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Fusion gene ID: 20871 |
FusionGeneSummary for MAP3K5_ARFIP1 |
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Fusion gene information | Fusion gene name: MAP3K5_ARFIP1 | Fusion gene ID: 20871 | Hgene | Tgene | Gene symbol | MAP3K5 | ARFIP1 | Gene ID | 4217 | 27236 |
Gene name | mitogen-activated protein kinase kinase kinase 5 | ADP ribosylation factor interacting protein 1 | |
Synonyms | ASK1|MAPKKK5|MEKK5 | HSU52521 | |
Cytomap | 6q23.3 | 4q31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | mitogen-activated protein kinase kinase kinase 5ASK-1MAP/ERK kinase kinase 5MAPK/ERK kinase kinase 5MEK kinase 5MEKK 5apoptosis signal-regulating kinase 1 | arfaptin-1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q99683 | P53367 | |
Ensembl transtripts involved in fusion gene | ENST00000359015, ENST00000355845, ENST00000463140, | ENST00000451320, ENST00000429148, ENST00000353617, ENST00000405727, ENST00000356064, ENST00000511289, | |
Fusion gene scores | * DoF score | 8 X 5 X 7=280 | 7 X 6 X 7=294 |
# samples | 8 | 10 | |
** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/294*10)=-1.55581615506164 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAP3K5 [Title/Abstract] AND ARFIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MAP3K5 | GO:0000165 | MAPK cascade | 17210579|21771788 |
Hgene | MAP3K5 | GO:0000186 | activation of MAPKK activity | 11959862 |
Hgene | MAP3K5 | GO:0006468 | protein phosphorylation | 11096076|15983381 |
Hgene | MAP3K5 | GO:0007254 | JNK cascade | 21771788 |
Hgene | MAP3K5 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | 21771788 |
Hgene | MAP3K5 | GO:0034198 | cellular response to amino acid starvation | 11096076 |
Hgene | MAP3K5 | GO:0043065 | positive regulation of apoptotic process | 21771788 |
Hgene | MAP3K5 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 20674765 |
Hgene | MAP3K5 | GO:0045893 | positive regulation of transcription, DNA-templated | 11096076 |
Hgene | MAP3K5 | GO:0051403 | stress-activated MAPK cascade | 11096076 |
Hgene | MAP3K5 | GO:0070301 | cellular response to hydrogen peroxide | 20674765 |
Tgene | ARFIP1 | GO:0006886 | intracellular protein transport | 12606037 |
Tgene | ARFIP1 | GO:0050708 | regulation of protein secretion | 12606037 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-CN-4736-01A | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000359015 | ENST00000451320 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
5CDS-intron | ENST00000359015 | ENST00000429148 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
5CDS-intron | ENST00000359015 | ENST00000353617 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
5CDS-intron | ENST00000359015 | ENST00000405727 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
5CDS-intron | ENST00000359015 | ENST00000356064 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
5CDS-3UTR | ENST00000359015 | ENST00000511289 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
intron-3CDS | ENST00000355845 | ENST00000451320 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
intron-intron | ENST00000355845 | ENST00000429148 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
intron-intron | ENST00000355845 | ENST00000353617 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
intron-intron | ENST00000355845 | ENST00000405727 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
intron-intron | ENST00000355845 | ENST00000356064 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
intron-3UTR | ENST00000355845 | ENST00000511289 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
intron-3CDS | ENST00000463140 | ENST00000451320 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
intron-intron | ENST00000463140 | ENST00000429148 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
intron-intron | ENST00000463140 | ENST00000353617 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
