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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 20868

FusionGeneSummary for MAP3K4_METTL24

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP3K4_METTL24
Fusion gene ID: 20868
HgeneTgene
Gene symbol

MAP3K4

METTL24

Gene ID

4216

728464

Gene namemitogen-activated protein kinase kinase kinase 4methyltransferase like 24
SynonymsMAPKKK4|MEKK 4|MEKK4|MTK1|PRO0412C6orf186
Cytomap

6q26

6q21

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 4MAP three kinase 1MAP/ERK kinase kinase 4MAPK/ERK kinase kinase 4MEK kinase 4SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog ofdJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)predictemethyltransferase-like protein 24UPF0624 protein C6orf186
Modification date2018052420180329
UniProtAcc

Q9Y6R4

Q5JXM2

Ensembl transtripts involved in fusion geneENST00000366919, ENST00000392142, 
ENST00000348824, ENST00000366920, 
ENST00000446500, 
ENST00000338882, 
ENST00000490043, 
Fusion gene scores* DoF score5 X 3 X 5=754 X 4 X 4=64
# samples 54
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP3K4 [Title/Abstract] AND METTL24 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP3K4

GO:0000186

activation of MAPKK activity

9305639|9827804

HgeneMAP3K4

GO:0043507

positive regulation of JUN kinase activity

9305639

HgeneMAP3K4

GO:1900745

positive regulation of p38MAPK cascade

9305639


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-E1-5304-01AMAP3K4chr6

161471011

+METTL24chr6

110636684

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000366919ENST00000338882MAP3K4chr6

161471011

+METTL24chr6

110636684

-
5CDS-intronENST00000366919ENST00000490043MAP3K4chr6

161471011

+METTL24chr6

110636684

-
In-frameENST00000392142ENST00000338882MAP3K4chr6

161471011

+METTL24chr6

110636684

-
5CDS-intronENST00000392142ENST00000490043MAP3K4chr6

161471011

+METTL24chr6

110636684

-
In-frameENST00000348824ENST00000338882MAP3K4chr6

161471011

+METTL24chr6

110636684

-
5CDS-intronENST00000348824ENST00000490043MAP3K4chr6

161471011

+METTL24chr6

110636684

-
In-frameENST00000366920ENST00000338882MAP3K4chr6

161471011

+METTL24chr6

110636684

-
5CDS-intronENST00000366920ENST00000490043MAP3K4chr6

161471011

+METTL24chr6

110636684

-
intron-3CDSENST00000446500ENST00000338882MAP3K4chr6

161471011

+METTL24chr6

110636684

-
intron-intronENST00000446500ENST00000490043MAP3K4chr6

161471011

+METTL24chr6

110636684

-

Top

FusionProtFeatures for MAP3K4_METTL24


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP3K4

Q9Y6R4

METTL24

Q5JXM2

Component of a protein kinase signal transductioncascade. Activates the CSBP2, P38 and JNK MAPK pathways, but notthe ERK pathway. Specifically phosphorylates and activates MAP2K4and MAP2K6. {ECO:0000269|PubMed:12052864,ECO:0000269|PubMed:9305639}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP3K4chr6:161471011chr6:110636684ENST00000366919+32625_385691559Compositional biasNote=Poly-Pro
HgeneMAP3K4chr6:161471011chr6:110636684ENST00000366919+3264_75691559Compositional biasNote=Poly-Ala
HgeneMAP3K4chr6:161471011chr6:110636684ENST00000392142+32725_385691609Compositional biasNote=Poly-Pro
HgeneMAP3K4chr6:161471011chr6:110636684ENST00000392142+3274_75691609Compositional biasNote=Poly-Ala

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP3K4chr6:161471011chr6:110636684ENST00000366919+3261190_12025691559Compositional biasNote=Poly-Ala
HgeneMAP3K4chr6:161471011chr6:110636684ENST00000392142+3271190_12025691609Compositional biasNote=Poly-Ala
HgeneMAP3K4chr6:161471011chr6:110636684ENST00000366919+3261343_16015691559DomainProtein kinase
HgeneMAP3K4chr6:161471011chr6:110636684ENST00000392142+3271343_16015691609DomainProtein kinase
HgeneMAP3K4chr6:161471011chr6:110636684ENST00000366919+3261349_13575691559Nucleotide bindingATP
HgeneMAP3K4chr6:161471011chr6:110636684ENST00000392142+3271349_13575691609Nucleotide bindingATP


Top

FusionGeneSequence for MAP3K4_METTL24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MAP3K4_ENST00000366919_chr6_161471011_+_METTL24_ENST00000338882_chr6_110636684_-_797aa
MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSACKSPESDLEDFSDETNTENLYGTSPPSTPR
QMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIP
DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQA
WHAGRTINDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGE
LKELESSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
KLILRLHKLMDGSLQRARIALVKNDRPVEIACNHMNTDSLATDSSPTHKPWSVCLDDRFNLAHQIRNKQCRLYSLGLGSDDTHFEVSMAN
NGCEVHRFDPSVKSAHILESQHLWYHRLSIDWRDPHPAVAAQKPHSNTRKLGSILNEFGHHKIDVLKADLESAEWKVLENLILEDVLEQI

>In-frame_MAP3K4_ENST00000392142_chr6_161471011_+_METTL24_ENST00000338882_chr6_110636684_-_797aa
MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSACKSPESDLEDFSDETNTENLYGTSPPSTPR
QMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIP
DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQA
WHAGRTINDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGE
LKELESSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
KLILRLHKLMDGSLQRARIALVKNDRPVEIACNHMNTDSLATDSSPTHKPWSVCLDDRFNLAHQIRNKQCRLYSLGLGSDDTHFEVSMAN
NGCEVHRFDPSVKSAHILESQHLWYHRLSIDWRDPHPAVAAQKPHSNTRKLGSILNEFGHHKIDVLKADLESAEWKVLENLILEDVLEQI

>In-frame_MAP3K4_ENST00000348824_chr6_161471011_+_METTL24_ENST00000338882_chr6_110636684_-_797aa
MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSACKSPESDLEDFSDETNTENLYGTSPPSTPR
QMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIP
DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQA
WHAGRTINDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGE
LKELESSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
KLILRLHKLMDGSLQRARIALVKNDRPVEIACNHMNTDSLATDSSPTHKPWSVCLDDRFNLAHQIRNKQCRLYSLGLGSDDTHFEVSMAN
NGCEVHRFDPSVKSAHILESQHLWYHRLSIDWRDPHPAVAAQKPHSNTRKLGSILNEFGHHKIDVLKADLESAEWKVLENLILEDVLEQI

>In-frame_MAP3K4_ENST00000366920_chr6_161471011_+_METTL24_ENST00000338882_chr6_110636684_-_797aa
MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSACKSPESDLEDFSDETNTENLYGTSPPSTPR
QMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIP
DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQA
WHAGRTINDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGE
LKELESSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
KLILRLHKLMDGSLQRARIALVKNDRPVEIACNHMNTDSLATDSSPTHKPWSVCLDDRFNLAHQIRNKQCRLYSLGLGSDDTHFEVSMAN
NGCEVHRFDPSVKSAHILESQHLWYHRLSIDWRDPHPAVAAQKPHSNTRKLGSILNEFGHHKIDVLKADLESAEWKVLENLILEDVLEQI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MAP3K4_ENST00000366919_chr6_161471011_+_METTL24_ENST00000338882_chr6_110636684_-_2391nt
ATGAGAGAAGCCGCTGCCGCGCTGGTCCCTCCTCCCGCCTTTGCCGTCACGCCTGCCGCCGCCATGGAGGAGCCGCCGCCACCGCCGCCG
CCGCCACCACCGCCACCGGAACCCGAGACCGAGTCAGAACCCGAGTGCTGCTTGGCGGCGAGGCAAGAGGGCACATTGGGAGATTCAGCT
TGCAAGAGTCCTGAATCTGATCTAGAAGACTTCTCCGATGAAACAAATACAGAGAATCTTTATGGTACCTCTCCCCCCAGCACACCTCGA
CAGATGAAACGCATGTCAACCAAACATCAGAGGAATAATGTGGGGAGGCCAGCCAGTCGGTCTAATTTGAAAGAAAAAATGAATGCACCA
AATCAGCCTCCACATAAAGACACTGGAAAAACAGTGGAGAATGTGGAAGAATACAGCTATAAGCAGGAGAAAAAGATCCGAGCAGCTCTT
AGAACAACAGAGCGTGATCGTAAAAAAAATGTACAGTGCTCATTCATGTTAGACTCAGTGGGTGGATCTTTGCCAAAAAAATCAATTCCA
GATGTGGATCTCAATAAGCCTTACCTCAGCCTTGGCTGTAGCAATGCTAAGCTTCCAGTATCTGTGCCCATGCCTATAGCCAGACCTGCA
CGCCAGACTTCTAGGACTGACTGTCCAGCAGATCGTTTAAAGTTTTTTGAAACTTTACGACTTTTGCTAAAGCTTACCTCAGTCTCAAAG
AAAAAAGACAGGGAGCAAAGAGGACAAGAAAATACGTCTGGTTTCTGGCTTAACCGATCTAACGAACTGATCTGGTTAGAGCTACAAGCC
TGGCATGCAGGACGGACAATTAACGACCAGGACTTCTTTTTATATACAGCCCGTCAAGCCATCCCAGATATTATTAATGAAATCCTTACT
TTCAAAGTCGACTATGGGAGCTTCGCCTTTGTTAGAGATAGAGCTGGTTTTAATGGTACTTCAGTAGAAGGGCAGTGCAAAGCCACTCCT
GGAACAAAGATTGTAGGTTACTCAACACATCATGAGCATCTCCAACGCCAGAGGGTCTCATTTGAGCAGGTAAAACGGATAATGGAGCTG
CTAGAGTACATAGAAGCACTTTATCCATCATTGCAGGCTCTTCAGAAGGACTATGAAAAATATGCTGCAAAAGACTTCCAGGACAGGGTG
CAGGCACTCTGTTTGTGGTTAAACATCACAAAAGACTTAAATCAGAAATTAAGGATTATGGGCACTGTTTTGGGCATCAAGAATTTATCA
GACATTGGCTGGCCAGTGTTTGAAATCCCTTCCCCTCGACCATCCAAAGGTAATGAGCCGGAGTATGAGGGTGATGACACAGAAGGAGAA
TTAAAGGAGTTGGAAAGTAGTACGGATGAGAGTGAAGAAGAACAAATCTCTGATCCTAGGGTACCGGAAATCAGACAGCCCATAGATAAC
AGCTTCGACATCCAGTCGCGGGACTGCATATCCAAGAAGCTTGAGAGGCTCGAATCTGAGGATGATTCTCTTGGCTGGGGAGCACCAGAC
TGGAGCACAGAAGCAGGCTTTAGTAGACATTGTCTGACTTCTATTTATAGACCATTTGTAGACAAAGCACTGAAGCAGATGGGGTTAAGA
AAGTTAATTTTAAGACTTCACAAGCTAATGGATGGTTCCTTGCAAAGGGCACGTATAGCATTGGTAAAGAACGATCGTCCAGTGGAGATT
GCATGCAATCACATGAATACAGACAGCCTGGCTACTGACTCTAGTCCTACACACAAGCCCTGGTCAGTGTGTCTTGACGACAGGTTCAAT
TTAGCTCATCAAATCCGCAACAAGCAGTGCCGCCTCTACTCCTTAGGGCTAGGAAGTGATGATACCCATTTTGAGGTTAGCATGGCCAAC
AACGGATGTGAAGTGCATCGTTTTGATCCTAGTGTCAAGTCAGCTCACATTCTGGAGAGTCAGCACCTTTGGTATCACCGCTTGTCCATT
GACTGGCGGGATCCCCATCCAGCTGTTGCTGCCCAAAAACCACATAGCAACACCAGAAAACTGGGAAGCATTTTGAATGAATTTGGACAT
CACAAGATTGACGTTCTCAAGGCAGATCTGGAAAGTGCAGAATGGAAAGTTTTGGAAAATCTTATTCTGGAAGATGTTCTTGAGCAGATT
GGACAGCTCATCTTTGAGATCCATCTCCACTGGCCTGGGTTTGAGGTCAGTGGCAGTGACAGCAGCGTTGTGCGGTTCTGGTACAGCCTT
CTCAAAGAGTTAGAACAAAAGGATTTCAGGCTTTTTCACAGTTACAAAGACTTATCTAAACCTCAGCTATTCTTGAAGAAAGACATTTTC

>In-frame_MAP3K4_ENST00000392142_chr6_161471011_+_METTL24_ENST00000338882_chr6_110636684_-_2391nt
ATGAGAGAAGCCGCTGCCGCGCTGGTCCCTCCTCCCGCCTTTGCCGTCACGCCTGCCGCCGCCATGGAGGAGCCGCCGCCACCGCCGCCG
CCGCCACCACCGCCACCGGAACCCGAGACCGAGTCAGAACCCGAGTGCTGCTTGGCGGCGAGGCAAGAGGGCACATTGGGAGATTCAGCT
TGCAAGAGTCCTGAATCTGATCTAGAAGACTTCTCCGATGAAACAAATACAGAGAATCTTTATGGTACCTCTCCCCCCAGCACACCTCGA
CAGATGAAACGCATGTCAACCAAACATCAGAGGAATAATGTGGGGAGGCCAGCCAGTCGGTCTAATTTGAAAGAAAAAATGAATGCACCA
AATCAGCCTCCACATAAAGACACTGGAAAAACAGTGGAGAATGTGGAAGAATACAGCTATAAGCAGGAGAAAAAGATCCGAGCAGCTCTT
AGAACAACAGAGCGTGATCGTAAAAAAAATGTACAGTGCTCATTCATGTTAGACTCAGTGGGTGGATCTTTGCCAAAAAAATCAATTCCA
GATGTGGATCTCAATAAGCCTTACCTCAGCCTTGGCTGTAGCAATGCTAAGCTTCCAGTATCTGTGCCCATGCCTATAGCCAGACCTGCA
CGCCAGACTTCTAGGACTGACTGTCCAGCAGATCGTTTAAAGTTTTTTGAAACTTTACGACTTTTGCTAAAGCTTACCTCAGTCTCAAAG
AAAAAAGACAGGGAGCAAAGAGGACAAGAAAATACGTCTGGTTTCTGGCTTAACCGATCTAACGAACTGATCTGGTTAGAGCTACAAGCC
TGGCATGCAGGACGGACAATTAACGACCAGGACTTCTTTTTATATACAGCCCGTCAAGCCATCCCAGATATTATTAATGAAATCCTTACT
TTCAAAGTCGACTATGGGAGCTTCGCCTTTGTTAGAGATAGAGCTGGTTTTAATGGTACTTCAGTAGAAGGGCAGTGCAAAGCCACTCCT
GGAACAAAGATTGTAGGTTACTCAACACATCATGAGCATCTCCAACGCCAGAGGGTCTCATTTGAGCAGGTAAAACGGATAATGGAGCTG
CTAGAGTACATAGAAGCACTTTATCCATCATTGCAGGCTCTTCAGAAGGACTATGAAAAATATGCTGCAAAAGACTTCCAGGACAGGGTG
CAGGCACTCTGTTTGTGGTTAAACATCACAAAAGACTTAAATCAGAAATTAAGGATTATGGGCACTGTTTTGGGCATCAAGAATTTATCA
GACATTGGCTGGCCAGTGTTTGAAATCCCTTCCCCTCGACCATCCAAAGGTAATGAGCCGGAGTATGAGGGTGATGACACAGAAGGAGAA
TTAAAGGAGTTGGAAAGTAGTACGGATGAGAGTGAAGAAGAACAAATCTCTGATCCTAGGGTACCGGAAATCAGACAGCCCATAGATAAC
AGCTTCGACATCCAGTCGCGGGACTGCATATCCAAGAAGCTTGAGAGGCTCGAATCTGAGGATGATTCTCTTGGCTGGGGAGCACCAGAC
TGGAGCACAGAAGCAGGCTTTAGTAGACATTGTCTGACTTCTATTTATAGACCATTTGTAGACAAAGCACTGAAGCAGATGGGGTTAAGA
AAGTTAATTTTAAGACTTCACAAGCTAATGGATGGTTCCTTGCAAAGGGCACGTATAGCATTGGTAAAGAACGATCGTCCAGTGGAGATT
GCATGCAATCACATGAATACAGACAGCCTGGCTACTGACTCTAGTCCTACACACAAGCCCTGGTCAGTGTGTCTTGACGACAGGTTCAAT
TTAGCTCATCAAATCCGCAACAAGCAGTGCCGCCTCTACTCCTTAGGGCTAGGAAGTGATGATACCCATTTTGAGGTTAGCATGGCCAAC
AACGGATGTGAAGTGCATCGTTTTGATCCTAGTGTCAAGTCAGCTCACATTCTGGAGAGTCAGCACCTTTGGTATCACCGCTTGTCCATT
GACTGGCGGGATCCCCATCCAGCTGTTGCTGCCCAAAAACCACATAGCAACACCAGAAAACTGGGAAGCATTTTGAATGAATTTGGACAT
CACAAGATTGACGTTCTCAAGGCAGATCTGGAAAGTGCAGAATGGAAAGTTTTGGAAAATCTTATTCTGGAAGATGTTCTTGAGCAGATT
GGACAGCTCATCTTTGAGATCCATCTCCACTGGCCTGGGTTTGAGGTCAGTGGCAGTGACAGCAGCGTTGTGCGGTTCTGGTACAGCCTT
CTCAAAGAGTTAGAACAAAAGGATTTCAGGCTTTTTCACAGTTACAAAGACTTATCTAAACCTCAGCTATTCTTGAAGAAAGACATTTTC

>In-frame_MAP3K4_ENST00000348824_chr6_161471011_+_METTL24_ENST00000338882_chr6_110636684_-_2391nt
ATGAGAGAAGCCGCTGCCGCGCTGGTCCCTCCTCCCGCCTTTGCCGTCACGCCTGCCGCCGCCATGGAGGAGCCGCCGCCACCGCCGCCG
CCGCCACCACCGCCACCGGAACCCGAGACCGAGTCAGAACCCGAGTGCTGCTTGGCGGCGAGGCAAGAGGGCACATTGGGAGATTCAGCT
TGCAAGAGTCCTGAATCTGATCTAGAAGACTTCTCCGATGAAACAAATACAGAGAATCTTTATGGTACCTCTCCCCCCAGCACACCTCGA
CAGATGAAACGCATGTCAACCAAACATCAGAGGAATAATGTGGGGAGGCCAGCCAGTCGGTCTAATTTGAAAGAAAAAATGAATGCACCA
AATCAGCCTCCACATAAAGACACTGGAAAAACAGTGGAGAATGTGGAAGAATACAGCTATAAGCAGGAGAAAAAGATCCGAGCAGCTCTT
AGAACAACAGAGCGTGATCGTAAAAAAAATGTACAGTGCTCATTCATGTTAGACTCAGTGGGTGGATCTTTGCCAAAAAAATCAATTCCA
GATGTGGATCTCAATAAGCCTTACCTCAGCCTTGGCTGTAGCAATGCTAAGCTTCCAGTATCTGTGCCCATGCCTATAGCCAGACCTGCA
CGCCAGACTTCTAGGACTGACTGTCCAGCAGATCGTTTAAAGTTTTTTGAAACTTTACGACTTTTGCTAAAGCTTACCTCAGTCTCAAAG
AAAAAAGACAGGGAGCAAAGAGGACAAGAAAATACGTCTGGTTTCTGGCTTAACCGATCTAACGAACTGATCTGGTTAGAGCTACAAGCC
TGGCATGCAGGACGGACAATTAACGACCAGGACTTCTTTTTATATACAGCCCGTCAAGCCATCCCAGATATTATTAATGAAATCCTTACT
TTCAAAGTCGACTATGGGAGCTTCGCCTTTGTTAGAGATAGAGCTGGTTTTAATGGTACTTCAGTAGAAGGGCAGTGCAAAGCCACTCCT
GGAACAAAGATTGTAGGTTACTCAACACATCATGAGCATCTCCAACGCCAGAGGGTCTCATTTGAGCAGGTAAAACGGATAATGGAGCTG
CTAGAGTACATAGAAGCACTTTATCCATCATTGCAGGCTCTTCAGAAGGACTATGAAAAATATGCTGCAAAAGACTTCCAGGACAGGGTG
CAGGCACTCTGTTTGTGGTTAAACATCACAAAAGACTTAAATCAGAAATTAAGGATTATGGGCACTGTTTTGGGCATCAAGAATTTATCA
GACATTGGCTGGCCAGTGTTTGAAATCCCTTCCCCTCGACCATCCAAAGGTAATGAGCCGGAGTATGAGGGTGATGACACAGAAGGAGAA
TTAAAGGAGTTGGAAAGTAGTACGGATGAGAGTGAAGAAGAACAAATCTCTGATCCTAGGGTACCGGAAATCAGACAGCCCATAGATAAC
AGCTTCGACATCCAGTCGCGGGACTGCATATCCAAGAAGCTTGAGAGGCTCGAATCTGAGGATGATTCTCTTGGCTGGGGAGCACCAGAC
TGGAGCACAGAAGCAGGCTTTAGTAGACATTGTCTGACTTCTATTTATAGACCATTTGTAGACAAAGCACTGAAGCAGATGGGGTTAAGA
AAGTTAATTTTAAGACTTCACAAGCTAATGGATGGTTCCTTGCAAAGGGCACGTATAGCATTGGTAAAGAACGATCGTCCAGTGGAGATT
GCATGCAATCACATGAATACAGACAGCCTGGCTACTGACTCTAGTCCTACACACAAGCCCTGGTCAGTGTGTCTTGACGACAGGTTCAAT
TTAGCTCATCAAATCCGCAACAAGCAGTGCCGCCTCTACTCCTTAGGGCTAGGAAGTGATGATACCCATTTTGAGGTTAGCATGGCCAAC
AACGGATGTGAAGTGCATCGTTTTGATCCTAGTGTCAAGTCAGCTCACATTCTGGAGAGTCAGCACCTTTGGTATCACCGCTTGTCCATT
GACTGGCGGGATCCCCATCCAGCTGTTGCTGCCCAAAAACCACATAGCAACACCAGAAAACTGGGAAGCATTTTGAATGAATTTGGACAT
CACAAGATTGACGTTCTCAAGGCAGATCTGGAAAGTGCAGAATGGAAAGTTTTGGAAAATCTTATTCTGGAAGATGTTCTTGAGCAGATT
GGACAGCTCATCTTTGAGATCCATCTCCACTGGCCTGGGTTTGAGGTCAGTGGCAGTGACAGCAGCGTTGTGCGGTTCTGGTACAGCCTT
CTCAAAGAGTTAGAACAAAAGGATTTCAGGCTTTTTCACAGTTACAAAGACTTATCTAAACCTCAGCTATTCTTGAAGAAAGACATTTTC

