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Fusion gene ID: 21002 |
FusionGeneSummary for MAPK6_USO1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPK6_USO1 | Fusion gene ID: 21002 | Hgene | Tgene | Gene symbol | MAPK6 | USO1 | Gene ID | 5597 | 8615 |
| Gene name | mitogen-activated protein kinase 6 | USO1 vesicle transport factor | |
| Synonyms | ERK3|HsT17250|PRKM6|p97MAPK | P115|TAP|VDP | |
| Cytomap | 15q21.2 | 4q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase 6ERK-3MAP kinase 6MAP kinase isoform p97MAPK 6extracellular signal-regulated kinase 3extracellular signal-regulated kinase, p97p97-MAPKprotein kinase, mitogen-activated 5protein kinase, mitogen-activated 6 | general vesicular transport factor p115USO1 vesicle docking protein homologtranscytosis associated proteinvesicle docking protein p115 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q16659 | O60763 | |
| Ensembl transtripts involved in fusion gene | ENST00000261845, ENST00000558841, | ENST00000538159, ENST00000514213, | |
| Fusion gene scores | * DoF score | 3 X 1 X 3=9 | 4 X 4 X 3=48 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/9*10)=2.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAPK6 [Title/Abstract] AND USO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-C8-A12P-01A | MAPK6 | chr15 | 52311573 | + | USO1 | chr4 | 76731585 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000261845 | ENST00000538159 | MAPK6 | chr15 | 52311573 | + | USO1 | chr4 | 76731585 | + |
| 5UTR-3CDS | ENST00000261845 | ENST00000514213 | MAPK6 | chr15 | 52311573 | + | USO1 | chr4 | 76731585 | + |
| intron-3CDS | ENST00000558841 | ENST00000538159 | MAPK6 | chr15 | 52311573 | + | USO1 | chr4 | 76731585 | + |
| intron-3CDS | ENST00000558841 | ENST00000514213 | MAPK6 | chr15 | 52311573 | + | USO1 | chr4 | 76731585 | + |
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FusionProtFeatures for MAPK6_USO1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPK6 | USO1 |
| Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of thecomplex formed with MAPKAPK5 is still unclear, but the complexfollows a complex set of phosphorylation events: upon interactionwith atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189and then mediates phosphorylation and activation of MAPKAPK5,which in turn phosphorylates ERK3/MAPK6. May promote entry in thecell cycle (By similarity). {ECO:0000250}. | General vesicular transport factor required forintercisternal transport in the Golgi stack; it is required fortranscytotic fusion and/or subsequent binding of the vesicles tothe target membrane. May well act as a vesicular anchor byinteracting with the target membrane and holding the vesicular andtarget membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAPK6_USO1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAPK6_USO1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAPK6 | ANK3, DST, CSE1L, HSP90AB1, HSPD1, HSP90B1, CCT3, MAPKAPK5, CNTRL, ZNF600, PHACTR3, HACL1, NAT9, PDCD6IP, EIF3C, ACTG1, STX7, RAB2A, BBS10, ZNF133, ATP5J, SNAPC4, MOK, RPL10, THAP4, SPRR2D, MZB1, ITSN1, ELOF1, PLK1, DBN1, FBXL16, UBA52, ATG9A, RGS19, TDP2, MBOAT7, NRXN2, ARPC3, MDK, C21orf59, COPS6, CYTH2, APBA2, RAP1GAP, MASP1, MTG2, ANAPC5, ACTR1B, GORASP1, FXYD3, NDUFS6, PPP1R7, CA12, HNRNPA0, KLC1, SLC41A3, METTL17, ZNF671, MYOZ3, PHGDH, PSIP1, HAUS2, CALR, EMD, AMPH, PIH1D1, SERPINA4, TTK, OSTF1, MAP3K12, BARX1, PPBP, SMS, MYBL2, HIP1, WWC1, SRSF5, RANBP9, ITGB3BP, PDLIM1, PVRL2, RAB31, APOA1, DPPA4, PRKAB1, RRP7A, HDAC11, WDR34, GLRX3, DDR1, URB1, PHC2, ZNF775, SHC1, PPP2R1A, CDH13, BAG6, CFL1, NELFB, KNSTRN, GATA1, RARA, TUBA1A, ZNF579, METTL2A, EDF1, DKC1, INS, SOCS3, DDOST, DNAJC28, DSCR3, MIPEP, RBL1, WFS1, ARHGDIA, SEPT5, MCM3, TPI1, PRKAR1A, CNTN1, NOL4, DGKZ, PRPF38A, CASP6, DCTN2, WDR26, FOXO3, ZNF205, LPXN, SNW1, MGAT1, EIF1, EEF1A2, HNRNPD, NUDT5, MAP3K7, SMAD6, SEPT3, SPTAN1, PLSCR1, FAM49B, PSAT1, MON1A, UBE2L3, EIF4A1, CA1, GNB2L1, ZNF331, PTPMT1, SPG7, HNRNPH3, APOA1BP, PLEKHM1, CERS1, IDH3B, GPX1, ELAVL1, UBE3A, NEURL4, CCND3, MBIP, KDSR, JUNB, SLC20A1, GALNT7, EGLN3, EIF2S3, A2M, MAPK6, HERC2, PSMA7, AURKA, USP20, ZNF7, SERPINA1, FGB, HP, HBB, FGG, FGA, HBA2, C3, ORM1, IGHG2, ALB, TF, ZNF28, AHSG, ZNF92, ZNF813, SERPINB4, TRIM25 | USO1 | GABPB1, C1orf94, GAK, PTP4A3, GOSR1, GOSR2, BET1, YKT6, STX5, SEC22A, SCFD1, GOLGA2, GOLGB1, RAB1A, CASP3, NCOA2, TRAF3, TP53, MAPK3, USO1, VCL, USP28, XIAP, ZNF593, PDE4DIP, SEC16A, PRKACA, CCDC168, TRIP11, PRKAR2B, CEP68, FAM184A, HUWE1, AKAP9, DUSP12, XPO7, PHYKPL, MDM2, RNF114, EFNB2, SETD9, TXNDC11, ACTL6A, SCN2B, CYP1A1, POLE3, CTTN, DNAJA1, HSP90B1, KHDRBS1, NTRK1, CEP290, TMEM17, CLTC, GTSE1, FOXQ1, CDC5L, CDH1, SLCO1B1, DDX20, ZNF488, SNRNP27, SEMA4F, CPNE5, FGB, TSNAXIP1, PDHA1, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAPK6_USO1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAPK6_USO1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MAPK6 | C0020507 | Hyperplasia | 1 | CTD_human |
| Tgene | USO1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | USO1 | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Tgene | USO1 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
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