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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20845

FusionGeneSummary for MAP3K13_UTS2B

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP3K13_UTS2B
Fusion gene ID: 20845
HgeneTgene
Gene symbol

MAP3K13

UTS2B

Gene ID

9175

257313

Gene namemitogen-activated protein kinase kinase kinase 13urotensin 2B
SynonymsLZK|MEKK13|MLKU2B|URP|UTS2D
Cytomap

3q27.2

3q28

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 13leucine zipper-bearing kinasemixed lineage kinaseurotensin-2BU-IIBUIIBprepro-URPurotensin 2 domain containingurotensin II-related peptideurotensin IIBurotensin-2 domain-containing protein
Modification date2018052320180523
UniProtAcc

O43283

Q765I0

Ensembl transtripts involved in fusion geneENST00000446828, ENST00000424227, 
ENST00000443863, ENST00000535426, 
ENST00000265026, ENST00000448876, 
ENST00000454237, ENST00000438798, 
ENST00000340524, ENST00000427544, 
ENST00000490825, 
Fusion gene scores* DoF score10 X 6 X 8=4801 X 1 X 1=1
# samples 111
** MAII scorelog2(11/480*10)=-2.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: MAP3K13 [Title/Abstract] AND UTS2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP3K13

GO:0000186

activation of MAPKK activity

11726277

HgeneMAP3K13

GO:0006468

protein phosphorylation

9353328|11726277

HgeneMAP3K13

GO:0007254

JNK cascade

9353328|11726277

HgeneMAP3K13

GO:0046777

protein autophosphorylation

9353328

HgeneMAP3K13

GO:0051092

positive regulation of NF-kappaB transcription factor activity

12492477


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-CS-4942-01AMAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000446828ENST00000340524MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-intronENST00000446828ENST00000427544MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000446828ENST00000490825MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000424227ENST00000340524MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-intronENST00000424227ENST00000427544MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000424227ENST00000490825MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000443863ENST00000340524MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-intronENST00000443863ENST00000427544MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000443863ENST00000490825MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000535426ENST00000340524MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-intronENST00000535426ENST00000427544MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000535426ENST00000490825MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
5UTR-5UTRENST00000265026ENST00000340524MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
5UTR-intronENST00000265026ENST00000427544MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
5UTR-5UTRENST00000265026ENST00000490825MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000448876ENST00000340524MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-intronENST00000448876ENST00000427544MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000448876ENST00000490825MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000454237ENST00000340524MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-intronENST00000454237ENST00000427544MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000454237ENST00000490825MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000438798ENST00000340524MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-intronENST00000438798ENST00000427544MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-
intron-5UTRENST00000438798ENST00000490825MAP3K13chr3

185081156

+UTS2Bchr3

191046498

-

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FusionProtFeatures for MAP3K13_UTS2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP3K13

O43283

UTS2B

Q765I0

Potent vasoconstrictor. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP3K13_UTS2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP3K13_UTS2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP3K13PRDX3, IKBKB, MAP3K13, MAP2K7, MAPK8IP1, MYC, GLO1, HLA-DRB3, STAT3, HIST2H2AC, INPPL1, KLHL20UTS2BUTS2R


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP3K13_UTS2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAP3K13_UTS2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource