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Fusion gene ID: 20967 |
FusionGeneSummary for MAPK10_PTPN13 |
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Fusion gene information | Fusion gene name: MAPK10_PTPN13 | Fusion gene ID: 20967 | Hgene | Tgene | Gene symbol | MAPK10 | PTPN13 | Gene ID | 5602 | 5783 |
Gene name | mitogen-activated protein kinase 10 | protein tyrosine phosphatase, non-receptor type 13 | |
Synonyms | JNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPK | FAP-1|PNP1|PTP-BAS|PTP-BL|PTP1E|PTPL1|PTPLE|hPTP1E | |
Cytomap | 4q21.3 | 4q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | mitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3 | tyrosine-protein phosphatase non-receptor type 13fas-associated protein-tyrosine phosphatase 1hPTPE1protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)protein-tyrosine phosphatase 1Eprotein-tyrosine phosphatas | |
Modification date | 20180524 | 20180519 | |
UniProtAcc | P53779 | Q12923 | |
Ensembl transtripts involved in fusion gene | ENST00000395169, ENST00000359221, ENST00000361569, ENST00000395166, ENST00000449047, ENST00000395161, ENST00000513839, ENST00000395157, ENST00000395160, | ENST00000427191, ENST00000436978, ENST00000502971, ENST00000411767, ENST00000316707, ENST00000511467, | |
Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 5 X 8 X 6=240 |
# samples | 9 | 11 | |
** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/240*10)=-1.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAPK10 [Title/Abstract] AND PTPN13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PTPN13 | GO:0006470 | protein dephosphorylation | 17657516 |
Tgene | PTPN13 | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | 23604317 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCS | TCGA-NA-A4QV-01A | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000395169 | ENST00000427191 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000395169 | ENST00000436978 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000395169 | ENST00000502971 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000395169 | ENST00000411767 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000395169 | ENST00000316707 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000395169 | ENST00000511467 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000359221 | ENST00000427191 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000359221 | ENST00000436978 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000359221 | ENST00000502971 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000359221 | ENST00000411767 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000359221 | ENST00000316707 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000359221 | ENST00000511467 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000361569 | ENST00000427191 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000361569 | ENST00000436978 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000361569 | ENST00000502971 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000361569 | ENST00000411767 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000361569 | ENST00000316707 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000361569 | ENST00000511467 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000395166 | ENST00000427191 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000395166 | ENST00000436978 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000395166 | ENST00000502971 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000395166 | ENST00000411767 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000395166 | ENST00000316707 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000395166 | ENST00000511467 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000449047 | ENST00000427191 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000449047 | ENST00000436978 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000449047 | ENST00000502971 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000449047 | ENST00000411767 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000449047 | ENST00000316707 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000449047 | ENST00000511467 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000395161 | ENST00000427191 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000395161 | ENST00000436978 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000395161 | ENST00000502971 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000395161 | ENST00000411767 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000395161 | ENST00000316707 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000395161 | ENST00000511467 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000513839 | ENST00000427191 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-3CDS | ENST00000513839 | ENST00000436978 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000513839 | ENST00000502971 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000513839 | ENST00000411767 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000513839 | ENST00000316707 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
5UTR-intron | ENST00000513839 | ENST00000511467 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
intron-3CDS | ENST00000395157 | ENST00000427191 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
intron-3CDS | ENST00000395157 | ENST00000436978 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
intron-intron | ENST00000395157 | ENST00000502971 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
intron-intron | ENST00000395157 | ENST00000411767 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
intron-intron | ENST00000395157 | ENST00000316707 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
intron-intron | ENST00000395157 | ENST00000511467 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
intron-3CDS | ENST00000395160 | ENST00000427191 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
intron-3CDS | ENST00000395160 | ENST00000436978 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
intron-intron | ENST00000395160 | ENST00000502971 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
intron-intron | ENST00000395160 | ENST00000411767 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
intron-intron | ENST00000395160 | ENST00000316707 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
intron-intron | ENST00000395160 | ENST00000511467 | MAPK10 | chr4 | 87275683 | - | PTPN13 | chr4 | 87679413 | + |
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FusionProtFeatures for MAPK10_PTPN13 |
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Hgene | Tgene |
MAPK10 | PTPN13 |
Serine/threonine-protein kinase involved in variousprocesses such as neuronal proliferation, differentiation,migration and programmed cell death. Extracellular stimuli such asproinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK)signaling pathway. In this cascade, two dual specificity kinasesMAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activateMAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number oftranscription factors, primarily components of AP-1 such as JUNand ATF2 and thus regulates AP-1 transcriptional activity. Playsregulatory roles in the signaling pathways during neuronalapoptosis. Phosphorylates the neuronal microtubule regulatorSTMN2. Acts in the regulation of the amyloid-beta precursorprotein/APP signaling during neuronal differentiation byphosphorylating APP. Participates also in neurite growth in spiralganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimerand plays a role in the photic regulation of the circadian clock(PubMed:22441692). {ECO:0000269|PubMed:11718727,ECO:0000269|PubMed:22441692}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAPK10_PTPN13 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAPK10_PTPN13 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAPK10 | MAPK8IP3, GTF3C1, UNC119, ARRB2, ARRB1, SH3BP5, DUSP1, DUSP10, DUSP16, TP53, MAPK8IP2, MCL1, CREBBP, CEP290, KIF26A, HDAC9, HDAC1, PLIN2, MAP2K4, CDKN1B, JUN, APP, ATF2, ELK1, PKMYT1, MAPK10, CDKN2A, CDKN2C, GCH1, RELA, HAX1, TNIP1, MAPK9, MSN, EZR, RDX, WDR62, IMPDH2, DDX5, LDHA, CCT7, CCT6B, CCT2, DDI1, DUSP9 | PTPN13 | PKN2, NFKBIA, EFNB1, ARHGAP29, FASLG, CTNNB1, GHR, FBXL2, LATS1, LATS2, YWHAB, RAPGEF2, RASSF10, WHSC1, FBXW11, DNM2, NINL, TMEM17, PLEKHA1, STXBP4, PTEN, RGS2, DFFB, KCTD3, KIF13B, CGN, ZBTB21, KSR1, GIGYF1, LPIN3, LRFN1, RTKN, DENND4C, MAST3, SH3RF3, DENND1A, SH3PXD2A, SRGAP2, PPM1H, TANC2, RALGPS2, EIF4E2, SIPA1L1, NF1, CDC25C, CBY1, GIGYF2, INPP5E, MTNR1A, HEY1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAPK10_PTPN13 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAPK10_PTPN13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |