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Fusion gene ID: 20857 |
FusionGeneSummary for MAP3K2_MAP3K2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP3K2_MAP3K2 | Fusion gene ID: 20857 | Hgene | Tgene | Gene symbol | MAP3K2 | MAP3K2 | Gene ID | 10746 | 10746 |
| Gene name | mitogen-activated protein kinase kinase kinase 2 | mitogen-activated protein kinase kinase kinase 2 | |
| Synonyms | MEKK2|MEKK2B | MEKK2|MEKK2B | |
| Cytomap | 2q14.3 | 2q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase 2MAP/ERK kinase kinase 2MAPK/ERK kinase kinase 2MEK kinase 2MEKK 2 | mitogen-activated protein kinase kinase kinase 2MAP/ERK kinase kinase 2MAPK/ERK kinase kinase 2MEK kinase 2MEKK 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y2U5 | Q9Y2U5 | |
| Ensembl transtripts involved in fusion gene | ENST00000409947, ENST00000344908, | ENST00000409947, ENST00000344908, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 2 X 3 X 2=12 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/50*10)=0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAP3K2 [Title/Abstract] AND MAP3K2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP3K2 | GO:0045893 | positive regulation of transcription, DNA-templated | 14515274 |
| Tgene | MAP3K2 | GO:0045893 | positive regulation of transcription, DNA-templated | 14515274 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AK074577 | MAP3K2 | chr2 | 128062312 | - | MAP3K2 | chr2 | 128064119 | - | ||
| ChiTaRS3.1 | AA830998 | MAP3K2 | chr2 | 128063602 | + | MAP3K2 | chr2 | 128062230 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000409947 | ENST00000409947 | MAP3K2 | chr2 | 128062312 | - | MAP3K2 | chr2 | 128064119 | - |
| intron-intron | ENST00000409947 | ENST00000344908 | MAP3K2 | chr2 | 128062312 | - | MAP3K2 | chr2 | 128064119 | - |
| intron-3UTR | ENST00000344908 | ENST00000409947 | MAP3K2 | chr2 | 128062312 | - | MAP3K2 | chr2 | 128064119 | - |
| intron-intron | ENST00000344908 | ENST00000344908 | MAP3K2 | chr2 | 128062312 | - | MAP3K2 | chr2 | 128064119 | - |
| intron-3UTR | ENST00000409947 | ENST00000409947 | MAP3K2 | chr2 | 128063602 | + | MAP3K2 | chr2 | 128062230 | + |
| intron-intron | ENST00000409947 | ENST00000344908 | MAP3K2 | chr2 | 128063602 | + | MAP3K2 | chr2 | 128062230 | + |
| intron-3UTR | ENST00000344908 | ENST00000409947 | MAP3K2 | chr2 | 128063602 | + | MAP3K2 | chr2 | 128062230 | + |
| intron-intron | ENST00000344908 | ENST00000344908 | MAP3K2 | chr2 | 128063602 | + | MAP3K2 | chr2 | 128062230 | + |
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FusionProtFeatures for MAP3K2_MAP3K2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP3K2 | MAP3K2 |
| Component of a protein kinase signal transductioncascade. Regulates the JNK and ERK5 pathways by phosphorylatingand activating MAP2K5 and MAP2K7 (By similarity). Plays a role incaveolae kiss-and-run dynamics. {ECO:0000250,ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. | Component of a protein kinase signal transductioncascade. Regulates the JNK and ERK5 pathways by phosphorylatingand activating MAP2K5 and MAP2K7 (By similarity). Plays a role incaveolae kiss-and-run dynamics. {ECO:0000250,ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAP3K2_MAP3K2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAP3K2_MAP3K2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP3K2_MAP3K2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MAP3K2 | Q9Y2U5 | DB06616 | Bosutinib | Mitogen-activated protein kinase kinase kinase 2 | small molecule | approved |
| Tgene | MAP3K2 | Q9Y2U5 | DB06616 | Bosutinib | Mitogen-activated protein kinase kinase kinase 2 | small molecule | approved |
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RelatedDiseases for MAP3K2_MAP3K2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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