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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20878

FusionGeneSummary for MAP3K5_PREP

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP3K5_PREP
Fusion gene ID: 20878
HgeneTgene
Gene symbol

MAP3K5

PREP

Gene ID

4217

5550

Gene namemitogen-activated protein kinase kinase kinase 5prolyl endopeptidase
SynonymsASK1|MAPKKK5|MEKK5PE|PEP
Cytomap

6q23.3

6q21

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 5ASK-1MAP/ERK kinase kinase 5MAPK/ERK kinase kinase 5MEK kinase 5MEKK 5apoptosis signal-regulating kinase 1prolyl endopeptidasedJ355L5.1 (prolyl endopeptidase)post-proline cleaving enzymeprolyl oligopeptidase
Modification date2018052320180523
UniProtAcc

Q99683

P48147

Ensembl transtripts involved in fusion geneENST00000359015, ENST00000355845, 
ENST00000463140, 
ENST00000369110, 
Fusion gene scores* DoF score8 X 5 X 7=2806 X 3 X 6=108
# samples 86
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP3K5 [Title/Abstract] AND PREP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP3K5

GO:0000165

MAPK cascade

17210579|21771788

HgeneMAP3K5

GO:0000186

activation of MAPKK activity

11959862

HgeneMAP3K5

GO:0006468

protein phosphorylation

11096076|15983381

HgeneMAP3K5

GO:0007254

JNK cascade

21771788

HgeneMAP3K5

GO:0008631

intrinsic apoptotic signaling pathway in response to oxidative stress

21771788

HgeneMAP3K5

GO:0034198

cellular response to amino acid starvation

11096076

HgeneMAP3K5

GO:0043065

positive regulation of apoptotic process

21771788

HgeneMAP3K5

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

20674765

HgeneMAP3K5

GO:0045893

positive regulation of transcription, DNA-templated

11096076

HgeneMAP3K5

GO:0051403

stress-activated MAPK cascade

11096076

HgeneMAP3K5

GO:0070301

cellular response to hydrogen peroxide

20674765


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUVMTCGA-VD-A8KJ-01AMAP3K5chr6

136960681

-PREPchr6

105781380

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000359015ENST00000369110MAP3K5chr6

136960681

-PREPchr6

105781380

-
5UTR-3CDSENST00000355845ENST00000369110MAP3K5chr6

136960681

-PREPchr6

105781380

-
intron-3CDSENST00000463140ENST00000369110MAP3K5chr6

136960681

-PREPchr6

105781380

-

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FusionProtFeatures for MAP3K5_PREP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP3K5

Q99683

PREP

P48147

Serine/threonine kinase which acts as an essentialcomponent of the MAP kinase signal transduction pathway. Plays animportant role in the cascades of cellular responses evoked bychanges in the environment. Mediates signaling for determinationof cell fate such as differentiation and survival. Plays a crucialrole in the apoptosis signal transduction pathway throughmitochondria-dependent caspase activation. MAP3K5/ASK1 is requiredfor the innate immune response, which is essential for hostdefense against a wide range of pathogens. Mediates signaltransduction of various stressors like oxidative stress as well asby receptor-mediated inflammatory signals, such as the tumornecrosis factor (TNF) or lipopolysaccharide (LPS). Once activated,acts as an upstream activator of the MKK/JNK signal transductioncascade and the p38 MAPK signal transduction cascade through thephosphorylation and activation of several MAP kinase kinases likeMAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. TheseMAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases(JNKs). Both p38 MAPK and JNKs control the transcription factorsactivator protein-1 (AP-1). {ECO:0000269|PubMed:10411906,ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426,ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276,ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685,ECO:0000269|PubMed:12697749, ECO:0000269|PubMed:14688258,ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544,ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297,ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:8940179,ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042,ECO:0000269|PubMed:9774977}. Cleaves peptide bonds on the C-terminal side of prolylresidues within peptides that are up to approximately 30 aminoacids long.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP3K5_PREP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP3K5_PREP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP3K5GADD45B, KMT2A, PDCD6, TRAF1, TRAF2, TRAF3, TRAF5, TRAF6, QARS, CDC25A, MAP3K5, DUSP19, MAP2K7, CDKN1A, RB1CC1, MAP2K6, YWHAZ, HSPA1A, TXN, MAP3K6, ERN1, RAF1, EIF2AK2, ARRB2, MAPK8IP3, PPP5C, GLRX, GSTM1, MAP3K7, DAXX, GNA12, GNA13, STUB1, ALK, SOCS1, SOCS3, PRKAA2, PRKAB2, CREBBP, DMD, EP300, USP9X, SMN1, NEDD4, ARRB1, TNFAIP3, NEDD4L, HSPA4, PSMC2, PSMC1, PSMC4, PSMC3, PSMC5, MAP2K4, FAS, YWHAQ, DAB2IP, JAK2, PTPN11, PARK7, MBP, DYRK1A, HSP90AA1, MCRS1, AKT2, MAP2K3, GEMIN5, AKT1, PIK3R1, TXN2, ATAD3A, NACC1, SIAH1, GAPDH, TNFSF13B, APP, APOBEC3G, YWHAG, CIB1PREPSIRT7, TARS, BRCA1, SGOL2, AIP, GLO1, HSPA4, HSPD1, HSPH1, KCNAB2, PABPC4, ALDOA, ALDOC, CTH, GDI2, ISYNA1, ME1, OAT, PABPC1, QDPR, NTRK1, SUCO, MTG2, NSMAF, RHPN1, KIF3A, SNCA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP3K5_PREP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAP3K5_PREP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP3K5C0011849Diabetes Mellitus1CTD_human
HgeneMAP3K5C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneMAP3K5C0025202melanoma1CTD_human
HgeneMAP3K5C0030567Parkinson Disease1CTD_human
HgeneMAP3K5C0878544Cardiomyopathies1CTD_human
HgeneMAP3K5C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgenePREPC0002622Amnesia1CTD_human
TgenePREPC0002624Retrograde amnesia1CTD_human
TgenePREPC0005586Bipolar Disorder1PSYGENET
TgenePREPC0038356Stomach Neoplasms1CTD_human
TgenePREPC0338831Manic1PSYGENET