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Fusion gene ID: 20784 |
FusionGeneSummary for MAP1B_PTCD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP1B_PTCD2 | Fusion gene ID: 20784 | Hgene | Tgene | Gene symbol | MAP1B | PTCD2 | Gene ID | 4131 | 79810 |
| Gene name | microtubule associated protein 1B | pentatricopeptide repeat domain 2 | |
| Synonyms | FUTSCH|MAP5|PPP1R102 | - | |
| Cytomap | 5q13.2 | 5q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | microtubule-associated protein 1Bprotein phosphatase 1, regulatory subunit 102 | pentatricopeptide repeat-containing protein 2, mitochondrialCTC-365E16.1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P46821 | Q8WV60 | |
| Ensembl transtripts involved in fusion gene | ENST00000296755, ENST00000504183, | ENST00000380639, ENST00000543322, ENST00000503868, ENST00000536805, ENST00000460837, | |
| Fusion gene scores | * DoF score | 9 X 8 X 5=360 | 2 X 2 X 2=8 |
| # samples | 11 | 2 | |
| ** MAII score | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: MAP1B [Title/Abstract] AND PTCD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP1B | GO:0009987 | cellular process | 19567321 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-85-6798-01A | MAP1B | chr5 | 71411626 | + | PTCD2 | chr5 | 71617999 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000296755 | ENST00000380639 | MAP1B | chr5 | 71411626 | + | PTCD2 | chr5 | 71617999 | + |
| In-frame | ENST00000296755 | ENST00000543322 | MAP1B | chr5 | 71411626 | + | PTCD2 | chr5 | 71617999 | + |
| In-frame | ENST00000296755 | ENST00000503868 | MAP1B | chr5 | 71411626 | + | PTCD2 | chr5 | 71617999 | + |
| 5CDS-5UTR | ENST00000296755 | ENST00000536805 | MAP1B | chr5 | 71411626 | + | PTCD2 | chr5 | 71617999 | + |
| 5CDS-intron | ENST00000296755 | ENST00000460837 | MAP1B | chr5 | 71411626 | + | PTCD2 | chr5 | 71617999 | + |
| 3UTR-3CDS | ENST00000504183 | ENST00000380639 | MAP1B | chr5 | 71411626 | + | PTCD2 | chr5 | 71617999 | + |
| 3UTR-3CDS | ENST00000504183 | ENST00000543322 | MAP1B | chr5 | 71411626 | + | PTCD2 | chr5 | 71617999 | + |
| 3UTR-3CDS | ENST00000504183 | ENST00000503868 | MAP1B | chr5 | 71411626 | + | PTCD2 | chr5 | 71617999 | + |
| 3UTR-5UTR | ENST00000504183 | ENST00000536805 | MAP1B | chr5 | 71411626 | + | PTCD2 | chr5 | 71617999 | + |
| 3UTR-intron | ENST00000504183 | ENST00000460837 | MAP1B | chr5 | 71411626 | + | PTCD2 | chr5 | 71617999 | + |
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FusionProtFeatures for MAP1B_PTCD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP1B | PTCD2 |
| Facilitates tyrosination of alpha-tubulin in neuronalmicrotubules (By similarity). Phosphorylated MAP1B may play a rolein the cytoskeletal changes that accompany neurite extension.Possibly MAP1B binds to at least two tubulin subunits in thepolymer, and this bridging of subunits might be involved innucleating microtubule polymerization and in stabilizingmicrotubules. Acts as a positive cofactor in DAPK1-mediatedautophagic vesicle formation and membrane blebbing. {ECO:0000250,ECO:0000269|PubMed:18195017}. | Involved in mitochondrial RNA maturation andmitochondrial respiratory chain function. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PTCD2 | chr5:71411626 | chr5:71617999 | ENST00000380639 | + | 0 | 10 | 166_200 | 42 | 389 | Repeat | Note=PPR |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MAP1B | chr5:71411626 | chr5:71617999 | ENST00000296755 | + | 2 | 7 | 589_790 | 95 | 2469 | Compositional bias | Note=Lys-rich (highly basic%2C contains many KKEE and KKEI/V repeats) |
| Hgene | >MAP1B | chr5:71411626 | chr5:71617999 | ENST00000296755 | + | 2 | 7 | 1878_1894 | 95 | 2469 | Repeat | Note=MAP1B 1 |
| Hgene | >MAP1B | chr5:71411626 | chr5:71617999 | ENST00000296755 | + | 2 | 7 | 1895_1911 | 95 | 2469 | Repeat | Note=MAP1B 2 |
| Hgene | >MAP1B | chr5:71411626 | chr5:71617999 | ENST00000296755 | + | 2 | 7 | 1912_1928 | 95 | 2469 | Repeat | Note=MAP1B 3 |
| Hgene | >MAP1B | chr5:71411626 | chr5:71617999 | ENST00000296755 | + | 2 | 7 | 1929_1945 | 95 | 2469 | Repeat | Note=MAP1B 4 |
| Hgene | >MAP1B | chr5:71411626 | chr5:71617999 | ENST00000296755 | + | 2 | 7 | 1946_1962 | 95 | 2469 | Repeat | Note=MAP1B 5 |
| Hgene | >MAP1B | chr5:71411626 | chr5:71617999 | ENST00000296755 | + | 2 | 7 | 1963_1979 | 95 | 2469 | Repeat | Note=MAP1B 6 |
| Hgene | >MAP1B | chr5:71411626 | chr5:71617999 | ENST00000296755 | + | 2 | 7 | 1997_2013 | 95 | 2469 | Repeat | Note=MAP1B 7 |
| Hgene | >MAP1B | chr5:71411626 | chr5:71617999 | ENST00000296755 | + | 2 | 7 | 2014_2030 | 95 | 2469 | Repeat | Note=MAP1B 8 |
| Hgene | >MAP1B | chr5:71411626 | chr5:71617999 | ENST00000296755 | + | 2 | 7 | 2031_2047 | 95 | 2469 | Repeat | Note=MAP1B 9 |
| Hgene | >MAP1B | chr5:71411626 | chr5:71617999 | ENST00000296755 | + | 2 | 7 | 2048_2064 | 95 | 2469 | Repeat | Note=MAP1B 10 |
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FusionGeneSequence for MAP1B_PTCD2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_PTCD2_ENST00000380639_chr5_71617999_+_442aa MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARF SPEVPAKRYLLTDNVVKLKEFQQKKVAVACNLSGTKETYFRNLKKKLTQNKLILKGELITLLHLCESRDHVELAKNVIYRYHAENKNFTL GEYKFGPLFVRLCYELDLEESAVELMKDQHLRGFFSDSTSFNILMDMLFIKGKYKSALQVLIEMKNQDVKFTKDTYVLAFAICYKLNSPE SFKICTTLREEALLKGEILSRRASCFAVALALNQNEMAKAVSIFSQIMNPESIACINLNIIIHIQSNMLENLIKTLKNAAEGNLSKFVKR >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_PTCD2_ENST00000543322_chr5_71617999_+_215aa MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARF SPEVPAKRYLLTDNVVKLKEFQQKKVAVACNLSGTKETYFRNLKKKLTQNKLILKGELITLLHLCESRDHVELAKNVIYRYHAENKNFTL >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_PTCD2_ENST00000503868_chr5_71617999_+_333aa MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARF SPEVPAKRYLLTDNVVKLKEFQQKKVAVACNLSGTKGALQVLIEMKNQDVKFTKDTYVLAFAICYKLNSPESFKICTTLREEALLKGEIL SRRASCFAVALALNQNEMAKAVSIFSQIMNPESIACINLNIIIHIQSNMLENLIKTLKNAAEGNLSKFVKRHVFSEEVLAKVREKVKDVP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_PTCD2_ENST00000380639_chr5_71617999_+_1326nt ATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGCGGCGTCCACCTCGCCTAGCCTGTCGCAC CGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCACCTGCGGCGTGCCATCGGCAACATCGAG CTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACTTTTTGTATCTCGACACTCTGCAAGATTC TCTCCTGAAGTCCCAGCTAAAAGATACCTACTTACAGATAATGTGGTGAAATTAAAAGAATTTCAACAAAAGAAAGTGGCTGTTGCATGT AATCTTTCTGGCACTAAAGAAACGTATTTTAGAAACTTGAAAAAGAAACTGACCCAGAACAAGCTCATCTTGAAGGGGGAGTTGATAACC TTACTACATTTGTGTGAGTCTCGGGACCATGTGGAACTGGCTAAAAATGTCATTTACAGGTACCATGCAGAGAACAAAAATTTCACTTTG GGGGAGTATAAATTTGGACCGCTTTTTGTGAGGTTGTGTTACGAGTTGGATCTCGAGGAATCTGCAGTGGAGCTCATGAAAGACCAGCAT TTACGAGGTTTCTTCTCAGACTCCACATCATTCAATATTTTGATGGATATGTTATTTATCAAAGGCAAATATAAAAGTGCTTTGCAAGTA TTGATAGAGATGAAAAACCAAGATGTGAAGTTCACCAAAGATACCTATGTTCTTGCTTTTGCAATTTGCTACAAACTGAATAGCCCTGAG TCTTTCAAAATCTGTACTACATTAAGAGAAGAAGCTCTACTCAAAGGAGAAATTCTCTCCAGGAGAGCATCCTGTTTCGCTGTGGCATTA GCTCTGAATCAGAATGAGATGGCAAAAGCTGTGTCCATTTTTTCTCAAATCATGAATCCAGAAAGCATAGCCTGCATTAATTTAAATATT ATAATCCATATCCAGTCAAATATGTTGGAAAACCTGATAAAGACTCTAAAAAATGCTGCAGAAGGAAATTTATCAAAATTTGTGAAAAGA CATGTGTTCTCGGAGGAAGTGCTGGCCAAAGTGAGGGAAAAAGTGAAGGATGTGCCTGCCCTTGTGGCCAAATTTGATGAGATCTATGGG ACACTGCACATCACTGGCCAGGTCACCACTGATTCTTTGGATGCTGTGCTCTGCCACACCCCCAGGGACAGGAAATCTCACACGTTGCTA >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_PTCD2_ENST00000543322_chr5_71617999_+_645nt ATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGCGGCGTCCACCTCGCCTAGCCTGTCGCAC CGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCACCTGCGGCGTGCCATCGGCAACATCGAG CTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACTTTTTGTATCTCGACACTCTGCAAGATTC TCTCCTGAAGTCCCAGCTAAAAGATACCTACTTACAGATAATGTGGTGAAATTAAAAGAATTTCAACAAAAGAAAGTGGCTGTTGCATGT AATCTTTCTGGCACTAAAGAAACGTATTTTAGAAACTTGAAAAAGAAACTGACCCAGAACAAGCTCATCTTGAAGGGGGAGTTGATAACC TTACTACATTTGTGTGAGTCTCGGGACCATGTGGAACTGGCTAAAAATGTCATTTACAGGTACCATGCAGAGAACAAAAATTTCACTTTG GGGGAGTATAAATTTGGACCGCTTTTTGTGAGGTTGTGTTACGAGTTGGATCTCGAGGAATCTGCAGTGGAGCTCATGAAAGACCAGGTG >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_PTCD2_ENST00000503868_chr5_71617999_+_999nt ATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGCGGCGTCCACCTCGCCTAGCCTGTCGCAC CGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCACCTGCGGCGTGCCATCGGCAACATCGAG CTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACTTTTTGTATCTCGACACTCTGCAAGATTC TCTCCTGAAGTCCCAGCTAAAAGATACCTACTTACAGATAATGTGGTGAAATTAAAAGAATTTCAACAAAAGAAAGTGGCTGTTGCATGT AATCTTTCTGGCACTAAAGGTGCTTTGCAAGTATTGATAGAGATGAAAAACCAAGATGTGAAGTTCACCAAAGATACCTATGTTCTTGCT TTTGCAATTTGCTACAAACTGAATAGCCCTGAGTCTTTCAAAATCTGTACTACATTAAGAGAAGAAGCTCTACTCAAAGGAGAAATTCTC TCCAGGAGAGCATCCTGTTTCGCTGTGGCATTAGCTCTGAATCAGAATGAGATGGCAAAAGCTGTGTCCATTTTTTCTCAAATCATGAAT CCAGAAAGCATAGCCTGCATTAATTTAAATATTATAATCCATATCCAGTCAAATATGTTGGAAAACCTGATAAAGACTCTAAAAAATGCT GCAGAAGGAAATTTATCAAAATTTGTGAAAAGACATGTGTTCTCGGAGGAAGTGCTGGCCAAAGTGAGGGAAAAAGTGAAGGATGTGCCT GCCCTTGTGGCCAAATTTGATGAGATCTATGGGACACTGCACATCACTGGCCAGGTCACCACTGATTCTTTGGATGCTGTGCTCTGCCAC ACCCCCAGGGACAGGAAATCTCACACGTTGCTATTAAACAAGAGGATGGTCAGCCGTCGCACCTTCCAGCCACTCAGCCAGTCCCTGTTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_PTCD2_ENST00000380639_chr5_71617999_+_2492nt GTGAGGATGTGCCGGGTGGTCCTTTCCTCCTCCTCTTCCTCCTCCTCCCGGCTCCCTGCCTAGTCTCCATATAAAAGCGGCGCCGCCTCC CCGCCCTCTCTCACTCCCCGCTCCTCTCCGCCGCGCACTCTCCGCGGCGCTGGGAGAGGGCGGAGGGGGAGGCGGCGCGCGGCGCCAGAG GAGGGGGGACGCAGGGGGCGGAGCGGAGACAGTACCTTCGGAGATAATCCTTTCTCCTGCCGCAGTGGAGAGGAGCGGCCGGAGCGAGAC ACTTCGCCGAGGCACAGCAGCCGGCAGGATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGC GGCGTCCACCTCGCCTAGCCTGTCGCACCGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCA CCTGCGGCGTGCCATCGGCAACATCGAGCTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACT TTTTGTATCTCGACACTCTGCAAGATTCTCTCCTGAAGTCCCAGCTAAAAGATACCTACTTACAGATAATGTGGTGAAATTAAAAGAATT TCAACAAAAGAAAGTGGCTGTTGCATGTAATCTTTCTGGCACTAAAGAAACGTATTTTAGAAACTTGAAAAAGAAACTGACCCAGAACAA GCTCATCTTGAAGGGGGAGTTGATAACCTTACTACATTTGTGTGAGTCTCGGGACCATGTGGAACTGGCTAAAAATGTCATTTACAGGTA CCATGCAGAGAACAAAAATTTCACTTTGGGGGAGTATAAATTTGGACCGCTTTTTGTGAGGTTGTGTTACGAGTTGGATCTCGAGGAATC TGCAGTGGAGCTCATGAAAGACCAGCATTTACGAGGTTTCTTCTCAGACTCCACATCATTCAATATTTTGATGGATATGTTATTTATCAA AGGCAAATATAAAAGTGCTTTGCAAGTATTGATAGAGATGAAAAACCAAGATGTGAAGTTCACCAAAGATACCTATGTTCTTGCTTTTGC AATTTGCTACAAACTGAATAGCCCTGAGTCTTTCAAAATCTGTACTACATTAAGAGAAGAAGCTCTACTCAAAGGAGAAATTCTCTCCAG GAGAGCATCCTGTTTCGCTGTGGCATTAGCTCTGAATCAGAATGAGATGGCAAAAGCTGTGTCCATTTTTTCTCAAATCATGAATCCAGA AAGCATAGCCTGCATTAATTTAAATATTATAATCCATATCCAGTCAAATATGTTGGAAAACCTGATAAAGACTCTAAAAAATGCTGCAGA AGGAAATTTATCAAAATTTGTGAAAAGACATGTGTTCTCGGAGGAAGTGCTGGCCAAAGTGAGGGAAAAAGTGAAGGATGTGCCTGCCCT TGTGGCCAAATTTGATGAGATCTATGGGACACTGCACATCACTGGCCAGGTCACCACTGATTCTTTGGATGCTGTGCTCTGCCACACCCC