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Fusion gene ID: 20869 |
FusionGeneSummary for MAP3K4_SERINC1 |
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Fusion gene information | Fusion gene name: MAP3K4_SERINC1 | Fusion gene ID: 20869 | Hgene | Tgene | Gene symbol | MAP3K4 | SERINC1 | Gene ID | 4216 | 57515 |
Gene name | mitogen-activated protein kinase kinase kinase 4 | serine incorporator 1 | |
Synonyms | MAPKKK4|MEKK 4|MEKK4|MTK1|PRO0412 | TDE1L|TDE2|TMS-2|TMS2 | |
Cytomap | 6q26 | 6q22.31 | |
Type of gene | protein-coding | protein-coding | |
Description | mitogen-activated protein kinase kinase kinase 4MAP three kinase 1MAP/ERK kinase kinase 4MAPK/ERK kinase kinase 4MEK kinase 4SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog ofdJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)predicte | serine incorporator 1tumor differentially expressed protein 2 | |
Modification date | 20180524 | 20180523 | |
UniProtAcc | Q9Y6R4 | Q9NRX5 | |
Ensembl transtripts involved in fusion gene | ENST00000366919, ENST00000392142, ENST00000348824, ENST00000366920, ENST00000446500, | ENST00000339697, | |
Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 8 X 9 X 4=288 |
# samples | 5 | 10 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAP3K4 [Title/Abstract] AND SERINC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MAP3K4 | GO:0000186 | activation of MAPKK activity | 9305639|9827804 |
Hgene | MAP3K4 | GO:0043507 | positive regulation of JUN kinase activity | 9305639 |
Hgene | MAP3K4 | GO:1900745 | positive regulation of p38MAPK cascade | 9305639 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | THCA | TCGA-CE-A482-01A | MAP3K4 | chr6 | 161413115 | + | SERINC1 | chr6 | 122779826 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000366919 | ENST00000339697 | MAP3K4 | chr6 | 161413115 | + | SERINC1 | chr6 | 122779826 | - |
Frame-shift | ENST00000392142 | ENST00000339697 | MAP3K4 | chr6 | 161413115 | + | SERINC1 | chr6 | 122779826 | - |
Frame-shift | ENST00000348824 | ENST00000339697 | MAP3K4 | chr6 | 161413115 | + | SERINC1 | chr6 | 122779826 | - |
Frame-shift | ENST00000366920 | ENST00000339697 | MAP3K4 | chr6 | 161413115 | + | SERINC1 | chr6 | 122779826 | - |
intron-3CDS | ENST00000446500 | ENST00000339697 | MAP3K4 | chr6 | 161413115 | + | SERINC1 | chr6 | 122779826 | - |
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FusionProtFeatures for MAP3K4_SERINC1 |
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Hgene | Tgene |
MAP3K4 | SERINC1 |
Component of a protein kinase signal transductioncascade. Activates the CSBP2, P38 and JNK MAPK pathways, but notthe ERK pathway. Specifically phosphorylates and activates MAP2K4and MAP2K6. {ECO:0000269|PubMed:12052864,ECO:0000269|PubMed:9305639}. | Enhances the incorporation of serine intophosphatidylserine and sphingolipids.{ECO:0000250|UniProtKB:Q7TNK0}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAP3K4_SERINC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAP3K4_SERINC1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAP3K4 | CDC42, RAC1, MAP2K1, MAP2K4, MAP2K3, MAP2K6, GADD45G, GADD45B, GADD45A, ALK, SH3KBP1, TPR, YWHAZ, CNTRL, ZFP36, TRAF4, MAP2K7, RIPK2, MAPK8, CHUK, GSK3B, MAP3K4, AXIN1, HNRNPD, POLR2F, RAP1B, SORT1, SRPR, KIF23, BAG3, SYNCRIP, AP4E1, GOLT1B, SGTB, KIF21A, VWA9, CNTROB, NEDD1, KIF7, BAG6, USF1, MAPK13, SPATA1, ACTBL2, SIGLECL1, BTK, TOP1, TOP2A, TOP3A | SERINC1 | ILF3, IGF2R, TMCO1, SAMM50, MAK, ZMYND10, CYP39A1, PAX8, ASGR2, P2RY8, LPAR1, UNK, CREB3, VPS18, NDUFV3, VIPR2, IPPK, LGALS3, CD97, TMEM63A, SLC2A12, SYNE4, HTR2C, GPR114, SLC9A6, GNB2, GPR89B, SLC1A5, SLC22A16, SLC22A9, SPPL2B, ARL15, AGPAT3, TMEM120A, TMEM120B, NCLN, NOMO1, METTL9 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP3K4_SERINC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP3K4_SERINC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MAP3K4 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |