![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 20845 |
FusionGeneSummary for MAP3K13_UTS2B |
![]() |
Fusion gene information | Fusion gene name: MAP3K13_UTS2B | Fusion gene ID: 20845 | Hgene | Tgene | Gene symbol | MAP3K13 | UTS2B | Gene ID | 9175 | 257313 |
Gene name | mitogen-activated protein kinase kinase kinase 13 | urotensin 2B | |
Synonyms | LZK|MEKK13|MLK | U2B|URP|UTS2D | |
Cytomap | 3q27.2 | 3q28 | |
Type of gene | protein-coding | protein-coding | |
Description | mitogen-activated protein kinase kinase kinase 13leucine zipper-bearing kinasemixed lineage kinase | urotensin-2BU-IIBUIIBprepro-URPurotensin 2 domain containingurotensin II-related peptideurotensin IIBurotensin-2 domain-containing protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O43283 | Q765I0 | |
Ensembl transtripts involved in fusion gene | ENST00000446828, ENST00000424227, ENST00000443863, ENST00000535426, ENST00000265026, ENST00000448876, ENST00000454237, ENST00000438798, | ENST00000340524, ENST00000427544, ENST00000490825, | |
Fusion gene scores | * DoF score | 10 X 6 X 8=480 | 1 X 1 X 1=1 |
# samples | 11 | 1 | |
** MAII score | log2(11/480*10)=-2.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: MAP3K13 [Title/Abstract] AND UTS2B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MAP3K13 | GO:0000186 | activation of MAPKK activity | 11726277 |
Hgene | MAP3K13 | GO:0006468 | protein phosphorylation | 9353328|11726277 |
Hgene | MAP3K13 | GO:0007254 | JNK cascade | 9353328|11726277 |
Hgene | MAP3K13 | GO:0046777 | protein autophosphorylation | 9353328 |
Hgene | MAP3K13 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 12492477 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LGG | TCGA-CS-4942-01A | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000446828 | ENST00000340524 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-intron | ENST00000446828 | ENST00000427544 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000446828 | ENST00000490825 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000424227 | ENST00000340524 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-intron | ENST00000424227 | ENST00000427544 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000424227 | ENST00000490825 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000443863 | ENST00000340524 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-intron | ENST00000443863 | ENST00000427544 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000443863 | ENST00000490825 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000535426 | ENST00000340524 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-intron | ENST00000535426 | ENST00000427544 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000535426 | ENST00000490825 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
5UTR-5UTR | ENST00000265026 | ENST00000340524 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
5UTR-intron | ENST00000265026 | ENST00000427544 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
5UTR-5UTR | ENST00000265026 | ENST00000490825 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000448876 | ENST00000340524 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-intron | ENST00000448876 | ENST00000427544 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000448876 | ENST00000490825 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000454237 | ENST00000340524 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-intron | ENST00000454237 | ENST00000427544 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000454237 | ENST00000490825 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000438798 | ENST00000340524 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-intron | ENST00000438798 | ENST00000427544 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
intron-5UTR | ENST00000438798 | ENST00000490825 | MAP3K13 | chr3 | 185081156 | + | UTS2B | chr3 | 191046498 | - |
Top |
FusionProtFeatures for MAP3K13_UTS2B |
![]() |
Hgene | Tgene |
MAP3K13 | UTS2B |
Potent vasoconstrictor. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MAP3K13_UTS2B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MAP3K13_UTS2B |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAP3K13 | PRDX3, IKBKB, MAP3K13, MAP2K7, MAPK8IP1, MYC, GLO1, HLA-DRB3, STAT3, HIST2H2AC, INPPL1, KLHL20 | UTS2B | UTS2R |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MAP3K13_UTS2B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MAP3K13_UTS2B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |