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Fusion gene ID: 2082 |
FusionGeneSummary for AP3B1_IPO11 |
Fusion gene summary |
Fusion gene information | Fusion gene name: AP3B1_IPO11 | Fusion gene ID: 2082 | Hgene | Tgene | Gene symbol | AP3B1 | IPO11 | Gene ID | 8546 | 51194 |
Gene name | adaptor related protein complex 3 subunit beta 1 | importin 11 | |
Synonyms | ADTB3|ADTB3A|HPS|HPS2|PE | RanBP11 | |
Cytomap | 5q14.1 | 5q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | AP-3 complex subunit beta-1AP-3 complex beta-3A subunitadaptor protein complex AP-3 subunit beta-1adaptor related protein complex 3 beta 1 subunitbeta-3A-adaptinclathrin assembly protein complex 3 beta-1 large chain | importin-11Ran binding protein 11imp11ran-binding protein 11 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O00203 | Q9UI26 | |
Ensembl transtripts involved in fusion gene | ENST00000255194, ENST00000519295, ENST00000523204, | ENST00000325324, ENST00000409296, ENST00000409534, ENST00000512177, | |
Fusion gene scores | * DoF score | 6 X 7 X 5=210 | 2 X 2 X 2=8 |
# samples | 7 | 2 | |
** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: AP3B1 [Title/Abstract] AND IPO11 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-D3-A51N-06A | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000255194 | ENST00000325324 | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
In-frame | ENST00000255194 | ENST00000409296 | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
5CDS-intron | ENST00000255194 | ENST00000409534 | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
5CDS-intron | ENST00000255194 | ENST00000512177 | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
intron-3CDS | ENST00000519295 | ENST00000325324 | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
intron-3CDS | ENST00000519295 | ENST00000409296 | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
intron-intron | ENST00000519295 | ENST00000409534 | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
intron-intron | ENST00000519295 | ENST00000512177 | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
intron-3CDS | ENST00000523204 | ENST00000325324 | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
intron-3CDS | ENST00000523204 | ENST00000409296 | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
intron-intron | ENST00000523204 | ENST00000409534 | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
intron-intron | ENST00000523204 | ENST00000512177 | AP3B1 | chr5 | 77590276 | - | IPO11 | chr5 | 61762958 | + |
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FusionProtFeatures for AP3B1_IPO11 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
AP3B1 | IPO11 |
