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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 20812

FusionGeneSummary for MAP2K4_MYH3

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP2K4_MYH3
Fusion gene ID: 20812
HgeneTgene
Gene symbol

MAP2K4

MYH3

Gene ID

6416

4621

Gene namemitogen-activated protein kinase kinase 4myosin heavy chain 3
SynonymsJNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1DA2A|DA2B|DA8|HEMHC|MYHC-EMB|MYHSE1|SMHCE
Cytomap

17p12

17p13.1

Type of geneprotein-codingprotein-coding
Descriptiondual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1myosin-3myosin heavy chain, fast skeletal muscle, embryonicmyosin, heavy chain 3, skeletal muscle, embryonicmyosin, heavy polypeptide 3, skeletal muscle, embryonicmyosin, skeletal, heavy chain, embryonic 1
Modification date2018052320180519
UniProtAcc

P45985

P11055

Ensembl transtripts involved in fusion geneENST00000353533, ENST00000415385, 
ENST00000581941, 
ENST00000226209, 
ENST00000583535, 
Fusion gene scores* DoF score6 X 4 X 5=1203 X 3 X 3=27
# samples 73
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAP2K4 [Title/Abstract] AND MYH3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1914-01AMAP2K4chr17

11924318

+MYH3chr17

10539170

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000353533ENST00000226209MAP2K4chr17

11924318

+MYH3chr17

10539170

-
In-frameENST00000353533ENST00000583535MAP2K4chr17

11924318

+MYH3chr17

10539170

-
In-frameENST00000415385ENST00000226209MAP2K4chr17

11924318

+MYH3chr17

10539170

-
In-frameENST00000415385ENST00000583535MAP2K4chr17

11924318

+MYH3chr17

10539170

-
intron-3CDSENST00000581941ENST00000226209MAP2K4chr17

11924318

+MYH3chr17

10539170

-
intron-3CDSENST00000581941ENST00000583535MAP2K4chr17

11924318

+MYH3chr17

10539170

-

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FusionProtFeatures for MAP2K4_MYH3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP2K4

P45985

MYH3

P11055

Dual specificity protein kinase which acts as anessential component of the MAP kinase signal transduction pathway.Essential component of the stress-activated protein kinase/c-JunN-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7,is the one of the only known kinase to directly activate thestress-activated protein kinase/c-Jun N-terminal kinasesMAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 andMAP2K7/MKK7 both activate the JNKs by phosphorylation, but theydiffer in their preference for the phosphorylation site in theThr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation ofthe Tyr residue and MAP2K7/MKK7 for the Thr residue. Thephosphorylation of the Thr residue by MAP2K7/MKK7 seems to be theprerequisite for JNK activation at least in response toproinflammatory cytokines, while other stimuli activate bothMAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylateJNKs. MAP2K4 is required for maintaining peripheral lymphoidhomeostasis. The MKK/JNK signaling pathway is also involved inmitochondrial death signaling pathway, including the releasecytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7exclusively activates JNKs, MAP2K4/MKK4 additionally activates thep38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.{ECO:0000269|PubMed:7716521}. Muscle contraction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP2K4chr17:11924318chr17:10539170ENST00000353533+1115_1938400Compositional biasNote=Gly/Ser-rich
HgeneMAP2K4chr17:11924318chr17:10539170ENST00000415385+1125_1938411Compositional biasNote=Gly/Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP2K4chr17:11924318chr17:10539170ENST00000353533+111102_36738400DomainProtein kinase
HgeneMAP2K4chr17:11924318chr17:10539170ENST00000415385+112102_36738411DomainProtein kinase
HgeneMAP2K4chr17:11924318chr17:10539170ENST00000353533+111108_11638400Nucleotide bindingATP
HgeneMAP2K4chr17:11924318chr17:10539170ENST00000415385+112108_11638411Nucleotide bindingATP
HgeneMAP2K4chr17:11924318chr17:10539170ENST00000353533+111364_38738400RegionNote=DVD domain
HgeneMAP2K4chr17:11924318chr17:10539170ENST00000353533+11137_5238400RegionNote=D domain
HgeneMAP2K4chr17:11924318chr17:10539170ENST00000415385+112364_38738411RegionNote=DVD domain
HgeneMAP2K4chr17:11924318chr17:10539170ENST00000415385+11237_5238411RegionNote=D domain
TgeneMYH3chr17:11924318chr17:10539170ENST00000226209-2640840_193312851941Coiled coilOntology_term=ECO:0000255
TgeneMYH3chr17:11924318chr17:10539170ENST00000583535-2741840_193312851941Coiled coilOntology_term=ECO:0000255
TgeneMYH3chr17:11924318chr17:10539170ENST00000226209-264033_8212851941DomainMyosin N-terminal SH3-like
TgeneMYH3chr17:11924318chr17:10539170ENST00000226209-2640782_81112851941DomainIQ
TgeneMYH3chr17:11924318chr17:10539170ENST00000226209-264086_77912851941DomainMyosin motor
TgeneMYH3chr17:11924318chr17:10539170ENST00000583535-274133_8212851941DomainMyosin N-terminal SH3-like
TgeneMYH3chr17:11924318chr17:10539170ENST00000583535-2741782_81112851941DomainIQ
TgeneMYH3chr17:11924318chr17:10539170ENST00000583535-274186_77912851941DomainMyosin motor
TgeneMYH3chr17:11924318chr17:10539170ENST00000226209-2640179_18612851941Nucleotide bindingATP
TgeneMYH3chr17:11924318chr17:10539170ENST00000583535-2741179_18612851941Nucleotide bindingATP
TgeneMYH3chr17:11924318chr17:10539170ENST00000226209-2640656_67812851941RegionNote=Actin-binding
TgeneMYH3chr17:11924318chr17:10539170ENST00000226209-2640758_77212851941RegionNote=Actin-binding
TgeneMYH3chr17:11924318chr17:10539170ENST00000583535-2741656_67812851941RegionNote=Actin-binding
TgeneMYH3chr17:11924318chr17:10539170ENST00000583535-2741758_77212851941RegionNote=Actin-binding


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FusionGeneSequence for MAP2K4_MYH3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MAP2K4_ENST00000353533_chr17_11924318_+_MYH3_ENST00000226209_chr17_10539170_-_694aa
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS
RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVE
DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI
AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR
SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE
RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL
EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVK

>In-frame_MAP2K4_ENST00000353533_chr17_11924318_+_MYH3_ENST00000583535_chr17_10539170_-_694aa
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS
RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVE
DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI
AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR
SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE
RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL
EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVK

>In-frame_MAP2K4_ENST00000415385_chr17_11924318_+_MYH3_ENST00000226209_chr17_10539170_-_694aa
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS
RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVE
DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI
AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR
SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE
RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL
EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVK

>In-frame_MAP2K4_ENST00000415385_chr17_11924318_+_MYH3_ENST00000583535_chr17_10539170_-_694aa
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS
RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVE
DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI
AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR
SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE
RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL
EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MAP2K4_ENST00000353533_chr17_11924318_+_MYH3_ENST00000226209_chr17_10539170_-_2082nt
ATGGCGGCTCCGAGCCCGAGCGGCGGCGGCGGCTCCGGGGGCGGCAGCGGCAGCGGCACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGC
CACCCGGCCGTCAGCAGCATGCAGGGTGAGCTGAGTCGTCAGCTGGAAGAAAAAGAAAGCATAGTATCCCAACTTTCCAGGAGCAAGCAA
GCCTTTACCCAGCAAACAGAAGAGCTCAAGAGGCAGCTGGAGGAAGAGAACAAGGCCAAGAACGCCCTGGCGCACGCCCTGCAGTCCTCC
CGCCACGACTGTGACCTGCTGCGGGAACAGTATGAGGAGGAGCAGGAAGGCAAAGCTGAGCTGCAGAGGGCGCTGTCCAAGGCCAATAGT
GAGGTTGCCCAGTGGAGAACCAAATACGAGACGGACGCCATCCAGCGCACAGAAGAGCTGGAGGAGGCCAAGAAAAAACTTGCTCAGCGC
CTTCAAGATTCCGAGGAACAGGTTGAGGCAGTGAATGCTAAATGTGCTTCACTGGAGAAGACCAAGCAGAGGCTGCAAGGAGAGGTGGAG
GATCTGATGGTTGATGTTGAAAGAGCCAATTCCTTGGCCGCCGCTCTGGACAAGAAGCAGAGGAACTTTGACAAGGTGTTGGCAGAGTGG
AAGACAAAGTGTGAGGAGAGCCAAGCAGAGCTGGAGGCATCCCTGAAGGAGTCCCGCTCCTTGAGCACTGAGCTCTTCAAACTGAAAAAT
GCCTACGAGGAAGCCTTAGATCAACTTGAAACTGTGAAACGGGAAAATAAGAACTTAGAGCAGGAGATAGCAGATCTCACAGAACAAATT
GCTGAAAATGGCAAAACCATCCATGAACTGGAGAAATCAAGAAAGCAGATTGAGCTGGAAAAGGCTGATATCCAGCTGGCTCTCGAGGAA
GCAGAGGCTGCTCTTGAGCATGAAGAAGCCAAGATCCTCCGAATCCAGCTTGAATTGACACAAGTGAAATCAGAAATTGATAGAAAGATC
GCCGAGAAGGATGAAGAGATCGAGCAGCTGAAGAGGAACTACCAGAGAACAGTGGAAACCATGCAGAGCGCCCTGGACGCCGAGGTGCGG
AGCAGGAATGAAGCCATCCGGCTCAAGAAGAAGATGGAGGGGGACCTGAATGAAATCGAGATCCAGCTGAGCCACGCCAACCGCCAGGCG
GCGGAGACCCTCAAACACCTCAGGAGTGTCCAGGGACAGCTGAAGGATACGCAGCTCCACCTGGATGATGCCCTCCGGGGCCAGGAGGAC
CTGAAGGAGCAGCTGGCGATTGTGGAGCGCAGAGCCAACCTGCTGCAGGCCGAGGTGGAGGAGCTGCGGGCTACTCTGGAGCAGACGGAG
AGGGCCCGGAAACTGGCGGAACAGGAGCTCCTGGACTCCAACGAGAGGGTGCAGCTGCTGCATACCCAGAACACCAGCCTCATCCACACC
AAGAAGAAGCTGGAGACAGACCTCATGCAGCTCCAGAGTGAGGTAGAAGATGCCAGCAGGGATGCAAGGAACGCTGAGGAGAAGGCCAAG
AAGGCCATCACGGACGCTGCCATGATGGCGGAGGAGCTGAAGAAGGAGCAGGACACCAGCGCCCACCTTGAGCGGATGAAGAAGAACCTG
GAACAGACGGTGAAGGACCTGCAGCATCGTCTAGATGAGGCCGAGCAGCTGGCGCTGAAGGGCGGGAAGAAGCAGATCCAGAAACTGGAG
ACCAGGATCCGAGAGCTGGAGTTTGAACTTGAGGGAGAGCAGAAGAAGAACACAGAGTCTGTTAAGGGCCTGAGGAAGTATGAGCGGAGG
GTCAAGGAGCTGACGTACCAGAGTGAAGAGGACAGGAAGAATGTGCTGAGATTGCAGGATCTGGTGGATAAACTGCAAGTGAAAGTCAAG
TCCTACAAGAGGCAGGCGGAGGAGGCTGATGAACAAGCCAATGCTCATCTCACCAAATTCCGAAAGGCTCAGCATGAGCTGGAGGAGGCC
GAGGAACGTGCGGATATCGCAGAATCTCAAGTCAACAAGCTCCGCGCTAAGACTCGAGACTTCACCTCCAGCAGGATGGTGGTCCACGAG

