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Fusion gene ID: 20786 |
FusionGeneSummary for MAP1B_SLC27A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP1B_SLC27A2 | Fusion gene ID: 20786 | Hgene | Tgene | Gene symbol | MAP1B | SLC27A2 | Gene ID | 4131 | 11001 |
| Gene name | microtubule associated protein 1B | solute carrier family 27 member 2 | |
| Synonyms | FUTSCH|MAP5|PPP1R102 | ACSVL1|FACVL1|FATP2|HsT17226|VLACS|VLCS|hFACVL1 | |
| Cytomap | 5q13.2 | 15q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | microtubule-associated protein 1Bprotein phosphatase 1, regulatory subunit 102 | very long-chain acyl-CoA synthetaseFATP-2THCA-CoA ligasefatty acid transport protein 2fatty-acid-coenzyme A ligase, very long-chain 1long-chain-fatty-acid--CoA ligasesolute carrier family 27 (fatty acid transporter), member 2very long-chain fatty-a | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P46821 | O14975 | |
| Ensembl transtripts involved in fusion gene | ENST00000296755, ENST00000504183, | ENST00000267842, ENST00000380902, ENST00000544960, | |
| Fusion gene scores | * DoF score | 9 X 8 X 5=360 | 4 X 2 X 4=32 |
| # samples | 11 | 4 | |
| ** MAII score | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAP1B [Title/Abstract] AND SLC27A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP1B | GO:0009987 | cellular process | 19567321 |
| Tgene | SLC27A2 | GO:0001561 | fatty acid alpha-oxidation | 10198260 |
| Tgene | SLC27A2 | GO:0001676 | long-chain fatty acid metabolic process | 22022213 |
| Tgene | SLC27A2 | GO:0006635 | fatty acid beta-oxidation | 10198260 |
| Tgene | SLC27A2 | GO:0006699 | bile acid biosynthetic process | 11980911 |
| Tgene | SLC27A2 | GO:0044539 | long-chain fatty acid import | 22022213 |
| Tgene | SLC27A2 | GO:0097089 | methyl-branched fatty acid metabolic process | 10198260 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-G9-6348-01A | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000296755 | ENST00000267842 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
| In-frame | ENST00000296755 | ENST00000380902 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
| 5CDS-5UTR | ENST00000296755 | ENST00000544960 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
| 3UTR-3CDS | ENST00000504183 | ENST00000267842 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
| 3UTR-3CDS | ENST00000504183 | ENST00000380902 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
| 3UTR-5UTR | ENST00000504183 | ENST00000544960 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
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FusionProtFeatures for MAP1B_SLC27A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP1B | SLC27A2 |
