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Fusion gene ID: 20909 |
FusionGeneSummary for MAP4K5_ADCK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP4K5_ADCK1 | Fusion gene ID: 20909 | Hgene | Tgene | Gene symbol | MAP4K5 | ADCK1 | Gene ID | 11183 | 57143 |
| Gene name | mitogen-activated protein kinase kinase kinase kinase 5 | aarF domain containing kinase 1 | |
| Synonyms | GCKR|KHS|KHS1|MAPKKKK5 | - | |
| Cytomap | 14q22.1 | 14q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase kinase 5MAPK/ERK kinase kinase kinase 5MEK kinase kinase 5MEKKK 5germinal center kinase-relatedkinase homologous to SPS1/STE20 | uncharacterized aarF domain-containing protein kinase 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y4K4 | Q86TW2 | |
| Ensembl transtripts involved in fusion gene | ENST00000013125, ENST00000557578, | ENST00000238561, ENST00000341211, ENST00000556560, | |
| Fusion gene scores | * DoF score | 9 X 9 X 8=648 | 3 X 3 X 4=36 |
| # samples | 13 | 4 | |
| ** MAII score | log2(13/648*10)=-2.31748218985617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAP4K5 [Title/Abstract] AND ADCK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP4K5 | GO:0006468 | protein phosphorylation | 9038372 |
| Hgene | MAP4K5 | GO:0035556 | intracellular signal transduction | 9038372 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-AAMW-01A | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000013125 | ENST00000238561 | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
| In-frame | ENST00000013125 | ENST00000341211 | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
| 5CDS-intron | ENST00000013125 | ENST00000556560 | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
| intron-3CDS | ENST00000557578 | ENST00000238561 | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
| intron-3CDS | ENST00000557578 | ENST00000341211 | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
| intron-intron | ENST00000557578 | ENST00000556560 | MAP4K5 | chr14 | 50971518 | - | ADCK1 | chr14 | 78353434 | + |
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FusionProtFeatures for MAP4K5_ADCK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP4K5 | ADCK1 |
| May play a role in the response to environmental stress.Appears to act upstream of the JUN N-terminal pathway.{ECO:0000269|PubMed:9038372}. | The function of this protein is not yet clear. It is notknown if it has protein kinase activity and what type of substrateit would phosphorylate (Ser, Thr or Tyr). |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAP4K5 | chr14:50971518 | chr14:78353434 | ENST00000013125 | - | 3 | 32 | 26_34 | 55 | 847 | Nucleotide binding | ATP |
| Tgene | >ADCK1 | chr14:50971518 | chr14:78353434 | ENST00000238561 | + | 3 | 11 | 155_467 | 141 | 524 | Domain | Note=Protein kinase |
| Tgene | >ADCK1 | chr14:50971518 | chr14:78353434 | ENST00000341211 | + | 2 | 10 | 155_467 | 73 | 456 | Domain | Note=Protein kinase |
| Tgene | >ADCK1 | chr14:50971518 | chr14:78353434 | ENST00000238561 | + | 3 | 11 | 161_169 | 141 | 524 | Nucleotide binding | ATP |
| Tgene | >ADCK1 | chr14:50971518 | chr14:78353434 | ENST00000341211 | + | 2 | 10 | 161_169 | 73 | 456 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MAP4K5 | chr14:50971518 | chr14:78353434 | ENST00000013125 | - | 3 | 32 | 20_277 | 55 | 847 | Domain | Protein kinase |
| Hgene | >MAP4K5 | chr14:50971518 | chr14:78353434 | ENST00000013125 | - | 3 | 32 | 506_819 | 55 | 847 | Domain | CNH |
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FusionGeneSequence for MAP4K5_ADCK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MAP4K5_ENST00000013125_chr14_50971518_-_ADCK1_ENST00000238561_chr14_78353434_+_438aa MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPDPXFVPELRXHPSGDGLPGPGPQGSAAXWADGGRE GPAPKGAGSELEGHSPDGGARSGCEAAVPRVXVYVACGXSQEEPAFGAGFPQXREECXEGVPDAQAFXLLEGPPNPLGPVHGAGPPDGVC GWRAGQXQRLHGEEQDRRQXDLTPPGQDVXXDDLRQWLRALRSPPRQCTGAEAPRHGKGGDCPVGPWALPDAHGRIPPELLPPLAVSDLD XHEESEGVQPATGSRGSLPLVCLHADGAIVGLGQQRHQPSSRHCHXGLRDSQQRGQLPPPDQPSPQPRAAPDAAHLEDQRPAAWHXGRPG >In-frame_MAP4K5_ENST00000013125_chr14_50971518_-_ADCK1_ENST00000341211_chr14_78353434_+_438aa MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPDPXFVPELRXHPSGDGLPGPGPQGSAAXWADGGRE GPAPKGAGSELEGHSPDGGARSGCEAAVPRVXVYVACGXSQEEPAFGAGFPQXREECXEGVPDAQAFXLLEGPPNPLGPVHGAGPPDGVC GWRAGQXQRLHGEEQDRRQXDLTPPGQDVXXDDLRQWLRALRSPPRQCTGAEAPRHGKGGDCPVGPWALPDAHGRIPPELLPPLAVSDLD XHEESEGVQPATGSRGSLPLVCLHADGAIVGLGQQRHQPSSRHCHXGLRDSQQRGQLPPPDQPSPQPRAAPDAAHLEDQRPAAWHXGRPG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MAP4K5_ENST00000013125_chr14_50971518_-_ADCK1_ENST00000238561_chr14_78353434_+_1315nt ATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCGGAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACC TACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGAGCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGATCCATGATTTGTT CCAGAGCTTCGATGACACCCCTCTGGGGACGGCCTCCCTGGCCCAGGTCCACAAGGCAGTGCTGCATGATGGGCGGACGGTGGCCGTGAA GGTCCAGCACCCAAAGGTGCGGGCTCAGAGCTCGAAGGACATTCTCCTGATGGAGGTGCTCGTTCTGGCTGTGAAGCAGCTGTTCCCAGA GTTTGAGTTTATGTGGCTTGTGGATGAAGCCAAGAAGAACCTGCCTTTGGAGCTGGATTTCCTCAATGAAGGGAGGAATGCTGAGAAGGT GTCCCAGATGCTCAGGCATTTTGACTTCTTGAAGGTCCCCCGAATCCACTGGGACCTGTCCACGGAGCGGGTCCTCCTGATGGAGTTTGT GGATGGCGGGCAGGTCAATGACAGAGACTACATGGAGAGGAACAAGATCGACGTCAATGAGATCTCACGCCACCTGGGCAAGATGTATAG TGAGATGATCTTCGTCAATGGCTTCGTGCACTGCGATCCCCACCCCGGCAATGTACTGGTGCGGAAGCACCCCGGCACGGGAAAGGCGGA GATTGTCCTGTTGGACCATGGGCTTTACCAGATGCTCACGGAAGAATTCCGCCTGAATTACTGCCACCTCTGGCAGTCTCTGATCTGGAC TGACATGAAGAGAGTGAAGGAGTACAGCCAGCGACTGGGAGCCGGGGATCTCTACCCCTTGTTTGCCTGCATGCTGACGGCGCGATCGTG GGACTCGGTCAACAGAGGCATCAGCCAAGCTCCCGTCACTGCCACTGAGGACTTAGAGATTCGCAACAACGCGGCCAACTACCTCCCCCA GATCAGCCATCTCCTCAACCACGTGCCGCGCCAGATGCTGCTCATCTTGAAGACCAACGACCTGCTGCGTGGCATTGAGGCCGCCCTGGG CACCCGCGCCAGCGCCAGCTCCTTTCTCAACATGTCACGTTGCTGCATCAGAGCGCTAGCTGAGCACAAGAAGAAGAATACCTGTTCATT CTTCAGAAGGACCCAGATCTCTTTCAGCGAGGCCTTCAACTTATGGCAGATCAACCTCCATGAGCTCATCCTGCGTGTGAAGGGGTTGAA >In-frame_MAP4K5_ENST00000013125_chr14_50971518_-_ADCK1_ENST00000341211_chr14_78353434_+_1315nt ATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCGGAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACC TACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGAGCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGATCCATGATTTGTT CCAGAGCTTCGATGACACCCCTCTGGGGACGGCCTCCCTGGCCCAGGTCCACAAGGCAGTGCTGCATGATGGGCGGACGGTGGCCGTGAA GGTCCAGCACCCAAAGGTGCGGGCTCAGAGCTCGAAGGACATTCTCCTGATGGAGGTGCTCGTTCTGGCTGTGAAGCAGCTGTTCCCAGA GTTTGAGTTTATGTGGCTTGTGGATGAAGCCAAGAAGAACCTGCCTTTGGAGCTGGATTTCCTCAATGAAGGGAGGAATGCTGAGAAGGT GTCCCAGATGCTCAGGCATTTTGACTTCTTGAAGGTCCCCCGAATCCACTGGGACCTGTCCACGGAGCGGGTCCTCCTGATGGAGTTTGT GGATGGCGGGCAGGTCAATGACAGAGACTACATGGAGAGGAACAAGATCGACGTCAATGAGATCTCACGCCACCTGGGCAAGATGTATAG TGAGATGATCTTCGTCAATGGCTTCGTGCACTGCGATCCCCACCCCGGCAATGTACTGGTGCGGAAGCACCCCGGCACGGGAAAGGCGGA GATTGTCCTGTTGGACCATGGGCTTTACCAGATGCTCACGGAAGAATTCCGCCTGAATTACTGCCACCTCTGGCAGTCTCTGATCTGGAC TGACATGAAGAGAGTGAAGGAGTACAGCCAGCGACTGGGAGCCGGGGATCTCTACCCCTTGTTTGCCTGCATGCTGACGGCGCGATCGTG GGACTCGGTCAACAGAGGCATCAGCCAAGCTCCCGTCACTGCCACTGAGGACTTAGAGATTCGCAACAACGCGGCCAACTACCTCCCCCA