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Fusion gene ID: 21014 |
FusionGeneSummary for MAPK8_ARFIP1 |
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Fusion gene information | Fusion gene name: MAPK8_ARFIP1 | Fusion gene ID: 21014 | Hgene | Tgene | Gene symbol | MAPK8 | ARFIP1 | Gene ID | 5599 | 27236 |
Gene name | mitogen-activated protein kinase 8 | ADP ribosylation factor interacting protein 1 | |
Synonyms | JNK|JNK-46|JNK1|JNK1A2|JNK21B1/2|PRKM8|SAPK1|SAPK1c | HSU52521 | |
Cytomap | 10q11.22 | 4q31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | mitogen-activated protein kinase 8JUN N-terminal kinaseMAP kinase 8c-Jun N-terminal kinase 1mitogen-activated protein kinase 8 isoform JNK1 alpha1mitogen-activated protein kinase 8 isoform JNK1 beta2stress-activated protein kinase 1stress-activated | arfaptin-1 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P45983 | P53367 | |
Ensembl transtripts involved in fusion gene | ENST00000374189, ENST00000374182, ENST00000360332, ENST00000374174, ENST00000395611, ENST00000459755, | ENST00000451320, ENST00000429148, ENST00000353617, ENST00000405727, ENST00000356064, ENST00000511289, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 7 X 6 X 7=294 |
# samples | 4 | 10 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/294*10)=-1.55581615506164 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAPK8 [Title/Abstract] AND ARFIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MAPK8 | GO:0006468 | protein phosphorylation | 21856198 |
Hgene | MAPK8 | GO:0007254 | JNK cascade | 8654373 |
Hgene | MAPK8 | GO:0007258 | JUN phosphorylation | 14967141|21095239 |
Hgene | MAPK8 | GO:0009411 | response to UV | 14967141 |
Hgene | MAPK8 | GO:0018105 | peptidyl-serine phosphorylation | 15850461|20027304|21095239 |
Hgene | MAPK8 | GO:0018107 | peptidyl-threonine phosphorylation | 21095239 |
Hgene | MAPK8 | GO:0032091 | negative regulation of protein binding | 21095239 |
Hgene | MAPK8 | GO:0032880 | regulation of protein localization | 20027304 |
Hgene | MAPK8 | GO:0034198 | cellular response to amino acid starvation | 11096076 |
Hgene | MAPK8 | GO:0043066 | negative regulation of apoptotic process | 14967141|21095239 |
Hgene | MAPK8 | GO:0051403 | stress-activated MAPK cascade | 11096076 |
Hgene | MAPK8 | GO:0071222 | cellular response to lipopolysaccharide | 23776175 |
Tgene | ARFIP1 | GO:0006886 | intracellular protein transport | 12606037 |
Tgene | ARFIP1 | GO:0050708 | regulation of protein secretion | 12606037 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | CESC | TCGA-C5-A2LT-01A | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
TCGA | LD | CESC | TCGA-C5-A2LT-01A | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000374189 | ENST00000451320 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
5UTR-5UTR | ENST00000374189 | ENST00000429148 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
5UTR-5UTR | ENST00000374189 | ENST00000353617 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
5UTR-5UTR | ENST00000374189 | ENST00000405727 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
5UTR-5UTR | ENST00000374189 | ENST00000356064 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
5UTR-intron | ENST00000374189 | ENST00000511289 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374182 | ENST00000451320 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374182 | ENST00000429148 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374182 | ENST00000353617 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374182 | ENST00000405727 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374182 | ENST00000356064 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-intron | ENST00000374182 | ENST00000511289 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000360332 | ENST00000451320 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000360332 | ENST00000429148 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000360332 | ENST00000353617 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000360332 | ENST00000405727 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000360332 | ENST00000356064 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-intron | ENST00000360332 | ENST00000511289 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374174 | ENST00000451320 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374174 | ENST00000429148 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374174 | ENST00000353617 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374174 | ENST00000405727 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374174 | ENST00000356064 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-intron | ENST00000374174 | ENST00000511289 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000395611 | ENST00000451320 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000395611 | ENST00000429148 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000395611 | ENST00000353617 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000395611 | ENST00000405727 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000395611 | ENST00000356064 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-intron | ENST00000395611 | ENST00000511289 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000459755 | ENST00000451320 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000459755 | ENST00000429148 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000459755 | ENST00000353617 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000459755 | ENST00000405727 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000459755 | ENST00000356064 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-intron | ENST00000459755 | ENST00000511289 | MAPK8 | chr10 | 49514864 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374189 | ENST00000451320 