|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 20867 |
FusionGeneSummary for MAP3K4_FRMD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP3K4_FRMD1 | Fusion gene ID: 20867 | Hgene | Tgene | Gene symbol | MAP3K4 | FRMD1 | Gene ID | 4216 | 79981 |
| Gene name | mitogen-activated protein kinase kinase kinase 4 | FERM domain containing 1 | |
| Synonyms | MAPKKK4|MEKK 4|MEKK4|MTK1|PRO0412 | bA164L23.1 | |
| Cytomap | 6q26 | 6q27 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase 4MAP three kinase 1MAP/ERK kinase kinase 4MAPK/ERK kinase kinase 4MEK kinase 4SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog ofdJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)predicte | FERM domain-containing protein 1 | |
| Modification date | 20180524 | 20180519 | |
| UniProtAcc | Q9Y6R4 | Q8N878 | |
| Ensembl transtripts involved in fusion gene | ENST00000366919, ENST00000392142, ENST00000348824, ENST00000366920, ENST00000446500, | ENST00000283309, ENST00000432403, ENST00000440994, ENST00000537786, | |
| Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MAP3K4 [Title/Abstract] AND FRMD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP3K4 | GO:0000186 | activation of MAPKK activity | 9305639|9827804 |
| Hgene | MAP3K4 | GO:0043507 | positive regulation of JUN kinase activity | 9305639 |
| Hgene | MAP3K4 | GO:1900745 | positive regulation of p38MAPK cascade | 9305639 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-NK-A5CR-01A | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000366919 | ENST00000283309 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| 5CDS-intron | ENST00000366919 | ENST00000432403 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| 5CDS-intron | ENST00000366919 | ENST00000440994 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| 5CDS-intron | ENST00000366919 | ENST00000537786 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| Frame-shift | ENST00000392142 | ENST00000283309 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| 5CDS-intron | ENST00000392142 | ENST00000432403 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| 5CDS-intron | ENST00000392142 | ENST00000440994 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| 5CDS-intron | ENST00000392142 | ENST00000537786 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| Frame-shift | ENST00000348824 | ENST00000283309 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| 5CDS-intron | ENST00000348824 | ENST00000432403 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| 5CDS-intron | ENST00000348824 | ENST00000440994 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| 5CDS-intron | ENST00000348824 | ENST00000537786 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| Frame-shift | ENST00000366920 | ENST00000283309 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| 5CDS-intron | ENST00000366920 | ENST00000432403 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| 5CDS-intron | ENST00000366920 | ENST00000440994 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| 5CDS-intron | ENST00000366920 | ENST00000537786 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| intron-3CDS | ENST00000446500 | ENST00000283309 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| intron-intron | ENST00000446500 | ENST00000432403 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| intron-intron | ENST00000446500 | ENST00000440994 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
| intron-intron | ENST00000446500 | ENST00000537786 | MAP3K4 | chr6 | 161413115 | + | FRMD1 | chr6 | 168479704 | - |
Top |
FusionProtFeatures for MAP3K4_FRMD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP3K4 | FRMD1 |
| Component of a protein kinase signal transductioncascade. Activates the CSBP2, P38 and JNK MAPK pathways, but notthe ERK pathway. Specifically phosphorylates and activates MAP2K4and MAP2K6. {ECO:0000269|PubMed:12052864,ECO:0000269|PubMed:9305639}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MAP3K4_FRMD1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MAP3K4_FRMD1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAP3K4 | CDC42, RAC1, MAP2K1, MAP2K4, MAP2K3, MAP2K6, GADD45G, GADD45B, GADD45A, ALK, SH3KBP1, TPR, YWHAZ, CNTRL, ZFP36, TRAF4, MAP2K7, RIPK2, MAPK8, CHUK, GSK3B, MAP3K4, AXIN1, HNRNPD, POLR2F, RAP1B, SORT1, SRPR, KIF23, BAG3, SYNCRIP, AP4E1, GOLT1B, SGTB, KIF21A, VWA9, CNTROB, NEDD1, KIF7, BAG6, USF1, MAPK13, SPATA1, ACTBL2, SIGLECL1, BTK, TOP1, TOP2A, TOP3A | FRMD1 | MUC7, BPIFA2, MUC5B, MPO, IGHA2, SCEL, SPRR3, PIGR, SKAP2, CRNN, AMY1C, GBP6, DSG3, CST2, A2ML1, IGHA1, ZG16B, BPIFB2, PPL, IGJ, LTF, TRAF7, CST1, CA6, IGLL5, EVPL, CST4, LYZ, DMBT1, ITPR3, KIAA0232, CST5, ALDH3A1, AMER1, CALML3, PASK, DSTYK, IGHG2, IVL, HBB, SERPINB5, ANXA1, ECM1, CALML5, SERPINB4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MAP3K4_FRMD1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MAP3K4_FRMD1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MAP3K4 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|