intron-intron | ENST00000463140 | ENST00000405727 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
intron-intron | ENST00000463140 | ENST00000356064 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
intron-3UTR | ENST00000463140 | ENST00000511289 | MAP3K5 | chr6 | 137112848 | - | ARFIP1 | chr4 | 153793604 | + |
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FusionProtFeatures for MAP3K5_ARFIP1 |
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Hgene | Tgene |
MAP3K5 | ARFIP1 |
Serine/threonine kinase which acts as an essentialcomponent of the MAP kinase signal transduction pathway. Plays animportant role in the cascades of cellular responses evoked bychanges in the environment. Mediates signaling for determinationof cell fate such as differentiation and survival. Plays a crucialrole in the apoptosis signal transduction pathway throughmitochondria-dependent caspase activation. MAP3K5/ASK1 is requiredfor the innate immune response, which is essential for hostdefense against a wide range of pathogens. Mediates signaltransduction of various stressors like oxidative stress as well asby receptor-mediated inflammatory signals, such as the tumornecrosis factor (TNF) or lipopolysaccharide (LPS). Once activated,acts as an upstream activator of the MKK/JNK signal transductioncascade and the p38 MAPK signal transduction cascade through thephosphorylation and activation of several MAP kinase kinases likeMAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. TheseMAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases(JNKs). Both p38 MAPK and JNKs control the transcription factorsactivator protein-1 (AP-1). {ECO:0000269|PubMed:10411906,ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426,ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276,ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685,ECO:0000269|PubMed:12697749, ECO:0000269|PubMed:14688258,ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544,ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297,ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:8940179,ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042,ECO:0000269|PubMed:9774977}. | Putative target protein of ADP-ribosylation factor. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAP3K5_ARFIP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAP3K5_ARFIP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAP3K5 | GADD45B, KMT2A, PDCD6, TRAF1, TRAF2, TRAF3, TRAF5, TRAF6, QARS, CDC25A, MAP3K5, DUSP19, MAP2K7, CDKN1A, RB1CC1, MAP2K6, YWHAZ, HSPA1A, TXN, MAP3K6, ERN1, RAF1, EIF2AK2, ARRB2, MAPK8IP3, PPP5C, GLRX, GSTM1, MAP3K7, DAXX, GNA12, GNA13, STUB1, ALK, SOCS1, SOCS3, PRKAA2, PRKAB2, CREBBP, DMD, EP300, USP9X, SMN1, NEDD4, ARRB1, TNFAIP3, NEDD4L, HSPA4, PSMC2, PSMC1, PSMC4, PSMC3, PSMC5, MAP2K4, FAS, YWHAQ, DAB2IP, JAK2, PTPN11, PARK7, MBP, DYRK1A, HSP90AA1, MCRS1, AKT2, MAP2K3, GEMIN5, AKT1, PIK3R1, TXN2, ATAD3A, NACC1, SIAH1, GAPDH, TNFSF13B, APP, APOBEC3G, YWHAG, CIB1 | ARFIP1 | ARF3, ARF1, ARF5, SLC2A4, ATP6V1C1, TBC1D15, TSNAX, YAP1, DNM1L, HIST1H4A, IDE, LUC7L2, PRMT3, PSMG3, SEC24A, SHMT2, STAT3, ARFIP2, PICK1, AACS, AKR1A1, ADSS, DPYSL2, G6PD, GART, HSD17B8, MVB12A, PFKM, PFKP, PPP3CA, PROSC, SARS, SEC24D, SHMT1, TSTA3, TXNDC9, USP14, ATOX1, ECH1, FLNB, LYPLA1, PAFAH1B2, PDCD6, PGM2L1, QDPR, STIP1, TBCA, DYNLT1, TMEM17, TMEM216, CDC5L, CDH1, CLPB, HSPA8, HSPBP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP3K5_ARFIP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP3K5_ARFIP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MAP3K5 | C0011849 | Diabetes Mellitus | 1 | CTD_human |
Hgene | MAP3K5 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
Hgene | MAP3K5 | C0025202 | melanoma | 1 | CTD_human |
Hgene | MAP3K5 | C0030567 | Parkinson Disease | 1 | CTD_human |
Hgene | MAP3K5 | C0878544 | Cardiomyopathies | 1 | CTD_human |
Hgene | MAP3K5 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |