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Fusion gene ID: 20933 |
FusionGeneSummary for MAP4_PLXNB1 |
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Fusion gene information | Fusion gene name: MAP4_PLXNB1 | Fusion gene ID: 20933 | Hgene | Tgene | Gene symbol | MAP4 | PLXNB1 | Gene ID | 4134 | 5364 |
Gene name | microtubule associated protein 4 | plexin B1 | |
Synonyms | - | PLEXIN-B1|PLXN5|SEP | |
Cytomap | 3p21.31 | 3p21.31 | |
Type of gene | protein-coding | protein-coding | |
Description | microtubule-associated protein 4MAP-4 | plexin-B1plexin 5semaphorin receptor SEP | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P27816 | O43157 | |
Ensembl transtripts involved in fusion gene | ENST00000383737, ENST00000395734, ENST00000426837, ENST00000360240, ENST00000439356, ENST00000264724, ENST00000420772, ENST00000441748, ENST00000462206, ENST00000434267, | ENST00000296440, ENST00000358459, ENST00000358536, ENST00000448774, ENST00000456774, ENST00000465117, | |
Fusion gene scores | * DoF score | 23 X 16 X 14=5152 | 6 X 6 X 3=108 |
# samples | 31 | 5 | |
** MAII score | log2(31/5152*10)=-4.05479247284038 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/108*10)=-1.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAP4 [Title/Abstract] AND PLXNB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PLXNB1 | GO:0007162 | negative regulation of cell adhesion | 15218527 |
Tgene | PLXNB1 | GO:0008360 | regulation of cell shape | 19843518 |
Tgene | PLXNB1 | GO:0051493 | regulation of cytoskeleton organization | 19843518 |
Tgene | PLXNB1 | GO:0071526 | semaphorin-plexin signaling pathway | 15218527|19843518 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-B5-A0JN-01A | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000383737 | ENST00000296440 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000383737 | ENST00000358459 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000383737 | ENST00000358536 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000383737 | ENST00000448774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000383737 | ENST00000456774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000383737 | ENST00000465117 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000395734 | ENST00000296440 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000395734 | ENST00000358459 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000395734 | ENST00000358536 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000395734 | ENST00000448774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000395734 | ENST00000456774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000395734 | ENST00000465117 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000426837 | ENST00000296440 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000426837 | ENST00000358459 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000426837 | ENST00000358536 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000426837 | ENST00000448774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000426837 | ENST00000456774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000426837 | ENST00000465117 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000360240 | ENST00000296440 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000360240 | ENST00000358459 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000360240 | ENST00000358536 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000360240 | ENST00000448774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000360240 | ENST00000456774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000360240 | ENST00000465117 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000439356 | ENST00000296440 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000439356 | ENST00000358459 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000439356 | ENST00000358536 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000439356 | ENST00000448774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000439356 | ENST00000456774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000439356 | ENST00000465117 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-3CDS | ENST00000264724 | ENST00000296440 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-3CDS | ENST00000264724 | ENST00000358459 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-3CDS | ENST00000264724 | ENST00000358536 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-intron | ENST00000264724 | ENST00000448774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-intron | ENST00000264724 | ENST00000456774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-intron | ENST00000264724 | ENST00000465117 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-3CDS | ENST00000420772 | ENST00000296440 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-3CDS | ENST00000420772 | ENST00000358459 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-3CDS | ENST00000420772 | ENST00000358536 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-intron | ENST00000420772 | ENST00000448774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-intron | ENST00000420772 | ENST00000456774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-intron | ENST00000420772 | ENST00000465117 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-3CDS | ENST00000441748 | ENST00000296440 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-3CDS | ENST00000441748 | ENST00000358459 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-3CDS | ENST00000441748 | ENST00000358536 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-intron | ENST00000441748 | ENST00000448774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-intron | ENST00000441748 | ENST00000456774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-intron | ENST00000441748 | ENST00000465117 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-3CDS | ENST00000462206 | ENST00000296440 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-3CDS | ENST00000462206 | ENST00000358459 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-3CDS | ENST00000462206 | ENST00000358536 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-intron | ENST00000462206 | ENST00000448774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-intron | ENST00000462206 | ENST00000456774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
intron-intron | ENST00000462206 | ENST00000465117 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000434267 | ENST00000296440 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000434267 | ENST00000358459 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
Frame-shift | ENST00000434267 | ENST00000358536 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000434267 | ENST00000448774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000434267 | ENST00000456774 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
5CDS-intron | ENST00000434267 | ENST00000465117 | MAP4 | chr3 | 48019355 | - | PLXNB1 | chr3 | 48457168 | - |
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FusionProtFeatures for MAP4_PLXNB1 |
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Hgene | Tgene |
MAP4 | PLXNB1 |
Non-neuronal microtubule-associated protein. Promotesmicrotubule assembly. {ECO:0000269|PubMed:10791892}. | Receptor for SEMA4D. Plays a role in RHOA activation andsubsequent changes of the actin cytoskeleton. Plays a role in axonguidance, invasive growth and cell migration.{ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496,ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518,ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAP4_PLXNB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAP4_PLXNB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAP4 | MARK4, ENO2, CDK1, FYCO1, NR1I3, RXRB, RXRG, GSK3B, HDGF, SIRT7, SH3KBP1, ISG15, TERF1, POT1, CUL4A, USP21, GRK5, EPS15, AP2M1, RPS20, UBC, TRAF3IP1, FN1, IL7R, ERBB2IP, SNTA1, BAG3, LDLR, TARDBP, HNRNPF, COG7, CSTF2, EIF2S1, HNRNPR, IARS, MTA2, POLR2A, POLR2C, PPP4R1, WDHD1, LSM8, PDCD6, RPA3, RPA2, RPA1, LGR4, CCDC8, ABCE1, FLNB, LSM3, HSPA5, LASP1, SERBP1, SLK, NTRK1, SRPK2, KIF11, CRY2, OTUB1, CDH1, EGFR, G3BP1, BRCA1, YAP1 | PLXNB1 | ARHGEF11, RND1, RND2, RND3, ARHGEF12, SEMA4D, RHOA, AKT1, GRB2, PLCG1, PLCG2, SOX4, DIAPH1, HNRNPD, SGTB, C21orf59, CENPO, CENPU, SMPX, HBB, HBA2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP4_PLXNB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | MAP4 | P27816 | DB01248 | Docetaxel | Microtubule-associated protein 4 | small molecule | approved|investigational |
Hgene | MAP4 | P27816 | DB11638 | Artenimol | Microtubule-associated protein 4 | small molecule | approved|investigational |
Hgene | MAP4 | P27816 | DB01229 | Paclitaxel | Microtubule-associated protein 4 | small molecule | approved|vet_approved |
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RelatedDiseases for MAP4_PLXNB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MAP4 | C0043094 | Weight Gain | 1 | CTD_human |