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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21002

FusionGeneSummary for MAPK6_USO1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK6_USO1
Fusion gene ID: 21002
HgeneTgene
Gene symbol

MAPK6

USO1

Gene ID

5597

8615

Gene namemitogen-activated protein kinase 6USO1 vesicle transport factor
SynonymsERK3|HsT17250|PRKM6|p97MAPKP115|TAP|VDP
Cytomap

15q21.2

4q21.1

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 6ERK-3MAP kinase 6MAP kinase isoform p97MAPK 6extracellular signal-regulated kinase 3extracellular signal-regulated kinase, p97p97-MAPKprotein kinase, mitogen-activated 5protein kinase, mitogen-activated 6general vesicular transport factor p115USO1 vesicle docking protein homologtranscytosis associated proteinvesicle docking protein p115
Modification date2018052320180523
UniProtAcc

Q16659

O60763

Ensembl transtripts involved in fusion geneENST00000261845, ENST00000558841, 
ENST00000538159, ENST00000514213, 
Fusion gene scores* DoF score3 X 1 X 3=94 X 4 X 3=48
# samples 45
** MAII scorelog2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAPK6 [Title/Abstract] AND USO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-C8-A12P-01AMAPK6chr15

52311573

+USO1chr4

76731585

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000261845ENST00000538159MAPK6chr15

52311573

+USO1chr4

76731585

+
5UTR-3CDSENST00000261845ENST00000514213MAPK6chr15

52311573

+USO1chr4

76731585

+
intron-3CDSENST00000558841ENST00000538159MAPK6chr15

52311573

+USO1chr4

76731585

+
intron-3CDSENST00000558841ENST00000514213MAPK6chr15

52311573

+USO1chr4

76731585

+

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FusionProtFeatures for MAPK6_USO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK6

Q16659

USO1

O60763

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of thecomplex formed with MAPKAPK5 is still unclear, but the complexfollows a complex set of phosphorylation events: upon interactionwith atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189and then mediates phosphorylation and activation of MAPKAPK5,which in turn phosphorylates ERK3/MAPK6. May promote entry in thecell cycle (By similarity). {ECO:0000250}. General vesicular transport factor required forintercisternal transport in the Golgi stack; it is required fortranscytotic fusion and/or subsequent binding of the vesicles tothe target membrane. May well act as a vesicular anchor byinteracting with the target membrane and holding the vesicular andtarget membranes in proximity. {ECO:0000250|UniProtKB:P41542}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAPK6_USO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAPK6_USO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAPK6ANK3, DST, CSE1L, HSP90AB1, HSPD1, HSP90B1, CCT3, MAPKAPK5, CNTRL, ZNF600, PHACTR3, HACL1, NAT9, PDCD6IP, EIF3C, ACTG1, STX7, RAB2A, BBS10, ZNF133, ATP5J, SNAPC4, MOK, RPL10, THAP4, SPRR2D, MZB1, ITSN1, ELOF1, PLK1, DBN1, FBXL16, UBA52, ATG9A, RGS19, TDP2, MBOAT7, NRXN2, ARPC3, MDK, C21orf59, COPS6, CYTH2, APBA2, RAP1GAP, MASP1, MTG2, ANAPC5, ACTR1B, GORASP1, FXYD3, NDUFS6, PPP1R7, CA12, HNRNPA0, KLC1, SLC41A3, METTL17, ZNF671, MYOZ3, PHGDH, PSIP1, HAUS2, CALR, EMD, AMPH, PIH1D1, SERPINA4, TTK, OSTF1, MAP3K12, BARX1, PPBP, SMS, MYBL2, HIP1, WWC1, SRSF5, RANBP9, ITGB3BP, PDLIM1, PVRL2, RAB31, APOA1, DPPA4, PRKAB1, RRP7A, HDAC11, WDR34, GLRX3, DDR1, URB1, PHC2, ZNF775, SHC1, PPP2R1A, CDH13, BAG6, CFL1, NELFB, KNSTRN, GATA1, RARA, TUBA1A, ZNF579, METTL2A, EDF1, DKC1, INS, SOCS3, DDOST, DNAJC28, DSCR3, MIPEP, RBL1, WFS1, ARHGDIA, SEPT5, MCM3, TPI1, PRKAR1A, CNTN1, NOL4, DGKZ, PRPF38A, CASP6, DCTN2, WDR26, FOXO3, ZNF205, LPXN, SNW1, MGAT1, EIF1, EEF1A2, HNRNPD, NUDT5, MAP3K7, SMAD6, SEPT3, SPTAN1, PLSCR1, FAM49B, PSAT1, MON1A, UBE2L3, EIF4A1, CA1, GNB2L1, ZNF331, PTPMT1, SPG7, HNRNPH3, APOA1BP, PLEKHM1, CERS1, IDH3B, GPX1, ELAVL1, UBE3A, NEURL4, CCND3, MBIP, KDSR, JUNB, SLC20A1, GALNT7, EGLN3, EIF2S3, A2M, MAPK6, HERC2, PSMA7, AURKA, USP20, ZNF7, SERPINA1, FGB, HP, HBB, FGG, FGA, HBA2, C3, ORM1, IGHG2, ALB, TF, ZNF28, AHSG, ZNF92, ZNF813, SERPINB4, TRIM25USO1GABPB1, C1orf94, GAK, PTP4A3, GOSR1, GOSR2, BET1, YKT6, STX5, SEC22A, SCFD1, GOLGA2, GOLGB1, RAB1A, CASP3, NCOA2, TRAF3, TP53, MAPK3, USO1, VCL, USP28, XIAP, ZNF593, PDE4DIP, SEC16A, PRKACA, CCDC168, TRIP11, PRKAR2B, CEP68, FAM184A, HUWE1, AKAP9, DUSP12, XPO7, PHYKPL, MDM2, RNF114, EFNB2, SETD9, TXNDC11, ACTL6A, SCN2B, CYP1A1, POLE3, CTTN, DNAJA1, HSP90B1, KHDRBS1, NTRK1, CEP290, TMEM17, CLTC, GTSE1, FOXQ1, CDC5L, CDH1, SLCO1B1, DDX20, ZNF488, SNRNP27, SEMA4F, CPNE5, FGB, TSNAXIP1, PDHA1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAPK6_USO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAPK6_USO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAPK6C0020507Hyperplasia1CTD_human
TgeneUSO1C0033578Prostatic Neoplasms1CTD_human
TgeneUSO1C0037274Dermatologic disorders1CTD_human
TgeneUSO1C0311375Arsenic Poisoning1CTD_human