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374189 | ENST00000429148 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374189 | ENST00000353617 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374189 | ENST00000405727 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374189 | ENST00000356064 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-intron | ENST00000374189 | ENST00000511289 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374182 | ENST00000451320 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374182 | ENST00000429148 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374182 | ENST00000353617 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374182 | ENST00000405727 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374182 | ENST00000356064 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-intron | ENST00000374182 | ENST00000511289 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000360332 | ENST00000451320 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000360332 | ENST00000429148 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000360332 | ENST00000353617 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000360332 | ENST00000405727 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000360332 | ENST00000356064 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-intron | ENST00000360332 | ENST00000511289 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374174 | ENST00000451320 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374174 | ENST00000429148 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374174 | ENST00000353617 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374174 | ENST00000405727 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000374174 | ENST00000356064 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-intron | ENST00000374174 | ENST00000511289 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000395611 | ENST00000451320 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000395611 | ENST00000429148 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000395611 | ENST00000353617 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000395611 | ENST00000405727 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000395611 | ENST00000356064 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-intron | ENST00000395611 | ENST00000511289 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000459755 | ENST00000451320 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000459755 | ENST00000429148 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000459755 | ENST00000353617 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000459755 | ENST00000405727 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-5UTR | ENST00000459755 | ENST00000356064 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
intron-intron | ENST00000459755 | ENST00000511289 | MAPK8 | chr10 | 49534008 | + | ARFIP1 | chr4 | 153750777 | + |
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FusionProtFeatures for MAPK8_ARFIP1 |
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Hgene | Tgene |
MAPK8 | ARFIP1 |
Putative target protein of ADP-ribosylation factor. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAPK8_ARFIP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAPK8_ARFIP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAPK8 | IRS1, DUSP10, TNFRSF10B, FADD, FASLG, BID, EZR, RHOA, ARHGDIA, FAS, MSN, CASP10, CASP8, TNFRSF1A, JUN, SPIB, SPI1, SH3BP5, MAP3K1, IKBKAP, PRKD1, ATF2, SPAG9, MAP2K4, CRK, BCAR1, SNCG, SNCA, JUND, SH2D3A, MAPK8IP1, MAPK8IP3, PAX2, PRKDC, TP53, REL, JUNB, DUSP16, ETV1, DUSP4, ELK1, DUSP1, MAP2K7, GSTP1, MYC, MAP3K2, PDPK1, NR4A1, CEBPA, CDKN1A, SIRT1, H2AFX, HDAC9, HDAC1, TFCP2, NFATC2, NFE2, PIAS2, ZNF605, DUSP8, FAM193B, BMPR2, PNRC1, HSPA8, CCDC88C, ZNF219, RBM15, SCAND1, STAT3, KRT8, NCOA3, CBL, FZR1, ITCH, RAD18, FLNB, RPTOR, MTOR, MAP3K7, TRAF2, MAP3K4, SP1, MAPK8, BCL2, MAP2K1, MAP2K2, CTNNB1, STAB2, CDKN1B, APP, HSF1, GORASP2, WDR62, DCP1A, IRF3, AIMP1, ELK4, BCL2L11, BMF, JKAMP, MAPKAP1, NFATC4, NFATC3, VRK2, CASP3, PKMYT1, SERPINB3, SERPINB4, CDKN2A, CDKN2C, RB1, ATF7, WWOX, MAPT, APLP2, GEMIN5, HIVEP1, CAMP, SSU72, SCOC, GARS, GFPT1, MKNK2, GUCY1A3, HSD17B4, ID2, RAF1, RPLP2, RPS6KB1, GANAB, C11orf57, MAPK9, NFE2L2, YWHAZ, EP300, EGFR, AKT1, CCT2, CCT3, CCT4, CCT6A, CCT8, NUP98, TCP1, TKT, SUN2, ATE1, KCNAB3, PPM1B, ANXA7, BCL7A, BLMH, CTSC, CSNK2A2, PSMD2, SF1, HIST2H2AA3, TJP2, COG2, PHLPP1, CRTC3, TAF1D, C2orf44, PRR3, STK11IP, RABL3, CDC42, BCL2L1, SMAD3, GPS1, GPS2, HRAS, MBP, VANGL2, LAMP3, MAPK14, BANP | ARFIP1 | ARF3, ARF1, ARF5, SLC2A4, ATP6V1C1, TBC1D15, TSNAX, YAP1, DNM1L, HIST1H4A, IDE, LUC7L2, PRMT3, PSMG3, SEC24A, SHMT2, STAT3, ARFIP2, PICK1, AACS, AKR1A1, ADSS, DPYSL2, G6PD, GART, HSD17B8, MVB12A, PFKM, PFKP, PPP3CA, PROSC, SARS, SEC24D, SHMT1, TSTA3, TXNDC9, USP14, ATOX1, ECH1, FLNB, LYPLA1, PAFAH1B2, PDCD6, PGM2L1, QDPR, STIP1, TBCA, DYNLT1, TMEM17, TMEM216, CDC5L, CDH1, CLPB, HSPA8, HSPBP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAPK8_ARFIP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAPK8_ARFIP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MAPK8 | C0011570 | Mental Depression | 2 | PSYGENET |
Hgene | MAPK8 | C0011581 | Depressive disorder | 2 | PSYGENET |
Hgene | MAPK8 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | MAPK8 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
Hgene | MAPK8 | C0020429 | Hyperalgesia | 1 | CTD_human |
Hgene | MAPK8 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Hgene | MAPK8 | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | MAPK8 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | MAPK8 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | MAPK8 | C0040997 | Trigeminal Neuralgia | 1 | CTD_human |
Hgene | MAPK8 | C0162557 | Liver Failure, Acute | 1 | CTD_human |