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Fusion gene ID: 20787 |
FusionGeneSummary for MAP1B_SUPT16H |
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Fusion gene information | Fusion gene name: MAP1B_SUPT16H | Fusion gene ID: 20787 | Hgene | Tgene | Gene symbol | MAP1B | SUPT16H | Gene ID | 4131 | 11198 |
Gene name | microtubule associated protein 1B | SPT16 homolog, facilitates chromatin remodeling subunit | |
Synonyms | FUTSCH|MAP5|PPP1R102 | CDC68|FACTP140|SPT16|SPT16/CDC68 | |
Cytomap | 5q13.2 | 14q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | microtubule-associated protein 1Bprotein phosphatase 1, regulatory subunit 102 | FACT complex subunit SPT16FACT 140 kDa subunitchromatin-specific transcription elongation factor 140 kDa subunitfacilitates chromatin remodeling 140 kDa subunitfacilitates chromatin transcription complex subunit SPT16hSPT16suppressor of Ty 16 homolo | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P46821 | Q9Y5B9 | |
Ensembl transtripts involved in fusion gene | ENST00000296755, ENST00000504183, | ENST00000216297, ENST00000555943, | |
Fusion gene scores | * DoF score | 9 X 8 X 5=360 | 37 X 4 X 15=2220 |
# samples | 11 | 40 | |
** MAII score | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(40/2220*10)=-2.47248777146274 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAP1B [Title/Abstract] AND SUPT16H [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MAP1B | GO:0009987 | cellular process | 19567321 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-77-8009-01A | MAP1B | chr5 | 71505395 | + | SUPT16H | chr14 | 21829491 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000296755 | ENST00000216297 | MAP1B | chr5 | 71505395 | + | SUPT16H | chr14 | 21829491 | - |
5CDS-intron | ENST00000296755 | ENST00000555943 | MAP1B | chr5 | 71505395 | + | SUPT16H | chr14 | 21829491 | - |
intron-intron | ENST00000504183 | ENST00000216297 | MAP1B | chr5 | 71505395 | + | SUPT16H | chr14 | 21829491 | - |
intron-intron | ENST00000504183 | ENST00000555943 | MAP1B | chr5 | 71505395 | + | SUPT16H | chr14 | 21829491 | - |
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FusionProtFeatures for MAP1B_SUPT16H |
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Hgene | Tgene |
MAP1B | SUPT16H |
Facilitates tyrosination of alpha-tubulin in neuronalmicrotubules (By similarity). Phosphorylated MAP1B may play a rolein the cytoskeletal changes that accompany neurite extension.Possibly MAP1B binds to at least two tubulin subunits in thepolymer, and this bridging of subunits might be involved innucleating microtubule polymerization and in stabilizingmicrotubules. Acts as a positive cofactor in DAPK1-mediatedautophagic vesicle formation and membrane blebbing. {ECO:0000250,ECO:0000269|PubMed:18195017}. | Component of the FACT complex, a general chromatinfactor that acts to reorganize nucleosomes. The FACT complex isinvolved in multiple processes that require DNA as a template suchas mRNA elongation, DNA replication and DNA repair. Duringtranscription elongation the FACT complex acts as a histonechaperone that both destabilizes and restores nucleosomalstructure. It facilitates the passage of RNA polymerase II andtranscription by promoting the dissociation of one histone H2A-H2Bdimer from the nucleosome, then subsequently promotes thereestablishment of the nucleosome following the passage of RNApolymerase II. The FACT complex is probably also involved inphosphorylation of 'Ser-392' of p53/TP53 via its association withCK2 (casein kinase II). {ECO:0000269|PubMed:10912001,ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006,ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704,ECO:0000269|PubMed:9836642}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAP1B_SUPT16H |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAP1B_SUPT16H |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAP1B | ANP32A, RASSF1, GAN, SNCA, MAG, RAE1, AMBRA1, ATG10, ATG12, ATG3, MAP1LC3A, MAP1LC3B, PRKAG2, RASSF5, STK4, HDAC5, ARRB1, ARRB2, SIRT7, SPP1, PINK1, MARCH5, CUL3, ACTN1, LRRK2, PARK7, EIF4A3, MAGOH, SMURF1, IQCB1, PAN2, NPM1, EEF1D, FOS, STK3, CUL7, CCDC8, EED, PPT1, ABCE1, FBXW11, MLF1, DBF4B, CRYAB, HSPB6, MAP1S, RASSF3, WHSC1, SFN, NTRK1, MED4, CACNA1B, CACNA1A, FOXK2, ALKBH3, ATOH1, CYLD, RUVBL2 | SUPT16H | BRCC3, PRKAA1, POLR1A, POLR1E, SSRP1, CHD1L, MCM4, PAF1, PARP1, H2AFX, MKL1, H3F3A, TRIM33, TAL1, CDK9, SUPT16H, MMS22L, TONSL, SMARCAD1, SREK1, SOX2, HDGF, ELAVL1, XRCC5, CUL3, CDK2, CAND1, FYTTD1, CSNK2A1, CSNK2B, SAP18, RTF1, LEO1, TOP1, DHX15, CTR9, IK, PRPF4B, SNRPD2, NCSTN, S100A9, HNRNPM, NHP2L1, DDX21, PRPF6, SF3A1, SNRPD1, PRPF3, ACIN1, EEF1A1, RBM25, MSH6, PRPF8, USP39, MSH2, PSIP1, CENPA, ESR1, FMNL1, VCP, PNKP, CD81, IGSF8, ICAM1, SRPK2, FTH1, QRICH1, RNF20, ATRX, HIST1H2AB, MOV10, NXF1, BRCA1, CUL7, OBSL1, EED, RNF2, BMI1, SUMO2, ABCE1, RPA4, SPIN2B, RPA2, SPIN1, TIPIN, RNF146, POLB, APLF, HIST1H2BA, MAFF, FBXW11, BRD3, CDK12, HMGB1, IWS1, NAP1L1, PES1, SRRM1, CDK11A, HMGB2, HMGB3, KRI1, TOP2B, ZC3H18, SFN, NTRK1, IFI16, MED4, EWSR1, CEP97, CNTROB, SPICE1, CEP164, DCTN1, POC1B, STIL, HIST1H3E, DAXX, HNRNPU, NPM1, RPL10, ETAA1, CENPQ, NF2, NANOG, UBR5, SBF1, HIST1H3A, MACROD1, H2AFY2, XPC, XRCC6, HIST1H4A, NAA40, WDR76, ALX3, TEAD2, L3MBTL1, CETN1, SIX2, POLL, RPA3, WRN, COX15, DLD, PDHA1, VDAC1, TRIM25, YAP1, MTF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP1B_SUPT16H |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP1B_SUPT16H |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |