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Fusion gene ID: 21011 |
FusionGeneSummary for MAPK8IP3_TELO2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPK8IP3_TELO2 | Fusion gene ID: 21011 | Hgene | Tgene | Gene symbol | MAPK8IP3 | TELO2 | Gene ID | 23162 | 9894 |
| Gene name | mitogen-activated protein kinase 8 interacting protein 3 | telomere maintenance 2 | |
| Synonyms | JIP-3|JIP3|JSAP1|SYD2|syd | CLK2|TEL2|YHFS | |
| Cytomap | 16p13.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | C-Jun-amino-terminal kinase-interacting protein 3C-jun-amino-terminal kinase interacting protein 3JNK MAP kinase scaffold protein 3JNK-interacting protein 3JNK/SAPK-associated protein-1JNK/stress-activated protein kinase-associated protein 1homolog | telomere length regulation protein TEL2 homologTEL2, telomere maintenance 2, homologprotein clk-2 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UPT6 | Q9Y4R8 | |
| Ensembl transtripts involved in fusion gene | ENST00000250894, ENST00000356010, ENST00000568271, | ENST00000262319, ENST00000564507, | |
| Fusion gene scores | * DoF score | 8 X 8 X 4=256 | 3 X 3 X 2=18 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/256*10)=-1.50814690367033 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAPK8IP3 [Title/Abstract] AND TELO2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-HC-8265-01A | MAPK8IP3 | chr16 | 1813007 | + | TELO2 | chr16 | 1551664 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000250894 | ENST00000262319 | MAPK8IP3 | chr16 | 1813007 | + | TELO2 | chr16 | 1551664 | + |
| 5CDS-intron | ENST00000250894 | ENST00000564507 | MAPK8IP3 | chr16 | 1813007 | + | TELO2 | chr16 | 1551664 | + |
| In-frame | ENST00000356010 | ENST00000262319 | MAPK8IP3 | chr16 | 1813007 | + | TELO2 | chr16 | 1551664 | + |
| 5CDS-intron | ENST00000356010 | ENST00000564507 | MAPK8IP3 | chr16 | 1813007 | + | TELO2 | chr16 | 1551664 | + |
| intron-3CDS | ENST00000568271 | ENST00000262319 | MAPK8IP3 | chr16 | 1813007 | + | TELO2 | chr16 | 1551664 | + |
| intron-intron | ENST00000568271 | ENST00000564507 | MAPK8IP3 | chr16 | 1813007 | + | TELO2 | chr16 | 1551664 | + |
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FusionProtFeatures for MAPK8IP3_TELO2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPK8IP3 | TELO2 |
| The JNK-interacting protein (JIP) group of scaffoldproteins selectively mediates JNK signaling by aggregatingspecific components of the MAPK cascade to form a functional JNKsignaling module. May function as a regulator of vesicletransport, through interactions with the JNK-signaling componentsand motor proteins (By similarity). {ECO:0000250|UniProtKB:Q9ESN9,ECO:0000269|PubMed:12189133}. | Regulator of the DNA damage response (DDR). Part of theTTT complex that is required to stabilize protein levels of thephosphatidylinositol 3-kinase-related protein kinase (PIKK) familyproteins. The TTT complex is involved in the cellular resistanceto DNA damage stresses, like ionizing radiation (IR), ultraviolet(UV) and mitomycin C (MMC). Together with the TTT complex andHSP90 may participate in the proper folding of newly synthesizedPIKKs. Promotes assembly, stabilizes and maintains the activity ofmTORC1 and mTORC2 complexes, which regulate cell growth andsurvival in response to nutrient and hormonal signals. May beinvolved in telomere length regulation.{ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAPK8IP3 | chr16:1813007 | chr16:1551664 | ENST00000250894 | + | 16 | 32 | 440_554 | 631 | 1337 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MAPK8IP3 | chr16:1813007 | chr16:1551664 | ENST00000250894 | + | 16 | 32 | 58_177 | 631 | 1337 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MAPK8IP3 | chr16:1813007 | chr16:1551664 | ENST00000250894 | + | 16 | 32 | 12_100 | 631 | 1337 | Domain | RH1 |
| Hgene | MAPK8IP3 | chr16:1813007 | chr16:1551664 | ENST00000250894 | + | 16 | 32 | 520_594 | 631 | 1337 | Domain | RH2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAPK8IP3_TELO2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MAPK8IP3_ENST00000250894_chr16_1813007_+_TELO2_ENST00000262319_chr16_1551664_+_1016aa MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQL LTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTG TKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQ LSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTTAGFSQRRNHAMCPISAGSRPLEFFP DDTSLVPATAEPPAETPAEIVDGGVPQAQLAGSDSDLDSDDEFVPYDMSGDRELKSSKAPAYVRDCVEALTTSEDIERWEAALRALEGLV YRSPTATREVSVELAKVLLHLEEKTCVVGFAGLRQRALVAVTVTDPAPVADYLTSQFYALNYSLRQRMDILDVLTLAAQELSRPGCLGRT PQPGSPSPNTPCLPEAAVSQPGSAVASDWRVVVEERIRSKTQRLSKGGPRQGPAGSPSRFNSVAGHFFFPLLQRFDRPLVTFDLLGEDQL VLGRLAHTLGALMCLAVNTTVAVAMGKALLEFVWALRFHIDAYVRQGLLSAVSSVLLSLPAARLLEDLMDELLEARSWLADVAEKDPDED >In-frame_MAPK8IP3_ENST00000356010_chr16_1813007_+_TELO2_ENST00000262319_chr16_1551664_+_1010aa MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQL LTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTG TKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQE VLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQ EAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDTSLV PATAEPPAETPAEIVDGGVPQAQLAGSDSDLDSDDEFVPYDMSGDRELKSSKAPAYVRDCVEALTTSEDIERWEAALRALEGLVYRSPTA TREVSVELAKVLLHLEEKTCVVGFAGLRQRALVAVTVTDPAPVADYLTSQFYALNYSLRQRMDILDVLTLAAQELSRPGCLGRTPQPGSP SPNTPCLPEAAVSQPGSAVASDWRVVVEERIRSKTQRLSKGGPRQGPAGSPSRFNSVAGHFFFPLLQRFDRPLVTFDLLGEDQLVLGRLA HTLGALMCLAVNTTVAVAMGKALLEFVWALRFHIDAYVRQGLLSAVSSVLLSLPAARLLEDLMDELLEARSWLADVAEKDPDEDCRTLAL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MAPK8IP3_ENST00000250894_chr16_1813007_+_TELO2_ENST00000262319_chr16_1551664_+_3048nt ATGATGGAGATCCAGATGGACGAGGGCGGCGGCGTGGTGGTGTACCAGGACGACTACTGCTCCGGCTCGGTGATGTCGGAGCGGGTGTCG GGCCTGGCGGGCTCCATCTACCGCGAGTTCGAGCGCCTCATCCACTGCTACGACGAGGAGGTGGTCAAGGAGCTCATGCCGCTGGTGGTG AACGTGCTGGAGAACCTAGACTCGGTGCTCAGCGAGAACCAGGAGCACGAGGTGGAGCTGGAGCTGCTGCGCGAGGACAACGAGCAGCTG CTCACCCAGTACGAGCGTGAGAAGGCGCTGCGCAGGCAGGCGGAGGAGAAATTCATTGAGTTTGAAGATGCTCTGGAACAAGAGAAGAAA GAGCTGCAAATCCAGGTGGAGCACTACGAGTTCCAGACGCGCCAGCTGGAGCTGAAGGCCAAGAACTATGCCGATCAGATTTCCCGGTTG GAGGAGCGGGAGTCGGAGATGAAGAAGGAGTACAATGCCCTGCACCAGCGGCACACAGAGATGATACAGACCTACGTGGAGCACATTGAG AGGTCCAAGATGCAGCAGGTCGGAGGAAACAGCCAGACCGAGAGCAGCCTGCCGGGGCGGAGGAAGGAGCGCCCCACCTCCCTGAACGTG TTCCCCCTGGCTGACGGCACGGTACGTGCACAGATCGGGGGCAAGCTCGTGCCTGCGGGGGACCACTGGCACCTGAGTGACCTCGGCCAG CTGCAGTCCAGCTCCAGCTACCAGTGTCCACAGGATGAAATGTCCGAGTCAGGCCAGTCCTCGGCGGCCGCCACACCCAGCACCACAGGC ACCAAGTCCAACACGCCCACATCCTCCGTGCCCTCGGCCGCCGTCACACCCCTCAACGAGAGCCTGCAGCCCCTGGGGGACTATGGCGTG GGCTCCAAGAACAGCAAGCGTGCCCGGGAGAAGCGCGACAGCCGCAACATGGAAGTACAGGTCACCCAGGAGATGCGCAACGTCAGTATA GGCATGGGCAGCAGTGACGAGTGGTCTGATGTTCAAGACATTATTGACTCCACGCCAGAGCTGGACATGTGTCCAGAGACCCGCCTGGAC CGCACAGGAAGCAGCCCAACCCAGGGCATCGTGAACAAAGCTTTCGGCATCAACACCGACTCCCTGTACCATGAGCTGTCGACGGCAGGG TCTGAGGTCATCGGGGATGTGGACGAAGGGGCCGACCTCCTAGGGGAGTTCTCAGTGCGCGATGATTTCTTTGGAATGGGCAAAGAAGTG GGGAATCTGCTACTGGAAAACTCACAGCTTCTGGAAACCAAAAACGCCTTGAATGTGGTGAAGAATGACCTGATTGCCAAGGTCGACCAG CTGTCCGGGGAGCAGGAGGTGCTGAGGGGCGAGTTGGAGGCTGCTAAGCAGGCCAAAGTCAAGCTGGAAAACCGTATCAAGGAGCTGGAA GAGGAACTGAAAAGAGTGAAGTCCGAGGCCATCATCGCCCGCCGTGAACCCAAAGAAGAGGCGGAGGATGTAAGCAGCTATCTCTGTACA GAATCGGACAAAATCCCCATGGCCCAGCGCCGCCGCTTCACGCGGGTGGAGATGGCCCGTGTGCTCATGGAGCGGAACCAGTACAAGGAG CGGCTGATGGAGCTGCAGGAGGCTGTGCGGTGGACTGAGATGATCAGAGCGTCCCGAGAGCACCCATCCGTCCAGGAGAAGAAGAAGTCG ACCATCTGGCAGTTCTTCAGCCGCCTCTTCAGCTCTTCCTCCAGCCCCCCTCCGGCCAAGCGCCCCTATCCCTCGGTGAACATCCACTAC AAGTCACCCACCACTGCCGGCTTCAGCCAGCGCCGCAACCATGCCATGTGCCCGATCTCGGCAGGCAGCCGGCCCCTGGAATTCTTCCCT GACGACACGTCCCTCGTTCCAGCCACGGCAGAGCCCCCTGCAGAGACCCCCGCAGAGATCGTGGATGGCGGCGTCCCCCAAGCACAGCTG GCGGGCTCTGACTCGGACCTGGACAGCGATGATGAGTTTGTCCCCTACGACATGTCGGGGGACAGAGAGCTGAAGAGCAGCAAGGCTCCT GCCTACGTCCGGGACTGCGTGGAAGCCCTGACCACGTCTGAGGACATAGAGCGCTGGGAGGCAGCCCTGCGGGCCCTTGAGGGCCTGGTC TACAGGAGCCCCACAGCCACTCGGGAGGTGAGCGTGGAGCTGGCCAAGGTGCTTCTGCATCTGGAGGAGAAGACCTGTGTGGTGGGATTT GCAGGGCTGCGCCAGAGAGCCCTGGTGGCCGTCACGGTCACAGACCCGGCCCCGGTGGCCGACTATCTGACCTCACAGTTCTATGCCCTC AACTACAGCCTCCGGCAGCGCATGGACATCCTGGATGTGCTGACTCTGGCTGCCCAGGAGCTGTCTAGGCCTGGGTGCCTCGGGAGGACT CCCCAACCTGGCTCCCCAAGTCCCAACACCCCGTGCCTGCCAGAGGCAGCCGTCTCTCAGCCTGGCAGTGCCGTGGCGTCTGACTGGCGG GTGGTGGTGGAGGAGCGGATCAGAAGCAAGACCCAGCGGCTCTCCAAGGGTGGCCCGAGGCAGGGCCCGGCAGGCAGCCCCAGCAGATTC AACTCCGTGGCCGGCCACTTCTTCTTCCCCCTCCTTCAGCGCTTTGACAGGCCTCTGGTGACCTTCGACCTCTTGGGAGAAGACCAGCTG GTTCTCGGAAGGCTGGCGCACACCTTAGGGGCCCTGATGTGCCTGGCTGTTAACACCACGGTGGCTGTGGCCATGGGCAAGGCCCTGCTG GAATTCGTGTGGGCCCTTCGCTTCCACATCGATGCCTACGTGCGCCAGGGGCTGTTGTCGGCCGTCTCCTCCGTCCTGCTCAGCCTGCCT GCTGCGCGCCTGCTGGAGGACCTGATGGACGAGCTGCTGGAAGCCCGGTCCTGGCTGGCGGACGTGGCTGAGAAAGACCCGGACGAGGAC >In-frame_MAPK8IP3_ENST00000356010_chr16_1813007_+_TELO2_ENST00000262319_chr16_1551664_+_3030nt ATGATGGAGATCCAGATGGACGAGGGCGGCGGCGTGGTGGTGTACCAGGACGACTACTGCTCCGGCTCGGTGATGTCGGAGCGGGTGTCG GGCCTGGCGGGCTCCATCTACCGCGAGTTCGAGCGCCTCATCCACTGCTACGACGAGGAGGTGGTCAAGGAGCTCATGCCGCTGGTGGTG AACGTGCTGGAGAACCTAGACTCGGTGCTCAGCGAGAACCAGGAGCACGAGGTGGAGCTGGAGCTGCTGCGCGAGGACAACGAGCAGCTG CTCACCCAGTACGAGCGTGAGAAGGCGCTGCGCAGGCAGGCGGAGGAGAAATTCATTGAGTTTGAAGATGCTCTGGAACAAGAGAAGAAA GAGCTGCAAATCCAGGTGGAGCACTACGAGTTCCAGACGCGCCAGCTGGAGCTGAAGGCCAAGAACTATGCCGATCAGATTTCCCGGTTG GAGGAGCGGGAGTCGGAGATGAAGAAGGAGTACAATGCCCTGCACCAGCGGCACACAGAGATGATACAGACCTACGTGGAGCACATTGAG AGGTCCAAGATGCAGCAGGTCGGAGGAAACAGCCAGACCGAGAGCAGCCTGCCGGGGCGGAGGAAGGAGCGCCCCACCTCCCTGAACGTG TTCCCCCTGGCTGACGGCACGGTACGTGCACAGATCGGGGGCAAGCTCGTGCCTGCGGGGGACCACTGGCACCTGAGTGACCTCGGCCAG CTGCAGTCCAGCTCCAGCTACCAGTGTCCACAGGATGAAATGTCCGAGTCAGGCCAGTCCTCGGCGGCCGCCACACCCAGCACCACAGGC ACCAAGTCCAACACGCCCACATCCTCCGTGCCCTCGGCCGCCGTCACACCCCTCAACGAGAGCCTGCAGCCCCTGGGGGACTATGGCGTG GGCTCCAAGAACAGCAAGCGTGCCCGGGAGAAGCGCGACAGCCGCAACATGGAAGTACAGGTCACCCAGGAGATGCGCAACGTCAGTATA GGCATGGGCAGCAGTGACGAGTGGTCTGATGTTCAAGACATTATTGACTCCACGCCAGAGCTGGACATGTGTCCAGAGACCCGCCTGGAC CGCACAGGAAGCAGCCCAACCCAGGGCATCGTGAACAAAGCTTTCGGCATCAACACCGACTCCCTGTACCATGAGCTGTCGACGGCAGGG TCTGAGGTCATCGGGGATGTGGACGAAGGGGCCGACCTCCTAGGGGAGTTCTCAGGAATGGGCAAAGAAGTGGGGAATCTGCTACTGGAA AACTCACAGCTTCTGGAAACCAAAAACGCCTTGAATGTGGTGAAGAATGACCTGATTGCCAAGGTCGACCAGCTGTCCGGGGAGCAGGAG GTGCTGAGGGGCGAGTTGGAGGCTGCTAAGCAGGCCAAAGTCAAGCTGGAAAACCGTATCAAGGAGCTGGAAGAGGAACTGAAAAGAGTG AAGTCCGAGGCCATCATCGCCCGCCGTGAACCCAAAGAAGAGGCGGAGGATGTAAGCAGCTATCTCTGTACAGAATCGGACAAAATCCCC ATGGCCCAGCGCCGCCGCTTCACGCGGGTGGAGATGGCCCGTGTGCTCATGGAGCGGAACCAGTACAAGGAGCGGCTGATGGAGCTGCAG GAGGCTGTGCGGTGGACTGAGATGATCAGAGCGTCCCGAGAGCACCCATCCGTCCAGGAGAAGAAGAAGTCGACCATCTGGCAGTTCTTC AGCCGCCTCTTCAGCTCTTCCTCCAGCCCCCCTCCGGCCAAGCGCCCCTATCCCTCGGTGAACATCCACTACAAGTCACCCACCACTGCC GGCTTCAGCCAGCGCCGCAACCATGCCATGTGCCCGATCTCGGCAGGCAGCCGGCCCCTGGAATTCTTCCCTGACGACACGTCCCTCGTT CCAGCCACGGCAGAGCCCCCTGCAGAGACCCCCGCAGAGATCGTGGATGGCGGCGTCCCCCAAGCACAGCTGGCGGGCTCTGACTCGGAC CTGGACAGCGATGATGAGTTTGTCCCCTACGACATGTCGGGGGACAGAGAGCTGAAGAGCAGCAAGGCTCCTGCCTACGTCCGGGACTGC GTGGAAGCCCTGACCACGTCTGAGGACATAGAGCGCTGGGAGGCAGCCCTGCGGGCCCTTGAGGGCCTGGTCTACAGGAGCCCCACAGCC ACTCGGGAGGTGAGCGTGGAGCTGGCCAAGGTGCTTCTGCATCTGGAGGAGAAGACCTGTGTGGTGGGATTTGCAGGGCTGCGCCAGAGA GCCCTGGTGGCCGTCACGGTCACAGACCCGGCCCCGGTGGCCGACTATCTGACCTCACAGTTCTATGCCCTCAACTACAGCCTCCGGCAG CGCATGGACATCCTGGATGTGCTGACTCTGGCTGCCCAGGAGCTGTCTAGGCCTGGGTGCCTCGGGAGGACTCCCCAACCTGGCTCCCCA AGTCCCAACACCCCGTGCCTGCCAGAGGCAGCCGTCTCTCAGCCTGGCAGTGCCGTGGCGTCTGACTGGCGGGTGGTGGTGGAGGAGCGG ATCAGAAGCAAGACCCAGCGGCTCTCCAAGGGTGGCCCGAGGCAGGGCCCGGCAGGCAGCCCCAGCAGATTCAACTCCGTGGCCGGCCAC TTCTTCTTCCCCCTCCTTCAGCGCTTTGACAGGCCTCTGGTGACCTTCGACCTCTTGGGAGAAGACCAGCTGGTTCTCGGAAGGCTGGCG CACACCTTAGGGGCCCTGATGTGCCTGGCTGTTAACACCACGGTGGCTGTGGCCATGGGCAAGGCCCTGCTGGAATTCGTGTGGGCCCTT CGCTTCCACATCGATGCCTACGTGCGCCAGGGGCTGTTGTCGGCCGTCTCCTCCGTCCTGCTCAGCCTGCCTGCTGCGCGCCTGCTGGAG GACCTGATGGACGAGCTGCTGGAAGCCCGGTCCTGGCTGGCGGACGTGGCTGAGAAAGACCCGGACGAGGACTGCAGGACGCTGGCACTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MAPK8IP3_ENST00000250894_chr16_1813007_+_TELO2_ENST00000262319_chr16_1551664_+_3726nt AGTGACGGGCGCAGCCTCGGCAGCGGCGGCGGCGGAGCCCTGAGGCGACAGCAGCTGCGGGAGGCGACGGGCTGCGGCCTGCGGAACCTG AGGCAGCTGGGGAGGGCCGGGCGCGCCGGCCGGATAGCGAGCCGCGCTGGCGGCGGCGGTGGCCGCGATGATGGAGATCCAGATGGACGA GGGCGGCGGCGTGGTGGTGTACCAGGACGACTACTGCTCCGGCTCGGTGATGTCGGAGCGGGTGTCGGGCCTGGCGGGCTCCATCTACCG CGAGTTCGAGCGCCTCATCCACTGCTACGACGAGGAGGTGGTCAAGGAGCTCATGCCGCTGGTGGTGAACGTGCTGGAGAACCTAGACTC GGTGCTCAGCGAGAACCAGGAGCACGAGGTGGAGCTGGAGCTGCTGCGCGAGGACAACGAGCAGCTGCTCACCCAGTACGAGCGTGAGAA GGCGCTGCGCAGGCAGGCGGAGGAGAAATTCATTGAGTTTGAAGATGCTCTGGAACAAGAGAAGAAAGAGCTGCAAATCCAGGTGGAGCA CTACGAGTTCCAGACGCGCCAGCTGGAGCTGAAGGCCAAGAACTATGCCGATCAGATTTCCCGGTTGGAGGAGCGGGAGTCGGAGATGAA GAAGGAGTACAATGCCCTGCACCAGCGGCACACAGAGATGATACAGACCTACGTGGAGCACATTGAGAGGTCCAAGATGCAGCAGGTCGG AGGAAACAGCCAGACCGAGAGCAGCCTGCCGGGGCGGAGGAAGGAGCGCCCCACCTCCCTGAACGTGTTCCCCCTGGCTGACGGCACGGT ACGTGCACAGATCGGGGGCAAGCTCGTGCCTGCGGGGGACCACTGGCACCTGAGTGACCTCGGCCAGCTGCAGTCCAGCTCCAGCTACCA GTGTCCACAGGATGAAATGTCCGAGTCAGGCCAGTCCTCGGCGGCCGCCACACCCAGCACCACAGGCACCAAGTCCAACACGCCCACATC CTCCGTGCCCTCGGCCGCCGTCACACCCCTCAACGAGAGCCTGCAGCCCCTGGGGGACTATGGCGTGGGCTCCAAGAACAGCAAGCGTGC CCGGGAGAAGCGCGACAGCCGCAACATGGAAGTACAGGTCACCCAGGAGATGCGCAACGTCAGTATAGGCATGGGCAGCAGTGACGAGTG GTCTGATGTTCAAGACATTATTGACTCCACGCCAGAGCTGGACATGTGTCCAGAGACCCGCCTGGACCGCACAGGAAGCAGCCCAACCCA GGGCATCGTGAACAAAGCTTTCGGCATCAACACCGACTCCCTGTACCATGAGCTGTCGACGGCAGGGTCTGAGGTCATCGGGGATGTGGA CGAAGGGGCCGACCTCCTAGGGGAGTTCTCAGTGCGCGATGATTTCTTTGGAATGGGCAAAGAAGTGGGGAATCTGCTACTGGAAAACTC ACAGCTTCTGGAAACCAAAAACGCCTTGAATGTGGTGAAGAATGACCTGATTGCCAAGGTCGACCAGCTGTCCGGGGAGCAGGAGGTGCT GAGGGGCGAGTTGGAGGCTGCTAAGCAGGCCAAAGTCAAGCTGGAAAACCGTATCAAGGAGCTGGAAGAGGAACTGAAAAGAGTGAAGTC CGAGGCCATCATCGCCCGCCGTGAACCCAAAGAAGAGGCGGAGGATGTAAGCAGCTATCTCTGTACAGAATCGGACAAAATCCCCATGGC CCAGCGCCGCCGCTTCACGCGGGTGGAGATGGCCCGTGTGCTCATGGAGCGGAACCAGTACAAGGAGCGGCTGATGGAGCTGCAGGAGGC TGTGCGGTGGACTGAGATGATCAGAGCGTCCCGAGAGCACCCATCCGTCCAGGAGAAGAAGAAGTCGACCATCTGGCAGTTCTTCAGCCG CCTCTTCAGCTCTTCCTCCAGCCCCCCTCCGGCCAAGCGCCCCTATCCCTCGGTGAACATCCACTACAAGTCACCCACCACTGCCGGCTT CAGCCAGCGCCGCAACCATGCCATGTGCCCGATCTCGGCAGGCAGCCGGCCCCTGGAATTCTTCCCTGACGACACGTCCCTCGTTCCAGC CACGGCAGAGCCCCCTGCAGAGACCCCCGCAGAGATCGTGGATGGCGGCGTCCCCCAAGCACAGCTGGCGGGCTCTGACTCGGACCTGGA CAGCGATGATGAGTTTGTCCCCTACGACATGTCGGGGGACAGAGAGCTGAAGAGCAGCAAGGCTCCTGCCTACGTCCGGGACTGCGTGGA AGCCCTGACCACGTCTGAGGACATAGAGCGCTGGGAGGCAGCCCTGCGGGCCCTTGAGGGCCTGGTCTACAGGAGCCCCACAGCCACTCG GGAGGTGAGCGTGGAGCTGGCCAAGGTGCTTCTGCATCTGGAGGAGAAGACCTGTGTGGTGGGATTTGCAGGGCTGCGCCAGAGAGCCCT GGTGGCCGTCACGGTCACAGACCCGGCCCCGGTGGCCGACTATCTGACCTCACAGTTCTATGCCCTCAACTACAGCCTCCGGCAGCGCAT GGACATCCTGGATGTGCTGACTCTGGCTGCCCAGGAGCTGTCTAGGCCTGGGTGCCTCGGGAGGACTCCCCAACCTGGCTCCCCAAGTCC CAACACCCCGTGCCTGCCAGAGGCAGCCGTCTCTCAGCCTGGCAGTGCCGTGGCGTCTGACTGGCGGGTGGTGGTGGAGGAGCGGATCAG AAGCAAGACCCAGCGGCTCTCCAAGGGTGGCCCGAGGCAGGGCCCGGCAGGCAGCCCCAGCAGATTCAACTCCGTGGCCGGCCACTTCTT CTTCCCCCTCCTTCAGCGCTTTGACAGGCCTCTGGTGACCTTCGACCTCTTGGGAGAAGACCAGCTGGTTCTCGGAAGGCTGGCGCACAC CTTAGGGGCCCTGATGTGCCTGGCTGTTAACACCACGGTGGCTGTGGCCATGGGCAAGGCCCTGCTGGAATTCGTGTGGGCCCTTCGCTT CCACATCGATGCCTACGTGCGCCAGGGGCTGTTGTCGGCCGTCTCCTCCGTCCTGCTCAGCCTGCCTGCTGCGCGCCTGCTGGAGGACCT GATGGACGAGCTGCTGGAAGCCCGGTCCTGGCTGGCGGACGTGGCTGAGAAAGACCCGGACGAGGACTGCAGGACGCTGGCACTGAGGGC CCTGCTGCTTCTGCAGAGACTCAAGAACAGGCTCCTCCCACCCGCGTCTCCCTAGTCCCTGGAGGCCTCCCCAGGACCACCCTCGCCGAC AGCAAGGCAGGCGGCTGAGCAGCGGCCTGGAGCAGCAGAGCCAGGCTTTGTAGCGAGGCCAGGTCTTCGGCCGCATCCGGTACGGAGAGT GCAGATGCAGGAAGGCCCGGCCTGCCGCTATTTATAGTGCAGCCAGTCCGCTAAAAATACACTGGGCCTGGGCACTGCCCGCCGGGACAT GGCAGCCTGGACGTGGGGCTGGGGCTGTGGGCGCTGCTGGCGGGGTTGACTCTTCCAGTGAGGGCAGAACCAGGCTGGCAGGAGGGGAGG ACGGTGTACCTGCTGCTCAGAGCCCCCAAGGCTCTCCTCTGAGAGCCACCAAGCAGGACAGAGCAGCTCTTGTCCCAGGTCCCTCGGGCT GAGCGCCGTGTCACCAGGAGAATAGTGCTCACAGCCCAGGCAGGGTGTGTGGCTCCTGGATGGGCTCGTGGGGCGGGATGGGACAGGGCA >In-frame_MAPK8IP3_ENST00000356010_chr16_1813007_+_TELO2_ENST00000262319_chr16_1551664_+_3698nt GCAGCCTCGGCAGCGGCGGCGGCGGAGCCCTGAGGCGACAGCAGCTGCGGGAGGCGACGGGCTGCGGCCTGCGGAACCTGAGGCAGCTGG GGAGGGCCGGGCGCGCCGGCCGGATAGCGAGCCGCGCTGGCGGCGGCGGTGGCCGCGATGATGGAGATCCAGATGGACGAGGGCGGCGGC GTGGTGGTGTACCAGGACGACTACTGCTCCGGCTCGGTGATGTCGGAGCGGGTGTCGGGCCTGGCGGGCTCCATCTACCGCGAGTTCGAG CGCCTCATCCACTGCTACGACGAGGAGGTGGTCAAGGAGCTCATGCCGCTGGTGGTGAACGTGCTGGAGAACCTAGACTCGGTGCTCAGC GAGAACCAGGAGCACGAGGTGGAGCTGGAGCTGCTGCGCGAGGACAACGAGCAGCTGCTCACCCAGTACGAGCGTGAGAAGGCGCTGCGC AGGCAGGCGGAGGAGAAATTCATTGAGTTTGAAGATGCTCTGGAACAAGAGAAGAAAGAGCTGCAAATCCAGGTGGAGCACTACGAGTTC CAGACGCGCCAGCTGGAGCTGAAGGCCAAGAACTATGCCGATCAGATTTCCCGGTTGGAGGAGCGGGAGTCGGAGATGAAGAAGGAGTAC AATGCCCTGCACCAGCGGCACACAGAGATGATACAGACCTACGTGGAGCACATTGAGAGGTCCAAGATGCAGCAGGTCGGAGGAAACAGC CAGACCGAGAGCAGCCTGCCGGGGCGGAGGAAGGAGCGCCCCACCTCCCTGAACGTGTTCCCCCTGGCTGACGGCACGGTACGTGCACAG ATCGGGGGCAAGCTCGTGCCTGCGGGGGACCACTGGCACCTGAGTGACCTCGGCCAGCTGCAGTCCAGCTCCAGCTACCAGTGTCCACAG GATGAAATGTCCGAGTCAGGCCAGTCCTCGGCGGCCGCCACACCCAGCACCACAGGCACCAAGTCCAACACGCCCACATCCTCCGTGCCC TCGGCCGCCGTCACACCCCTCAACGAGAGCCTGCAGCCCCTGGGGGACTATGGCGTGGGCTCCAAGAACAGCAAGCGTGCCCGGGAGAAG CGCGACAGCCGCAACATGGAAGTACAGGTCACCCAGGAGATGCGCAACGTCAGTATAGGCATGGGCAGCAGTGACGAGTGGTCTGATGTT CAAGACATTATTGACTCCACGCCAGAGCTGGACATGTGTCCAGAGACCCGCCTGGACCGCACAGGAAGCAGCCCAACCCAGGGCATCGTG AACAAAGCTTTCGGCATCAACACCGACTCCCTGTACCATGAGCTGTCGACGGCAGGGTCTGAGGTCATCGGGGATGTGGACGAAGGGGCC GACCTCCTAGGGGAGTTCTCAGGAATGGGCAAAGAAGTGGGGAATCTGCTACTGGAAAACTCACAGCTTCTGGAAACCAAAAACGCCTTG AATGTGGTGAAGAATGACCTGATTGCCAAGGTCGACCAGCTGTCCGGGGAGCAGGAGGTGCTGAGGGGCGAGTTGGAGGCTGCTAAGCAG GCCAAAGTCAAGCTGGAAAACCGTATCAAGGAGCTGGAAGAGGAACTGAAAAGAGTGAAGTCCGAGGCCATCATCGCCCGCCGTGAACCC AAAGAAGAGGCGGAGGATGTAAGCAGCTATCTCTGTACAGAATCGGACAAAATCCCCATGGCCCAGCGCCGCCGCTTCACGCGGGTGGAG ATGGCCCGTGTGCTCATGGAGCGGAACCAGTACAAGGAGCGGCTGATGGAGCTGCAGGAGGCTGTGCGGTGGACTGAGATGATCAGAGCG TCCCGAGAGCACCCATCCGTCCAGGAGAAGAAGAAGTCGACCATCTGGCAGTTCTTCAGCCGCCTCTTCAGCTCTTCCTCCAGCCCCCCT CCGGCCAAGCGCCCCTATCCCTCGGTGAACATCCACTACAAGTCACCCACCACTGCCGGCTTCAGCCAGCGCCGCAACCATGCCATGTGC CCGATCTCGGCAGGCAGCCGGCCCCTGGAATTCTTCCCTGACGACACGTCCCTCGTTCCAGCCACGGCAGAGCCCCCTGCAGAGACCCCC GCAGAGATCGTGGATGGCGGCGTCCCCCAAGCACAGCTGGCGGGCTCTGACTCGGACCTGGACAGCGATGATGAGTTTGTCCCCTACGAC ATGTCGGGGGACAGAGAGCTGAAGAGCAGCAAGGCTCCTGCCTACGTCCGGGACTGCGTGGAAGCCCTGACCACGTCTGAGGACATAGAG CGCTGGGAGGCAGCCCTGCGGGCCCTTGAGGGCCTGGTCTACAGGAGCCCCACAGCCACTCGGGAGGTGAGCGTGGAGCTGGCCAAGGTG CTTCTGCATCTGGAGGAGAAGACCTGTGTGGTGGGATTTGCAGGGCTGCGCCAGAGAGCCCTGGTGGCCGTCACGGTCACAGACCCGGCC CCGGTGGCCGACTATCTGACCTCACAGTTCTATGCCCTCAACTACAGCCTCCGGCAGCGCATGGACATCCTGGATGTGCTGACTCTGGCT GCCCAGGAGCTGTCTAGGCCTGGGTGCCTCGGGAGGACTCCCCAACCTGGCTCCCCAAGTCCCAACACCCCGTGCCTGCCAGAGGCAGCC GTCTCTCAGCCTGGCAGTGCCGTGGCGTCTGACTGGCGGGTGGTGGTGGAGGAGCGGATCAGAAGCAAGACCCAGCGGCTCTCCAAGGGT GGCCCGAGGCAGGGCCCGGCAGGCAGCCCCAGCAGATTCAACTCCGTGGCCGGCCACTTCTTCTTCCCCCTCCTTCAGCGCTTTGACAGG CCTCTGGTGACCTTCGACCTCTTGGGAGAAGACCAGCTGGTTCTCGGAAGGCTGGCGCACACCTTAGGGGCCCTGATGTGCCTGGCTGTT AACACCACGGTGGCTGTGGCCATGGGCAAGGCCCTGCTGGAATTCGTGTGGGCCCTTCGCTTCCACATCGATGCCTACGTGCGCCAGGGG CTGTTGTCGGCCGTCTCCTCCGTCCTGCTCAGCCTGCCTGCTGCGCGCCTGCTGGAGGACCTGATGGACGAGCTGCTGGAAGCCCGGTCC TGGCTGGCGGACGTGGCTGAGAAAGACCCGGACGAGGACTGCAGGACGCTGGCACTGAGGGCCCTGCTGCTTCTGCAGAGACTCAAGAAC AGGCTCCTCCCACCCGCGTCTCCCTAGTCCCTGGAGGCCTCCCCAGGACCACCCTCGCCGACAGCAAGGCAGGCGGCTGAGCAGCGGCCT GGAGCAGCAGAGCCAGGCTTTGTAGCGAGGCCAGGTCTTCGGCCGCATCCGGTACGGAGAGTGCAGATGCAGGAAGGCCCGGCCTGCCGC TATTTATAGTGCAGCCAGTCCGCTAAAAATACACTGGGCCTGGGCACTGCCCGCCGGGACATGGCAGCCTGGACGTGGGGCTGGGGCTGT GGGCGCTGCTGGCGGGGTTGACTCTTCCAGTGAGGGCAGAACCAGGCTGGCAGGAGGGGAGGACGGTGTACCTGCTGCTCAGAGCCCCCA AGGCTCTCCTCTGAGAGCCACCAAGCAGGACAGAGCAGCTCTTGTCCCAGGTCCCTCGGGCTGAGCGCCGTGTCACCAGGAGAATAGTGC TCACAGCCCAGGCAGGGTGTGTGGCTCCTGGATGGGCTCGTGGGGCGGGATGGGACAGGGCACGGGCTCTCAGAAAATAAACTGCTTTAT |
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FusionGenePPI for MAPK8IP3_TELO2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAPK8IP3 | KLC1, MAPK10, ARL4D, RIC8A, PTK2, SRC, MAP2K1, RAF1, MAPK8, MAPK9, MAP2K4, MAP3K1, MAP2K7, MAP3K11, MAPK8IP2, KLC2, MAP3K5, ALK, KAT2A, BCL6, MAP2K3, KIF1A, NTRK1, RAD51, TNKS2, MAPK8IP1, SPAG9, RCCD1, SMCO1, TNKS, DCTN6, ACTR10, WDR54, DCTN4 | TELO2 | PSMD6, MAGED1, RUVBL2, TTI1, ATM, ATR, PRKDC, SMG1, TRRAP, CLN3, RUVBL1, RPAP3, HSPA4, DNAJB1, TTI2, MTOR, CACNA1A, PIDD1, TPM4, AK2, CORO1B, VCP, EGFR, COPB2, COPG1, PIH1D1, RUFY1, SMEK1, BSG, HTR6, NTRK1, KRT15, XPO1, APC, CRKL, DSP, MASTL, SENP3, PTPRN2, C5AR2, NPY2R, CHRM3, WDR92, C19orf40, FANCM, ATRIP, TOPBP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAPK8IP3_TELO2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAPK8IP3_TELO2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MAPK8IP3 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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