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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20811

FusionGeneSummary for MAP2K4_HCG18

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP2K4_HCG18
Fusion gene ID: 20811
HgeneTgene
Gene symbol

MAP2K4

HCG18

Gene ID

6416

414777

Gene namemitogen-activated protein kinase kinase 4HLA complex group 18
SynonymsJNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1-
Cytomap

17p12

6p22.1

Type of geneprotein-codingncRNA
Descriptiondual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1HLA complex group 18 (non-protein coding)
Modification date2018052320180517
UniProtAcc

P45985

Ensembl transtripts involved in fusion geneENST00000353533, ENST00000415385, 
ENST00000581941, 		ENST00000602550, 
ENST00000438412, ENST00000444126, 
ENST00000449544, ENST00000454129, 
ENST00000454269, ENST00000426882, 
ENST00000412685, ENST00000413358, 
ENST00000602290, ENST00000602498, 
ENST00000602591, ENST00000602698, 
ENST00000602861, ENST00000602319, 
ENST00000602516, ENST00000421520, 
ENST00000416289, ENST00000458584, 
ENST00000443909, ENST00000443079, 
ENST00000432895, 
Fusion gene scores* DoF score6 X 4 X 5=1202 X 2 X 2=8
# samples 72
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: MAP2K4 [Title/Abstract] AND HCG18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-06-0221-02AMAP2K4chr17

11999011

+HCG18chr6

30264014

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000353533ENST00000602550MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000353533ENST00000438412MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000353533ENST00000444126MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000353533ENST00000449544MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000353533ENST00000454129MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000353533ENST00000454269MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000353533ENST00000426882MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000353533ENST00000412685MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000353533ENST00000413358MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000353533ENST00000602290MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000353533ENST00000602498MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000353533ENST00000602591MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000353533ENST00000602698MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000353533ENST00000602861MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000353533ENST00000602319MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000353533ENST00000602516MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000353533ENST00000421520MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000353533ENST00000416289MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000353533ENST00000458584MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000353533ENST00000443909MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000353533ENST00000443079MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000353533ENST00000432895MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000415385ENST00000602550MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000415385ENST00000438412MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000415385ENST00000444126MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000415385ENST00000449544MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000415385ENST00000454129MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000415385ENST00000454269MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000415385ENST00000426882MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000415385ENST00000412685MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000415385ENST00000413358MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-5UTRENST00000415385ENST00000602290MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000415385ENST00000602498MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000415385ENST00000602591MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000415385ENST00000602698MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000415385ENST00000602861MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000415385ENST00000602319MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000415385ENST00000602516MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000415385ENST00000421520MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000415385ENST00000416289MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000415385ENST00000458584MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000415385ENST00000443909MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000415385ENST00000443079MAP2K4chr17

11999011

+HCG18chr6

30264014

-
5CDS-intronENST00000415385ENST00000432895MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-5UTRENST00000581941ENST00000602550MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-5UTRENST00000581941ENST00000438412MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-5UTRENST00000581941ENST00000444126MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-5UTRENST00000581941ENST00000449544MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-5UTRENST00000581941ENST00000454129MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-5UTRENST00000581941ENST00000454269MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-5UTRENST00000581941ENST00000426882MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-5UTRENST00000581941ENST00000412685MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-5UTRENST00000581941ENST00000413358MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-5UTRENST00000581941ENST00000602290MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-intronENST00000581941ENST00000602498MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-intronENST00000581941ENST00000602591MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-intronENST00000581941ENST00000602698MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-intronENST00000581941ENST00000602861MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-intronENST00000581941ENST00000602319MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-intronENST00000581941ENST00000602516MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-intronENST00000581941ENST00000421520MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-intronENST00000581941ENST00000416289MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-intronENST00000581941ENST00000458584MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-intronENST00000581941ENST00000443909MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-intronENST00000581941ENST00000443079MAP2K4chr17

11999011

+HCG18chr6

30264014

-
3UTR-intronENST00000581941ENST00000432895MAP2K4chr17

11999011

+HCG18chr6

30264014

-

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FusionProtFeatures for MAP2K4_HCG18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP2K4

P45985

HCG18

Dual specificity protein kinase which acts as anessential component of the MAP kinase signal transduction pathway.Essential component of the stress-activated protein kinase/c-JunN-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7,is the one of the only known kinase to directly activate thestress-activated protein kinase/c-Jun N-terminal kinasesMAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 andMAP2K7/MKK7 both activate the JNKs by phosphorylation, but theydiffer in their preference for the phosphorylation site in theThr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation ofthe Tyr residue and MAP2K7/MKK7 for the Thr residue. Thephosphorylation of the Thr residue by MAP2K7/MKK7 seems to be theprerequisite for JNK activation at least in response toproinflammatory cytokines, while other stimuli activate bothMAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylateJNKs. MAP2K4 is required for maintaining peripheral lymphoidhomeostasis. The MKK/JNK signaling pathway is also involved inmitochondrial death signaling pathway, including the releasecytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7exclusively activates JNKs, MAP2K4/MKK4 additionally activates thep38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.{ECO:0000269|PubMed:7716521}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP2K4_HCG18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP2K4_HCG18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP2K4FLNC, SPAG9, MAPK8, MAP4K2, MAP2K7, MAP3K8, AKT1, MAPK8IP3, MAP3K11, MAP3K4, ARRB2, MAP3K2, MAP3K1, NPHS1, ITCH, MAPK9, BLNK, PML, MAPK10, MAP3K5, MAP2K6, MAP2K4, MAPK14, MAP3K3, LRRK2, APP, JUN, MAP3K7, ARRB1, MAPK1, GCH1, GEMIN5, RBBP8, EGFR, MAP3K10, NBR1, KTI12, VASP, FLNB, CDC5L, UBC, TRIM25HCG18


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP2K4_HCG18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAP2K4_HCG18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource