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Fusion gene ID: 20960 |
FusionGeneSummary for MAP9_TAT |
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Fusion gene information | Fusion gene name: MAP9_TAT | Fusion gene ID: 20960 | Hgene | Tgene | Gene symbol | MAP9 | TAT | Gene ID | 79884 | 79969 |
Gene name | microtubule associated protein 9 | alpha tubulin acetyltransferase 1 | |
Synonyms | ASAP | C6orf134|MEC17|Nbla00487|TAT|alpha-TAT|alpha-TAT1 | |
Cytomap | 4q32.1 | 6p21.33 | |
Type of gene | protein-coding | protein-coding | |
Description | microtubule-associated protein 9aster-associated protein | alpha-tubulin N-acetyltransferase 1acetyltransferase mec-17 homolog | |
Modification date | 20180522 | 20180527 | |
UniProtAcc | Q49MG5 | P17735 | |
Ensembl transtripts involved in fusion gene | ENST00000311277, ENST00000515654, ENST00000379248, | ENST00000355962, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: MAP9 [Title/Abstract] AND TAT [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MAP9 | GO:0090307 | mitotic spindle assembly | 16049101 |
Tgene | TAT | GO:0071929 | alpha-tubulin acetylation | 23071314|24906155 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-HT-7857-01A | MAP9 | chr4 | 156281320 | - | TAT | chr16 | 71610330 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000311277 | ENST00000355962 | MAP9 | chr4 | 156281320 | - | TAT | chr16 | 71610330 | - |
5CDS-5UTR | ENST00000515654 | ENST00000355962 | MAP9 | chr4 | 156281320 | - | TAT | chr16 | 71610330 | - |
intron-5UTR | ENST00000379248 | ENST00000355962 | MAP9 | chr4 | 156281320 | - | TAT | chr16 | 71610330 | - |
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FusionProtFeatures for MAP9_TAT |
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Hgene | Tgene |
MAP9 | TAT |
Involved in organization of the bipolar mitotic spindle.Required for bipolar spindle assembly, mitosis progression andcytokinesis. May act by stabilizing interphase microtubules.{ECO:0000269|PubMed:16049101}. | Transaminase involved in tyrosine breakdown. Convertstyrosine to p-hydroxyphenylpyruvate. Can catalyze the reversereaction, using glutamic acid, with 2-oxoglutarate as cosubstrate(in vitro). Has much lower affinity and transaminase activitytowards phenylalanine. {ECO:0000269|PubMed:16640556,ECO:0000269|PubMed:7999802}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAP9_TAT |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAP9_TAT |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAP9 | TP53, EP300, SH3KBP1, AURKB, SPICE1, DCTN1, LCA5 | TAT | GRN, UBE3A, TAT, AARSD1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP9_TAT |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | TAT | P17735 | DB00114 | Pyridoxal Phosphate | Tyrosine aminotransferase | small molecule | approved|investigational|nutraceutical |
Tgene | TAT | P17735 | DB00142 | Glutamic Acid | Tyrosine aminotransferase | small molecule | approved|nutraceutical |
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RelatedDiseases for MAP9_TAT |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TAT | C0268487 | Tyrosine Transaminase Deficiency Disease | 1 | ORPHANET;UNIPROT |