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FusionGeneSummary

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Fusion gene ID: 2082

FusionGeneSummary for AP3B1_IPO11

check button Fusion gene summary
Fusion gene informationFusion gene name: AP3B1_IPO11
Fusion gene ID: 2082
HgeneTgene
Gene symbol

AP3B1

IPO11

Gene ID

8546

51194

Gene nameadaptor related protein complex 3 subunit beta 1importin 11
SynonymsADTB3|ADTB3A|HPS|HPS2|PERanBP11
Cytomap

5q14.1

5q12.1

Type of geneprotein-codingprotein-coding
DescriptionAP-3 complex subunit beta-1AP-3 complex beta-3A subunitadaptor protein complex AP-3 subunit beta-1adaptor related protein complex 3 beta 1 subunitbeta-3A-adaptinclathrin assembly protein complex 3 beta-1 large chainimportin-11Ran binding protein 11imp11ran-binding protein 11
Modification date2018051920180523
UniProtAcc

O00203

Q9UI26

Ensembl transtripts involved in fusion geneENST00000255194, ENST00000519295, 
ENST00000523204, 		ENST00000325324, 
ENST00000409296, ENST00000409534, 
ENST00000512177, 
Fusion gene scores* DoF score6 X 7 X 5=2102 X 2 X 2=8
# samples 72
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: AP3B1 [Title/Abstract] AND IPO11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D3-A51N-06AAP3B1chr5

77590276

-IPO11chr5

61762958

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000255194ENST00000325324AP3B1chr5

77590276

-IPO11chr5

61762958

+
In-frameENST00000255194ENST00000409296AP3B1chr5

77590276

-IPO11chr5

61762958

+
5CDS-intronENST00000255194ENST00000409534AP3B1chr5

77590276

-IPO11chr5

61762958

+
5CDS-intronENST00000255194ENST00000512177AP3B1chr5

77590276

-IPO11chr5

61762958

+
intron-3CDSENST00000519295ENST00000325324AP3B1chr5

77590276

-IPO11chr5

61762958

+
intron-3CDSENST00000519295ENST00000409296AP3B1chr5

77590276

-IPO11chr5

61762958

+
intron-intronENST00000519295ENST00000409534AP3B1chr5

77590276

-IPO11chr5

61762958

+
intron-intronENST00000519295ENST00000512177AP3B1chr5

77590276

-IPO11chr5

61762958

+
intron-3CDSENST00000523204ENST00000325324AP3B1chr5

77590276

-IPO11chr5

61762958

+
intron-3CDSENST00000523204ENST00000409296AP3B1chr5

77590276

-IPO11chr5

61762958

+
intron-intronENST00000523204ENST00000409534AP3B1chr5

77590276

-IPO11chr5

61762958

+
intron-intronENST00000523204ENST00000512177AP3B1chr5

77590276

-IPO11chr5

61762958

+

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FusionProtFeatures for AP3B1_IPO11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AP3B1

O00203

IPO11

Q9UI26

Subunit of non-clathrin- and clathrin-associated adaptorprotein complex 3 (AP-3) that plays a role in protein sorting inthe late-Golgi/trans-Golgi network (TGN) and/or endosomes. The APcomplexes mediate both the recruitment of clathrin to membranesand the recognition of sorting signals within the cytosolic tailsof transmembrane cargo molecules. AP-3 appears to be involved inthe sorting of a subset of transmembrane proteins targeted tolysosomes and lysosome-related organelles. In concert with theBLOC-1 complex, AP-3 is required to target cargos into vesiclesassembled at cell bodies for delivery into neurites and nerveterminals. Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC)through binding to nucleoporin and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Mediates the nuclear import of UBE2E3,and of RPL12 (By similarity). {ECO:0000250,ECO:0000269|PubMed:11032817}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430209_248172976RepeatNote=HEAT 2
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430318_356172976RepeatNote=HEAT 3
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430422_459172976RepeatNote=HEAT 4
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430473_509172976RepeatNote=HEAT 5
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430511_548172976RepeatNote=HEAT 6
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430555_593172976RepeatNote=HEAT 7
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430600_636172976RepeatNote=HEAT 8
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430640_677172976RepeatNote=HEAT 9
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430683_720172976RepeatNote=HEAT 10
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430743_764172976RepeatNote=HEAT 11
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430765_804172976RepeatNote=HEAT 12
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430819_849172976RepeatNote=HEAT 13
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430850_887172976RepeatNote=HEAT 14
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430957_974172976RepeatNote=HEAT 15
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430209_2482121016RepeatNote=HEAT 2
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430318_3562121016RepeatNote=HEAT 3
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430422_4592121016RepeatNote=HEAT 4
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430473_5092121016RepeatNote=HEAT 5
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430511_5482121016RepeatNote=HEAT 6
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430555_5932121016RepeatNote=HEAT 7
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430600_6362121016RepeatNote=HEAT 8
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430640_6772121016RepeatNote=HEAT 9
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430683_7202121016RepeatNote=HEAT 10
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430743_7642121016RepeatNote=HEAT 11
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430765_8042121016RepeatNote=HEAT 12
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430819_8492121016RepeatNote=HEAT 13
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430850_8872121016RepeatNote=HEAT 14
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430957_9742121016RepeatNote=HEAT 15

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAP3B1chr5:77590276chr5:61762958ENST00000255194-127677_802421095Compositional biasNote=Glu/Ser-rich
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+43028_100172976DomainImportin N-terminal
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+43028_1002121016DomainImportin N-terminal
TgeneIPO11chr5:77590276chr5:61762958ENST00000325324+430123_160172976RepeatNote=HEAT 1
TgeneIPO11chr5:77590276chr5:61762958ENST00000409296+430123_1602121016RepeatNote=HEAT 1


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FusionGeneSequence for AP3B1_IPO11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AP3B1_ENST00000255194_chr5_77590276_-_IPO11_ENST00000325324_chr5_61762958_+_846aa
MSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKNXLLEFIILPALCGITTQTHSCKKFLLAMKLQFXVHXNEHCYHXKCCV
SXLLMDLWNLIRIWRXWVFYMEYLNVXNSFWNAVEVXVQIMCVEIDWKRPSFFLLKCFWTSWISILFHLLLXFRDHWNFLXAMFLQKLVK
ALHLNDSLSNVXILLRXLSKIMLISHPKILKIAALKLLKPIRLRWHSSHILLXQRYVEDXSLIISYXLKKNXQCGKKTQKALQWKKQEEI
LGNIVXGHALKYYLXIYSMNIIRLLLLYFXKXCKHFKDPQMWKIXMHCXSKMLCIMLLDXLLMSSLTVLILISGLKTSFFQNYKSFTIGI
SHCDAGXFGSSVSGFLXNSSLTXDPCFMKQSVTCFKIKIXWSVLKQLQLXSXLLMILNLEQISFYRIWKPCSHYFFSYCSKLQNVTQRCM
FCMSFLVXSKESTCRYDHMWDVWYNICPSFGSRVKNTICXDVLFXQHLFILFRDXEQTARTCTLSCSQLFNXVQMFHSLHMFIFWKMVXN
YGXXLWKTVHVLHQSCFVYFRICHHFLNXVQKILELALRSSMVISFYHQQNFYRHTQXVYASPFVNFXRKLLQKVKFRCSRLWKMPLKXT
QYXVHKCFNRFYPMFSRVLXKGRGILXXCPRILELWVEFYYKTLVFFLHYLMRWPINLIRRWTSFWEIXLKCGLIEWTTLPSLKEENFQL
WLCSLFCHLIIVLSKINSVGLXTFQXKACMMSXRKILKQELIKTVCXCLILRNQKXQKMKNHPQNKIRGKRCWPXRTLFIQCHCSSSSTR

>In-frame_AP3B1_ENST00000255194_chr5_77590276_-_IPO11_ENST00000409296_chr5_61762958_+_846aa
MSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKNXLLEFIILPALCGITTQTHSCKKFLLAMKLQFXVHXNEHCYHXKCCV
SXLLMDLWNLIRIWRXWVFYMEYLNVXNSFWNAVEVXVQIMCVEIDWKRPSFFLLKCFWTSWISILFHLLLXFRDHWNFLXAMFLQKLVK
ALHLNDSLSNVXILLRXLSKIMLISHPKILKIAALKLLKPIRLRWHSSHILLXQRYVEDXSLIISYXLKKNXQCGKKTQKALQWKKQEEI
LGNIVXGHALKYYLXIYSMNIIRLLLLYFXKXCKHFKDPQMWKIXMHCXSKMLCIMLLDXLLMSSLTVLILISGLKTSFFQNYKSFTIGI
SHCDAGXFGSSVSGFLXNSSLTXDPCFMKQSVTCFKIKIXWSVLKQLQLXSXLLMILNLEQISFYRIWKPCSHYFFSYCSKLQNVTQRCM
FCMSFLVXSKESTCRYDHMWDVWYNICPSFGSRVKNTICXDVLFXQHLFILFRDXEQTARTCTLSCSQLFNXVQMFHSLHMFIFWKMVXN
YGXXLWKTVHVLHQSCFVYFRICHHFLNXVQKILELALRSSMVISFYHQQNFYRHTQXVYASPFVNFXRKLLQKVKFRCSRLWKMPLKXT
QYXVHKCFNRFYPMFSRVLXKGRGILXXCPRILELWVEFYYKTLVFFLHYLMRWPINLIRRWTSFWEIXLKCGLIEWTTLPSLKEENFQL
WLCSLFCHLIIVLSKINSVGLXTFQXKACMMSXRKILKQELIKTVCXCLILRNQKXQKMKNHPQNKIRGKRCWPXRTLFIQCHCSSSSTR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AP3B1_ENST00000255194_chr5_77590276_-_IPO11_ENST00000325324_chr5_61762958_+_2540nt
ATGTCCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCC
TCGGGGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAATTAGCTTCTGGAATTTATAATTTTGCCTGCTCTCTGTGGAATCACCACACAG
ACACATTCCTGCAAGAAGTTTCTTCTGGCAATGAAGCTGCAATTTTGAGTTCACTAGAACGAACACTGCTATCATTGAAAGTGCTGCGTA
AGTTAACTGTTAATGGATTTGTGGAACCTCATAAGAATATGGAGGTGATGGGTTTTTTACATGGAATATTTGAACGTCTAAAACAGTTTC
TGGAATGCAGTAGAAGTATAGGTACAGATAATGTGTGTAGAGATAGACTGGAAAAGACCATCATTCTTTTTACTAAAGTGCTTTTGGACT
TCTTGGATCAGCATCCTTTTTCATTTACTCCTCTAATTCAGAGATCACTGGAATTTTCTGTAAGCTATGTTTTTACAGAAGTTGGTGAAG
GCGTTACATTTGAACGATTCATTGTCCAATGTATGAATCTTATTAAGATGATTGTCAAAAATTATGCTTATAAGCCATCCAAAAATTTTG
AAGATAGCAGCCCTGAAACTCTTGAAGCCCATAAGATTAAGATGGCATTCTTCACATATCCTACTTTGACAGAGATATGTAGAAGATTAG
TCTCTCATTATTTCCTATTAACTGAAGAAGAACTGACAATGTGGGAAGAAGACCCAGAAGGCTTTACAGTGGAAGAAACAGGAGGAGATT
CTTGGAAATATAGTTTGAGGCCATGCACTGAAGTATTATTTATAGATATATTCCATGAATATAATCAGACTCTTACTCCTGTACTTCTAG
AAATGATGCAAACACTTCAAGGACCCACAAATGTGGAAGATATGAATGCACTGTTAATCAAAGATGCTGTGTATAATGCTGTTGGATTAG
CTGCTTATGAGCTCTTTGACAGTGTTGATTTTGATCAGTGGTTTAAAAACCAGCTTCTTCCAGAATTACAAGTCATTCACAATAGGTATA
AGCCATTGCGACGCAGGGTGATTTGGCTCATCGGTCAGTGGATTTCTGTGAAATTCAAGTCTGACTTAAGACCCATGCTTTATGAAGCAA
TCTGTAACTTGCTTCAAGATCAAGATTTAGTGGTCCGTATTGAAACAGCTACAACTTTGAAGTTAACTGTTGATGATTTTGAATTTAGAA
CAGATCAGTTTCTACCGTATTTGGAAACCATGTTCACACTACTTTTTCAGTTACTGCAGCAAGTTACAGAATGTGACACAAAGATGCATG
TTTTGCATGTCCTTTCTTGTGTGATCGAAAGAGTCAACATGCAGATACGACCATATGTGGGATGTTTGGTACAATATTTGCCCCTCCTTT
GGAAGCAGAGTGAAGAACACAATATGTTGAGATGTGCTATTTTGACAACACTTATTCATCTTGTTCAGGGATTAGGAGCAGACAGCAAGA
ACCTGTACCCTTTCCTGCTCCCAGTTATTCAACTGAGTACAGATGTTTCACAGCCTCCACATGTTTATCTTCTGGAAGATGGTTTAGAAT
TATGGTTAGTAACTTTGGAAAACAGTCCATGTATTACACCAGAGTTGCTTCGTATATTTCAGAATATGTCACCACTTCTTGAACTAAGTT
CAGAAAATCTTAGAACTTGCTTTAAGATCATCAATGGTTATATCTTTTTATCATCAACAGAATTTTTACAGACATACGCAGTAGGTCTAT
GCCAGTCCTTTTGTGAACTTTTAAAGGAAATTACTACAGAAGGTCAAGTTCAGGTGCTCAAGGTTGTGGAAAATGCCCTTAAAGTGAACC
CAATACTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCA
CGTATCTTGGAGTTATGGGTCGAGTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGG
AGATGGACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTT
TGGCTTTGCTCTCTCTTCTGCCATCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATG
ATGTCATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAG
AACCACCCACAGAACAAGATAAGAGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGA
AGCTCAAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGG

>In-frame_AP3B1_ENST00000255194_chr5_77590276_-_IPO11_ENST00000409296_chr5_61762958_+_2540nt
ATGTCCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCC
TCGGGGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAATTAGCTTCTGGAATTTATAATTTTGCCTGCTCTCTGTGGAATCACCACACAG
ACACATTCCTGCAAGAAGTTTCTTCTGGCAATGAAGCTGCAATTTTGAGTTCACTAGAACGAACACTGCTATCATTGAAAGTGCTGCGTA
AGTTAACTGTTAATGGATTTGTGGAACCTCATAAGAATATGGAGGTGATGGGTTTTTTACATGGAATATTTGAACGTCTAAAACAGTTTC
TGGAATGCAGTAGAAGTATAGGTACAGATAATGTGTGTAGAGATAGACTGGAAAAGACCATCATTCTTTTTACTAAAGTGCTTTTGGACT
TCTTGGATCAGCATCCTTTTTCATTTACTCCTCTAATTCAGAGATCACTGGAATTTTCTGTAAGCTATGTTTTTACAGAAGTTGGTGAAG
GCGTTACATTTGAACGATTCATTGTCCAATGTATGAATCTTATTAAGATGATTGTCAAAAATTATGCTTATAAGCCATCCAAAAATTTTG
AAGATAGCAGCCCTGAAACTCTTGAAGCCCATAAGATTAAGATGGCATTCTTCACATATCCTACTTTGACAGAGATATGTAGAAGATTAG
TCTCTCATTATTTCCTATTAACTGAAGAAGAACTGACAATGTGGGAAGAAGACCCAGAAGGCTTTACAGTGGAAGAAACAGGAGGAGATT
CTTGGAAATATAGTTTGAGGCCATGCACTGAAGTATTATTTATAGATATATTCCATGAATATAATCAGACTCTTACTCCTGTACTTCTAG
AAATGATGCAAACACTTCAAGGACCCACAAATGTGGAAGATATGAATGCACTGTTAATCAAAGATGCTGTGTATAATGCTGTTGGATTAG
CTGCTTATGAGCTCTTTGACAGTGTTGATTTTGATCAGTGGTTTAAAAACCAGCTTCTTCCAGAATTACAAGTCATTCACAATAGGTATA
AGCCATTGCGACGCAGGGTGATTTGGCTCATCGGTCAGTGGATTTCTGTGAAATTCAAGTCTGACTTAAGACCCATGCTTTATGAAGCAA
TCTGTAACTTGCTTCAAGATCAAGATTTAGTGGTCCGTATTGAAACAGCTACAACTTTGAAGTTAACTGTTGATGATTTTGAATTTAGAA
CAGATCAGTTTCTACCGTATTTGGAAACCATGTTCACACTACTTTTTCAGTTACTGCAGCAAGTTACAGAATGTGACACAAAGATGCATG
TTTTGCATGTCCTTTCTTGTGTGATCGAAAGAGTCAACATGCAGATACGACCATATGTGGGATGTTTGGTACAATATTTGCCCCTCCTTT
GGAAGCAGAGTGAAGAACACAATATGTTGAGATGTGCTATTTTGACAACACTTATTCATCTTGTTCAGGGATTAGGAGCAGACAGCAAGA
ACCTGTACCCTTTCCTGCTCCCAGTTATTCAACTGAGTACAGATGTTTCACAGCCTCCACATGTTTATCTTCTGGAAGATGGTTTAGAAT
TATGGTTAGTAACTTTGGAAAACAGTCCATGTATTACACCAGAGTTGCTTCGTATATTTCAGAATATGTCACCACTTCTTGAACTAAGTT
CAGAAAATCTTAGAACTTGCTTTAAGATCATCAATGGTTATATCTTTTTATCATCAACAGAATTTTTACAGACATACGCAGTAGGTCTAT
GCCAGTCCTTTTGTGAACTTTTAAAGGAAATTACTACAGAAGGTCAAGTTCAGGTGCTCAAGGTTGTGGAAAATGCCCTTAAAGTGAACC
CAATACTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCA
CGTATCTTGGAGTTATGGGTCGAGTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGG
AGATGGACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTT
TGGCTTTGCTCTCTCTTCTGCCATCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATG
ATGTCATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAG
AACCACCCACAGAACAAGATAAGAGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGA
AGCTCAAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_AP3B1_ENST00000255194_chr5_77590276_-_IPO11_ENST00000325324_chr5_61762958_+_3975nt
ACTGCGCATGCGCAGGGGGTGGACTGCCAGGTCGGCTCAGGGAGCCGTGACGAGTCCGGAAGCGCCTGCGCGCGCTCCTCCGTACGAGAA
CTAGTTTTGTTCCGTGCCCTCTGGACTGGAACCTTTTGGAGAGAACCCCCGGCAGGACCAACCCCGCACCCGCCAGCACCGCGGCAATGT
CCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCCTCGG
GGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAATTAGCTTCTGGAATTTATAATTTTGCCTGCTCTCTGTGGAATCACCACACAGACAC
ATTCCTGCAAGAAGTTTCTTCTGGCAATGAAGCTGCAATTTTGAGTTCACTAGAACGAACACTGCTATCATTGAAAGTGCTGCGTAAGTT
AACTGTTAATGGATTTGTGGAACCTCATAAGAATATGGAGGTGATGGGTTTTTTACATGGAATATTTGAACGTCTAAAACAGTTTCTGGA
ATGCAGTAGAAGTATAGGTACAGATAATGTGTGTAGAGATAGACTGGAAAAGACCATCATTCTTTTTACTAAAGTGCTTTTGGACTTCTT
GGATCAGCATCCTTTTTCATTTACTCCTCTAATTCAGAGATCACTGGAATTTTCTGTAAGCTATGTTTTTACAGAAGTTGGTGAAGGCGT
TACATTTGAACGATTCATTGTCCAATGTATGAATCTTATTAAGATGATTGTCAAAAATTATGCTTATAAGCCATCCAAAAATTTTGAAGA
TAGCAGCCCTGAAACTCTTGAAGCCCATAAGATTAAGATGGCATTCTTCACATATCCTACTTTGACAGAGATATGTAGAAGATTAGTCTC
TCATTATTTCCTATTAACTGAAGAAGAACTGACAATGTGGGAAGAAGACCCAGAAGGCTTTACAGTGGAAGAAACAGGAGGAGATTCTTG
GAAATATAGTTTGAGGCCATGCACTGAAGTATTATTTATAGATATATTCCATGAATATAATCAGACTCTTACTCCTGTACTTCTAGAAAT
GATGCAAACACTTCAAGGACCCACAAATGTGGAAGATATGAATGCACTGTTAATCAAAGATGCTGTGTATAATGCTGTTGGATTAGCTGC
TTATGAGCTCTTTGACAGTGTTGATTTTGATCAGTGGTTTAAAAACCAGCTTCTTCCAGAATTACAAGTCATTCACAATAGGTATAAGCC
ATTGCGACGCAGGGTGATTTGGCTCATCGGTCAGTGGATTTCTGTGAAATTCAAGTCTGACTTAAGACCCATGCTTTATGAAGCAATCTG
TAACTTGCTTCAAGATCAAGATTTAGTGGTCCGTATTGAAACAGCTACAACTTTGAAGTTAACTGTTGATGATTTTGAATTTAGAACAGA
TCAGTTTCTACCGTATTTGGAAACCATGTTCACACTACTTTTTCAGTTACTGCAGCAAGTTACAGAATGTGACACAAAGATGCATGTTTT
GCATGTCCTTTCTTGTGTGATCGAAAGAGTCAACATGCAGATACGACCATATGTGGGATGTTTGGTACAATATTTGCCCCTCCTTTGGAA
GCAGAGTGAAGAACACAATATGTTGAGATGTGCTATTTTGACAACACTTATTCATCTTGTTCAGGGATTAGGAGCAGACAGCAAGAACCT
GTACCCTTTCCTGCTCCCAGTTATTCAACTGAGTACAGATGTTTCACAGCCTCCACATGTTTATCTTCTGGAAGATGGTTTAGAATTATG
GTTAGTAACTTTGGAAAACAGTCCATGTATTACACCAGAGTTGCTTCGTATATTTCAGAATATGTCACCACTTCTTGAACTAAGTTCAGA
AAATCTTAGAACTTGCTTTAAGATCATCAATGGTTATATCTTTTTATCATCAACAGAATTTTTACAGACATACGCAGTAGGTCTATGCCA
GTCCTTTTGTGAACTTTTAAAGGAAATTACTACAGAAGGTCAAGTTCAGGTGCTCAAGGTTGTGGAAAATGCCCTTAAAGTGAACCCAAT
ACTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCACGTA
TCTTGGAGTTATGGGTCGAGTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGGAGAT
GGACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTTTGGC
TTTGCTCTCTCTTCTGCCATCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATGATGT
CATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAGAACC
ACCCACAGAACAAGATAAGAGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGAAGCT
CAAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGGAGTT
TTTGCAAGGATTCTAAGAGCACATGACATGTGGCTGCCTCCCCTTTCAGAAACAAGCTGAGTAACCCAGCCTGCCGTTTGTATGTGAGAG
CCTGCTGAGATGAAGAAATCACTTCATGAAAATAAGCAAAGACCACACATTTTTTACTACAAAATGTAAAGGATAAATGTAAATCCTGCA
TAACTAAAATCACAAACCTATTCCTCAAAAGAATTTAATTTTATATTTATGAGGGGGCCCTTCACTAAAAAGTACATGTAAAAGTACATT
TGATGACAATAGCTGCTTAGTTTCCTGTTAAGAGAAGAAACTTTATCTTTTAATTATGTGCTCTTAATATTTGAAGATGAGAGTTAATAC
CTGAGATGTTTTTCTGCAACCAAAATTCATTAAATTTGGCTGCCTTATCCTTTTTTTAAGCTAATGAAACTACAGGTTTGAAAAATGACA
AAGCTGTTCAGATGATGCTATTAAAGAAATGTGTGTACTAAGCAAAAATATATAAATAGTGACAAATACACATTACCAAGCTTATCTTGC
AAGGGAGTTATTTTCATCTAACATAGAAAGTGTGTTTTATCAGACAAATGCTTTTATTTTCATTCTAATAATTTGATACAGAAATTAGTA
AAGGCATTTTTTTCTTTTTTTTTCCAGTAAATACATTGGGTCTATAAATGTGCATTTGTAAGGGCCACAAAAGTGAACGTGTGGTACTGT
AGTACCACGTGGGAGACCTCTGGTTATGGTTTAGTCCTAGTTCCTTTGTTACTCCTGTGAGCACCGAGAAGAACTGGGCGACTCCCAGTC
CCACCTGTGCTGTGACAGTCCCACGTGGCTATGACAGACTGTTTAGTACTTACCCTTCTCAGGTTCCTCAGTGCAGGGGTGCATCAGGGC
CTCAATAATAGGGGTATACCTGGGAGGATCCAGCAGTAATCCCCAGGGTACTAGGATTACTAGTACTCTGATGGAACTAGTCTTCCTTCC
TTATTCCTCGAACATGCAGTACATAAAAAGGGGAAAAGGAGAAAAAAAAAGCCTTACTTTGTTTTACTTGCCATTTATTGTAAGGAAACT
TTAAAGCATTTTTTAGGAAATACTCAAAAGCAAGGTTGGAAAATGTTTTATCTTTCTATAGAAAGTTGGGTACAGTATGTAACTGCGGGA
AACCCACTGCCCCTTTGTAAGCTGTGGAACCCAAACTGTATGGGGATATTTGATGTTTTCAGAAAGAGGAAGAAAATATGGTCCAAATTA

>In-frame_AP3B1_ENST00000255194_chr5_77590276_-_IPO11_ENST00000409296_chr5_61762958_+_3102nt
ACTGCGCATGCGCAGGGGGTGGACTGCCAGGTCGGCTCAGGGAGCCGTGACGAGTCCGGAAGCGCCTGCGCGCGCTCCTCCGTACGAGAA
CTAGTTTTGTTCCGTGCCCTCTGGACTGGAACCTTTTGGAGAGAACCCCCGGCAGGACCAACCCCGCACCCGCCAGCACCGCGGCAATGT
CCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCCTCGG
GGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAATTAGCTTCTGGAATTTATAATTTTGCCTGCTCTCTGTGGAATCACCACACAGACAC
ATTCCTGCAAGAAGTTTCTTCTGGCAATGAAGCTGCAATTTTGAGTTCACTAGAACGAACACTGCTATCATTGAAAGTGCTGCGTAAGTT
AACTGTTAATGGATTTGTGGAACCTCATAAGAATATGGAGGTGATGGGTTTTTTACATGGAATATTTGAACGTCTAAAACAGTTTCTGGA
ATGCAGTAGAAGTATAGGTACAGATAATGTGTGTAGAGATAGACTGGAAAAGACCATCATTCTTTTTACTAAAGTGCTTTTGGACTTCTT
GGATCAGCATCCTTTTTCATTTACTCCTCTAATTCAGAGATCACTGGAATTTTCTGTAAGCTATGTTTTTACAGAAGTTGGTGAAGGCGT
TACATTTGAACGATTCATTGTCCAATGTATGAATCTTATTAAGATGATTGTCAAAAATTATGCTTATAAGCCATCCAAAAATTTTGAAGA
TAGCAGCCCTGAAACTCTTGAAGCCCATAAGATTAAGATGGCATTCTTCACATATCCTACTTTGACAGAGATATGTAGAAGATTAGTCTC
TCATTATTTCCTATTAACTGAAGAAGAACTGACAATGTGGGAAGAAGACCCAGAAGGCTTTACAGTGGAAGAAACAGGAGGAGATTCTTG
GAAATATAGTTTGAGGCCATGCACTGAAGTATTATTTATAGATATATTCCATGAATATAATCAGACTCTTACTCCTGTACTTCTAGAAAT
GATGCAAACACTTCAAGGACCCACAAATGTGGAAGATATGAATGCACTGTTAATCAAAGATGCTGTGTATAATGCTGTTGGATTAGCTGC
TTATGAGCTCTTTGACAGTGTTGATTTTGATCAGTGGTTTAAAAACCAGCTTCTTCCAGAATTACAAGTCATTCACAATAGGTATAAGCC
ATTGCGACGCAGGGTGATTTGGCTCATCGGTCAGTGGATTTCTGTGAAATTCAAGTCTGACTTAAGACCCATGCTTTATGAAGCAATCTG
TAACTTGCTTCAAGATCAAGATTTAGTGGTCCGTATTGAAACAGCTACAACTTTGAAGTTAACTGTTGATGATTTTGAATTTAGAACAGA
TCAGTTTCTACCGTATTTGGAAACCATGTTCACACTACTTTTTCAGTTACTGCAGCAAGTTACAGAATGTGACACAAAGATGCATGTTTT
GCATGTCCTTTCTTGTGTGATCGAAAGAGTCAACATGCAGATACGACCATATGTGGGATGTTTGGTACAATATTTGCCCCTCCTTTGGAA
GCAGAGTGAAGAACACAATATGTTGAGATGTGCTATTTTGACAACACTTATTCATCTTGTTCAGGGATTAGGAGCAGACAGCAAGAACCT
GTACCCTTTCCTGCTCCCAGTTATTCAACTGAGTACAGATGTTTCACAGCCTCCACATGTTTATCTTCTGGAAGATGGTTTAGAATTATG
GTTAGTAACTTTGGAAAACAGTCCATGTATTACACCAGAGTTGCTTCGTATATTTCAGAATATGTCACCACTTCTTGAACTAAGTTCAGA
AAATCTTAGAACTTGCTTTAAGATCATCAATGGTTATATCTTTTTATCATCAACAGAATTTTTACAGACATACGCAGTAGGTCTATGCCA
GTCCTTTTGTGAACTTTTAAAGGAAATTACTACAGAAGGTCAAGTTCAGGTGCTCAAGGTTGTGGAAAATGCCCTTAAAGTGAACCCAAT
ACTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCACGTA
TCTTGGAGTTATGGGTCGAGTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGGAGAT
GGACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTTTGGC
TTTGCTCTCTCTTCTGCCATCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATGATGT
CATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAGAACC
ACCCACAGAACAAGATAAGAGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGAAGCT
CAAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGGAGTT
TTTGCAAGGATTCTAAGAGCACATGACATGTGGCTGCCTCCCCTTTCAGAAACAAGCTGAGTAACCCAGCCTGCCGTTTGTATGTGAGAG
CCTGCTGAGATGAAGAAATCACTTCATGAAAATAAGCAAAGACCACACATTTTTTACTACAAAATGTAAAGGATAAATGTAAATCCTGCA
TAACTAAAATCACAAACCTATTCCTCAAAAGAATTTAATTTTATATTTATGAGGGGGCCCTTCACTAAAAAGTACATGTAAAAGTACATT
TGATGACAATAGCTGCTTAGTTTCCTGTTAAGAGAAGAAACTTTATCTTTTAATTATGTGCTCTTAATATTTGAAGATGAGAGTTAATAC


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FusionGenePPI for AP3B1_IPO11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AP3B1ARRB2, ARRB1, SLC30A3, ARF5, ARF6, AP3S2, GRK5, AP3D1, AP3S1, AP3M1, COG3, SEPT7, LRSAM1, VTI1B, SNX11, AGO3, CREB3, FAM9A, DTNBP1, EDA, PTGER3, EPB41L3, NTRK1, CDK11A, CDC73, JMJD6, PELP1, ATR, ATM, CENPJ, XPO1, DLG3, YWHAZ, NLRP3, SKA3, SNW1, DUSP14, CAMKV, AP3M2, PIP4K2A, TMEM63A, VASN, TPCN2, ERMAP, EPB41L2, FGF8, CREB3L1, PES1, EPB41L5, EAF1, DDX20, POLD1, MFAP1, NAF1, EIF2AK1, NOLC1, ATRX, RBM14, CCDC154, MCM3, PRPF38A, TRIM25IPO11TRAF2, PLCD4, C20orf24, RPL12, DDX5, KEAP1, RAN, UBE2E1, UBE2E3, UBE2E2, NXF1, SH3GL2, CFTR, PHB, EGFR, FBXO6, MOB1A, MOB1B, AARS, CACYBP, DR1, EIF4A3, HNRNPD, HNRNPH1, AGFG1, ARPC1B, CALU, HSF1, LPP, METTL1, TPD52L2, TTLL12, UBE3A, PDLIM5, PKM, PLIN3, PRDX2, RANGAP1, SRP9, TPRKB, EIF4A2, C1orf94, ADORA3, COMTD1, BSG, TNFSF13B, PNKD, LPAR6, P2RY12, PTGER3, ARL13B, SCN2B, XPO1, NTRK1, CEP128, SIGLECL1, IL13RA2, HTR2C, FZD10, CHRM4, TMEM206, OPRM1, CD70, SLC15A1, APLNR, STOM, AAR2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AP3B1_IPO11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AP3B1_IPO11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAP3B1C1842362HERMANSKY-PUDLAK SYNDROME 21CTD_human;ORPHANET;UNIPROT
TgeneIPO11C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneIPO11C0043094Weight Gain1CTD_human