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Fusion gene ID: 20908 |
FusionGeneSummary for MAP4K4_TSSK6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP4K4_TSSK6 | Fusion gene ID: 20908 | Hgene | Tgene | Gene symbol | MAP4K4 | TSSK6 | Gene ID | 9448 | 83983 |
| Gene name | mitogen-activated protein kinase kinase kinase kinase 4 | testis specific serine kinase 6 | |
| Synonyms | FLH21957|HEL-S-31|HGK|MEKKK4|NIK | CT72|FKSG82|SSTK|TSSK4 | |
| Cytomap | 2q11.2 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase kinase 4HPK/GCK-like kinase HGKMAPK/ERK kinase kinase kinase 4MEK kinase kinase 4Ste20 group protein kinase HGKepididymis secretory protein Li 31hepatocyte progenitor kinase-like/germinal center kinase- | testis-specific serine/threonine-protein kinase 6TSK-6cancer/testis antigen 72serine/threonine protein kinase SSTKsmall serine/threonine kinasetestis secretory sperm-binding protein Li 205a | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O95819 | Q9BXA6 | |
| Ensembl transtripts involved in fusion gene | ENST00000425019, ENST00000324219, ENST00000350198, ENST00000302217, ENST00000413150, ENST00000347699, ENST00000456652, ENST00000350878, ENST00000498066, | ENST00000360913, ENST00000585580, | |
| Fusion gene scores | * DoF score | 11 X 7 X 8=616 | 2 X 1 X 2=4 |
| # samples | 11 | 2 | |
| ** MAII score | log2(11/616*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: MAP4K4 [Title/Abstract] AND TSSK6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP4K4 | GO:0006468 | protein phosphorylation | 9890973 |
| Hgene | MAP4K4 | GO:0035556 | intracellular signal transduction | 9890973 |
| Hgene | MAP4K4 | GO:0046328 | regulation of JNK cascade | 14966141 |
| Tgene | TSSK6 | GO:0006468 | protein phosphorylation | 15870294 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-CH-5766-01A | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000425019 | ENST00000360913 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-intron | ENST00000425019 | ENST00000585580 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-3UTR | ENST00000324219 | ENST00000360913 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-intron | ENST00000324219 | ENST00000585580 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-3UTR | ENST00000350198 | ENST00000360913 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-intron | ENST00000350198 | ENST00000585580 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-3UTR | ENST00000302217 | ENST00000360913 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-intron | ENST00000302217 | ENST00000585580 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-3UTR | ENST00000413150 | ENST00000360913 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-intron | ENST00000413150 | ENST00000585580 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-3UTR | ENST00000347699 | ENST00000360913 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-intron | ENST00000347699 | ENST00000585580 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-3UTR | ENST00000456652 | ENST00000360913 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| 5CDS-intron | ENST00000456652 | ENST00000585580 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| intron-3UTR | ENST00000350878 | ENST00000360913 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| intron-intron | ENST00000350878 | ENST00000585580 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| intron-3UTR | ENST00000498066 | ENST00000360913 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
| intron-intron | ENST00000498066 | ENST00000585580 | MAP4K4 | chr2 | 102315000 | + | TSSK6 | chr19 | 19623351 | - |
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FusionProtFeatures for MAP4K4_TSSK6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP4K4 | TSSK6 |
| Serine/threonine kinase that may play a role in theresponse to environmental stress and cytokines such as TNF-alpha.Appears to act upstream of the JUN N-terminal pathway.Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:21690388,ECO:0000269|PubMed:9890973}. | Required for sperm production and function. Plays a rolein DNA condensation during postmeiotic chromatin remodeling (Bysimilarity). {ECO:0000250|UniProtKB:Q925K9,ECO:0000269|PubMed:15870294}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAP4K4_TSSK6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAP4K4_TSSK6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAP4K4 | BRCA1, RASA1, ITGB1, NCK1, MAP3K1, GBP3, ZRANB1, KIF5A, PRKCE, SLC9A1, HIST2H2BE, KIF26B, PPP1CA, GRK5, PAXIP1, PPP1CC, HSP90AA1, NME7, MOB1B, TBPL2, OBSL1, MINK1, SLC25A41, TEX264, NCK2, PTGER3, LTBR, HEPACAM2, NTRK1, CDK12, NOP2, CEP152, CNTRL, TMEM17, XPO1, PPP2CB, RNH1, STRN, FGFR1OP2, STRN3, RAP2C, NANOS2, ATG14, CNOT11, MANSC1, TRIM25, G3BP1 | TSSK6 | MBP, HSP90AA1, HSPA8, HSPA4, HIST2H2AC, HIST1H3A, H2AFX, APP, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, FKBP5, TCP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP4K4_TSSK6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP4K4_TSSK6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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