Subunit of non-clathrin- and clathrin-associated adaptorprotein complex 3 (AP-3) that plays a role in protein sorting inthe late-Golgi/trans-Golgi network (TGN) and/or endosomes. The APcomplexes mediate both the recruitment of clathrin to membranesand the recognition of sorting signals within the cytosolic tailsof transmembrane cargo molecules. AP-3 appears to be involved inthe sorting of a subset of transmembrane proteins targeted tolysosomes and lysosome-related organelles. In concert with theBLOC-1 complex, AP-3 is required to target cargos into vesiclesassembled at cell bodies for delivery into neurites and nerveterminals. | Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC)through binding to nucleoporin and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Mediates the nuclear import of UBE2E3,and of RPL12 (By similarity). {ECO:0000250,ECO:0000269|PubMed:11032817}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 209_248 | 172 | 976 | Repeat | Note=HEAT 2 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 318_356 | 172 | 976 | Repeat | Note=HEAT 3 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 422_459 | 172 | 976 | Repeat | Note=HEAT 4 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 473_509 | 172 | 976 | Repeat | Note=HEAT 5 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 511_548 | 172 | 976 | Repeat | Note=HEAT 6 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 555_593 | 172 | 976 | Repeat | Note=HEAT 7 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 600_636 | 172 | 976 | Repeat | Note=HEAT 8 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 640_677 | 172 | 976 | Repeat | Note=HEAT 9 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 683_720 | 172 | 976 | Repeat | Note=HEAT 10 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 743_764 | 172 | 976 | Repeat | Note=HEAT 11 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 765_804 | 172 | 976 | Repeat | Note=HEAT 12 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 819_849 | 172 | 976 | Repeat | Note=HEAT 13 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 850_887 | 172 | 976 | Repeat | Note=HEAT 14 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 957_974 | 172 | 976 | Repeat | Note=HEAT 15 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 209_248 | 212 | 1016 | Repeat | Note=HEAT 2 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 318_356 | 212 | 1016 | Repeat | Note=HEAT 3 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 422_459 | 212 | 1016 | Repeat | Note=HEAT 4 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 473_509 | 212 | 1016 | Repeat | Note=HEAT 5 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 511_548 | 212 | 1016 | Repeat | Note=HEAT 6 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 555_593 | 212 | 1016 | Repeat | Note=HEAT 7 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 600_636 | 212 | 1016 | Repeat | Note=HEAT 8 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 640_677 | 212 | 1016 | Repeat | Note=HEAT 9 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 683_720 | 212 | 1016 | Repeat | Note=HEAT 10 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 743_764 | 212 | 1016 | Repeat | Note=HEAT 11 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 765_804 | 212 | 1016 | Repeat | Note=HEAT 12 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 819_849 | 212 | 1016 | Repeat | Note=HEAT 13 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 850_887 | 212 | 1016 | Repeat | Note=HEAT 14 |
Tgene | >IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 957_974 | 212 | 1016 | Repeat | Note=HEAT 15 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >AP3B1 | chr5:77590276 | chr5:61762958 | ENST00000255194 | - | 1 | 27 | 677_802 | 42 | 1095 | Compositional bias | Note=Glu/Ser-rich |
Tgene | IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 28_100 | 172 | 976 | Domain | Importin N-terminal |
Tgene | IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 28_100 | 212 | 1016 | Domain | Importin N-terminal |
Tgene | IPO11 | chr5:77590276 | chr5:61762958 | ENST00000325324 | + | 4 | 30 | 123_160 | 172 | 976 | Repeat | Note=HEAT 1 |
Tgene | IPO11 | chr5:77590276 | chr5:61762958 | ENST00000409296 | + | 4 | 30 | 123_160 | 212 | 1016 | Repeat | Note=HEAT 1 |
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FusionGeneSequence for AP3B1_IPO11 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_AP3B1_ENST00000255194_chr5_77590276_-_IPO11_ENST00000325324_chr5_61762958_+_846aa MSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKNXLLEFIILPALCGITTQTHSCKKFLLAMKLQFXVHXNEHCYHXKCCV SXLLMDLWNLIRIWRXWVFYMEYLNVXNSFWNAVEVXVQIMCVEIDWKRPSFFLLKCFWTSWISILFHLLLXFRDHWNFLXAMFLQKLVK ALHLNDSLSNVXILLRXLSKIMLISHPKILKIAALKLLKPIRLRWHSSHILLXQRYVEDXSLIISYXLKKNXQCGKKTQKALQWKKQEEI LGNIVXGHALKYYLXIYSMNIIRLLLLYFXKXCKHFKDPQMWKIXMHCXSKMLCIMLLDXLLMSSLTVLILISGLKTSFFQNYKSFTIGI SHCDAGXFGSSVSGFLXNSSLTXDPCFMKQSVTCFKIKIXWSVLKQLQLXSXLLMILNLEQISFYRIWKPCSHYFFSYCSKLQNVTQRCM FCMSFLVXSKESTCRYDHMWDVWYNICPSFGSRVKNTICXDVLFXQHLFILFRDXEQTARTCTLSCSQLFNXVQMFHSLHMFIFWKMVXN YGXXLWKTVHVLHQSCFVYFRICHHFLNXVQKILELALRSSMVISFYHQQNFYRHTQXVYASPFVNFXRKLLQKVKFRCSRLWKMPLKXT QYXVHKCFNRFYPMFSRVLXKGRGILXXCPRILELWVEFYYKTLVFFLHYLMRWPINLIRRWTSFWEIXLKCGLIEWTTLPSLKEENFQL WLCSLFCHLIIVLSKINSVGLXTFQXKACMMSXRKILKQELIKTVCXCLILRNQKXQKMKNHPQNKIRGKRCWPXRTLFIQCHCSSSSTR >In-frame_AP3B1_ENST00000255194_chr5_77590276_-_IPO11_ENST00000409296_chr5_61762958_+_846aa MSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKNXLLEFIILPALCGITTQTHSCKKFLLAMKLQFXVHXNEHCYHXKCCV SXLLMDLWNLIRIWRXWVFYMEYLNVXNSFWNAVEVXVQIMCVEIDWKRPSFFLLKCFWTSWISILFHLLLXFRDHWNFLXAMFLQKLVK ALHLNDSLSNVXILLRXLSKIMLISHPKILKIAALKLLKPIRLRWHSSHILLXQRYVEDXSLIISYXLKKNXQCGKKTQKALQWKKQEEI LGNIVXGHALKYYLXIYSMNIIRLLLLYFXKXCKHFKDPQMWKIXMHCXSKMLCIMLLDXLLMSSLTVLILISGLKTSFFQNYKSFTIGI SHCDAGXFGSSVSGFLXNSSLTXDPCFMKQSVTCFKIKIXWSVLKQLQLXSXLLMILNLEQISFYRIWKPCSHYFFSYCSKLQNVTQRCM FCMSFLVXSKESTCRYDHMWDVWYNICPSFGSRVKNTICXDVLFXQHLFILFRDXEQTARTCTLSCSQLFNXVQMFHSLHMFIFWKMVXN YGXXLWKTVHVLHQSCFVYFRICHHFLNXVQKILELALRSSMVISFYHQQNFYRHTQXVYASPFVNFXRKLLQKVKFRCSRLWKMPLKXT QYXVHKCFNRFYPMFSRVLXKGRGILXXCPRILELWVEFYYKTLVFFLHYLMRWPINLIRRWTSFWEIXLKCGLIEWTTLPSLKEENFQL WLCSLFCHLIIVLSKINSVGLXTFQXKACMMSXRKILKQELIKTVCXCLILRNQKXQKMKNHPQNKIRGKRCWPXRTLFIQCHCSSSSTR |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_AP3B1_ENST00000255194_chr5_77590276_-_IPO11_ENST00000325324_chr5_61762958_+_2540nt ATGTCCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCC TCGGGGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAATTAGCTTCTGGAATTTATAATTTTGCCTGCTCTCTGTGGAATCACCACACAG ACACATTCCTGCAAGAAGTTTCTTCTGGCAATGAAGCTGCAATTTTGAGTTCACTAGAACGAACACTGCTATCATTGAAAGTGCTGCGTA AGTTAACTGTTAATGGATTTGTGGAACCTCATAAGAATATGGAGGTGATGGGTTTTTTACATGGAATATTTGAACGTCTAAAACAGTTTC TGGAATGCAGTAGAAGTATAGGTACAGATAATGTGTGTAGAGATAGACTGGAAAAGACCATCATTCTTTTTACTAAAGTGCTTTTGGACT TCTTGGATCAGCATCCTTTTTCATTTACTCCTCTAATTCAGAGATCACTGGAATTTTCTGTAAGCTATGTTTTTACAGAAGTTGGTGAAG GCGTTACATTTGAACGATTCATTGTCCAATGTATGAATCTTATTAAGATGATTGTCAAAAATTATGCTTATAAGCCATCCAAAAATTTTG AAGATAGCAGCCCTGAAACTCTTGAAGCCCATAAGATTAAGATGGCATTCTTCACATATCCTACTTTGACAGAGATATGTAGAAGATTAG TCTCTCATTATTTCCTATTAACTGAAGAAGAACTGACAATGTGGGAAGAAGACCCAGAAGGCTTTACAGTGGAAGAAACAGGAGGAGATT CTTGGAAATATAGTTTGAGGCCATGCACTGAAGTATTATTTATAGATATATTCCATGAATATAATCAGACTCTTACTCCTGTACTTCTAG AAATGATGCAAACACTTCAAGGACCCACAAATGTGGAAGATATGAATGCACTGTTAATCAAAGATGCTGTGTATAATGCTGTTGGATTAG CTGCTTATGAGCTCTTTGACAGTGTTGATTTTGATCAGTGGTTTAAAAACCAGCTTCTTCCAGAATTACAAGTCATTCACAATAGGTATA AGCCATTGCGACGCAGGGTGATTTGGCTCATCGGTCAGTGGATTTCTGTGAAATTCAAGTCTGACTTAAGACCCATGCTTTATGAAGCAA TCTGTAACTTGCTTCAAGATCAAGATTTAGTGGTCCGTATTGAAACAGCTACAACTTTGAAGTTAACTGTTGATGATTTTGAATTTAGAA CAGATCAGTTTCTACCGTATTTGGAAACCATGTTCACACTACTTTTTCAGTTACTGCAGCAAGTTACAGAATGTGACACAAAGATGCATG TTTTGCATGTCCTTTCTTGTGTGATCGAAAGAGTCAACATGCAGATACGACCATATGTGGGATGTTTGGTACAATATTTGCCCCTCCTTT GGAAGCAGAGTGAAGAACACAATATGTTGAGATGTGCTATTTTGACAACACTTATTCATCTTGTTCAGGGATTAGGAGCAGACAGCAAGA ACCTGTACCCTTTCCTGCTCCCAGTTATTCAACTGAGTACAGATGTTTCACAGCCTCCACATGTTTATCTTCTGGAAGATGGTTTAGAAT TATGGTTAGTAACTTTGGAAAACAGTCCATGTATTACACCAGAGTTGCTTCGTATATTTCAGAATATGTCACCACTTCTTGAACTAAGTT CAGAAAATCTTAGAACTTGCTTTAAGATCATCAATGGTTATATCTTTTTATCATCAACAGAATTTTTACAGACATACGCAGTAGGTCTAT GCCAGTCCTTTTGTGAACTTTTAAAGGAAATTACTACAGAAGGTCAAGTTCAGGTGCTCAAGGTTGTGGAAAATGCCCTTAAAGTGAACC CAATACTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCA CGTATCTTGGAGTTATGGGTCGAGTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGG AGATGGACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTT TGGCTTTGCTCTCTCTTCTGCCATCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATG ATGTCATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAG AACCACCCACAGAACAAGATAAGAGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGA AGCTCAAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGG >In-frame_AP3B1_ENST00000255194_chr5_77590276_-_IPO11_ENST00000409296_chr5_61762958_+_2540nt ATGTCCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCC TCGGGGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAATTAGCTTCTGGAATTTATAATTTTGCCTGCTCTCTGTGGAATCACCACACAG ACACATTCCTGCAAGAAGTTTCTTCTGGCAATGAAGCTGCAATTTTGAGTTCACTAGAACGAACACTGCTATCATTGAAAGTGCTGCGTA AGTTAACTGTTAATGGATTTGTGGAACCTCATAAGAATATGGAGGTGATGGGTTTTTTACATGGAATATTTGAACGTCTAAAACAGTTTC TGGAATGCAGTAGAAGTATAGGTACAGATAATGTGTGTAGAGATAGACTGGAAAAGACCATCATTCTTTTTACTAAAGTGCTTTTGGACT TCTTGGATCAGCATCCTTTTTCATTTACTCCTCTAATTCAGAGATCACTGGAATTTTCTGTAAGCTATGTTTTTACAGAAGTTGGTGAAG GCGTTACATTTGAACGATTCATTGTCCAATGTATGAATCTTATTAAGATGATTGTCAAAAATTATGCTTATAAGCCATCCAAAAATTTTG AAGATAGCAGCCCTGAAACTCTTGAAGCCCATAAGATTAAGATGGCATTCTTCACATATCCTACTTTGACAGAGATATGTAGAAGATTAG TCTCTCATTATTTCCTATTAACTGAAGAAGAACTGACAATGTGGGAAGAAGACCCAGAAGGCTTTACAGTGGAAGAAACAGGAGGAGATT CTTGGAAATATAGTTTGAGGCCATGCACTGAAGTATTATTTATAGATATATTCCATGAATATAATCAGACTCTTACTCCTGTACTTCTAG AAATGATGCAAACACTTCAAGGACCCACAAATGTGGAAGATATGAATGCACTGTTAATCAAAGATGCTGTGTATAATGCTGTTGGATTAG CTGCTTATGAGCTCTTTGACAGTGTTGATTTTGATCAGTGGTTTAAAAACCAGCTTCTTCCAGAATTACAAGTCATTCACAATAGGTATA AGCCATTGCGACGCAGGGTGATTTGGCTCATCGGTCAGTGGATTTCTGTGAAATTCAAGTCTGACTTAAGACCCATGCTTTATGAAGCAA TCTGTAACTTGCTTCAAGATCAAGATTTAGTGGTCCGTATTGAAACAGCTACAACTTTGAAGTTAACTGTTGATGATTTTGAATTTAGAA CAGATCAGTTTCTACCGTATTTGGAAACCATGTTCACACTACTTTTTCAGTTACTGCAGCAAGTTACAGAATGTGACACAAAGATGCATG TTTTGCATGTCCTTTCTTGTGTGATCGAAAGAGTCAACATGCAGATACGACCATATGTGGGATGTTTGGTACAATATTTGCCCCTCCTTT GGAAGCAGAGTGAAGAACACAATATGTTGAGATGTGCTATTTTGACAACACTTATTCATCTTGTTCAGGGATTAGGAGCAGACAGCAAGA ACCTGTACCCTTTCCTGCTCCCAGTTATTCAACTGAGTACAGATGTTTCACAGCCTCCACATGTTTATCTTCTGGAAGATGGTTTAGAAT TATGGTTAGTAACTTTGGAAAACAGTCCATGTATTACACCAGAGTTGCTTCGTATATTTCAGAATATGTCACCACTTCTTGAACTAAGTT CAGAAAATCTTAGAACTTGCTTTAAGATCATCAATGGTTATATCTTTTTATCATCAACAGAATTTTTACAGACATACGCAGTAGGTCTAT GCCAGTCCTTTTGTGAACTTTTAAAGGAAATTACTACAGAAGGTCAAGTTCAGGTGCTCAAGGTTGTGGAAAATGCCCTTAAAGTGAACC CAATACTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCA CGTATCTTGGAGTTATGGGTCGAGTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGG AGATGGACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTT TGGCTTTGCTCTCTCTTCTGCCATCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATG ATGTCATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAG AACCACCCACAGAACAAGATAAGAGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGA AGCTCAAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_AP3B1_ENST00000255194_chr5_77590276_-_IPO11_ENST00000325324_chr5_61762958_+_3975nt ACTGCGCATGCGCAGGGGGTGGACTGCCAGGTCGGCTCAGGGAGCCGTGACGAGTCCGGAAGCGCCTGCGCGCGCTCCTCCGTACGAGAA CTAGTTTTGTTCCGTGCCCTCTGGACTGGAACCTTTTGGAGAGAACCCCCGGCAGGACCAACCCCGCACCCGCCAGCACCGCGGCAATGT CCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCCTCGG GGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAATTAGCTTCTGGAATTTATAATTTTGCCTGCTCTCTGTGGAATCACCACACAGACAC ATTCCTGCAAGAAGTTTCTTCTGGCAATGAAGCTGCAATTTTGAGTTCACTAGAACGAACACTGCTATCATTGAAAGTGCTGCGTAAGTT AACTGTTAATGGATTTGTGGAACCTCATAAGAATATGGAGGTGATGGGTTTTTTACATGGAATATTTGAACGTCTAAAACAGTTTCTGGA ATGCAGTAGAAGTATAGGTACAGATAATGTGTGTAGAGATAGACTGGAAAAGACCATCATTCTTTTTACTAAAGTGCTTTTGGACTTCTT GGATCAGCATCCTTTTTCATTTACTCCTCTAATTCAGAGATCACTGGAATTTTCTGTAAGCTATGTTTTTACAGAAGTTGGTGAAGGCGT TACATTTGAACGATTCATTGTCCAATGTATGAATCTTATTAAGATGATTGTCAAAAATTATGCTTATAAGCCATCCAAAAATTTTGAAGA TAGCAGCCCTGAAACTCTTGAAGCCCATAAGATTAAGATGGCATTCTTCACATATCCTACTTTGACAGAGATATGTAGAAGATTAGTCTC TCATTATTTCCTATTAACTGAAGAAGAACTGACAATGTGGGAAGAAGACCCAGAAGGCTTTACAGTGGAAGAAACAGGAGGAGATTCTTG GAAATATAGTTTGAGGCCATGCACTGAAGTATTATTTATAGATATATTCCATGAATATAATCAGACTCTTACTCCTGTACTTCTAGAAAT GATGCAAACACTTCAAGGACCCACAAATGTGGAAGATATGAATGCACTGTTAATCAAAGATGCTGTGTATAATGCTGTTGGATTAGCTGC TTATGAGCTCTTTGACAGTGTTGATTTTGATCAGTGGTTTAAAAACCAGCTTCTTCCAGAATTACAAGTCATTCACAATAGGTATAAGCC ATTGCGACGCAGGGTGATTTGGCTCATCGGTCAGTGGATTTCTGTGAAATTCAAGTCTGACTTAAGACCCATGCTTTATGAAGCAATCTG TAACTTGCTTCAAGATCAAGATTTAGTGGTCCGTATTGAAACAGCTACAACTTTGAAGTTAACTGTTGATGATTTTGAATTTAGAACAGA TCAGTTTCTACCGTATTTGGAAACCATGTTCACACTACTTTTTCAGTTACTGCAGCAAGTTACAGAATGTGACACAAAGATGCATGTTTT GCATGTCCTTTCTTGTGTGATCGAAAGAGTCAACATGCAGATACGACCATATGTGGGATGTTTGGTACAATATTTGCCCCTCCTTTGGAA GCAGAGTGAAGAACACAATATGTTGAGATGTGCTATTTTGACAACACTTATTCATCTTGTTCAGGGATTAGGAGCAGACAGCAAGAACCT GTACCCTTTCCTGCTCCCAGTTATTCAACTGAGTACAGATGTTTCACAGCCTCCACATGTTTATCTTCTGGAAGATGGTTTAGAATTATG GTTAGTAACTTTGGAAAACAGTCCATGTATTACACCAGAGTTGCTTCGTATATTTCAGAATATGTCACCACTTCTTGAACTAAGTTCAGA AAATCTTAGAACTTGCTTTAAGATCATCAATGGTTATATCTTTTTATCATCAACAGAATTTTTACAGACATACGCAGTAGGTCTATGCCA GTCCTTTTGTGAACTTTTAAAGGAAATTACTACAGAAGGTCAAGTTCAGGTGCTCAAGGTTGTGGAAAATGCCCTTAAAGTGAACCCAAT ACTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCACGTA TCTTGGAGTTATGGGTCGAGTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGGAGAT GGACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTTTGGC TTTGCTCTCTCTTCTGCCATCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATGATGT CATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAGAACC ACCCACAGAACAAGATAAGAGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGAAGCT CAAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGGAGTT TTTGCAAGGATTCTAAGAGCACATGACATGTGGCTGCCTCCCCTTTCAGAAACAAGCTGAGTAACCCAGCCTGCCGTTTGTATGTGAGAG CCTGCTGAGATGAAGAAATCACTTCATGAAAATAAGCAAAGACCACACATTTTTTACTACAAAATGTAAAGGATAAATGTAAATCCTGCA TAACTAAAATCACAAACCTATTCCTCAAAAGAATTTAATTTTATATTTATGAGGGGGCCCTTCACTAAAAAGTACATGTAAAAGTACATT TGATGACAATAGCTGCTTAGTTTCCTGTTAAGAGAAGAAACTTTATCTTTTAATTATGTGCTCTTAATATTTGAAGATGAGAGTTAATAC CTGAGATGTTTTTCTGCAACCAAAATTCATTAAATTTGGCTGCCTTATCCTTTTTTTAAGCTAATGAAACTACAGGTTTGAAAAATGACA AAGCTGTTCAGATGATGCTATTAAAGAAATGTGTGTACTAAGCAAAAATATATAAATAGTGACAAATACACATTACCAAGCTTATCTTGC AAGGGAGTTATTTTCATCTAACATAGAAAGTGTGTTTTATCAGACAAATGCTTTTATTTTCATTCTAATAATTTGATACAGAAATTAGTA AAGGCATTTTTTTCTTTTTTTTTCCAGTAAATACATTGGGTCTATAAATGTGCATTTGTAAGGGCCACAAAAGTGAACGTGTGGTACTGT AGTACCACGTGGGAGACCTCTGGTTATGGTTTAGTCCTAGTTCCTTTGTTACTCCTGTGAGCACCGAGAAGAACTGGGCGACTCCCAGTC CCACCTGTGCTGTGACAGTCCCACGTGGCTATGACAGACTGTTTAGTACTTACCCTTCTCAGGTTCCTCAGTGCAGGGGTGCATCAGGGC CTCAATAATAGGGGTATACCTGGGAGGATCCAGCAGTAATCCCCAGGGTACTAGGATTACTAGTACTCTGATGGAACTAGTCTTCCTTCC TTATTCCTCGAACATGCAGTACATAAAAAGGGGAAAAGGAGAAAAAAAAAGCCTTACTTTGTTTTACTTGCCATTTATTGTAAGGAAACT TTAAAGCATTTTTTAGGAAATACTCAAAAGCAAGGTTGGAAAATGTTTTATCTTTCTATAGAAAGTTGGGTACAGTATGTAACTGCGGGA AACCCACTGCCCCTTTGTAAGCTGTGGAACCCAAACTGTATGGGGATATTTGATGTTTTCAGAAAGAGGAAGAAAATATGGTCCAAATTA >In-frame_AP3B1_ENST00000255194_chr5_77590276_-_IPO11_ENST00000409296_chr5_61762958_+_3102nt ACTGCGCATGCGCAGGGGGTGGACTGCCAGGTCGGCTCAGGGAGCCGTGACGAGTCCGGAAGCGCCTGCGCGCGCTCCTCCGTACGAGAA CTAGTTTTGTTCCGTGCCCTCTGGACTGGAACCTTTTGGAGAGAACCCCCGGCAGGACCAACCCCGCACCCGCCAGCACCGCGGCAATGT CCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCCTCGG GGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAATTAGCTTCTGGAATTTATAATTTTGCCTGCTCTCTGTGGAATCACCACACAGACAC ATTCCTGCAAGAAGTTTCTTCTGGCAATGAAGCTGCAATTTTGAGTTCACTAGAACGAACACTGCTATCATTGAAAGTGCTGCGTAAGTT AACTGTTAATGGATTTGTGGAACCTCATAAGAATATGGAGGTGATGGGTTTTTTACATGGAATATTTGAACGTCTAAAACAGTTTCTGGA ATGCAGTAGAAGTATAGGTACAGATAATGTGTGTAGAGATAGACTGGAAAAGACCATCATTCTTTTTACTAAAGTGCTTTTGGACTTCTT GGATCAGCATCCTTTTTCATTTACTCCTCTAATTCAGAGATCACTGGAATTTTCTGTAAGCTATGTTTTTACAGAAGTTGGTGAAGGCGT TACATTTGAACGATTCATTGTCCAATGTATGAATCTTATTAAGATGATTGTCAAAAATTATGCTTATAAGCCATCCAAAAATTTTGAAGA TAGCAGCCCTGAAACTCTTGAAGCCCATAAGATTAAGATGGCATTCTTCACATATCCTACTTTGACAGAGATATGTAGAAGATTAGTCTC TCATTATTTCCTATTAACTGAAGAAGAACTGACAATGTGGGAAGAAGACCCAGAAGGCTTTACAGTGGAAGAAACAGGAGGAGATTCTTG GAAATATAGTTTGAGGCCATGCACTGAAGTATTATTTATAGATATATTCCATGAATATAATCAGACTCTTACTCCTGTACTTCTAGAAAT GATGCAAACACTTCAAGGACCCACAAATGTGGAAGATATGAATGCACTGTTAATCAAAGATGCTGTGTATAATGCTGTTGGATTAGCTGC TTATGAGCTCTTTGACAGTGTTGATTTTGATCAGTGGTTTAAAAACCAGCTTCTTCCAGAATTACAAGTCATTCACAATAGGTATAAGCC ATTGCGACGCAGGGTGATTTGGCTCATCGGTCAGTGGATTTCTGTGAAATTCAAGTCTGACTTAAGACCCATGCTTTATGAAGCAATCTG TAACTTGCTTCAAGATCAAGATTTAGTGGTCCGTATTGAAACAGCTACAACTTTGAAGTTAACTGTTGATGATTTTGAATTTAGAACAGA TCAGTTTCTACCGTATTTGGAAACCATGTTCACACTACTTTTTCAGTTACTGCAGCAAGTTACAGAATGTGACACAAAGATGCATGTTTT GCATGTCCTTTCTTGTGTGATCGAAAGAGTCAACATGCAGATACGACCATATGTGGGATGTTTGGTACAATATTTGCCCCTCCTTTGGAA GCAGAGTGAAGAACACAATATGTTGAGATGTGCTATTTTGACAACACTTATTCATCTTGTTCAGGGATTAGGAGCAGACAGCAAGAACCT GTACCCTTTCCTGCTCCCAGTTATTCAACTGAGTACAGATGTTTCACAGCCTCCACATGTTTATCTTCTGGAAGATGGTTTAGAATTATG GTTAGTAACTTTGGAAAACAGTCCATGTATTACACCAGAGTTGCTTCGTATATTTCAGAATATGTCACCACTTCTTGAACTAAGTTCAGA AAATCTTAGAACTTGCTTTAAGATCATCAATGGTTATATCTTTTTATCATCAACAGAATTTTTACAGACATACGCAGTAGGTCTATGCCA GTCCTTTTGTGAACTTTTAAAGGAAATTACTACAGAAGGTCAAGTTCAGGTGCTCAAGGTTGTGGAAAATGCCCTTAAAGTGAACCCAAT ACTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCACGTA TCTTGGAGTTATGGGTCGAGTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGGAGAT GGACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTTTGGC TTTGCTCTCTCTTCTGCCATCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATGATGT CATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAGAACC ACCCACAGAACAAGATAAGAGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGAAGCT CAAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGGAGTT TTTGCAAGGATTCTAAGAGCACATGACATGTGGCTGCCTCCCCTTTCAGAAACAAGCTGAGTAACCCAGCCTGCCGTTTGTATGTGAGAG CCTGCTGAGATGAAGAAATCACTTCATGAAAATAAGCAAAGACCACACATTTTTTACTACAAAATGTAAAGGATAAATGTAAATCCTGCA TAACTAAAATCACAAACCTATTCCTCAAAAGAATTTAATTTTATATTTATGAGGGGGCCCTTCACTAAAAAGTACATGTAAAAGTACATT TGATGACAATAGCTGCTTAGTTTCCTGTTAAGAGAAGAAACTTTATCTTTTAATTATGTGCTCTTAATATTTGAAGATGAGAGTTAATAC |
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FusionGenePPI for AP3B1_IPO11 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AP3B1 | ARRB2, ARRB1, SLC30A3, ARF5, ARF6, AP3S2, GRK5, AP3D1, AP3S1, AP3M1, COG3, SEPT7, LRSAM1, VTI1B, SNX11, AGO3, CREB3, FAM9A, DTNBP1, EDA, PTGER3, EPB41L3, NTRK1, CDK11A, CDC73, JMJD6, PELP1, ATR, ATM, CENPJ, XPO1, DLG3, YWHAZ, NLRP3, SKA3, SNW1, DUSP14, CAMKV, AP3M2, PIP4K2A, TMEM63A, VASN, TPCN2, ERMAP, EPB41L2, FGF8, CREB3L1, PES1, EPB41L5, EAF1, DDX20, POLD1, MFAP1, NAF1, EIF2AK1, NOLC1, ATRX, RBM14, CCDC154, MCM3, PRPF38A, TRIM25 | IPO11 | TRAF2, PLCD4, C20orf24, RPL12, DDX5, KEAP1, RAN, UBE2E1, UBE2E3, UBE2E2, NXF1, SH3GL2, CFTR, PHB, EGFR, FBXO6, MOB1A, MOB1B, AARS, CACYBP, DR1, EIF4A3, HNRNPD, HNRNPH1, AGFG1, ARPC1B, CALU, HSF1, LPP, METTL1, TPD52L2, TTLL12, UBE3A, PDLIM5, PKM, PLIN3, PRDX2, RANGAP1, SRP9, TPRKB, EIF4A2, C1orf94, ADORA3, COMTD1, BSG, TNFSF13B, PNKD, LPAR6, P2RY12, PTGER3, ARL13B, SCN2B, XPO1, NTRK1, CEP128, SIGLECL1, IL13RA2, HTR2C, FZD10, CHRM4, TMEM206, OPRM1, CD70, SLC15A1, APLNR, STOM, AAR2, TRIM25 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AP3B1_IPO11 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AP3B1_IPO11 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AP3B1 | C1842362 | HERMANSKY-PUDLAK SYNDROME 2 | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | IPO11 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | IPO11 | C0043094 | Weight Gain | 1 | CTD_human |