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Fusion gene ID: 20856 |
FusionGeneSummary for MAP3K2_IWS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP3K2_IWS1 | Fusion gene ID: 20856 | Hgene | Tgene | Gene symbol | MAP3K2 | IWS1 | Gene ID | 10746 | 55677 |
| Gene name | mitogen-activated protein kinase kinase kinase 2 | IWS1, SUPT6H interacting protein | |
| Synonyms | MEKK2|MEKK2B | - | |
| Cytomap | 2q14.3 | 2q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase 2MAP/ERK kinase kinase 2MAPK/ERK kinase kinase 2MEK kinase 2MEKK 2 | protein IWS1 homologIWS1 homologIWS1-like proteininteracts with Spt6 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y2U5 | Q96ST2 | |
| Ensembl transtripts involved in fusion gene | ENST00000409947, ENST00000344908, | ENST00000295321, ENST00000455721, ENST00000486662, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 3 X 4 X 2=24 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/50*10)=0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAP3K2 [Title/Abstract] AND IWS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP3K2 | GO:0045893 | positive regulation of transcription, DNA-templated | 14515274 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AC-A2BM-01A | MAP3K2 | chr2 | 128093446 | - | IWS1 | chr2 | 128238751 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000409947 | ENST00000295321 | MAP3K2 | chr2 | 128093446 | - | IWS1 | chr2 | 128238751 | - |
| 5CDS-intron | ENST00000409947 | ENST00000455721 | MAP3K2 | chr2 | 128093446 | - | IWS1 | chr2 | 128238751 | - |
| 5CDS-intron | ENST00000409947 | ENST00000486662 | MAP3K2 | chr2 | 128093446 | - | IWS1 | chr2 | 128238751 | - |
| Frame-shift | ENST00000344908 | ENST00000295321 | MAP3K2 | chr2 | 128093446 | - | IWS1 | chr2 | 128238751 | - |
| 5CDS-intron | ENST00000344908 | ENST00000455721 | MAP3K2 | chr2 | 128093446 | - | IWS1 | chr2 | 128238751 | - |
| 5CDS-intron | ENST00000344908 | ENST00000486662 | MAP3K2 | chr2 | 128093446 | - | IWS1 | chr2 | 128238751 | - |
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FusionProtFeatures for MAP3K2_IWS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP3K2 | IWS1 |
| Component of a protein kinase signal transductioncascade. Regulates the JNK and ERK5 pathways by phosphorylatingand activating MAP2K5 and MAP2K7 (By similarity). Plays a role incaveolae kiss-and-run dynamics. {ECO:0000250,ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. | Transcription factor which plays a key role in definingthe composition of the RNA polymerase II (RNAPII) elongationcomplex and in modulating the production of mature mRNAtranscripts. Acts as an assembly factor to recruit various factorsto the RNAPII elongation complex and is recruited to the complexvia binding to the transcription elongation factor SUPT6H bound tothe C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A).The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (suchas SETD2) to ensure proper mRNA splicing, efficient mRNA exportand elongation-coupled H3K36 methylation, a signature chromatinmark of active transcription. {ECO:0000269|PubMed:17184735,ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MAP3K2 | chr2:128093446 | chr2:128238751 | ENST00000344908 | - | 4 | 16 | 357_617 | 88 | 620 | Domain | Protein kinase |
| Hgene | >MAP3K2 | chr2:128093446 | chr2:128238751 | ENST00000344908 | - | 4 | 16 | 43_122 | 88 | 620 | Domain | PB1 |
| Hgene | >MAP3K2 | chr2:128093446 | chr2:128238751 | ENST00000409947 | - | 5 | 17 | 357_617 | 88 | 620 | Domain | Protein kinase |
| Hgene | >MAP3K2 | chr2:128093446 | chr2:128238751 | ENST00000409947 | - | 5 | 17 | 43_122 | 88 | 620 | Domain | PB1 |
| Hgene | >MAP3K2 | chr2:128093446 | chr2:128238751 | ENST00000344908 | - | 4 | 16 | 362_371 | 88 | 620 | Nucleotide binding | ATP |
| Hgene | >MAP3K2 | chr2:128093446 | chr2:128238751 | ENST00000409947 | - | 5 | 17 | 362_371 | 88 | 620 | Nucleotide binding | ATP |
| Tgene | IWS1 | chr2:128093446 | chr2:128238751 | ENST00000295321 | - | 12 | 14 | 83_509 | 776 | 820 | Compositional bias | Note=Glu-rich |
| Tgene | IWS1 | chr2:128093446 | chr2:128238751 | ENST00000295321 | - | 12 | 14 | 614_692 | 776 | 820 | Domain | TFIIS N-terminal |
| Tgene | IWS1 | chr2:128093446 | chr2:128238751 | ENST00000295321 | - | 12 | 14 | 235_296 | 776 | 820 | Region | Note=3 X approximate tandem repeats |
| Tgene | IWS1 | chr2:128093446 | chr2:128238751 | ENST00000295321 | - | 12 | 14 | 235_260 | 776 | 820 | Repeat | Note=1 |
| Tgene | IWS1 | chr2:128093446 | chr2:128238751 | ENST00000295321 | - | 12 | 14 | 261_286 | 776 | 820 | Repeat | Note=2 |
| Tgene | IWS1 | chr2:128093446 | chr2:128238751 | ENST00000295321 | - | 12 | 14 | 287_296 | 776 | 820 | Repeat | Note=3%3B half-length |
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FusionGeneSequence for MAP3K2_IWS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MAP3K2_ENST00000409947_chr2_128093446_-_IWS1_ENST00000295321_chr2_128238751_-_132aa MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNEFQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MAP3K2_ENST00000409947_chr2_128093446_-_IWS1_ENST00000295321_chr2_128238751_-_396nt ATGGATGATCAGCAAGCTTTGAACTCAATCATGCAAGATTTGGCTGTCCTTCATAAGGCCAGTCGACCAGCATTATCCTTGCAGGAAACC AGAAAAGCAAAATCTTCATCACCAAAAAAACAGAATGATGTCCGAGTCAAATTTGAACATAGAGGAGAAAAAAGAATCCTTCAGTTCCCC AGACCAGTTAAACTGGAAGATCTGAGATCTAAAGCTAAAATTGCCTTTGGACAGTCTATGGATCTACATTATACCAATAACGAGTTTCAG GCGACCTCCAAGAAGGGTATCAGTCGACTGGATAAACAGATGAGAAAGTTCACAGATATAAGGAAAAAAAGCAGATCTGCACACGCAGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MAP3K2_ENST00000409947_chr2_128093446_-_IWS1_ENST00000295321_chr2_128238751_-_917nt TTTCTAAAGTCCCTCAGGAAAAAAATTCTGAAACTTGAGCCACAAATTAAGAGGCAGACGGCTTTTCTCCTTGCAAATGACCTGCCACAC AGTCCGTCACTGCCTCTGCTAGCTCTGCTACCCTTGGGCCCTGTCCACAGCCCACGTGGGAGACCTTTTCACGGGATCTACTCGGATGTC TGGGATCTGGCCACTACCGCAGGCTCGAGACAACCCAGGCCATAAAGAATGCTGATGGGAGAACCATTTTCCTAATTTTCAAATTGTTGA GCTGTTTGCCATAATGGATGATCAGCAAGCTTTGAACTCAATCATGCAAGATTTGGCTGTCCTTCATAAGGCCAGTCGACCAGCATTATC CTTGCAGGAAACCAGAAAAGCAAAATCTTCATCACCAAAAAAACAGAATGATGTCCGAGTCAAATTTGAACATAGAGGAGAAAAAAGAAT CCTTCAGTTCCCCAGACCAGTTAAACTGGAAGATCTGAGATCTAAAGCTAAAATTGCCTTTGGACAGTCTATGGATCTACATTATACCAA TAACGAGTTTCAGGCGACCTCCAAGAAGGGTATCAGTCGACTGGATAAACAGATGAGAAAGTTCACAGATATAAGGAAAAAAAGCAGATC TGCACACGCAGTGAAAATCAGCATTGAGGGCAACAAAATGCCATTGTGACCTTGCCTGGAATGTGTCCCCATCTCTACTCTAAGAAATGC GCAATGGACTCTTTGGAGAAAGAAGATATTTTAAAACATTTTTAGTGTGTCTGTAAATGGTTCAGCGTGTATCAGATGTTGTCATAGGAC TCACATTTCTCTCAGTTATATTTAAAACCGTTGTGTACTTTGTACAAAGGAATACTAGTCATACTTCTATAAACTTTACACAATAAAATT |
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FusionGenePPI for MAP3K2_IWS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAP3K2 | SFN, MAP2K5, SH2D2A, YWHAE, MAP2K7, MAP2K4, MAPK8, XIAP, IKBKG, PIBF1, NEDD4, YWHAB, YWHAG, NEDD4L, STUB1, SMURF1, MAP3K2, MAP2K3, STK38, HSP90AA1, BIRC2, STAMBP, USP2, MAP3K3, MAPK7, STX3, YWHAZ, YWHAQ, TRAF7, CTNNB1, GSK3B, BTRC, AXIN1, AXIN2, RAB3IP, CBY1, TRIM25 | IWS1 | WDR48, SUPT6H, SETD2, POLR2A, SDHB, DHX15, FAM162A, CSNK2A1, STAT2, ELP6, ERICH2, KRTAP10-3, ENO1, SHMT2, MOV10, NXF1, CTR9, SUPT16H, HIST1H2BG, XPO1, PRCC, SUPT5H, CTDP1, RNF40, ACTR1A, LLGL2, CCDC88A, SAMD1, SF3B5, DAB2IP, PPM1A, PIP4K2A, RUVBL2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | IWS1 | chr2:128093446 | chr2:128238751 | ENST00000295321 | - | 12 | 14 | 523_819 | 776 | 820 | SUPT6H and ALYREF |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP3K2_IWS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MAP3K2 | Q9Y2U5 | DB06616 | Bosutinib | Mitogen-activated protein kinase kinase kinase 2 | small molecule | approved |
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RelatedDiseases for MAP3K2_IWS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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