GATCAGCCATCTCCTCAACCACGTGCCGCGCCAGATGCTGCTCATCTTGAAGACCAACGACCTGCTGCGTGGCATTGAGGCCGCCCTGGG CACCCGCGCCAGCGCCAGCTCCTTTCTCAACATGTCACGTTGCTGCATCAGAGCGCTAGCTGAGCACAAGAAGAAGAATACCTGTTCATT CTTCAGAAGGACCCAGATCTCTTTCAGCGAGGCCTTCAACTTATGGCAGATCAACCTCCATGAGCTCATCCTGCGTGTGAAGGGGTTGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MAP4K5_ENST00000013125_chr14_50971518_-_ADCK1_ENST00000238561_chr14_78353434_+_2197nt GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGATCCATGATTTGTTCCAGAGCTTCGATGACACCCCTCTGGGGACGGCCTCCCTGG CCCAGGTCCACAAGGCAGTGCTGCATGATGGGCGGACGGTGGCCGTGAAGGTCCAGCACCCAAAGGTGCGGGCTCAGAGCTCGAAGGACA TTCTCCTGATGGAGGTGCTCGTTCTGGCTGTGAAGCAGCTGTTCCCAGAGTTTGAGTTTATGTGGCTTGTGGATGAAGCCAAGAAGAACC TGCCTTTGGAGCTGGATTTCCTCAATGAAGGGAGGAATGCTGAGAAGGTGTCCCAGATGCTCAGGCATTTTGACTTCTTGAAGGTCCCCC GAATCCACTGGGACCTGTCCACGGAGCGGGTCCTCCTGATGGAGTTTGTGGATGGCGGGCAGGTCAATGACAGAGACTACATGGAGAGGA ACAAGATCGACGTCAATGAGATCTCACGCCACCTGGGCAAGATGTATAGTGAGATGATCTTCGTCAATGGCTTCGTGCACTGCGATCCCC ACCCCGGCAATGTACTGGTGCGGAAGCACCCCGGCACGGGAAAGGCGGAGATTGTCCTGTTGGACCATGGGCTTTACCAGATGCTCACGG AAGAATTCCGCCTGAATTACTGCCACCTCTGGCAGTCTCTGATCTGGACTGACATGAAGAGAGTGAAGGAGTACAGCCAGCGACTGGGAG CCGGGGATCTCTACCCCTTGTTTGCCTGCATGCTGACGGCGCGATCGTGGGACTCGGTCAACAGAGGCATCAGCCAAGCTCCCGTCACTG CCACTGAGGACTTAGAGATTCGCAACAACGCGGCCAACTACCTCCCCCAGATCAGCCATCTCCTCAACCACGTGCCGCGCCAGATGCTGC TCATCTTGAAGACCAACGACCTGCTGCGTGGCATTGAGGCCGCCCTGGGCACCCGCGCCAGCGCCAGCTCCTTTCTCAACATGTCACGTT GCTGCATCAGAGCGCTAGCTGAGCACAAGAAGAAGAATACCTGTTCATTCTTCAGAAGGACCCAGATCTCTTTCAGCGAGGCCTTCAACT TATGGCAGATCAACCTCCATGAGCTCATCCTGCGTGTGAAGGGGTTGAAGCTGGCTGACCGGGTCTTGGCCCTAATATGCTGGCTGTTCC CTGCTCCACTCTGAGTGGAATTGCTCTCCCTGCCCCATTCTGGTGTCTTTCCACTCCTCAGCCCCTCATCTTGCCTCCACCCAGCTGCTC CATTTTTGCCACATCGTGGCCCGCAGCCCCAGAGTCACTGTCCATGTCACCATCCTTCTCCTCCTTTGGAATCCTCTCCGCACACTGTGG CCCTTGTCTCAGGGCCCACAAGCTGAACTGTGGCATAGCTCTCTCTTCTTCTCCAAGAAGACTCAGCAGCCTACATTCCCATTCCTGGTA TGTGCCATTGGGTTGGATGTCCCCACTACTTCCGTTAACCCTTCCCATTGTCAAGATGTGCCACGGGTGCCACTGGGGGCACACTGAACT TGTAGGGAGTGTGATTTTGTTGGAGGTGCACATGGTCTCTGAATTTGACAGAGAACACCTTCCCTTTCCTTGCCATGTCACCCTCCAGAG GAAGTCACACCTCAGCGAGGTGGTTTGGCATCTGGGGCCAACTCCATTACAGCTATGAGCTCACTGCTGTCAGTGACGTTTGGTGTTTTC >In-frame_MAP4K5_ENST00000013125_chr14_50971518_-_ADCK1_ENST00000341211_chr14_78353434_+_2195nt GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGATCCATGATTTGTTCCAGAGCTTCGATGACACCCCTCTGGGGACGGCCTCCCTGG CCCAGGTCCACAAGGCAGTGCTGCATGATGGGCGGACGGTGGCCGTGAAGGTCCAGCACCCAAAGGTGCGGGCTCAGAGCTCGAAGGACA TTCTCCTGATGGAGGTGCTCGTTCTGGCTGTGAAGCAGCTGTTCCCAGAGTTTGAGTTTATGTGGCTTGTGGATGAAGCCAAGAAGAACC TGCCTTTGGAGCTGGATTTCCTCAATGAAGGGAGGAATGCTGAGAAGGTGTCCCAGATGCTCAGGCATTTTGACTTCTTGAAGGTCCCCC GAATCCACTGGGACCTGTCCACGGAGCGGGTCCTCCTGATGGAGTTTGTGGATGGCGGGCAGGTCAATGACAGAGACTACATGGAGAGGA ACAAGATCGACGTCAATGAGATCTCACGCCACCTGGGCAAGATGTATAGTGAGATGATCTTCGTCAATGGCTTCGTGCACTGCGATCCCC ACCCCGGCAATGTACTGGTGCGGAAGCACCCCGGCACGGGAAAGGCGGAGATTGTCCTGTTGGACCATGGGCTTTACCAGATGCTCACGG AAGAATTCCGCCTGAATTACTGCCACCTCTGGCAGTCTCTGATCTGGACTGACATGAAGAGAGTGAAGGAGTACAGCCAGCGACTGGGAG CCGGGGATCTCTACCCCTTGTTTGCCTGCATGCTGACGGCGCGATCGTGGGACTCGGTCAACAGAGGCATCAGCCAAGCTCCCGTCACTG CCACTGAGGACTTAGAGATTCGCAACAACGCGGCCAACTACCTCCCCCAGATCAGCCATCTCCTCAACCACGTGCCGCGCCAGATGCTGC TCATCTTGAAGACCAACGACCTGCTGCGTGGCATTGAGGCCGCCCTGGGCACCCGCGCCAGCGCCAGCTCCTTTCTCAACATGTCACGTT GCTGCATCAGAGCGCTAGCTGAGCACAAGAAGAAGAATACCTGTTCATTCTTCAGAAGGACCCAGATCTCTTTCAGCGAGGCCTTCAACT TATGGCAGATCAACCTCCATGAGCTCATCCTGCGTGTGAAGGGGTTGAAGCTGGCTGACCGGGTCTTGGCCCTAATATGCTGGCTGTTCC CTGCTCCACTCTGAGTGGAATTGCTCTCCCTGCCCCATTCTGGTGTCTTTCCACTCCTCAGCCCCTCATCTTGCCTCCACCCAGCTGCTC CATTTTTGCCACATCGTGGCCCGCAGCCCCAGAGTCACTGTCCATGTCACCATCCTTCTCCTCCTTTGGAATCCTCTCCGCACACTGTGG CCCTTGTCTCAGGGCCCACAAGCTGAACTGTGGCATAGCTCTCTCTTCTTCTCCAAGAAGACTCAGCAGCCTACATTCCCATTCCTGGTA TGTGCCATTGGGTTGGATGTCCCCACTACTTCCGTTAACCCTTCCCATTGTCAAGATGTGCCACGGGTGCCACTGGGGGCACACTGAACT TGTAGGGAGTGTGATTTTGTTGGAGGTGCACATGGTCTCTGAATTTGACAGAGAACACCTTCCCTTTCCTTGCCATGTCACCCTCCAGAG GAAGTCACACCTCAGCGAGGTGGTTTGGCATCTGGGGCCAACTCCATTACAGCTATGAGCTCACTGCTGTCAGTGACGTTTGGTGTTTTC |
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FusionGenePPI for MAP4K5_ADCK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAP4K5 | CRK, CRKL, TRAF2, HCK, COPS5, GRB2, ZNF440, SETDB1, NEDD4, ELAVL1, CDRT15, NTRK1, PPM1A, PPM1B, SMURF1, MAP4K3 | ADCK1 | EXOC5, MOV10, NXF1, SPACA1, PLAUR, GNAI2, MKNK2, ADCK1, STOML2, PRELID1, TOMM5, CHCHD3, IMMT, ATP5H, MLYCD, CHCHD2, ECH1, PMPCB, ATP5O, MTX1, C1QBP, MTCH2, APLNR, NPY2R, C5AR2, VIPR2, GRPR, SLC15A1, LYPD4, SLC18A1, CHRM4, C1orf85, OPRM1, P2RX5, FAM131B, IL13RA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP4K5_ADCK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP4K5_ADCK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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