	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
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Fusion gene ID: 20967

FusionGeneSummary for MAPK10_PTPN13

Fusion gene summary

Fusion gene information	Fusion gene name: MAPK10_PTPN13
	Fusion gene ID: 20967
		Hgene	Tgene
	Gene symbol	MAPK10	PTPN13
	Gene ID	5602	5783
	Gene name	mitogen-activated protein kinase 10	protein tyrosine phosphatase, non-receptor type 13
	Synonyms	JNK3\|JNK3A\|PRKM10\|SAPK1b\|p493F12\|p54bSAPK	FAP-1\|PNP1\|PTP-BAS\|PTP-BL\|PTP1E\|PTPL1\|PTPLE\|hPTP1E
	Cytomap	4q21.3	4q21.3
	Type of gene	protein-coding	protein-coding
	Description	mitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3	tyrosine-protein phosphatase non-receptor type 13fas-associated protein-tyrosine phosphatase 1hPTPE1protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)protein-tyrosine phosphatase 1Eprotein-tyrosine phosphatas
	Modification date	20180524	20180519
	UniProtAcc	P53779	Q12923
	Ensembl transtripts involved in fusion gene	ENST00000395169, ENST00000359221, ENST00000361569, ENST00000395166, ENST00000449047, ENST00000395161, ENST00000513839, ENST00000395157, ENST00000395160,	ENST00000427191, ENST00000436978, ENST00000502971, ENST00000411767, ENST00000316707, ENST00000511467,
Fusion gene scores	* DoF score	8 X 6 X 6=288	5 X 8 X 6=240
	# samples	9	11
	** MAII score	log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/240*10)=-1.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MAPK10 [Title/Abstract] AND PTPN13 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PTPN13	GO:0006470	protein dephosphorylation	17657516
Tgene	PTPN13	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	23604317

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	UCS	TCGA-NA-A4QV-01A	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000395169	ENST00000427191	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000395169	ENST00000436978	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000395169	ENST00000502971	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000395169	ENST00000411767	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000395169	ENST00000316707	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000395169	ENST00000511467	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000359221	ENST00000427191	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000359221	ENST00000436978	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000359221	ENST00000502971	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000359221	ENST00000411767	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000359221	ENST00000316707	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000359221	ENST00000511467	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000361569	ENST00000427191	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000361569	ENST00000436978	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000361569	ENST00000502971	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000361569	ENST00000411767	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000361569	ENST00000316707	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000361569	ENST00000511467	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000395166	ENST00000427191	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000395166	ENST00000436978	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000395166	ENST00000502971	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000395166	ENST00000411767	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000395166	ENST00000316707	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000395166	ENST00000511467	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000449047	ENST00000427191	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000449047	ENST00000436978	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000449047	ENST00000502971	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000449047	ENST00000411767	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000449047	ENST00000316707	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000449047	ENST00000511467	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000395161	ENST00000427191	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000395161	ENST00000436978	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000395161	ENST00000502971	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000395161	ENST00000411767	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000395161	ENST00000316707	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000395161	ENST00000511467	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000513839	ENST00000427191	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-3CDS	ENST00000513839	ENST00000436978	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000513839	ENST00000502971	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000513839	ENST00000411767	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000513839	ENST00000316707	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
5UTR-intron	ENST00000513839	ENST00000511467	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
intron-3CDS	ENST00000395157	ENST00000427191	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
intron-3CDS	ENST00000395157	ENST00000436978	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
intron-intron	ENST00000395157	ENST00000502971	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
intron-intron	ENST00000395157	ENST00000411767	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
intron-intron	ENST00000395157	ENST00000316707	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
intron-intron	ENST00000395157	ENST00000511467	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
intron-3CDS	ENST00000395160	ENST00000427191	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
intron-3CDS	ENST00000395160	ENST00000436978	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
intron-intron	ENST00000395160	ENST00000502971	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
intron-intron	ENST00000395160	ENST00000411767	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
intron-intron	ENST00000395160	ENST00000316707	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+
intron-intron	ENST00000395160	ENST00000511467	MAPK10	chr4	87275683	-	PTPN13	chr4	87679413	+

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FusionProtFeatures for MAPK10_PTPN13

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAPK10 P53779	PTPN13 Q12923
Serine/threonine-protein kinase involved in variousprocesses such as neuronal proliferation, differentiation,migration and programmed cell death. Extracellular stimuli such asproinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK)signaling pathway. In this cascade, two dual specificity kinasesMAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activateMAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number oftranscription factors, primarily components of AP-1 such as JUNand ATF2 and thus regulates AP-1 transcriptional activity. Playsregulatory roles in the signaling pathways during neuronalapoptosis. Phosphorylates the neuronal microtubule regulatorSTMN2. Acts in the regulation of the amyloid-beta precursorprotein/APP signaling during neuronal differentiation byphosphorylating APP. Participates also in neurite growth in spiralganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimerand plays a role in the photic regulation of the circadian clock(PubMed:22441692). {ECO:0000269\|PubMed:11718727,ECO:0000269\|PubMed:22441692}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for MAPK10_PTPN13

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAPK10_PTPN13

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
MAPK10	MAPK8IP3, GTF3C1, UNC119, ARRB2, ARRB1, SH3BP5, DUSP1, DUSP10, DUSP16, TP53, MAPK8IP2, MCL1, CREBBP, CEP290, KIF26A, HDAC9, HDAC1, PLIN2, MAP2K4, CDKN1B, JUN, APP, ATF2, ELK1, PKMYT1, MAPK10, CDKN2A, CDKN2C, GCH1, RELA, HAX1, TNIP1, MAPK9, MSN, EZR, RDX, WDR62, IMPDH2, DDX5, LDHA, CCT7, CCT6B, CCT2, DDI1, DUSP9	PTPN13	PKN2, NFKBIA, EFNB1, ARHGAP29, FASLG, CTNNB1, GHR, FBXL2, LATS1, LATS2, YWHAB, RAPGEF2, RASSF10, WHSC1, FBXW11, DNM2, NINL, TMEM17, PLEKHA1, STXBP4, PTEN, RGS2, DFFB, KCTD3, KIF13B, CGN, ZBTB21, KSR1, GIGYF1, LPIN3, LRFN1, RTKN, DENND4C, MAST3, SH3RF3, DENND1A, SH3PXD2A, SRGAP2, PPM1H, TANC2, RALGPS2, EIF4E2, SIPA1L1, NF1, CDC25C, CBY1, GIGYF2, INPP5E, MTNR1A, HEY1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for MAPK10_PTPN13

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MAPK10_PTPN13

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 20967

FusionGeneSummary for MAPK10_PTPN13

FusionProtFeatures for MAPK10_PTPN13

FusionGeneSequence for MAPK10_PTPN13

FusionGenePPI for MAPK10_PTPN13

RelatedDrugs for MAPK10_PTPN13

RelatedDiseases for MAPK10_PTPN13