| Facilitates tyrosination of alpha-tubulin in neuronalmicrotubules (By similarity). Phosphorylated MAP1B may play a rolein the cytoskeletal changes that accompany neurite extension.Possibly MAP1B binds to at least two tubulin subunits in thepolymer, and this bridging of subunits might be involved innucleating microtubule polymerization and in stabilizingmicrotubules. Acts as a positive cofactor in DAPK1-mediatedautophagic vesicle formation and membrane blebbing. {ECO:0000250,ECO:0000269|PubMed:18195017}. | Acyl-CoA synthetase probably involved in bile acidmetabolism. Proposed to activate C27 precursors of bile acids totheir CoA thioesters derivatives before side chain cleavage viaperoxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27precursor of cholic acid deriving from the de novo synthesis fromcholesterol. Does not utilize C24 bile acids as substrates. Invitro, also activates long- and branched-chain fatty acids and mayhave additional roles in fatty acid metabolism. May be involved intranslocation of long-chain fatty acids (LFCA) across membranes(By similarity). {ECO:0000250, ECO:0000269|PubMed:11980911}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 222_233 | 159 | 621 | Nucleotide binding | AMP |
| Tgene | >SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 222_233 | 159 | 568 | Nucleotide binding | AMP |
| Tgene | >SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 283_620 | 159 | 621 | Topological domain | Cytoplasmic |
| Tgene | >SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 283_620 | 159 | 568 | Topological domain | Cytoplasmic |
| Tgene | >SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 262_282 | 159 | 621 | Transmembrane | Helical |
| Tgene | >SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 262_282 | 159 | 568 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 589_790 | 95 | 2469 | Compositional bias | Note=Lys-rich (highly basic%2C contains many KKEE and KKEI/V repeats) |
| Hgene | >MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1878_1894 | 95 | 2469 | Repeat | Note=MAP1B 1 |
| Hgene | >MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1895_1911 | 95 | 2469 | Repeat | Note=MAP1B 2 |
| Hgene | >MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1912_1928 | 95 | 2469 | Repeat | Note=MAP1B 3 |
| Hgene | >MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1929_1945 | 95 | 2469 | Repeat | Note=MAP1B 4 |
| Hgene | >MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1946_1962 | 95 | 2469 | Repeat | Note=MAP1B 5 |
| Hgene | >MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1963_1979 | 95 | 2469 | Repeat | Note=MAP1B 6 |
| Hgene | >MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1997_2013 | 95 | 2469 | Repeat | Note=MAP1B 7 |
| Hgene | >MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 2014_2030 | 95 | 2469 | Repeat | Note=MAP1B 8 |
| Hgene | >MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 2031_2047 | 95 | 2469 | Repeat | Note=MAP1B 9 |
| Hgene | >MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 2048_2064 | 95 | 2469 | Repeat | Note=MAP1B 10 |
| Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 128_261 | 159 | 621 | Topological domain | Lumenal |
| Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 1_4 | 159 | 621 | Topological domain | Lumenal |
| Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 28_106 | 159 | 621 | Topological domain | Cytoplasmic |
| Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 128_261 | 159 | 568 | Topological domain | Lumenal |
| Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 1_4 | 159 | 568 | Topological domain | Lumenal |
| Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 28_106 | 159 | 568 | Topological domain | Cytoplasmic |
| Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 107_127 | 159 | 621 | Transmembrane | Helical |
| Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | + | 0 | 10 | 5_27 | 159 | 621 | Transmembrane | Helical |
| Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 107_127 | 159 | 568 | Transmembrane | Helical |
| Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | + | 0 | 9 | 5_27 | 159 | 568 | Transmembrane | Helical |
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FusionGeneSequence for MAP1B_SLC27A2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_SLC27A2_ENST00000267842_chr15_50489697_+_557aa MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARF SPEVPELQAAVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQRIWY GTGLTFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVR LALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGL LVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYG VHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAKMYVP >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_SLC27A2_ENST00000380902_chr15_50489697_+_504aa MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARF SPEVPELQAAVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGATLALRTKFSASQF WDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYL QKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYF HDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_SLC27A2_ENST00000267842_chr15_50489697_+_1671nt ATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGCGGCGTCCACCTCGCCTAGCCTGTCGCAC CGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCACCTGCGGCGTGCCATCGGCAACATCGAG CTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACTTTTTGTATCTCGACACTCTGCAAGATTC TCTCCTGAAGTCCCAGAACTACAAGCAGCTGTCGAAGAGATACTGCCAAGCCTTAAAAAAGATGATGTGTCCATCTATTATGTGAGCAGA ACTTCTAACACAGATGGGATTGACTCTTTCCTGGACAAAGTGGATGAAGTATCAACTGAACCTATCCCAGAGTCATGGAGGTCTGAAGTC