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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20961

FusionGeneSummary for MAPK10_ARHGAP24

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK10_ARHGAP24
Fusion gene ID: 20961
HgeneTgene
Gene symbol

MAPK10

ARHGAP24

Gene ID

5602

83478

Gene namemitogen-activated protein kinase 10Rho GTPase activating protein 24
SynonymsJNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPKFILGAP|RC-GAP72|RCGAP72|p73|p73RhoGAP
Cytomap

4q21.3

4q21.23-q21.3

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3rho GTPase-activating protein 24RAC1- and CDC42-specific GTPase-activating protein of 72 kDafilamin-A-associated RhoGAPrhoGAP of 73 kDasarcoma antigen NY-SAR-88
Modification date2018052420180519
UniProtAcc

P53779

Q8N264

Ensembl transtripts involved in fusion geneENST00000395169, ENST00000359221, 
ENST00000361569, ENST00000395166, 
ENST00000449047, ENST00000395161, 
ENST00000513839, ENST00000395157, 
ENST00000395160, 		ENST00000395184, 
ENST00000503995, ENST00000506421, 
ENST00000395183, ENST00000264343, 
Fusion gene scores* DoF score8 X 6 X 6=2884 X 4 X 3=48
# samples 96
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAPK10 [Title/Abstract] AND ARHGAP24 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DH-A669-01AMAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
TCGARVLGGTCGA-DH-A669-02AMAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000395169ENST00000395184MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000395169ENST00000503995MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000395169ENST00000506421MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000395169ENST00000395183MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000395169ENST00000264343MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000359221ENST00000395184MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000359221ENST00000503995MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000359221ENST00000506421MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000359221ENST00000395183MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000359221ENST00000264343MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000361569ENST00000395184MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000361569ENST00000503995MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000361569ENST00000506421MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000361569ENST00000395183MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000361569ENST00000264343MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000395166ENST00000395184MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000395166ENST00000503995MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000395166ENST00000506421MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000395166ENST00000395183MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000395166ENST00000264343MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000449047ENST00000395184MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000449047ENST00000503995MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000449047ENST00000506421MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000449047ENST00000395183MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000449047ENST00000264343MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000395161ENST00000395184MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000395161ENST00000503995MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000395161ENST00000506421MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000395161ENST00000395183MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000395161ENST00000264343MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000513839ENST00000395184MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-3CDSENST00000513839ENST00000503995MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000513839ENST00000506421MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000513839ENST00000395183MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
5UTR-intronENST00000513839ENST00000264343MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
intron-3CDSENST00000395157ENST00000395184MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
intron-3CDSENST00000395157ENST00000503995MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
intron-intronENST00000395157ENST00000506421MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
intron-intronENST00000395157ENST00000395183MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
intron-intronENST00000395157ENST00000264343MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
intron-3CDSENST00000395160ENST00000395184MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
intron-3CDSENST00000395160ENST00000503995MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
intron-intronENST00000395160ENST00000506421MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
intron-intronENST00000395160ENST00000395183MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+
intron-intronENST00000395160ENST00000264343MAPK10chr4

87275683

-ARHGAP24chr4

86893189

+

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FusionProtFeatures for MAPK10_ARHGAP24


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK10

P53779

ARHGAP24

Q8N264

Serine/threonine-protein kinase involved in variousprocesses such as neuronal proliferation, differentiation,migration and programmed cell death. Extracellular stimuli such asproinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK)signaling pathway. In this cascade, two dual specificity kinasesMAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activateMAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number oftranscription factors, primarily components of AP-1 such as JUNand ATF2 and thus regulates AP-1 transcriptional activity. Playsregulatory roles in the signaling pathways during neuronalapoptosis. Phosphorylates the neuronal microtubule regulatorSTMN2. Acts in the regulation of the amyloid-beta precursorprotein/APP signaling during neuronal differentiation byphosphorylating APP. Participates also in neurite growth in spiralganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimerand plays a role in the photic regulation of the circadian clock(PubMed:22441692). {ECO:0000269|PubMed:11718727,ECO:0000269|PubMed:22441692}. Rho GTPase-activating protein involved in cell polarity,cell morphology and cytoskeletal organization. Acts as a GTPaseactivator for the Rac-type GTPase by converting it to an inactiveGDP-bound state. Controls actin remodeling by inactivating Racdownstream of Rho leading to suppress leading edge protrusion andpromotes cell retraction to achieve cellular polarity. Able tosuppress RAC1 and CDC42 activity in vitro. Overexpression inducescell rounding with partial or complete disruption of actin stressfibers and formation of membrane ruffles, lamellipodia, andfilopodia. Isoform 2 is a vascular cell-specific GAP involved inmodulation of angiogenesis. {ECO:0000269|PubMed:15302923,ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAPK10_ARHGAP24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAPK10_ARHGAP24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAPK10MAPK8IP3, GTF3C1, UNC119, ARRB2, ARRB1, SH3BP5, DUSP1, DUSP10, DUSP16, TP53, MAPK8IP2, MCL1, CREBBP, CEP290, KIF26A, HDAC9, HDAC1, PLIN2, MAP2K4, CDKN1B, JUN, APP, ATF2, ELK1, PKMYT1, MAPK10, CDKN2A, CDKN2C, GCH1, RELA, HAX1, TNIP1, MAPK9, MSN, EZR, RDX, WDR62, IMPDH2, DDX5, LDHA, CCT7, CCT6B, CCT2, DDI1, DUSP9ARHGAP24APP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAPK10_ARHGAP24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAPK10_ARHGAP24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource