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Fusion gene ID: 20789 |
FusionGeneSummary for MAP1LC3B_BCL2L11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP1LC3B_BCL2L11 | Fusion gene ID: 20789 | Hgene | Tgene | Gene symbol | MAP1LC3B | BCL2L11 | Gene ID | 81631 | 10018 |
| Gene name | microtubule associated protein 1 light chain 3 beta | BCL2 like 11 | |
| Synonyms | ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a | BAM|BIM|BOD | |
| Cytomap | 16q24.2 | 2q13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | microtubule-associated proteins 1A/1B light chain 3BMAP1 light chain 3-like protein 2MAP1A/MAP1B LC3 BMAP1A/MAP1B light chain 3 Bautophagy-related ubiquitin-like modifier LC3 B | bcl-2-like protein 11BCL2-like 11 (apoptosis facilitator)bcl-2 interacting mediator of cell deathbcl-2 interacting protein Bimbcl-2-related ovarian death agonist | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9GZQ8 | O43521 | |
| Ensembl transtripts involved in fusion gene | ENST00000562778, ENST00000268607, ENST00000565788, ENST00000534986, | ENST00000337565, ENST00000393253, ENST00000357757, ENST00000308659, ENST00000393256, ENST00000405953, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: MAP1LC3B [Title/Abstract] AND BCL2L11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP1LC3B | GO:0006914 | autophagy | 23629966 |
| Hgene | MAP1LC3B | GO:0009267 | cellular response to starvation | 28223137 |
| Hgene | MAP1LC3B | GO:0016236 | macroautophagy | 28223137 |
| Hgene | MAP1LC3B | GO:0097352 | autophagosome maturation | 28223137 |
| Tgene | BCL2L11 | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 11546872 |
| Tgene | BCL2L11 | GO:0032464 | positive regulation of protein homooligomerization | 21041309 |
| Tgene | BCL2L11 | GO:0034976 | response to endoplasmic reticulum stress | 22761832 |
| Tgene | BCL2L11 | GO:2000271 | positive regulation of fibroblast apoptotic process | 11997495 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ368756 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000562778 | ENST00000337565 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| intron-intron | ENST00000562778 | ENST00000393253 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| intron-intron | ENST00000562778 | ENST00000357757 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| intron-intron | ENST00000562778 | ENST00000308659 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| intron-intron | ENST00000562778 | ENST00000393256 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| intron-intron | ENST00000562778 | ENST00000405953 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| 3UTR-intron | ENST00000268607 | ENST00000337565 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| 3UTR-intron | ENST00000268607 | ENST00000393253 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| 3UTR-intron | ENST00000268607 | ENST00000357757 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| 3UTR-intron | ENST00000268607 | ENST00000308659 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| 3UTR-intron | ENST00000268607 | ENST00000393256 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| 3UTR-intron | ENST00000268607 | ENST00000405953 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| intron-intron | ENST00000565788 | ENST00000337565 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| intron-intron | ENST00000565788 | ENST00000393253 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| intron-intron | ENST00000565788 | ENST00000357757 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| intron-intron | ENST00000565788 | ENST00000308659 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| intron-intron | ENST00000565788 | ENST00000393256 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| intron-intron | ENST00000565788 | ENST00000405953 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| 3UTR-intron | ENST00000534986 | ENST00000337565 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| 3UTR-intron | ENST00000534986 | ENST00000393253 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| 3UTR-intron | ENST00000534986 | ENST00000357757 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| 3UTR-intron | ENST00000534986 | ENST00000308659 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| 3UTR-intron | ENST00000534986 | ENST00000393256 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
| 3UTR-intron | ENST00000534986 | ENST00000405953 | MAP1LC3B | chr16 | 87437454 | - | BCL2L11 | chr2 | 111902373 | - |
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FusionProtFeatures for MAP1LC3B_BCL2L11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP1LC3B | BCL2L11 |
| Ubiquitin-like modifier involved in formation ofautophagosomal vacuoles (autophagosomes). Plays a role inmitophagy which contributes to regulate mitochondrial quantity andquality by eliminating the mitochondria to a basal level tofulfill cellular energy requirements and preventing excess ROSproduction. Whereas LC3s are involved in elongation of thephagophore membrane, the GABARAP/GATE-16 subfamily is essentialfor a later stage in autophagosome maturation. Promotes primaryciliogenesis by removing OFD1 from centriolar satellites via theautophagic pathway. {ECO:0000269|PubMed:20418806,ECO:0000269|PubMed:23209295, ECO:0000269|PubMed:24089205}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAP1LC3B_BCL2L11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAP1LC3B_BCL2L11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP1LC3B_BCL2L11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP1LC3B_BCL2L11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MAP1LC3B | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | BCL2L11 | C0008313 | Cholangitis, Sclerosing | 1 | CTD_human |
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