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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20933

FusionGeneSummary for MAP4_PLXNB1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4_PLXNB1
Fusion gene ID: 20933
HgeneTgene
Gene symbol

MAP4

PLXNB1

Gene ID

4134

5364

Gene namemicrotubule associated protein 4plexin B1
Synonyms-PLEXIN-B1|PLXN5|SEP
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated protein 4MAP-4plexin-B1plexin 5semaphorin receptor SEP
Modification date2018052320180523
UniProtAcc

P27816

O43157

Ensembl transtripts involved in fusion geneENST00000383737, ENST00000395734, 
ENST00000426837, ENST00000360240, 
ENST00000439356, ENST00000264724, 
ENST00000420772, ENST00000441748, 
ENST00000462206, ENST00000434267, 
ENST00000296440, ENST00000358459, 
ENST00000358536, ENST00000448774, 
ENST00000456774, ENST00000465117, 
Fusion gene scores* DoF score23 X 16 X 14=51526 X 6 X 3=108
# samples 315
** MAII scorelog2(31/5152*10)=-4.05479247284038
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/108*10)=-1.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP4 [Title/Abstract] AND PLXNB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLXNB1

GO:0007162

negative regulation of cell adhesion

15218527

TgenePLXNB1

GO:0008360

regulation of cell shape

19843518

TgenePLXNB1

GO:0051493

regulation of cytoskeleton organization

19843518

TgenePLXNB1

GO:0071526

semaphorin-plexin signaling pathway

15218527|19843518


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-B5-A0JN-01AMAP4chr3

48019355

-PLXNB1chr3

48457168

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000383737ENST00000296440MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000383737ENST00000358459MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000383737ENST00000358536MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000383737ENST00000448774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000383737ENST00000456774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000383737ENST00000465117MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000395734ENST00000296440MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000395734ENST00000358459MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000395734ENST00000358536MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000395734ENST00000448774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000395734ENST00000456774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000395734ENST00000465117MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000426837ENST00000296440MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000426837ENST00000358459MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000426837ENST00000358536MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000426837ENST00000448774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000426837ENST00000456774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000426837ENST00000465117MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000360240ENST00000296440MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000360240ENST00000358459MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000360240ENST00000358536MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000360240ENST00000448774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000360240ENST00000456774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000360240ENST00000465117MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000439356ENST00000296440MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000439356ENST00000358459MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000439356ENST00000358536MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000439356ENST00000448774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000439356ENST00000456774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000439356ENST00000465117MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-3CDSENST00000264724ENST00000296440MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-3CDSENST00000264724ENST00000358459MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-3CDSENST00000264724ENST00000358536MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-intronENST00000264724ENST00000448774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-intronENST00000264724ENST00000456774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-intronENST00000264724ENST00000465117MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-3CDSENST00000420772ENST00000296440MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-3CDSENST00000420772ENST00000358459MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-3CDSENST00000420772ENST00000358536MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-intronENST00000420772ENST00000448774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-intronENST00000420772ENST00000456774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-intronENST00000420772ENST00000465117MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-3CDSENST00000441748ENST00000296440MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-3CDSENST00000441748ENST00000358459MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-3CDSENST00000441748ENST00000358536MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-intronENST00000441748ENST00000448774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-intronENST00000441748ENST00000456774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-intronENST00000441748ENST00000465117MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-3CDSENST00000462206ENST00000296440MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-3CDSENST00000462206ENST00000358459MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-3CDSENST00000462206ENST00000358536MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-intronENST00000462206ENST00000448774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-intronENST00000462206ENST00000456774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
intron-intronENST00000462206ENST00000465117MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000434267ENST00000296440MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000434267ENST00000358459MAP4chr3

48019355

-PLXNB1chr3

48457168

-
Frame-shitENST00000434267ENST00000358536MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000434267ENST00000448774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000434267ENST00000456774MAP4chr3

48019355

-PLXNB1chr3

48457168

-
5CDS-intronENST00000434267ENST00000465117MAP4chr3

48019355

-PLXNB1chr3

48457168

-

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FusionProtFeatures for MAP4_PLXNB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP4

P27816

PLXNB1

O43157

Non-neuronal microtubule-associated protein. Promotesmicrotubule assembly. {ECO:0000269|PubMed:10791892}. Receptor for SEMA4D. Plays a role in RHOA activation andsubsequent changes of the actin cytoskeleton. Plays a role in axonguidance, invasive growth and cell migration.{ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496,ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518,ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP4_PLXNB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP4_PLXNB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP4MARK4, ENO2, CDK1, FYCO1, NR1I3, RXRB, RXRG, GSK3B, HDGF, SIRT7, SH3KBP1, ISG15, TERF1, POT1, CUL4A, USP21, GRK5, EPS15, AP2M1, RPS20, UBC, TRAF3IP1, FN1, IL7R, ERBB2IP, SNTA1, BAG3, LDLR, TARDBP, HNRNPF, COG7, CSTF2, EIF2S1, HNRNPR, IARS, MTA2, POLR2A, POLR2C, PPP4R1, WDHD1, LSM8, PDCD6, RPA3, RPA2, RPA1, LGR4, CCDC8, ABCE1, FLNB, LSM3, HSPA5, LASP1, SERBP1, SLK, NTRK1, SRPK2, KIF11, CRY2, OTUB1, CDH1, EGFR, G3BP1, BRCA1, YAP1PLXNB1ARHGEF11, RND1, RND2, RND3, ARHGEF12, SEMA4D, RHOA, AKT1, GRB2, PLCG1, PLCG2, SOX4, DIAPH1, HNRNPD, SGTB, C21orf59, CENPO, CENPU, SMPX, HBB, HBA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP4_PLXNB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAP4P27816DB01248DocetaxelMicrotubule-associated protein 4small moleculeapproved|investigational
HgeneMAP4P27816DB11638ArtenimolMicrotubule-associated protein 4small moleculeapproved|investigational
HgeneMAP4P27816DB01229PaclitaxelMicrotubule-associated protein 4small moleculeapproved|vet_approved

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RelatedDiseases for MAP4_PLXNB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP4C0043094Weight Gain1CTD_human