ACTTTTTCCACTCCTGCCTTATACATTTATACTTCTGGAACCACAGGTCTTCCAAAAGCAGCCATGATCACTCATCAGCGCATATGGTAT GGAACTGGCCTCACTTTTGTAAGCGGATTGAAGGCAGATGATGTCATCTATATCACTCTGCCCTTTTACCACAGTGCTGCACTACTGATT GGCATTCACGGATGTATTGTGGCTGGTGCTACTCTTGCCTTGCGGACTAAATTTTCAGCCAGCCAGTTTTGGGATGACTGCAGAAAATAC AACGTCACTGTCATTCAGTATATCGGTGAACTGCTTCGGTATTTATGCAACTCACCACAGAAACCAAATGACCGTGATCATAAAGTGAGA CTGGCACTGGGAAATGGCTTACGAGGAGATGTGTGGAGACAATTTGTCAAGAGATTTGGGGACATATGCATCTATGAGTTCTATGCTGCC ACTGAAGGCAATATTGGATTTATGAATTATGCGAGAAAAGTTGGTGCTGTTGGAAGAGTAAACTACCTACAGAAAAAAATCATAACTTAT GACCTGATTAAATATGATGTGGAGAAAGATGAACCTGTCCGTGATGAAAATGGATATTGCGTCAGAGTTCCCAAAGGTGAAGTTGGACTT CTGGTTTGCAAAATCACACAACTTACACCATTTAATGGCTATGCTGGAGCAAAGGCTCAGACAGAGAAGAAAAAACTGAGAGATGTCTTT AAGAAAGGAGACCTCTATTTCAACAGTGGAGATCTCTTAATGGTTGACCATGAAAATTTCATCTATTTCCACGACAGAGTTGGAGATACA TTCCGGTGGAAAGGGGAAAATGTGGCCACCACTGAAGTTGCTGATACAGTTGGACTGGTTGATTTTGTCCAAGAAGTAAATGTTTATGGA GTGCATGTGCCAGATCATGAGGGTCGCATTGGCATGGCCTCCATCAAAATGAAAGAAAACCATGAATTTGATGGAAAGAAACTCTTTCAG CACATTGCTGATTACCTACCTAGTTATGCAAGGCCCCGGTTTCTAAGAATACAGGACACCATTGAGATCACTGGAACTTTTAAACACCGC AAAATGACCCTGGTGGAGGAGGGCTTTAACCCTGCTGTCATCAAAGATGCCTTGTATTTCTTGGATGACACAGCAAAAATGTATGTGCCT >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_SLC27A2_ENST00000380902_chr15_50489697_+_1512nt ATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGCGGCGTCCACCTCGCCTAGCCTGTCGCAC CGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCACCTGCGGCGTGCCATCGGCAACATCGAG CTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACTTTTTGTATCTCGACACTCTGCAAGATTC TCTCCTGAAGTCCCAGAACTACAAGCAGCTGTCGAAGAGATACTGCCAAGCCTTAAAAAAGATGATGTGTCCATCTATTATGTGAGCAGA ACTTCTAACACAGATGGGATTGACTCTTTCCTGGACAAAGTGGATGAAGTATCAACTGAACCTATCCCAGAGTCATGGAGGTCTGAAGTC ACTTTTTCCACTCCTGCCTTATACATTTATACTTCTGGAACCACAGGTGCTACTCTTGCCTTGCGGACTAAATTTTCAGCCAGCCAGTTT TGGGATGACTGCAGAAAATACAACGTCACTGTCATTCAGTATATCGGTGAACTGCTTCGGTATTTATGCAACTCACCACAGAAACCAAAT GACCGTGATCATAAAGTGAGACTGGCACTGGGAAATGGCTTACGAGGAGATGTGTGGAGACAATTTGTCAAGAGATTTGGGGACATATGC ATCTATGAGTTCTATGCTGCCACTGAAGGCAATATTGGATTTATGAATTATGCGAGAAAAGTTGGTGCTGTTGGAAGAGTAAACTACCTA CAGAAAAAAATCATAACTTATGACCTGATTAAATATGATGTGGAGAAAGATGAACCTGTCCGTGATGAAAATGGATATTGCGTCAGAGTT CCCAAAGGTGAAGTTGGACTTCTGGTTTGCAAAATCACACAACTTACACCATTTAATGGCTATGCTGGAGCAAAGGCTCAGACAGAGAAG AAAAAACTGAGAGATGTCTTTAAGAAAGGAGACCTCTATTTCAACAGTGGAGATCTCTTAATGGTTGACCATGAAAATTTCATCTATTTC CACGACAGAGTTGGAGATACATTCCGGTGGAAAGGGGAAAATGTGGCCACCACTGAAGTTGCTGATACAGTTGGACTGGTTGATTTTGTC CAAGAAGTAAATGTTTATGGAGTGCATGTGCCAGATCATGAGGGTCGCATTGGCATGGCCTCCATCAAAATGAAAGAAAACCATGAATTT GATGGAAAGAAACTCTTTCAGCACATTGCTGATTACCTACCTAGTTATGCAAGGCCCCGGTTTCTAAGAATACAGGACACCATTGAGATC ACTGGAACTTTTAAACACCGCAAAATGACCCTGGTGGAGGAGGGCTTTAACCCTGCTGTCATCAAAGATGCCTTGTATTTCTTGGATGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_SLC27A2_ENST00000267842_chr15_50489697_+_2268nt GTGAGGATGTGCCGGGTGGTCCTTTCCTCCTCCTCTTCCTCCTCCTCCCGGCTCCCTGCCTAGTCTCCATATAAAAGCGGCGCCGCCTCC CCGCCCTCTCTCACTCCCCGCTCCTCTCCGCCGCGCACTCTCCGCGGCGCTGGGAGAGGGCGGAGGGGGAGGCGGCGCGCGGCGCCAGAG GAGGGGGGACGCAGGGGGCGGAGCGGAGACAGTACCTTCGGAGATAATCCTTTCTCCTGCCGCAGTGGAGAGGAGCGGCCGGAGCGAGAC ACTTCGCCGAGGCACAGCAGCCGGCAGGATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGC GGCGTCCACCTCGCCTAGCCTGTCGCACCGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCA CCTGCGGCGTGCCATCGGCAACATCGAGCTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACT TTTTGTATCTCGACACTCTGCAAGATTCTCTCCTGAAGTCCCAGAACTACAAGCAGCTGTCGAAGAGATACTGCCAAGCCTTAAAAAAGA TGATGTGTCCATCTATTATGTGAGCAGAACTTCTAACACAGATGGGATTGACTCTTTCCTGGACAAAGTGGATGAAGTATCAACTGAACC TATCCCAGAGTCATGGAGGTCTGAAGTCACTTTTTCCACTCCTGCCTTATACATTTATACTTCTGGAACCACAGGTCTTCCAAAAGCAGC CATGATCACTCATCAGCGCATATGGTATGGAACTGGCCTCACTTTTGTAAGCGGATTGAAGGCAGATGATGTCATCTATATCACTCTGCC CTTTTACCACAGTGCTGCACTACTGATTGGCATTCACGGATGTATTGTGGCTGGTGCTACTCTTGCCTTGCGGACTAAATTTTCAGCCAG CCAGTTTTGGGATGACTGCAGAAAATACAACGTCACTGTCATTCAGTATATCGGTGAACTGCTTCGGTATTTATGCAACTCACCACAGAA ACCAAATGACCGTGATCATAAAGTGAGACTGGCACTGGGAAATGGCTTACGAGGAGATGTGTGGAGACAATTTGTCAAGAGATTTGGGGA CATATGCATCTATGAGTTCTATGCTGCCACTGAAGGCAATATTGGATTTATGAATTATGCGAGAAAAGTTGGTGCTGTTGGAAGAGTAAA CTACCTACAGAAAAAAATCATAACTTATGACCTGATTAAATATGATGTGGAGAAAGATGAACCTGTCCGTGATGAAAATGGATATTGCGT CAGAGTTCCCAAAGGTGAAGTTGGACTTCTGGTTTGCAAAATCACACAACTTACACCATTTAATGGCTATGCTGGAGCAAAGGCTCAGAC AGAGAAGAAAAAACTGAGAGATGTCTTTAAGAAAGGAGACCTCTATTTCAACAGTGGAGATCTCTTAATGGTTGACCATGAAAATTTCAT CTATTTCCACGACAGAGTTGGAGATACATTCCGGTGGAAAGGGGAAAATGTGGCCACCACTGAAGTTGCTGATACAGTTGGACTGGTTGA TTTTGTCCAAGAAGTAAATGTTTATGGAGTGCATGTGCCAGATCATGAGGGTCGCATTGGCATGGCCTCCATCAAAATGAAAGAAAACCA TGAATTTGATGGAAAGAAACTCTTTCAGCACATTGCTGATTACCTACCTAGTTATGCAAGGCCCCGGTTTCTAAGAATACAGGACACCAT TGAGATCACTGGAACTTTTAAACACCGCAAAATGACCCTGGTGGAGGAGGGCTTTAACCCTGCTGTCATCAAAGATGCCTTGTATTTCTT GGATGACACAGCAAAAATGTATGTGCCTATGACTGAGGACATCTATAATGCCATAAGTGCTAAAACCCTGAAACTCTGAATATTCCCAGG AGGATAACTCAACATTTCCAGAAAGAAACTGAATGGACAGCCACTTGATATAATCCAACTTTAATTTGATTGAAGATTGTGAGGAAATTT TGTAGGAAATTTGCATACCCGTAAAGGGAGACTTTTTTAAATAACAGTTGAGTCTTTGCAAGTAAAAAGATTTAGAGATTATTATTTTTC AGTGTGCACCTACTGTTTGTATTTGCAAACTGAGCTTGTTGGAGGGAAGGCATTATTTTTTAAAATACTTAGTAAATTAAATGAACACCA >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_SLC27A2_ENST00000380902_chr15_50489697_+_2092nt GTGAGGATGTGCCGGGTGGTCCTTTCCTCCTCCTCTTCCTCCTCCTCCCGGCTCCCTGCCTAGTCTCCATATAAAAGCGGCGCCGCCTCC CCGCCCTCTCTCACTCCCCGCTCCTCTCCGCCGCGCACTCTCCGCGGCGCTGGGAGAGGGCGGAGGGGGAGGCGGCGCGCGGCGCCAGAG GAGGGGGGACGCAGGGGGCGGAGCGGAGACAGTACCTTCGGAGATAATCCTTTCTCCTGCCGCAGTGGAGAGGAGCGGCCGGAGCGAGAC ACTTCGCCGAGGCACAGCAGCCGGCAGGATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGC GGCGTCCACCTCGCCTAGCCTGTCGCACCGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCA CCTGCGGCGTGCCATCGGCAACATCGAGCTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACT TTTTGTATCTCGACACTCTGCAAGATTCTCTCCTGAAGTCCCAGAACTACAAGCAGCTGTCGAAGAGATACTGCCAAGCCTTAAAAAAGA TGATGTGTCCATCTATTATGTGAGCAGAACTTCTAACACAGATGGGATTGACTCTTTCCTGGACAAAGTGGATGAAGTATCAACTGAACC TATCCCAGAGTCATGGAGGTCTGAAGTCACTTTTTCCACTCCTGCCTTATACATTTATACTTCTGGAACCACAGGTGCTACTCTTGCCTT GCGGACTAAATTTTCAGCCAGCCAGTTTTGGGATGACTGCAGAAAATACAACGTCACTGTCATTCAGTATATCGGTGAACTGCTTCGGTA TTTATGCAACTCACCACAGAAACCAAATGACCGTGATCATAAAGTGAGACTGGCACTGGGAAATGGCTTACGAGGAGATGTGTGGAGACA ATTTGTCAAGAGATTTGGGGACATATGCATCTATGAGTTCTATGCTGCCACTGAAGGCAATATTGGATTTATGAATTATGCGAGAAAAGT TGGTGCTGTTGGAAGAGTAAACTACCTACAGAAAAAAATCATAACTTATGACCTGATTAAATATGATGTGGAGAAAGATGAACCTGTCCG TGATGAAAATGGATATTGCGTCAGAGTTCCCAAAGGTGAAGTTGGACTTCTGGTTTGCAAAATCACACAACTTACACCATTTAATGGCTA TGCTGGAGCAAAGGCTCAGACAGAGAAGAAAAAACTGAGAGATGTCTTTAAGAAAGGAGACCTCTATTTCAACAGTGGAGATCTCTTAAT GGTTGACCATGAAAATTTCATCTATTTCCACGACAGAGTTGGAGATACATTCCGGTGGAAAGGGGAAAATGTGGCCACCACTGAAGTTGC TGATACAGTTGGACTGGTTGATTTTGTCCAAGAAGTAAATGTTTATGGAGTGCATGTGCCAGATCATGAGGGTCGCATTGGCATGGCCTC CATCAAAATGAAAGAAAACCATGAATTTGATGGAAAGAAACTCTTTCAGCACATTGCTGATTACCTACCTAGTTATGCAAGGCCCCGGTT TCTAAGAATACAGGACACCATTGAGATCACTGGAACTTTTAAACACCGCAAAATGACCCTGGTGGAGGAGGGCTTTAACCCTGCTGTCAT CAAAGATGCCTTGTATTTCTTGGATGACACAGCAAAAATGTATGTGCCTATGACTGAGGACATCTATAATGCCATAAGTGCTAAAACCCT GAAACTCTGAATATTCCCAGGAGGATAACTCAACATTTCCAGAAAGAAACTGAATGGACAGCCACTTGATATAATCCAACTTTAATTTGA TTGAAGATTGTGAGGAAATTTTGTAGGAAATTTGCATACCCGTAAAGGGAGACTTTTTTAAATAACAGTTGAGTCTTTGCAAGTAAAAAG ATTTAGAGATTATTATTTTTCAGTGTGCACCTACTGTTTGTATTTGCAAACTGAGCTTGTTGGAGGGAAGGCATTATTTTTTAAAATACT |
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FusionGenePPI for MAP1B_SLC27A2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAP1B | ANP32A, RASSF1, GAN, SNCA, MAG, RAE1, AMBRA1, ATG10, ATG12, ATG3, MAP1LC3A, MAP1LC3B, PRKAG2, RASSF5, STK4, HDAC5, ARRB1, ARRB2, SIRT7, SPP1, PINK1, MARCH5, CUL3, ACTN1, LRRK2, PARK7, EIF4A3, MAGOH, SMURF1, IQCB1, PAN2, NPM1, EEF1D, FOS, STK3, CUL7, CCDC8, EED, PPT1, ABCE1, FBXW11, MLF1, DBF4B, CRYAB, HSPB6, MAP1S, RASSF3, WHSC1, SFN, NTRK1, MED4, CACNA1B, CACNA1A, FOXK2, ALKBH3, ATOH1, CYLD, RUVBL2 | SLC27A2 | NCSTN, SDHA, PEX5, ABCD1, PEX14, CALR, YWHAQ, TSPAN5, HPS1, EID3, HAUS7, SLC39A4, SMPD1, LPCAT1, PRKCSH, FAM63B, PNPLA3, FAM177A1, CCNB1, KPNB1, SLC33A1, CTDSPL2, FAM134A, SPC24, RANBP6, PPP6R2, SCGB2A2, ARMC6, BCL2L2, EXOC8, CNPPD1, DFNA5, UNC45A, ATP6V0D1, FAM73B, EIF2B2, MRPL34, HEATR1, BZW2, ROPN1, UBC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP1B_SLC27A2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP1B_SLC27A2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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