>In-frame_MAP3K4_ENST00000366920_chr6_161471011_+_METTL24_ENST00000338882_chr6_110636684_-_2391nt
ATGAGAGAAGCCGCTGCCGCGCTGGTCCCTCCTCCCGCCTTTGCCGTCACGCCTGCCGCCGCCATGGAGGAGCCGCCGCCACCGCCGCCG
CCGCCACCACCGCCACCGGAACCCGAGACCGAGTCAGAACCCGAGTGCTGCTTGGCGGCGAGGCAAGAGGGCACATTGGGAGATTCAGCT
TGCAAGAGTCCTGAATCTGATCTAGAAGACTTCTCCGATGAAACAAATACAGAGAATCTTTATGGTACCTCTCCCCCCAGCACACCTCGA
CAGATGAAACGCATGTCAACCAAACATCAGAGGAATAATGTGGGGAGGCCAGCCAGTCGGTCTAATTTGAAAGAAAAAATGAATGCACCA
AATCAGCCTCCACATAAAGACACTGGAAAAACAGTGGAGAATGTGGAAGAATACAGCTATAAGCAGGAGAAAAAGATCCGAGCAGCTCTT
AGAACAACAGAGCGTGATCGTAAAAAAAATGTACAGTGCTCATTCATGTTAGACTCAGTGGGTGGATCTTTGCCAAAAAAATCAATTCCA
GATGTGGATCTCAATAAGCCTTACCTCAGCCTTGGCTGTAGCAATGCTAAGCTTCCAGTATCTGTGCCCATGCCTATAGCCAGACCTGCA
CGCCAGACTTCTAGGACTGACTGTCCAGCAGATCGTTTAAAGTTTTTTGAAACTTTACGACTTTTGCTAAAGCTTACCTCAGTCTCAAAG
AAAAAAGACAGGGAGCAAAGAGGACAAGAAAATACGTCTGGTTTCTGGCTTAACCGATCTAACGAACTGATCTGGTTAGAGCTACAAGCC
TGGCATGCAGGACGGACAATTAACGACCAGGACTTCTTTTTATATACAGCCCGTCAAGCCATCCCAGATATTATTAATGAAATCCTTACT
TTCAAAGTCGACTATGGGAGCTTCGCCTTTGTTAGAGATAGAGCTGGTTTTAATGGTACTTCAGTAGAAGGGCAGTGCAAAGCCACTCCT
GGAACAAAGATTGTAGGTTACTCAACACATCATGAGCATCTCCAACGCCAGAGGGTCTCATTTGAGCAGGTAAAACGGATAATGGAGCTG
CTAGAGTACATAGAAGCACTTTATCCATCATTGCAGGCTCTTCAGAAGGACTATGAAAAATATGCTGCAAAAGACTTCCAGGACAGGGTG
CAGGCACTCTGTTTGTGGTTAAACATCACAAAAGACTTAAATCAGAAATTAAGGATTATGGGCACTGTTTTGGGCATCAAGAATTTATCA
GACATTGGCTGGCCAGTGTTTGAAATCCCTTCCCCTCGACCATCCAAAGGTAATGAGCCGGAGTATGAGGGTGATGACACAGAAGGAGAA
TTAAAGGAGTTGGAAAGTAGTACGGATGAGAGTGAAGAAGAACAAATCTCTGATCCTAGGGTACCGGAAATCAGACAGCCCATAGATAAC
AGCTTCGACATCCAGTCGCGGGACTGCATATCCAAGAAGCTTGAGAGGCTCGAATCTGAGGATGATTCTCTTGGCTGGGGAGCACCAGAC
TGGAGCACAGAAGCAGGCTTTAGTAGACATTGTCTGACTTCTATTTATAGACCATTTGTAGACAAAGCACTGAAGCAGATGGGGTTAAGA
AAGTTAATTTTAAGACTTCACAAGCTAATGGATGGTTCCTTGCAAAGGGCACGTATAGCATTGGTAAAGAACGATCGTCCAGTGGAGATT
GCATGCAATCACATGAATACAGACAGCCTGGCTACTGACTCTAGTCCTACACACAAGCCCTGGTCAGTGTGTCTTGACGACAGGTTCAAT
TTAGCTCATCAAATCCGCAACAAGCAGTGCCGCCTCTACTCCTTAGGGCTAGGAAGTGATGATACCCATTTTGAGGTTAGCATGGCCAAC
AACGGATGTGAAGTGCATCGTTTTGATCCTAGTGTCAAGTCAGCTCACATTCTGGAGAGTCAGCACCTTTGGTATCACCGCTTGTCCATT
GACTGGCGGGATCCCCATCCAGCTGTTGCTGCCCAAAAACCACATAGCAACACCAGAAAACTGGGAAGCATTTTGAATGAATTTGGACAT
CACAAGATTGACGTTCTCAAGGCAGATCTGGAAAGTGCAGAATGGAAAGTTTTGGAAAATCTTATTCTGGAAGATGTTCTTGAGCAGATT
GGACAGCTCATCTTTGAGATCCATCTCCACTGGCCTGGGTTTGAGGTCAGTGGCAGTGACAGCAGCGTTGTGCGGTTCTGGTACAGCCTT
CTCAAAGAGTTAGAACAAAAGGATTTCAGGCTTTTTCACAGTTACAAAGACTTATCTAAACCTCAGCTATTCTTGAAGAAAGACATTTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_MAP3K4_ENST00000366919_chr6_161471011_+_METTL24_ENST00000338882_chr6_110636684_-_2614nt
GATCTGGGAGGCTTGTCCCTCGCCGCCCACCGTAGCCCCGGCGCTCGGCCGGTCGCCGTTTCCAAGATGGCCGCGGCGCGCACGGCTCCT
GCGGCGGGGTAGAGGCGGAGGCGGAGTCGAGTCACTCCCGCACTTCGGGGCTCCGGTGCCCCGCGCCAGGCTGCAGCTTACTGCCCGCCG
CGGCCATGCGGGGCTCCGTGCACGGATGAGAGAAGCCGCTGCCGCGCTGGTCCCTCCTCCCGCCTTTGCCGTCACGCCTGCCGCCGCCAT
GGAGGAGCCGCCGCCACCGCCGCCGCCGCCACCACCGCCACCGGAACCCGAGACCGAGTCAGAACCCGAGTGCTGCTTGGCGGCGAGGCA
AGAGGGCACATTGGGAGATTCAGCTTGCAAGAGTCCTGAATCTGATCTAGAAGACTTCTCCGATGAAACAAATACAGAGAATCTTTATGG
TACCTCTCCCCCCAGCACACCTCGACAGATGAAACGCATGTCAACCAAACATCAGAGGAATAATGTGGGGAGGCCAGCCAGTCGGTCTAA
TTTGAAAGAAAAAATGAATGCACCAAATCAGCCTCCACATAAAGACACTGGAAAAACAGTGGAGAATGTGGAAGAATACAGCTATAAGCA
GGAGAAAAAGATCCGAGCAGCTCTTAGAACAACAGAGCGTGATCGTAAAAAAAATGTACAGTGCTCATTCATGTTAGACTCAGTGGGTGG
ATCTTTGCCAAAAAAATCAATTCCAGATGTGGATCTCAATAAGCCTTACCTCAGCCTTGGCTGTAGCAATGCTAAGCTTCCAGTATCTGT
GCCCATGCCTATAGCCAGACCTGCACGCCAGACTTCTAGGACTGACTGTCCAGCAGATCGTTTAAAGTTTTTTGAAACTTTACGACTTTT
GCTAAAGCTTACCTCAGTCTCAAAGAAAAAAGACAGGGAGCAAAGAGGACAAGAAAATACGTCTGGTTTCTGGCTTAACCGATCTAACGA
ACTGATCTGGTTAGAGCTACAAGCCTGGCATGCAGGACGGACAATTAACGACCAGGACTTCTTTTTATATACAGCCCGTCAAGCCATCCC
AGATATTATTAATGAAATCCTTACTTTCAAAGTCGACTATGGGAGCTTCGCCTTTGTTAGAGATAGAGCTGGTTTTAATGGTACTTCAGT
AGAAGGGCAGTGCAAAGCCACTCCTGGAACAAAGATTGTAGGTTACTCAACACATCATGAGCATCTCCAACGCCAGAGGGTCTCATTTGA
GCAGGTAAAACGGATAATGGAGCTGCTAGAGTACATAGAAGCACTTTATCCATCATTGCAGGCTCTTCAGAAGGACTATGAAAAATATGC
TGCAAAAGACTTCCAGGACAGGGTGCAGGCACTCTGTTTGTGGTTAAACATCACAAAAGACTTAAATCAGAAATTAAGGATTATGGGCAC
TGTTTTGGGCATCAAGAATTTATCAGACATTGGCTGGCCAGTGTTTGAAATCCCTTCCCCTCGACCATCCAAAGGTAATGAGCCGGAGTA
TGAGGGTGATGACACAGAAGGAGAATTAAAGGAGTTGGAAAGTAGTACGGATGAGAGTGAAGAAGAACAAATCTCTGATCCTAGGGTACC
GGAAATCAGACAGCCCATAGATAACAGCTTCGACATCCAGTCGCGGGACTGCATATCCAAGAAGCTTGAGAGGCTCGAATCTGAGGATGA
TTCTCTTGGCTGGGGAGCACCAGACTGGAGCACAGAAGCAGGCTTTAGTAGACATTGTCTGACTTCTATTTATAGACCATTTGTAGACAA
AGCACTGAAGCAGATGGGGTTAAGAAAGTTAATTTTAAGACTTCACAAGCTAATGGATGGTTCCTTGCAAAGGGCACGTATAGCATTGGT
AAAGAACGATCGTCCAGTGGAGATTGCATGCAATCACATGAATACAGACAGCCTGGCTACTGACTCTAGTCCTACACACAAGCCCTGGTC
AGTGTGTCTTGACGACAGGTTCAATTTAGCTCATCAAATCCGCAACAAGCAGTGCCGCCTCTACTCCTTAGGGCTAGGAAGTGATGATAC
CCATTTTGAGGTTAGCATGGCCAACAACGGATGTGAAGTGCATCGTTTTGATCCTAGTGTCAAGTCAGCTCACATTCTGGAGAGTCAGCA
CCTTTGGTATCACCGCTTGTCCATTGACTGGCGGGATCCCCATCCAGCTGTTGCTGCCCAAAAACCACATAGCAACACCAGAAAACTGGG
AAGCATTTTGAATGAATTTGGACATCACAAGATTGACGTTCTCAAGGCAGATCTGGAAAGTGCAGAATGGAAAGTTTTGGAAAATCTTAT
TCTGGAAGATGTTCTTGAGCAGATTGGACAGCTCATCTTTGAGATCCATCTCCACTGGCCTGGGTTTGAGGTCAGTGGCAGTGACAGCAG
CGTTGTGCGGTTCTGGTACAGCCTTCTCAAAGAGTTAGAACAAAAGGATTTCAGGCTTTTTCACAGTTACAAAGACTTATCTAAACCTCA
GCTATTCTTGAAGAAAGACATTTTCAATGCAAGTAGCTGTTATACTCTGAGTTGGGTGAATACAAGATGGAAATAGGATGCAGGATGTCA