CAGGGACAGGAAATCTCACACGTTGCTATTAAACAAGAGGATGGTCAGCCGTCGCACCTTCCAGCCACTCAGCCAGTCCCTGTTGGCTGA GTAACCCTGGTTTCAGTCCACCTATGGATCTGAGGGGCCTGCTTCTAGTGAGTTATTACCTTTCCTAAGAAGCCAGGTATCGCACTTCAG CAGACAGTGTGCTGACACTTGGTCTTCTCCTGAAATTCCCAAATTCACTGAATGGTACCATGCCGATCTCTGAGAAGTTATGTTGCACCA CTGTGAAGGTCTAGATGCAAGCTTGGCTCCCTCAGAAAGGCGCTTCCCTTTTGCATGGCTGAGGATCCTTGAAGGAACCTGGTCAGTCTC CGGTTCAGCTTCCGACACCAGAGTGGAACCCAGTAAGCACCATCAGGAATGAATTTCACTACAAGTGTGGATAACTCTGATTTTCAAAGG AGTAGTTACTTGCAAATTACATCCTTGCTGAATTCAGGAGGTATGAAACCCTATTTTACCATGTTAGAAAACAGCCCAGGATTTTCTCAT TGCTCTGCCATCATATATGTCTATGACTTGAGCCCTTATTTTTCCATCTGCAAAACAATAATGCCTATGTGTCTTTGCATATAGATTTGA AATCTTCATTCAAGGTTTAGTAGGATCATATTTTCTCAAAAATAAGAGAAATAAGGTTCATAAGGAAACTTGCTGGGATTGTGGTTGTTT TGTTTTCTCAGCAGCACAAACAAAACCAGAATTTAGCCTTTAGGACTGCTGAGTAAGCCAAATTTAAATGACTACTGCTTTGTTCATGGG TAAGCCATGTGCTTTTCAAAATAAGTGCCACTAAAAACCACATAATGCTTTGGTTTCTATGTGGATAATAAATATTTAGTCCTATAGTTT >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_PTCD2_ENST00000543322_chr5_71617999_+_1336nt GTGAGGATGTGCCGGGTGGTCCTTTCCTCCTCCTCTTCCTCCTCCTCCCGGCTCCCTGCCTAGTCTCCATATAAAAGCGGCGCCGCCTCC CCGCCCTCTCTCACTCCCCGCTCCTCTCCGCCGCGCACTCTCCGCGGCGCTGGGAGAGGGCGGAGGGGGAGGCGGCGCGCGGCGCCAGAG GAGGGGGGACGCAGGGGGCGGAGCGGAGACAGTACCTTCGGAGATAATCCTTTCTCCTGCCGCAGTGGAGAGGAGCGGCCGGAGCGAGAC ACTTCGCCGAGGCACAGCAGCCGGCAGGATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGC GGCGTCCACCTCGCCTAGCCTGTCGCACCGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCA CCTGCGGCGTGCCATCGGCAACATCGAGCTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACT TTTTGTATCTCGACACTCTGCAAGATTCTCTCCTGAAGTCCCAGCTAAAAGATACCTACTTACAGATAATGTGGTGAAATTAAAAGAATT TCAACAAAAGAAAGTGGCTGTTGCATGTAATCTTTCTGGCACTAAAGAAACGTATTTTAGAAACTTGAAAAAGAAACTGACCCAGAACAA GCTCATCTTGAAGGGGGAGTTGATAACCTTACTACATTTGTGTGAGTCTCGGGACCATGTGGAACTGGCTAAAAATGTCATTTACAGGTA CCATGCAGAGAACAAAAATTTCACTTTGGGGGAGTATAAATTTGGACCGCTTTTTGTGAGGTTGTGTTACGAGTTGGATCTCGAGGAATC TGCAGTGGAGCTCATGAAAGACCAGGTGCTTTGCAAGTATTGATAGAGATGAAAAACCAAGATGTGAAGTTCACCAAAGATACCTATGTT CTTGCTTTTGCAATTTGCTACAAACTGAATAGCCCTGAGTCTTTCAAAATCTGTACTACATTAAGAGAAGAAGCTCTACTCAAAGGAGAA ATTCTCTCCAGGAGAGCATCCTGTTTCGCTGTGGCATTAGCTCTGAATCAGAATGAGATGGCAAAAGCTGTGTCCATTTTTTCTCAAATC ATGAATCCAGAAAGCATAGCCTGCATTAATTTAAATATTATAATCCATATCCAGTCAAATATGTTGGAAAACCTGATAAAGACTCTAAAA >In-frame_MAP1B_ENST00000296755_chr5_71411626_+_PTCD2_ENST00000503868_chr5_71617999_+_2103nt GTGAGGATGTGCCGGGTGGTCCTTTCCTCCTCCTCTTCCTCCTCCTCCCGGCTCCCTGCCTAGTCTCCATATAAAAGCGGCGCCGCCTCC CCGCCCTCTCTCACTCCCCGCTCCTCTCCGCCGCGCACTCTCCGCGGCGCTGGGAGAGGGCGGAGGGGGAGGCGGCGCGCGGCGCCAGAG GAGGGGGGACGCAGGGGGCGGAGCGGAGACAGTACCTTCGGAGATAATCCTTTCTCCTGCCGCAGTGGAGAGGAGCGGCCGGAGCGAGAC ACTTCGCCGAGGCACAGCAGCCGGCAGGATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGC GGCGTCCACCTCGCCTAGCCTGTCGCACCGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCA CCTGCGGCGTGCCATCGGCAACATCGAGCTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACT TTTTGTATCTCGACACTCTGCAAGATTCTCTCCTGAAGTCCCAGCTAAAAGATACCTACTTACAGATAATGTGGTGAAATTAAAAGAATT TCAACAAAAGAAAGTGGCTGTTGCATGTAATCTTTCTGGCACTAAAGGTGCTTTGCAAGTATTGATAGAGATGAAAAACCAAGATGTGAA GTTCACCAAAGATACCTATGTTCTTGCTTTTGCAATTTGCTACAAACTGAATAGCCCTGAGTCTTTCAAAATCTGTACTACATTAAGAGA AGAAGCTCTACTCAAAGGAGAAATTCTCTCCAGGAGAGCATCCTGTTTCGCTGTGGCATTAGCTCTGAATCAGAATGAGATGGCAAAAGC TGTGTCCATTTTTTCTCAAATCATGAATCCAGAAAGCATAGCCTGCATTAATTTAAATATTATAATCCATATCCAGTCAAATATGTTGGA AAACCTGATAAAGACTCTAAAAAATGCTGCAGAAGGAAATTTATCAAAATTTGTGAAAAGACATGTGTTCTCGGAGGAAGTGCTGGCCAA AGTGAGGGAAAAAGTGAAGGATGTGCCTGCCCTTGTGGCCAAATTTGATGAGATCTATGGGACACTGCACATCACTGGCCAGGTCACCAC TGATTCTTTGGATGCTGTGCTCTGCCACACCCCCAGGGACAGGAAATCTCACACGTTGCTATTAAACAAGAGGATGGTCAGCCGTCGCAC CTTCCAGCCACTCAGCCAGTCCCTGTTGGCTGAGTAACCCTGGTTTCAGTCCACCTATGGATCTGAGGGGCCTGCTTCTAGTGAGTTATT ACCTTTCCTAAGAAGCCAGGTATCGCACTTCAGCAGACAGTGTGCTGACACTTGGTCTTCTCCTGAAATTCCCAAATTCACTGAATGGTA CCATGCCGATCTCTGAGAAGTTATGTTGCACCACTGTGAAGGTCTAGATGCAAGCTTGGCTCCCTCAGAAAGGCGCTTCCCTTTTGCATG GCTGAGGATCCTTGAAGGAACCTGGTCAGTCTCCGGTTCAGCTTCCGACACCAGAGTGGAACCCAGTAAGCACCATCAGGAATGAATTTC ACTACAAGTGTGGATAACTCTGATTTTCAAAGGAGTAGTTACTTGCAAATTACATCCTTGCTGAATTCAGGAGGTATGAAACCCTATTTT ACCATGTTAGAAAACAGCCCAGGATTTTCTCATTGCTCTGCCATCATATATGTCTATGACTTGAGCCCTTATTTTTCCATCTGCAAAACA ATAATGCCTATGTGTCTTTGCATATAGATTTGAAATCTTCATTCAAGGTTTAGTAGGATCATATTTTCTCAAAAATAAGAGAAATAAGGT TCATAAGGAAACTTGCTGGGATTGTGGTTGTTTTGTTTTCTCAGCAGCACAAACAAAACCAGAATTTAGCCTTTAGGACTGCTGAGTAAG CCAAATTTAAATGACTACTGCTTTGTTCATGGGTAAGCCATGTGCTTTTCAAAATAAGTGCCACTAAAAACCACATAATGCTTTGGTTTC |
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FusionGenePPI for MAP1B_PTCD2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAP1B | ANP32A, RASSF1, GAN, SNCA, MAG, RAE1, AMBRA1, ATG10, ATG12, ATG3, MAP1LC3A, MAP1LC3B, PRKAG2, RASSF5, STK4, HDAC5, ARRB1, ARRB2, SIRT7, SPP1, PINK1, MARCH5, CUL3, ACTN1, LRRK2, PARK7, EIF4A3, MAGOH, SMURF1, IQCB1, PAN2, NPM1, EEF1D, FOS, STK3, CUL7, CCDC8, EED, PPT1, ABCE1, FBXW11, MLF1, DBF4B, CRYAB, HSPB6, MAP1S, RASSF3, WHSC1, SFN, NTRK1, MED4, CACNA1B, CACNA1A, FOXK2, ALKBH3, ATOH1, CYLD, RUVBL2 | PTCD2 | MID2, TRIM32, MOV10, NXF1, SLAMF7, SLAMF1, HLA-E, VSIG4, GTF2A1, VTN, SALL2, NTRK3, CDH8, CLEC14A, APP, LRP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP1B_PTCD2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP1B_PTCD2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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