>In-frame_MAP2K4_ENST00000353533_chr17_11924318_+_MYH3_ENST00000583535_chr17_10539170_-_2082nt
ATGGCGGCTCCGAGCCCGAGCGGCGGCGGCGGCTCCGGGGGCGGCAGCGGCAGCGGCACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGC
CACCCGGCCGTCAGCAGCATGCAGGGTGAGCTGAGTCGTCAGCTGGAAGAAAAAGAAAGCATAGTATCCCAACTTTCCAGGAGCAAGCAA
GCCTTTACCCAGCAAACAGAAGAGCTCAAGAGGCAGCTGGAGGAAGAGAACAAGGCCAAGAACGCCCTGGCGCACGCCCTGCAGTCCTCC
CGCCACGACTGTGACCTGCTGCGGGAACAGTATGAGGAGGAGCAGGAAGGCAAAGCTGAGCTGCAGAGGGCGCTGTCCAAGGCCAATAGT
GAGGTTGCCCAGTGGAGAACCAAATACGAGACGGACGCCATCCAGCGCACAGAAGAGCTGGAGGAGGCCAAGAAAAAACTTGCTCAGCGC
CTTCAAGATTCCGAGGAACAGGTTGAGGCAGTGAATGCTAAATGTGCTTCACTGGAGAAGACCAAGCAGAGGCTGCAAGGAGAGGTGGAG
GATCTGATGGTTGATGTTGAAAGAGCCAATTCCTTGGCCGCCGCTCTGGACAAGAAGCAGAGGAACTTTGACAAGGTGTTGGCAGAGTGG
AAGACAAAGTGTGAGGAGAGCCAAGCAGAGCTGGAGGCATCCCTGAAGGAGTCCCGCTCCTTGAGCACTGAGCTCTTCAAACTGAAAAAT
GCCTACGAGGAAGCCTTAGATCAACTTGAAACTGTGAAACGGGAAAATAAGAACTTAGAGCAGGAGATAGCAGATCTCACAGAACAAATT
GCTGAAAATGGCAAAACCATCCATGAACTGGAGAAATCAAGAAAGCAGATTGAGCTGGAAAAGGCTGATATCCAGCTGGCTCTCGAGGAA
GCAGAGGCTGCTCTTGAGCATGAAGAAGCCAAGATCCTCCGAATCCAGCTTGAATTGACACAAGTGAAATCAGAAATTGATAGAAAGATC
GCCGAGAAGGATGAAGAGATCGAGCAGCTGAAGAGGAACTACCAGAGAACAGTGGAAACCATGCAGAGCGCCCTGGACGCCGAGGTGCGG
AGCAGGAATGAAGCCATCCGGCTCAAGAAGAAGATGGAGGGGGACCTGAATGAAATCGAGATCCAGCTGAGCCACGCCAACCGCCAGGCG
GCGGAGACCCTCAAACACCTCAGGAGTGTCCAGGGACAGCTGAAGGATACGCAGCTCCACCTGGATGATGCCCTCCGGGGCCAGGAGGAC
CTGAAGGAGCAGCTGGCGATTGTGGAGCGCAGAGCCAACCTGCTGCAGGCCGAGGTGGAGGAGCTGCGGGCTACTCTGGAGCAGACGGAG
AGGGCCCGGAAACTGGCGGAACAGGAGCTCCTGGACTCCAACGAGAGGGTGCAGCTGCTGCATACCCAGAACACCAGCCTCATCCACACC
AAGAAGAAGCTGGAGACAGACCTCATGCAGCTCCAGAGTGAGGTAGAAGATGCCAGCAGGGATGCAAGGAACGCTGAGGAGAAGGCCAAG
AAGGCCATCACGGACGCTGCCATGATGGCGGAGGAGCTGAAGAAGGAGCAGGACACCAGCGCCCACCTTGAGCGGATGAAGAAGAACCTG
GAACAGACGGTGAAGGACCTGCAGCATCGTCTAGATGAGGCCGAGCAGCTGGCGCTGAAGGGCGGGAAGAAGCAGATCCAGAAACTGGAG
ACCAGGATCCGAGAGCTGGAGTTTGAACTTGAGGGAGAGCAGAAGAAGAACACAGAGTCTGTTAAGGGCCTGAGGAAGTATGAGCGGAGG
GTCAAGGAGCTGACGTACCAGAGTGAAGAGGACAGGAAGAATGTGCTGAGATTGCAGGATCTGGTGGATAAACTGCAAGTGAAAGTCAAG
TCCTACAAGAGGCAGGCGGAGGAGGCTGATGAACAAGCCAATGCTCATCTCACCAAATTCCGAAAGGCTCAGCATGAGCTGGAGGAGGCC
GAGGAACGTGCGGATATCGCAGAATCTCAAGTCAACAAGCTCCGCGCTAAGACTCGAGACTTCACCTCCAGCAGGATGGTGGTCCACGAG

>In-frame_MAP2K4_ENST00000415385_chr17_11924318_+_MYH3_ENST00000226209_chr17_10539170_-_2082nt
ATGGCGGCTCCGAGCCCGAGCGGCGGCGGCGGCTCCGGGGGCGGCAGCGGCAGCGGCACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGC
CACCCGGCCGTCAGCAGCATGCAGGGTGAGCTGAGTCGTCAGCTGGAAGAAAAAGAAAGCATAGTATCCCAACTTTCCAGGAGCAAGCAA
GCCTTTACCCAGCAAACAGAAGAGCTCAAGAGGCAGCTGGAGGAAGAGAACAAGGCCAAGAACGCCCTGGCGCACGCCCTGCAGTCCTCC
CGCCACGACTGTGACCTGCTGCGGGAACAGTATGAGGAGGAGCAGGAAGGCAAAGCTGAGCTGCAGAGGGCGCTGTCCAAGGCCAATAGT
GAGGTTGCCCAGTGGAGAACCAAATACGAGACGGACGCCATCCAGCGCACAGAAGAGCTGGAGGAGGCCAAGAAAAAACTTGCTCAGCGC
CTTCAAGATTCCGAGGAACAGGTTGAGGCAGTGAATGCTAAATGTGCTTCACTGGAGAAGACCAAGCAGAGGCTGCAAGGAGAGGTGGAG
GATCTGATGGTTGATGTTGAAAGAGCCAATTCCTTGGCCGCCGCTCTGGACAAGAAGCAGAGGAACTTTGACAAGGTGTTGGCAGAGTGG
AAGACAAAGTGTGAGGAGAGCCAAGCAGAGCTGGAGGCATCCCTGAAGGAGTCCCGCTCCTTGAGCACTGAGCTCTTCAAACTGAAAAAT
GCCTACGAGGAAGCCTTAGATCAACTTGAAACTGTGAAACGGGAAAATAAGAACTTAGAGCAGGAGATAGCAGATCTCACAGAACAAATT
GCTGAAAATGGCAAAACCATCCATGAACTGGAGAAATCAAGAAAGCAGATTGAGCTGGAAAAGGCTGATATCCAGCTGGCTCTCGAGGAA
GCAGAGGCTGCTCTTGAGCATGAAGAAGCCAAGATCCTCCGAATCCAGCTTGAATTGACACAAGTGAAATCAGAAATTGATAGAAAGATC
GCCGAGAAGGATGAAGAGATCGAGCAGCTGAAGAGGAACTACCAGAGAACAGTGGAAACCATGCAGAGCGCCCTGGACGCCGAGGTGCGG
AGCAGGAATGAAGCCATCCGGCTCAAGAAGAAGATGGAGGGGGACCTGAATGAAATCGAGATCCAGCTGAGCCACGCCAACCGCCAGGCG
GCGGAGACCCTCAAACACCTCAGGAGTGTCCAGGGACAGCTGAAGGATACGCAGCTCCACCTGGATGATGCCCTCCGGGGCCAGGAGGAC
CTGAAGGAGCAGCTGGCGATTGTGGAGCGCAGAGCCAACCTGCTGCAGGCCGAGGTGGAGGAGCTGCGGGCTACTCTGGAGCAGACGGAG
AGGGCCCGGAAACTGGCGGAACAGGAGCTCCTGGACTCCAACGAGAGGGTGCAGCTGCTGCATACCCAGAACACCAGCCTCATCCACACC
AAGAAGAAGCTGGAGACAGACCTCATGCAGCTCCAGAGTGAGGTAGAAGATGCCAGCAGGGATGCAAGGAACGCTGAGGAGAAGGCCAAG
AAGGCCATCACGGACGCTGCCATGATGGCGGAGGAGCTGAAGAAGGAGCAGGACACCAGCGCCCACCTTGAGCGGATGAAGAAGAACCTG
GAACAGACGGTGAAGGACCTGCAGCATCGTCTAGATGAGGCCGAGCAGCTGGCGCTGAAGGGCGGGAAGAAGCAGATCCAGAAACTGGAG
ACCAGGATCCGAGAGCTGGAGTTTGAACTTGAGGGAGAGCAGAAGAAGAACACAGAGTCTGTTAAGGGCCTGAGGAAGTATGAGCGGAGG
GTCAAGGAGCTGACGTACCAGAGTGAAGAGGACAGGAAGAATGTGCTGAGATTGCAGGATCTGGTGGATAAACTGCAAGTGAAAGTCAAG
TCCTACAAGAGGCAGGCGGAGGAGGCTGATGAACAAGCCAATGCTCATCTCACCAAATTCCGAAAGGCTCAGCATGAGCTGGAGGAGGCC
GAGGAACGTGCGGATATCGCAGAATCTCAAGTCAACAAGCTCCGCGCTAAGACTCGAGACTTCACCTCCAGCAGGATGGTGGTCCACGAG

>In-frame_MAP2K4_ENST00000415385_chr17_11924318_+_MYH3_ENST00000583535_chr17_10539170_-_2082nt
ATGGCGGCTCCGAGCCCGAGCGGCGGCGGCGGCTCCGGGGGCGGCAGCGGCAGCGGCACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGC
CACCCGGCCGTCAGCAGCATGCAGGGTGAGCTGAGTCGTCAGCTGGAAGAAAAAGAAAGCATAGTATCCCAACTTTCCAGGAGCAAGCAA
GCCTTTACCCAGCAAACAGAAGAGCTCAAGAGGCAGCTGGAGGAAGAGAACAAGGCCAAGAACGCCCTGGCGCACGCCCTGCAGTCCTCC
CGCCACGACTGTGACCTGCTGCGGGAACAGTATGAGGAGGAGCAGGAAGGCAAAGCTGAGCTGCAGAGGGCGCTGTCCAAGGCCAATAGT
GAGGTTGCCCAGTGGAGAACCAAATACGAGACGGACGCCATCCAGCGCACAGAAGAGCTGGAGGAGGCCAAGAAAAAACTTGCTCAGCGC
CTTCAAGATTCCGAGGAACAGGTTGAGGCAGTGAATGCTAAATGTGCTTCACTGGAGAAGACCAAGCAGAGGCTGCAAGGAGAGGTGGAG
GATCTGATGGTTGATGTTGAAAGAGCCAATTCCTTGGCCGCCGCTCTGGACAAGAAGCAGAGGAACTTTGACAAGGTGTTGGCAGAGTGG
AAGACAAAGTGTGAGGAGAGCCAAGCAGAGCTGGAGGCATCCCTGAAGGAGTCCCGCTCCTTGAGCACTGAGCTCTTCAAACTGAAAAAT
GCCTACGAGGAAGCCTTAGATCAACTTGAAACTGTGAAACGGGAAAATAAGAACTTAGAGCAGGAGATAGCAGATCTCACAGAACAAATT
GCTGAAAATGGCAAAACCATCCATGAACTGGAGAAATCAAGAAAGCAGATTGAGCTGGAAAAGGCTGATATCCAGCTGGCTCTCGAGGAA
GCAGAGGCTGCTCTTGAGCATGAAGAAGCCAAGATCCTCCGAATCCAGCTTGAATTGACACAAGTGAAATCAGAAATTGATAGAAAGATC
GCCGAGAAGGATGAAGAGATCGAGCAGCTGAAGAGGAACTACCAGAGAACAGTGGAAACCATGCAGAGCGCCCTGGACGCCGAGGTGCGG
AGCAGGAATGAAGCCATCCGGCTCAAGAAGAAGATGGAGGGGGACCTGAATGAAATCGAGATCCAGCTGAGCCACGCCAACCGCCAGGCG
GCGGAGACCCTCAAACACCTCAGGAGTGTCCAGGGACAGCTGAAGGATACGCAGCTCCACCTGGATGATGCCCTCCGGGGCCAGGAGGAC
CTGAAGGAGCAGCTGGCGATTGTGGAGCGCAGAGCCAACCTGCTGCAGGCCGAGGTGGAGGAGCTGCGGGCTACTCTGGAGCAGACGGAG
AGGGCCCGGAAACTGGCGGAACAGGAGCTCCTGGACTCCAACGAGAGGGTGCAGCTGCTGCATACCCAGAACACCAGCCTCATCCACACC
AAGAAGAAGCTGGAGACAGACCTCATGCAGCTCCAGAGTGAGGTAGAAGATGCCAGCAGGGATGCAAGGAACGCTGAGGAGAAGGCCAAG
AAGGCCATCACGGACGCTGCCATGATGGCGGAGGAGCTGAAGAAGGAGCAGGACACCAGCGCCCACCTTGAGCGGATGAAGAAGAACCTG
GAACAGACGGTGAAGGACCTGCAGCATCGTCTAGATGAGGCCGAGCAGCTGGCGCTGAAGGGCGGGAAGAAGCAGATCCAGAAACTGGAG
ACCAGGATCCGAGAGCTGGAGTTTGAACTTGAGGGAGAGCAGAAGAAGAACACAGAGTCTGTTAAGGGCCTGAGGAAGTATGAGCGGAGG
GTCAAGGAGCTGACGTACCAGAGTGAAGAGGACAGGAAGAATGTGCTGAGATTGCAGGATCTGGTGGATAAACTGCAAGTGAAAGTCAAG
TCCTACAAGAGGCAGGCGGAGGAGGCTGATGAACAAGCCAATGCTCATCTCACCAAATTCCGAAAGGCTCAGCATGAGCTGGAGGAGGCC
GAGGAACGTGCGGATATCGCAGAATCTCAAGTCAACAAGCTCCGCGCTAAGACTCGAGACTTCACCTCCAGCAGGATGGTGGTCCACGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_MAP2K4_ENST00000353533_chr17_11924318_+_MYH3_ENST00000226209_chr17_10539170_-_2272nt
GCGAGAGGCCGAGCTTGCTGCATTGCAGCCGCCGCGGCGCCGCTCGGCTCTTCACTCCCAACAATGGCGGCTCCGAGCCCGAGCGGCGGC
GGCGGCTCCGGGGGCGGCAGCGGCAGCGGCACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGCCACCCGGCCGTCAGCAGCATGCAGGGT
GAGCTGAGTCGTCAGCTGGAAGAAAAAGAAAGCATAGTATCCCAACTTTCCAGGAGCAAGCAAGCCTTTACCCAGCAAACAGAAGAGCTC
AAGAGGCAGCTGGAGGAAGAGAACAAGGCCAAGAACGCCCTGGCGCACGCCCTGCAGTCCTCCCGCCACGACTGTGACCTGCTGCGGGAA
CAGTATGAGGAGGAGCAGGAAGGCAAAGCTGAGCTGCAGAGGGCGCTGTCCAAGGCCAATAGTGAGGTTGCCCAGTGGAGAACCAAATAC
GAGACGGACGCCATCCAGCGCACAGAAGAGCTGGAGGAGGCCAAGAAAAAACTTGCTCAGCGCCTTCAAGATTCCGAGGAACAGGTTGAG
GCAGTGAATGCTAAATGTGCTTCACTGGAGAAGACCAAGCAGAGGCTGCAAGGAGAGGTGGAGGATCTGATGGTTGATGTTGAAAGAGCC
AATTCCTTGGCCGCCGCTCTGGACAAGAAGCAGAGGAACTTTGACAAGGTGTTGGCAGAGTGGAAGACAAAGTGTGAGGAGAGCCAAGCA
GAGCTGGAGGCATCCCTGAAGGAGTCCCGCTCCTTGAGCACTGAGCTCTTCAAACTGAAAAATGCCTACGAGGAAGCCTTAGATCAACTT
GAAACTGTGAAACGGGAAAATAAGAACTTAGAGCAGGAGATAGCAGATCTCACAGAACAAATTGCTGAAAATGGCAAAACCATCCATGAA
CTGGAGAAATCAAGAAAGCAGATTGAGCTGGAAAAGGCTGATATCCAGCTGGCTCTCGAGGAAGCAGAGGCTGCTCTTGAGCATGAAGAA
GCCAAGATCCTCCGAATCCAGCTTGAATTGACACAAGTGAAATCAGAAATTGATAGAAAGATCGCCGAGAAGGATGAAGAGATCGAGCAG
CTGAAGAGGAACTACCAGAGAACAGTGGAAACCATGCAGAGCGCCCTGGACGCCGAGGTGCGGAGCAGGAATGAAGCCATCCGGCTCAAG
AAGAAGATGGAGGGGGACCTGAATGAAATCGAGATCCAGCTGAGCCACGCCAACCGCCAGGCGGCGGAGACCCTCAAACACCTCAGGAGT
GTCCAGGGACAGCTGAAGGATACGCAGCTCCACCTGGATGATGCCCTCCGGGGCCAGGAGGACCTGAAGGAGCAGCTGGCGATTGTGGAG
CGCAGAGCCAACCTGCTGCAGGCCGAGGTGGAGGAGCTGCGGGCTACTCTGGAGCAGACGGAGAGGGCCCGGAAACTGGCGGAACAGGAG
CTCCTGGACTCCAACGAGAGGGTGCAGCTGCTGCATACCCAGAACACCAGCCTCATCCACACCAAGAAGAAGCTGGAGACAGACCTCATG
CAGCTCCAGAGTGAGGTAGAAGATGCCAGCAGGGATGCAAGGAACGCTGAGGAGAAGGCCAAGAAGGCCATCACGGACGCTGCCATGATG
GCGGAGGAGCTGAAGAAGGAGCAGGACACCAGCGCCCACCTTGAGCGGATGAAGAAGAACCTGGAACAGACGGTGAAGGACCTGCAGCAT
CGTCTAGATGAGGCCGAGCAGCTGGCGCTGAAGGGCGGGAAGAAGCAGATCCAGAAACTGGAGACCAGGATCCGAGAGCTGGAGTTTGAA
CTTGAGGGAGAGCAGAAGAAGAACACAGAGTCTGTTAAGGGCCTGAGGAAGTATGAGCGGAGGGTCAAGGAGCTGACGTACCAGAGTGAA
GAGGACAGGAAGAATGTGCTGAGATTGCAGGATCTGGTGGATAAACTGCAAGTGAAAGTCAAGTCCTACAAGAGGCAGGCGGAGGAGGCT
GATGAACAAGCCAATGCTCATCTCACCAAATTCCGAAAGGCTCAGCATGAGCTGGAGGAGGCCGAGGAACGTGCGGATATCGCAGAATCT
CAAGTCAACAAGCTCCGCGCTAAGACTCGAGACTTCACCTCCAGCAGGATGGTGGTCCACGAGAGTGAAGAGTGAGCCAGCCCTTCTGGA
GCAGGACAGAAGATATGCAAAATGTATATTTTCTTGATTCCTGACCATTGATACTTAATGTCCATGTGACTCTTTTTCACATGCAATAAA

>In-frame_MAP2K4_ENST00000353533_chr17_11924318_+_MYH3_ENST00000583535_chr17_10539170_-_2271nt
GCGAGAGGCCGAGCTTGCTGCATTGCAGCCGCCGCGGCGCCGCTCGGCTCTTCACTCCCAACAATGGCGGCTCCGAGCCCGAGCGGCGGC
GGCGGCTCCGGGGGCGGCAGCGGCAGCGGCACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGCCACCCGGCCGTCAGCAGCATGCAGGGT
GAGCTGAGTCGTCAGCTGGAAGAAAAAGAAAGCATAGTATCCCAACTTTCCAGGAGCAAGCAAGCCTTTACCCAGCAAACAGAAGAGCTC
AAGAGGCAGCTGGAGGAAGAGAACAAGGCCAAGAACGCCCTGGCGCACGCCCTGCAGTCCTCCCGCCACGACTGTGACCTGCTGCGGGAA
CAGTATGAGGAGGAGCAGGAAGGCAAAGCTGAGCTGCAGAGGGCGCTGTCCAAGGCCAATAGTGAGGTTGCCCAGTGGAGAACCAAATAC
GAGACGGACGCCATCCAGCGCACAGAAGAGCTGGAGGAGGCCAAGAAAAAACTTGCTCAGCGCCTTCAAGATTCCGAGGAACAGGTTGAG
GCAGTGAATGCTAAATGTGCTTCACTGGAGAAGACCAAGCAGAGGCTGCAAGGAGAGGTGGAGGATCTGATGGTTGATGTTGAAAGAGCC
AATTCCTTGGCCGCCGCTCTGGACAAGAAGCAGAGGAACTTTGACAAGGTGTTGGCAGAGTGGAAGACAAAGTGTGAGGAGAGCCAAGCA
GAGCTGGAGGCATCCCTGAAGGAGTCCCGCTCCTTGAGCACTGAGCTCTTCAAACTGAAAAATGCCTACGAGGAAGCCTTAGATCAACTT
GAAACTGTGAAACGGGAAAATAAGAACTTAGAGCAGGAGATAGCAGATCTCACAGAACAAATTGCTGAAAATGGCAAAACCATCCATGAA
CTGGAGAAATCAAGAAAGCAGATTGAGCTGGAAAAGGCTGATATCCAGCTGGCTCTCGAGGAAGCAGAGGCTGCTCTTGAGCATGAAGAA
GCCAAGATCCTCCGAATCCAGCTTGAATTGACACAAGTGAAATCAGAAATTGATAGAAAGATCGCCGAGAAGGATGAAGAGATCGAGCAG
CTGAAGAGGAACTACCAGAGAACAGTGGAAACCATGCAGAGCGCCCTGGACGCCGAGGTGCGGAGCAGGAATGAAGCCATCCGGCTCAAG
AAGAAGATGGAGGGGGACCTGAATGAAATCGAGATCCAGCTGAGCCACGCCAACCGCCAGGCGGCGGAGACCCTCAAACACCTCAGGAGT
GTCCAGGGACAGCTGAAGGATACGCAGCTCCACCTGGATGATGCCCTCCGGGGCCAGGAGGACCTGAAGGAGCAGCTGGCGATTGTGGAG
CGCAGAGCCAACCTGCTGCAGGCCGAGGTGGAGGAGCTGCGGGCTACTCTGGAGCAGACGGAGAGGGCCCGGAAACTGGCGGAACAGGAG
CTCCTGGACTCCAACGAGAGGGTGCAGCTGCTGCATACCCAGAACACCAGCCTCATCCACACCAAGAAGAAGCTGGAGACAGACCTCATG
CAGCTCCAGAGTGAGGTAGAAGATGCCAGCAGGGATGCAAGGAACGCTGAGGAGAAGGCCAAGAAGGCCATCACGGACGCTGCCATGATG
GCGGAGGAGCTGAAGAAGGAGCAGGACACCAGCGCCCACCTTGAGCGGATGAAGAAGAACCTGGAACAGACGGTGAAGGACCTGCAGCAT
CGTCTAGATGAGGCCGAGCAGCTGGCGCTGAAGGGCGGGAAGAAGCAGATCCAGAAACTGGAGACCAGGATCCGAGAGCTGGAGTTTGAA
CTTGAGGGAGAGCAGAAGAAGAACACAGAGTCTGTTAAGGGCCTGAGGAAGTATGAGCGGAGGGTCAAGGAGCTGACGTACCAGAGTGAA
GAGGACAGGAAGAATGTGCTGAGATTGCAGGATCTGGTGGATAAACTGCAAGTGAAAGTCAAGTCCTACAAGAGGCAGGCGGAGGAGGCT
GATGAACAAGCCAATGCTCATCTCACCAAATTCCGAAAGGCTCAGCATGAGCTGGAGGAGGCCGAGGAACGTGCGGATATCGCAGAATCT
CAAGTCAACAAGCTCCGCGCTAAGACTCGAGACTTCACCTCCAGCAGGATGGTGGTCCACGAGAGTGAAGAGTGAGCCAGCCCTTCTGGA
GCAGGACAGAAGATATGCAAAATGTATATTTTCTTGATTCCTGACCATTGATACTTAATGTCCATGTGACTCTTTTTCACATGCAATAAA

>In-frame_MAP2K4_ENST00000415385_chr17_11924318_+_MYH3_ENST00000226209_chr17_10539170_-_2262nt
GAGCTTGCTGCATTGCAGCCGCCGCGGCGCCGCTCGGCTCTTCACTCCCAACAATGGCGGCTCCGAGCCCGAGCGGCGGCGGCGGCTCCG
GGGGCGGCAGCGGCAGCGGCACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGCCACCCGGCCGTCAGCAGCATGCAGGGTGAGCTGAGTC
GTCAGCTGGAAGAAAAAGAAAGCATAGTATCCCAACTTTCCAGGAGCAAGCAAGCCTTTACCCAGCAAACAGAAGAGCTCAAGAGGCAGC
TGGAGGAAGAGAACAAGGCCAAGAACGCCCTGGCGCACGCCCTGCAGTCCTCCCGCCACGACTGTGACCTGCTGCGGGAACAGTATGAGG
AGGAGCAGGAAGGCAAAGCTGAGCTGCAGAGGGCGCTGTCCAAGGCCAATAGTGAGGTTGCCCAGTGGAGAACCAAATACGAGACGGACG
CCATCCAGCGCACAGAAGAGCTGGAGGAGGCCAAGAAAAAACTTGCTCAGCGCCTTCAAGATTCCGAGGAACAGGTTGAGGCAGTGAATG
CTAAATGTGCTTCACTGGAGAAGACCAAGCAGAGGCTGCAAGGAGAGGTGGAGGATCTGATGGTTGATGTTGAAAGAGCCAATTCCTTGG
CCGCCGCTCTGGACAAGAAGCAGAGGAACTTTGACAAGGTGTTGGCAGAGTGGAAGACAAAGTGTGAGGAGAGCCAAGCAGAGCTGGAGG
CATCCCTGAAGGAGTCCCGCTCCTTGAGCACTGAGCTCTTCAAACTGAAAAATGCCTACGAGGAAGCCTTAGATCAACTTGAAACTGTGA
AACGGGAAAATAAGAACTTAGAGCAGGAGATAGCAGATCTCACAGAACAAATTGCTGAAAATGGCAAAACCATCCATGAACTGGAGAAAT
CAAGAAAGCAGATTGAGCTGGAAAAGGCTGATATCCAGCTGGCTCTCGAGGAAGCAGAGGCTGCTCTTGAGCATGAAGAAGCCAAGATCC
TCCGAATCCAGCTTGAATTGACACAAGTGAAATCAGAAATTGATAGAAAGATCGCCGAGAAGGATGAAGAGATCGAGCAGCTGAAGAGGA
ACTACCAGAGAACAGTGGAAACCATGCAGAGCGCCCTGGACGCCGAGGTGCGGAGCAGGAATGAAGCCATCCGGCTCAAGAAGAAGATGG
AGGGGGACCTGAATGAAATCGAGATCCAGCTGAGCCACGCCAACCGCCAGGCGGCGGAGACCCTCAAACACCTCAGGAGTGTCCAGGGAC
AGCTGAAGGATACGCAGCTCCACCTGGATGATGCCCTCCGGGGCCAGGAGGACCTGAAGGAGCAGCTGGCGATTGTGGAGCGCAGAGCCA
ACCTGCTGCAGGCCGAGGTGGAGGAGCTGCGGGCTACTCTGGAGCAGACGGAGAGGGCCCGGAAACTGGCGGAACAGGAGCTCCTGGACT
CCAACGAGAGGGTGCAGCTGCTGCATACCCAGAACACCAGCCTCATCCACACCAAGAAGAAGCTGGAGACAGACCTCATGCAGCTCCAGA
GTGAGGTAGAAGATGCCAGCAGGGATGCAAGGAACGCTGAGGAGAAGGCCAAGAAGGCCATCACGGACGCTGCCATGATGGCGGAGGAGC
TGAAGAAGGAGCAGGACACCAGCGCCCACCTTGAGCGGATGAAGAAGAACCTGGAACAGACGGTGAAGGACCTGCAGCATCGTCTAGATG
AGGCCGAGCAGCTGGCGCTGAAGGGCGGGAAGAAGCAGATCCAGAAACTGGAGACCAGGATCCGAGAGCTGGAGTTTGAACTTGAGGGAG
AGCAGAAGAAGAACACAGAGTCTGTTAAGGGCCTGAGGAAGTATGAGCGGAGGGTCAAGGAGCTGACGTACCAGAGTGAAGAGGACAGGA
AGAATGTGCTGAGATTGCAGGATCTGGTGGATAAACTGCAAGTGAAAGTCAAGTCCTACAAGAGGCAGGCGGAGGAGGCTGATGAACAAG
CCAATGCTCATCTCACCAAATTCCGAAAGGCTCAGCATGAGCTGGAGGAGGCCGAGGAACGTGCGGATATCGCAGAATCTCAAGTCAACA
AGCTCCGCGCTAAGACTCGAGACTTCACCTCCAGCAGGATGGTGGTCCACGAGAGTGAAGAGTGAGCCAGCCCTTCTGGAGCAGGACAGA
AGATATGCAAAATGTATATTTTCTTGATTCCTGACCATTGATACTTAATGTCCATGTGACTCTTTTTCACATGCAATAAACTTTGCTTTG

>In-frame_MAP2K4_ENST00000415385_chr17_11924318_+_MYH3_ENST00000583535_chr17_10539170_-_2261nt
GAGCTTGCTGCATTGCAGCCGCCGCGGCGCCGCTCGGCTCTTCACTCCCAACAATGGCGGCTCCGAGCCCGAGCGGCGGCGGCGGCTCCG
GGGGCGGCAGCGGCAGCGGCACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGCCACCCGGCCGTCAGCAGCATGCAGGGTGAGCTGAGTC
GTCAGCTGGAAGAAAAAGAAAGCATAGTATCCCAACTTTCCAGGAGCAAGCAAGCCTTTACCCAGCAAACAGAAGAGCTCAAGAGGCAGC
TGGAGGAAGAGAACAAGGCCAAGAACGCCCTGGCGCACGCCCTGCAGTCCTCCCGCCACGACTGTGACCTGCTGCGGGAACAGTATGAGG
AGGAGCAGGAAGGCAAAGCTGAGCTGCAGAGGGCGCTGTCCAAGGCCAATAGTGAGGTTGCCCAGTGGAGAACCAAATACGAGACGGACG
CCATCCAGCGCACAGAAGAGCTGGAGGAGGCCAAGAAAAAACTTGCTCAGCGCCTTCAAGATTCCGAGGAACAGGTTGAGGCAGTGAATG
CTAAATGTGCTTCACTGGAGAAGACCAAGCAGAGGCTGCAAGGAGAGGTGGAGGATCTGATGGTTGATGTTGAAAGAGCCAATTCCTTGG
CCGCCGCTCTGGACAAGAAGCAGAGGAACTTTGACAAGGTGTTGGCAGAGTGGAAGACAAAGTGTGAGGAGAGCCAAGCAGAGCTGGAGG
CATCCCTGAAGGAGTCCCGCTCCTTGAGCACTGAGCTCTTCAAACTGAAAAATGCCTACGAGGAAGCCTTAGATCAACTTGAAACTGTGA
AACGGGAAAATAAGAACTTAGAGCAGGAGATAGCAGATCTCACAGAACAAATTGCTGAAAATGGCAAAACCATCCATGAACTGGAGAAAT
CAAGAAAGCAGATTGAGCTGGAAAAGGCTGATATCCAGCTGGCTCTCGAGGAAGCAGAGGCTGCTCTTGAGCATGAAGAAGCCAAGATCC
TCCGAATCCAGCTTGAATTGACACAAGTGAAATCAGAAATTGATAGAAAGATCGCCGAGAAGGATGAAGAGATCGAGCAGCTGAAGAGGA
ACTACCAGAGAACAGTGGAAACCATGCAGAGCGCCCTGGACGCCGAGGTGCGGAGCAGGAATGAAGCCATCCGGCTCAAGAAGAAGATGG
AGGGGGACCTGAATGAAATCGAGATCCAGCTGAGCCACGCCAACCGCCAGGCGGCGGAGACCCTCAAACACCTCAGGAGTGTCCAGGGAC
AGCTGAAGGATACGCAGCTCCACCTGGATGATGCCCTCCGGGGCCAGGAGGACCTGAAGGAGCAGCTGGCGATTGTGGAGCGCAGAGCCA
ACCTGCTGCAGGCCGAGGTGGAGGAGCTGCGGGCTACTCTGGAGCAGACGGAGAGGGCCCGGAAACTGGCGGAACAGGAGCTCCTGGACT
CCAACGAGAGGGTGCAGCTGCTGCATACCCAGAACACCAGCCTCATCCACACCAAGAAGAAGCTGGAGACAGACCTCATGCAGCTCCAGA
GTGAGGTAGAAGATGCCAGCAGGGATGCAAGGAACGCTGAGGAGAAGGCCAAGAAGGCCATCACGGACGCTGCCATGATGGCGGAGGAGC
TGAAGAAGGAGCAGGACACCAGCGCCCACCTTGAGCGGATGAAGAAGAACCTGGAACAGACGGTGAAGGACCTGCAGCATCGTCTAGATG
AGGCCGAGCAGCTGGCGCTGAAGGGCGGGAAGAAGCAGATCCAGAAACTGGAGACCAGGATCCGAGAGCTGGAGTTTGAACTTGAGGGAG
AGCAGAAGAAGAACACAGAGTCTGTTAAGGGCCTGAGGAAGTATGAGCGGAGGGTCAAGGAGCTGACGTACCAGAGTGAAGAGGACAGGA
AGAATGTGCTGAGATTGCAGGATCTGGTGGATAAACTGCAAGTGAAAGTCAAGTCCTACAAGAGGCAGGCGGAGGAGGCTGATGAACAAG
CCAATGCTCATCTCACCAAATTCCGAAAGGCTCAGCATGAGCTGGAGGAGGCCGAGGAACGTGCGGATATCGCAGAATCTCAAGTCAACA
AGCTCCGCGCTAAGACTCGAGACTTCACCTCCAGCAGGATGGTGGTCCACGAGAGTGAAGAGTGAGCCAGCCCTTCTGGAGCAGGACAGA
AGATATGCAAAATGTATATTTTCTTGATTCCTGACCATTGATACTTAATGTCCATGTGACTCTTTTTCACATGCAATAAACTTTGCTTTG


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FusionGenePPI for MAP2K4_MYH3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP2K4FLNC, SPAG9, MAPK8, MAP4K2, MAP2K7, MAP3K8, AKT1, MAPK8IP3, MAP3K11, MAP3K4, ARRB2, MAP3K2, MAP3K1, NPHS1, ITCH, MAPK9, BLNK, PML, MAPK10, MAP3K5, MAP2K6, MAP2K4, MAPK14, MAP3K3, LRRK2, APP, JUN, MAP3K7, ARRB1, MAPK1, GCH1, GEMIN5, RBBP8, EGFR, MAP3K10, NBR1, KTI12, VASP, FLNB, CDC5L, UBC, TRIM25MYH3CUL1, IGSF8, ICAM1, CDCA8, SIX1, TMEM260, ACTN2, TNNI1, TPM2, TLE3, HIF1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP2K4_MYH3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAP2K4_MYH3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMYH3C0265224Freeman-Sheldon syndrome1CTD_human;ORPHANET;UNIPROT
TgeneMYH3C1834523ARTHROGRYPOSIS, DISTAL, TYPE 2B1CTD_human;ORPHANET;UNIPROT
TgeneMYH3C1867440Multiple Pterygium Syndrome, Autosomal Dominant1ORPHANET;UNIPROT