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Fusion gene ID: 20968 |
FusionGeneSummary for MAPK10_UGT8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPK10_UGT8 | Fusion gene ID: 20968 | Hgene | Tgene | Gene symbol | MAPK10 | UGT8 | Gene ID | 5602 | 7368 |
| Gene name | mitogen-activated protein kinase 10 | UDP glycosyltransferase 8 | |
| Synonyms | JNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPK | CGT|UGT4 | |
| Cytomap | 4q21.3 | 4q26 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3 | 2-hydroxyacylsphingosine 1-beta-galactosyltransferaseUDP-galactose-ceramide galactosyltransferaseceramide UDP-galactosyltransferasecerebroside synthaseuridine diphosphate glycosyltransferase 8 | |
| Modification date | 20180524 | 20180523 | |
| UniProtAcc | P53779 | Q16880 | |
| Ensembl transtripts involved in fusion gene | ENST00000395169, ENST00000359221, ENST00000361569, ENST00000395166, ENST00000449047, ENST00000395161, ENST00000513839, ENST00000395157, ENST00000395160, | ENST00000310836, ENST00000394511, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 1 X 1 X 1=1 |
| # samples | 9 | 1 | |
| ** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MAPK10 [Title/Abstract] AND UGT8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-18-3421-01A | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000395169 | ENST00000310836 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000395169 | ENST00000394511 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000359221 | ENST00000310836 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000359221 | ENST00000394511 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| 5UTR-5UTR | ENST00000361569 | ENST00000310836 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| 5UTR-5UTR | ENST00000361569 | ENST00000394511 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000395166 | ENST00000310836 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000395166 | ENST00000394511 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000449047 | ENST00000310836 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000449047 | ENST00000394511 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000395161 | ENST00000310836 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000395161 | ENST00000394511 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000513839 | ENST00000310836 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000513839 | ENST00000394511 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000395157 | ENST00000310836 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000395157 | ENST00000394511 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000395160 | ENST00000310836 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
| intron-5UTR | ENST00000395160 | ENST00000394511 | MAPK10 | chr4 | 87374183 | - | UGT8 | chr4 | 115544035 | + |
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FusionProtFeatures for MAPK10_UGT8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPK10 | UGT8 |
| Serine/threonine-protein kinase involved in variousprocesses such as neuronal proliferation, differentiation,migration and programmed cell death. Extracellular stimuli such asproinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK)signaling pathway. In this cascade, two dual specificity kinasesMAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activateMAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number oftranscription factors, primarily components of AP-1 such as JUNand ATF2 and thus regulates AP-1 transcriptional activity. Playsregulatory roles in the signaling pathways during neuronalapoptosis. Phosphorylates the neuronal microtubule regulatorSTMN2. Acts in the regulation of the amyloid-beta precursorprotein/APP signaling during neuronal differentiation byphosphorylating APP. Participates also in neurite growth in spiralganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimerand plays a role in the photic regulation of the circadian clock(PubMed:22441692). {ECO:0000269|PubMed:11718727,ECO:0000269|PubMed:22441692}. | Catalyzes the transfer of galactose to ceramide, a keyenzymatic step in the biosynthesis of galactocerebrosides, whichare abundant sphingolipids of the myelin membrane of the centralnervous system and peripheral nervous system.{ECO:0000250|UniProtKB:Q09426}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAPK10_UGT8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAPK10_UGT8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAPK10 | MAPK8IP3, GTF3C1, UNC119, ARRB2, ARRB1, SH3BP5, DUSP1, DUSP10, DUSP16, TP53, MAPK8IP2, MCL1, CREBBP, CEP290, KIF26A, HDAC9, HDAC1, PLIN2, MAP2K4, CDKN1B, JUN, APP, ATF2, ELK1, PKMYT1, MAPK10, CDKN2A, CDKN2C, GCH1, RELA, HAX1, TNIP1, MAPK9, MSN, EZR, RDX, WDR62, IMPDH2, DDX5, LDHA, CCT7, CCT6B, CCT2, DDI1, DUSP9 | UGT8 | FBXO6, STX6, HMOX1, HSD11B1, HMOX2, PTCH1, PLTP, PON2, TCTN3, TMEM216, DUSP3, SEC22B, ADPGK, SCGB2A2, NCEH1, MPPE1, FUT1, UPK1A, TRDN, LMAN2L, CSGALNACT2, B4GAT1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAPK10_UGT8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAPK10_UGT8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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