kinasePRKC apoptosis WT1 regulator proteinPRKC, apoptosis, WT1, regulatorWT1-interacting proteinprostate apoptosis response protein 4prostate apoptosis response protein PAR-4prostate apoptosis response-4transcriptional repressor PAR4
Modification date2018052320180523
UniProtAcc

Q8IW41

Q96IZ0

Ensembl transtripts involved in fusion geneENST00000550735, ENST00000551404, 
ENST00000547305, ENST00000546394, 
ENST00000328827, ENST00000547571, 
Fusion gene scores* DoF score8 X 8 X 7=4488 X 6 X 5=240
# samples 128
** MAII scorelog2(12/448*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPKAPK5 [Title/Abstract] AND PAWR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPKAPK5

GO:0006417

regulation of translation

21329882

HgeneMAPKAPK5

GO:0007265

Ras protein signal transduction

17254968

HgeneMAPKAPK5

GO:0046777

protein autophosphorylation

21329882

HgeneMAPKAPK5

GO:0090400

stress-induced premature senescence

17254968


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-PC-A5DN-01AMAPKAPK5chr12

112326422

+PAWRchr12

80007389

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000550735ENST00000328827MAPKAPK5chr12

112326422

+PAWRchr12

80007389

-
5CDS-intronENST00000550735ENST00000547571MAPKAPK5chr12

112326422

+PAWRchr12

80007389

-
Frame-shitENST00000551404ENST00000328827MAPKAPK5chr12

112326422

+PAWRchr12

80007389

-
5CDS-intronENST00000551404ENST00000547571MAPKAPK5chr12

112326422

+PAWRchr12

80007389

-
intron-3CDSENST00000547305ENST00000328827MAPKAPK5chr12

112326422

+PAWRchr12

80007389

-
intron-intronENST00000547305ENST00000547571MAPKAPK5chr12

112326422

+PAWRchr12

80007389

-
intron-3CDSENST00000546394ENST00000328827MAPKAPK5chr12

112326422

+PAWRchr12

80007389

-
intron-intronENST00000546394ENST00000547571MAPKAPK5chr12

112326422

+PAWRchr12

80007389

-

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FusionProtFeatures for MAPKAPK5_PAWR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPKAPK5

Q8IW41

PAWR

Q96IZ0

Tumor suppressor serine/threonine-protein kinaseinvolved in mTORC1 signaling and post-transcriptional regulation.Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1,p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation ofFOXO3: phosphorylation of FOXO3 leads to promote nuclearlocalization of FOXO3, enabling expression of miR-34b and miR-34c,2 post-transcriptional regulators of MYC that bind to the 3'UTR ofMYC transcript and prevent MYC translation. Acts as a negativeregulator of mTORC1 signaling by mediating phosphorylation andinhibition of RHEB. Part of the atypical MAPK signaling via itsinteraction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of thecomplex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, butthe complex follows a complex set of phosphorylation events: uponinteraction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4),ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediatesphosphorylation and activation of MAPKAPK5, which in turnphosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediatesphosphorylation of HSP27/HSPB1 in response to PKA/PRKACAstimulation, inducing F-actin rearrangement.{ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103,ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882,ECO:0000269|PubMed:9628874}. Pro-apoptopic protein capable of selectively inducingapoptosis in cancer cells, sensitizing the cells to diverseapoptotic stimuli and causing regression of tumors in animalmodels. Induces apoptosis in certain cancer cells by activation ofthe Fas prodeath pathway and coparallel inhibition of NF-kappa-Btranscriptional activity. Inhibits the transcriptional activationand augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction withWT1. Seems also to be a transcriptional repressor by itself. Maybe directly involved in regulating the amyloid precursor protein(APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAPKAPK5_PAWR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAPKAPK5_PAWR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAPKAPK5HSPB1, HSPB2, MAPK6, MAPK14, RPL13, ZNF282, TAB1, MAPK4, MAPKAPK2, LSR, CDCA8, ZNF576, SRPK2, SRPK1, TP53, MAPK9, MAPK1, EIF4EBP1, MAPKAPK5PAWRTHAP1, SLC5A7, SLC5A1, AATF, DAPK3, PRKCZ, WT1, HSPA5, FBXO25, SPSB1, SPSB2, SPSB4, SQSTM1, DRD2, PAN2, APEH, CAND1, CARS, FAM129B, H3F3A, IDE, JMJD6, ATP6V1C1, SHMT1, PPM1G, SHMT2, SNX2, SNX6, STAT1, VPS29, FBXO45, CCDC8, EED, LUZP4, DDX39A, CEP290, CEP128, MYH9, HMG20A, IKBIP, SCOC, SLC25A41, G3BP1, HDAC6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAPKAPK5_PAWR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAPKAPK5_PAWR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePAWRC0036341Schizophrenia2PSYGENET
TgenePAWRC0041696Unipolar Depression2PSYGENET
TgenePAWRC1269683Major Depressive Disorder2PSYGENET
TgenePAWRC0001418Adenocarcinoma1CTD_human
TgenePAWRC0005586Bipolar Disorder1PSYGENET
TgenePAWRC0014170Endometrial Neoplasms1CTD_human
TgenePAWRC0033578Prostatic Neoplasms1CTD_human
TgenePAWRC0033975Psychotic Disorders1PSYGENET
TgenePAWRC0525045Mood Disorders1PSYGENET
TgenePAWRC0600427Cocaine Dependence1PSYGENET