>In-frame_MAP3K4_ENST00000392142_chr6_161471011_+_METTL24_ENST00000338882_chr6_110636684_-_2557nt
GTTTCCAAGATGGCCGCGGCGCGCACGGCTCCTGCGGCGGGGTAGAGGCGGAGGCGGAGTCGAGTCACTCCCGCACTTCGGGGCTCCGGT
GCCCCGCGCCAGGCTGCAGCTTACTGCCCGCCGCGGCCATGCGGGGCTCCGTGCACGGATGAGAGAAGCCGCTGCCGCGCTGGTCCCTCC
TCCCGCCTTTGCCGTCACGCCTGCCGCCGCCATGGAGGAGCCGCCGCCACCGCCGCCGCCGCCACCACCGCCACCGGAACCCGAGACCGA
GTCAGAACCCGAGTGCTGCTTGGCGGCGAGGCAAGAGGGCACATTGGGAGATTCAGCTTGCAAGAGTCCTGAATCTGATCTAGAAGACTT
CTCCGATGAAACAAATACAGAGAATCTTTATGGTACCTCTCCCCCCAGCACACCTCGACAGATGAAACGCATGTCAACCAAACATCAGAG
GAATAATGTGGGGAGGCCAGCCAGTCGGTCTAATTTGAAAGAAAAAATGAATGCACCAAATCAGCCTCCACATAAAGACACTGGAAAAAC
AGTGGAGAATGTGGAAGAATACAGCTATAAGCAGGAGAAAAAGATCCGAGCAGCTCTTAGAACAACAGAGCGTGATCGTAAAAAAAATGT
ACAGTGCTCATTCATGTTAGACTCAGTGGGTGGATCTTTGCCAAAAAAATCAATTCCAGATGTGGATCTCAATAAGCCTTACCTCAGCCT
TGGCTGTAGCAATGCTAAGCTTCCAGTATCTGTGCCCATGCCTATAGCCAGACCTGCACGCCAGACTTCTAGGACTGACTGTCCAGCAGA
TCGTTTAAAGTTTTTTGAAACTTTACGACTTTTGCTAAAGCTTACCTCAGTCTCAAAGAAAAAAGACAGGGAGCAAAGAGGACAAGAAAA
TACGTCTGGTTTCTGGCTTAACCGATCTAACGAACTGATCTGGTTAGAGCTACAAGCCTGGCATGCAGGACGGACAATTAACGACCAGGA
CTTCTTTTTATATACAGCCCGTCAAGCCATCCCAGATATTATTAATGAAATCCTTACTTTCAAAGTCGACTATGGGAGCTTCGCCTTTGT
TAGAGATAGAGCTGGTTTTAATGGTACTTCAGTAGAAGGGCAGTGCAAAGCCACTCCTGGAACAAAGATTGTAGGTTACTCAACACATCA
TGAGCATCTCCAACGCCAGAGGGTCTCATTTGAGCAGGTAAAACGGATAATGGAGCTGCTAGAGTACATAGAAGCACTTTATCCATCATT
GCAGGCTCTTCAGAAGGACTATGAAAAATATGCTGCAAAAGACTTCCAGGACAGGGTGCAGGCACTCTGTTTGTGGTTAAACATCACAAA
AGACTTAAATCAGAAATTAAGGATTATGGGCACTGTTTTGGGCATCAAGAATTTATCAGACATTGGCTGGCCAGTGTTTGAAATCCCTTC
CCCTCGACCATCCAAAGGTAATGAGCCGGAGTATGAGGGTGATGACACAGAAGGAGAATTAAAGGAGTTGGAAAGTAGTACGGATGAGAG
TGAAGAAGAACAAATCTCTGATCCTAGGGTACCGGAAATCAGACAGCCCATAGATAACAGCTTCGACATCCAGTCGCGGGACTGCATATC
CAAGAAGCTTGAGAGGCTCGAATCTGAGGATGATTCTCTTGGCTGGGGAGCACCAGACTGGAGCACAGAAGCAGGCTTTAGTAGACATTG
TCTGACTTCTATTTATAGACCATTTGTAGACAAAGCACTGAAGCAGATGGGGTTAAGAAAGTTAATTTTAAGACTTCACAAGCTAATGGA
TGGTTCCTTGCAAAGGGCACGTATAGCATTGGTAAAGAACGATCGTCCAGTGGAGATTGCATGCAATCACATGAATACAGACAGCCTGGC
TACTGACTCTAGTCCTACACACAAGCCCTGGTCAGTGTGTCTTGACGACAGGTTCAATTTAGCTCATCAAATCCGCAACAAGCAGTGCCG
CCTCTACTCCTTAGGGCTAGGAAGTGATGATACCCATTTTGAGGTTAGCATGGCCAACAACGGATGTGAAGTGCATCGTTTTGATCCTAG
TGTCAAGTCAGCTCACATTCTGGAGAGTCAGCACCTTTGGTATCACCGCTTGTCCATTGACTGGCGGGATCCCCATCCAGCTGTTGCTGC
CCAAAAACCACATAGCAACACCAGAAAACTGGGAAGCATTTTGAATGAATTTGGACATCACAAGATTGACGTTCTCAAGGCAGATCTGGA
AAGTGCAGAATGGAAAGTTTTGGAAAATCTTATTCTGGAAGATGTTCTTGAGCAGATTGGACAGCTCATCTTTGAGATCCATCTCCACTG
GCCTGGGTTTGAGGTCAGTGGCAGTGACAGCAGCGTTGTGCGGTTCTGGTACAGCCTTCTCAAAGAGTTAGAACAAAAGGATTTCAGGCT
TTTTCACAGTTACAAAGACTTATCTAAACCTCAGCTATTCTTGAAGAAAGACATTTTCAATGCAAGTAGCTGTTATACTCTGAGTTGGGT

>In-frame_MAP3K4_ENST00000348824_chr6_161471011_+_METTL24_ENST00000338882_chr6_110636684_-_2527nt
CCTGCGGCGGGGTAGAGGCGGAGGCGGAGTCGAGTCACTCCCGCACTTCGGGGCTCCGGTGCCCCGCGCCAGGCTGCAGCTTACTGCCCG
CCGCGGCCATGCGGGGCTCCGTGCACGGATGAGAGAAGCCGCTGCCGCGCTGGTCCCTCCTCCCGCCTTTGCCGTCACGCCTGCCGCCGC
CATGGAGGAGCCGCCGCCACCGCCGCCGCCGCCACCACCGCCACCGGAACCCGAGACCGAGTCAGAACCCGAGTGCTGCTTGGCGGCGAG
GCAAGAGGGCACATTGGGAGATTCAGCTTGCAAGAGTCCTGAATCTGATCTAGAAGACTTCTCCGATGAAACAAATACAGAGAATCTTTA
TGGTACCTCTCCCCCCAGCACACCTCGACAGATGAAACGCATGTCAACCAAACATCAGAGGAATAATGTGGGGAGGCCAGCCAGTCGGTC
TAATTTGAAAGAAAAAATGAATGCACCAAATCAGCCTCCACATAAAGACACTGGAAAAACAGTGGAGAATGTGGAAGAATACAGCTATAA
GCAGGAGAAAAAGATCCGAGCAGCTCTTAGAACAACAGAGCGTGATCGTAAAAAAAATGTACAGTGCTCATTCATGTTAGACTCAGTGGG
TGGATCTTTGCCAAAAAAATCAATTCCAGATGTGGATCTCAATAAGCCTTACCTCAGCCTTGGCTGTAGCAATGCTAAGCTTCCAGTATC
TGTGCCCATGCCTATAGCCAGACCTGCACGCCAGACTTCTAGGACTGACTGTCCAGCAGATCGTTTAAAGTTTTTTGAAACTTTACGACT
TTTGCTAAAGCTTACCTCAGTCTCAAAGAAAAAAGACAGGGAGCAAAGAGGACAAGAAAATACGTCTGGTTTCTGGCTTAACCGATCTAA
CGAACTGATCTGGTTAGAGCTACAAGCCTGGCATGCAGGACGGACAATTAACGACCAGGACTTCTTTTTATATACAGCCCGTCAAGCCAT
CCCAGATATTATTAATGAAATCCTTACTTTCAAAGTCGACTATGGGAGCTTCGCCTTTGTTAGAGATAGAGCTGGTTTTAATGGTACTTC
AGTAGAAGGGCAGTGCAAAGCCACTCCTGGAACAAAGATTGTAGGTTACTCAACACATCATGAGCATCTCCAACGCCAGAGGGTCTCATT
TGAGCAGGTAAAACGGATAATGGAGCTGCTAGAGTACATAGAAGCACTTTATCCATCATTGCAGGCTCTTCAGAAGGACTATGAAAAATA
TGCTGCAAAAGACTTCCAGGACAGGGTGCAGGCACTCTGTTTGTGGTTAAACATCACAAAAGACTTAAATCAGAAATTAAGGATTATGGG
CACTGTTTTGGGCATCAAGAATTTATCAGACATTGGCTGGCCAGTGTTTGAAATCCCTTCCCCTCGACCATCCAAAGGTAATGAGCCGGA
GTATGAGGGTGATGACACAGAAGGAGAATTAAAGGAGTTGGAAAGTAGTACGGATGAGAGTGAAGAAGAACAAATCTCTGATCCTAGGGT
ACCGGAAATCAGACAGCCCATAGATAACAGCTTCGACATCCAGTCGCGGGACTGCATATCCAAGAAGCTTGAGAGGCTCGAATCTGAGGA
TGATTCTCTTGGCTGGGGAGCACCAGACTGGAGCACAGAAGCAGGCTTTAGTAGACATTGTCTGACTTCTATTTATAGACCATTTGTAGA
CAAAGCACTGAAGCAGATGGGGTTAAGAAAGTTAATTTTAAGACTTCACAAGCTAATGGATGGTTCCTTGCAAAGGGCACGTATAGCATT
GGTAAAGAACGATCGTCCAGTGGAGATTGCATGCAATCACATGAATACAGACAGCCTGGCTACTGACTCTAGTCCTACACACAAGCCCTG
GTCAGTGTGTCTTGACGACAGGTTCAATTTAGCTCATCAAATCCGCAACAAGCAGTGCCGCCTCTACTCCTTAGGGCTAGGAAGTGATGA
TACCCATTTTGAGGTTAGCATGGCCAACAACGGATGTGAAGTGCATCGTTTTGATCCTAGTGTCAAGTCAGCTCACATTCTGGAGAGTCA
GCACCTTTGGTATCACCGCTTGTCCATTGACTGGCGGGATCCCCATCCAGCTGTTGCTGCCCAAAAACCACATAGCAACACCAGAAAACT
GGGAAGCATTTTGAATGAATTTGGACATCACAAGATTGACGTTCTCAAGGCAGATCTGGAAAGTGCAGAATGGAAAGTTTTGGAAAATCT
TATTCTGGAAGATGTTCTTGAGCAGATTGGACAGCTCATCTTTGAGATCCATCTCCACTGGCCTGGGTTTGAGGTCAGTGGCAGTGACAG
CAGCGTTGTGCGGTTCTGGTACAGCCTTCTCAAAGAGTTAGAACAAAAGGATTTCAGGCTTTTTCACAGTTACAAAGACTTATCTAAACC
TCAGCTATTCTTGAAGAAAGACATTTTCAATGCAAGTAGCTGTTATACTCTGAGTTGGGTGAATACAAGATGGAAATAGGATGCAGGATG

>In-frame_MAP3K4_ENST00000366920_chr6_161471011_+_METTL24_ENST00000338882_chr6_110636684_-_2527nt
CCTGCGGCGGGGTAGAGGCGGAGGCGGAGTCGAGTCACTCCCGCACTTCGGGGCTCCGGTGCCCCGCGCCAGGCTGCAGCTTACTGCCCG
CCGCGGCCATGCGGGGCTCCGTGCACGGATGAGAGAAGCCGCTGCCGCGCTGGTCCCTCCTCCCGCCTTTGCCGTCACGCCTGCCGCCGC
CATGGAGGAGCCGCCGCCACCGCCGCCGCCGCCACCACCGCCACCGGAACCCGAGACCGAGTCAGAACCCGAGTGCTGCTTGGCGGCGAG
GCAAGAGGGCACATTGGGAGATTCAGCTTGCAAGAGTCCTGAATCTGATCTAGAAGACTTCTCCGATGAAACAAATACAGAGAATCTTTA
TGGTACCTCTCCCCCCAGCACACCTCGACAGATGAAACGCATGTCAACCAAACATCAGAGGAATAATGTGGGGAGGCCAGCCAGTCGGTC
TAATTTGAAAGAAAAAATGAATGCACCAAATCAGCCTCCACATAAAGACACTGGAAAAACAGTGGAGAATGTGGAAGAATACAGCTATAA
GCAGGAGAAAAAGATCCGAGCAGCTCTTAGAACAACAGAGCGTGATCGTAAAAAAAATGTACAGTGCTCATTCATGTTAGACTCAGTGGG
TGGATCTTTGCCAAAAAAATCAATTCCAGATGTGGATCTCAATAAGCCTTACCTCAGCCTTGGCTGTAGCAATGCTAAGCTTCCAGTATC
TGTGCCCATGCCTATAGCCAGACCTGCACGCCAGACTTCTAGGACTGACTGTCCAGCAGATCGTTTAAAGTTTTTTGAAACTTTACGACT
TTTGCTAAAGCTTACCTCAGTCTCAAAGAAAAAAGACAGGGAGCAAAGAGGACAAGAAAATACGTCTGGTTTCTGGCTTAACCGATCTAA
CGAACTGATCTGGTTAGAGCTACAAGCCTGGCATGCAGGACGGACAATTAACGACCAGGACTTCTTTTTATATACAGCCCGTCAAGCCAT
CCCAGATATTATTAATGAAATCCTTACTTTCAAAGTCGACTATGGGAGCTTCGCCTTTGTTAGAGATAGAGCTGGTTTTAATGGTACTTC
AGTAGAAGGGCAGTGCAAAGCCACTCCTGGAACAAAGATTGTAGGTTACTCAACACATCATGAGCATCTCCAACGCCAGAGGGTCTCATT
TGAGCAGGTAAAACGGATAATGGAGCTGCTAGAGTACATAGAAGCACTTTATCCATCATTGCAGGCTCTTCAGAAGGACTATGAAAAATA
TGCTGCAAAAGACTTCCAGGACAGGGTGCAGGCACTCTGTTTGTGGTTAAACATCACAAAAGACTTAAATCAGAAATTAAGGATTATGGG
CACTGTTTTGGGCATCAAGAATTTATCAGACATTGGCTGGCCAGTGTTTGAAATCCCTTCCCCTCGACCATCCAAAGGTAATGAGCCGGA
GTATGAGGGTGATGACACAGAAGGAGAATTAAAGGAGTTGGAAAGTAGTACGGATGAGAGTGAAGAAGAACAAATCTCTGATCCTAGGGT
ACCGGAAATCAGACAGCCCATAGATAACAGCTTCGACATCCAGTCGCGGGACTGCATATCCAAGAAGCTTGAGAGGCTCGAATCTGAGGA
TGATTCTCTTGGCTGGGGAGCACCAGACTGGAGCACAGAAGCAGGCTTTAGTAGACATTGTCTGACTTCTATTTATAGACCATTTGTAGA
CAAAGCACTGAAGCAGATGGGGTTAAGAAAGTTAATTTTAAGACTTCACAAGCTAATGGATGGTTCCTTGCAAAGGGCACGTATAGCATT
GGTAAAGAACGATCGTCCAGTGGAGATTGCATGCAATCACATGAATACAGACAGCCTGGCTACTGACTCTAGTCCTACACACAAGCCCTG
GTCAGTGTGTCTTGACGACAGGTTCAATTTAGCTCATCAAATCCGCAACAAGCAGTGCCGCCTCTACTCCTTAGGGCTAGGAAGTGATGA
TACCCATTTTGAGGTTAGCATGGCCAACAACGGATGTGAAGTGCATCGTTTTGATCCTAGTGTCAAGTCAGCTCACATTCTGGAGAGTCA
GCACCTTTGGTATCACCGCTTGTCCATTGACTGGCGGGATCCCCATCCAGCTGTTGCTGCCCAAAAACCACATAGCAACACCAGAAAACT
GGGAAGCATTTTGAATGAATTTGGACATCACAAGATTGACGTTCTCAAGGCAGATCTGGAAAGTGCAGAATGGAAAGTTTTGGAAAATCT
TATTCTGGAAGATGTTCTTGAGCAGATTGGACAGCTCATCTTTGAGATCCATCTCCACTGGCCTGGGTTTGAGGTCAGTGGCAGTGACAG
CAGCGTTGTGCGGTTCTGGTACAGCCTTCTCAAAGAGTTAGAACAAAAGGATTTCAGGCTTTTTCACAGTTACAAAGACTTATCTAAACC
TCAGCTATTCTTGAAGAAAGACATTTTCAATGCAAGTAGCTGTTATACTCTGAGTTGGGTGAATACAAGATGGAAATAGGATGCAGGATG


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FusionGenePPI for MAP3K4_METTL24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP3K4CDC42, RAC1, MAP2K1, MAP2K4, MAP2K3, MAP2K6, GADD45G, GADD45B, GADD45A, ALK, SH3KBP1, TPR, YWHAZ, CNTRL, ZFP36, TRAF4, MAP2K7, RIPK2, MAPK8, CHUK, GSK3B, MAP3K4, AXIN1, HNRNPD, POLR2F, RAP1B, SORT1, SRPR, KIF23, BAG3, SYNCRIP, AP4E1, GOLT1B, SGTB, KIF21A, VWA9, CNTROB, NEDD1, KIF7, BAG6, USF1, MAPK13, SPATA1, ACTBL2, SIGLECL1, BTK, TOP1, TOP2A, TOP3AMETTL24


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP3K4_METTL24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAP3K4_METTL24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP3K4C0014170Endometrial Neoplasms1CTD_human