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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20781

FusionGeneSummary for MAP1B_CACNA1C

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP1B_CACNA1C
Fusion gene ID: 20781
HgeneTgene
Gene symbol

MAP1B

CACNA1C

Gene ID

4131

775

Gene namemicrotubule associated protein 1Bcalcium voltage-gated channel subunit alpha1 C
SynonymsFUTSCH|MAP5|PPP1R102CACH2|CACN2|CACNL1A1|CCHL1A1|CaV1.2|LQT8|TS
Cytomap

5q13.2

12p13.33

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated protein 1Bprotein phosphatase 1, regulatory subunit 102voltage-dependent L-type calcium channel subunit alpha-1CDHPR, alpha-1 subunitcalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac musclecalcium channel, cardic dihydropyridine-sensitive, alpha-1 subunitcalcium channel, voltage-dependent,
Modification date2018052320180523
UniProtAcc

P46821

Q13936

Ensembl transtripts involved in fusion geneENST00000296755, ENST00000504183, 
ENST00000335762, ENST00000399655, 
ENST00000480911, ENST00000399644, 
ENST00000344100, ENST00000399638, 
ENST00000399629, ENST00000399597, 
ENST00000327702, ENST00000399621, 
ENST00000399649, ENST00000399637, 
ENST00000402845, ENST00000399591, 
ENST00000399641, ENST00000347598, 
ENST00000399606, ENST00000399595, 
ENST00000399601, ENST00000399603, 
ENST00000399634, ENST00000399617, 
ENST00000406454, ENST00000491104, 
Fusion gene scores* DoF score9 X 8 X 5=36015 X 14 X 8=1680
# samples 1117
** MAII scorelog2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1680*10)=-3.30485458152842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP1B [Title/Abstract] AND CACNA1C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP1B

GO:0009987

cellular process

19567321

TgeneCACNA1C

GO:0007204

positive regulation of cytosolic calcium ion concentration

12130699

TgeneCACNA1C

GO:0061577

calcium ion transmembrane transport via high voltage-gated calcium channel

15454078

TgeneCACNA1C

GO:0070588

calcium ion transmembrane transport

15454078


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF960613MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296755ENST00000335762MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-3UTRENST00000296755ENST00000399655MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000480911MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399644MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000344100MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399638MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399629MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399597MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000327702MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399621MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399649MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399637MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000402845MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399591MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399641MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000347598MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399606MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399595MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399601MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399603MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399634MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000399617MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000406454MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
5CDS-intronENST00000296755ENST00000491104MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000335762MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-3UTRENST00000504183ENST00000399655MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000480911MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399644MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000344100MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399638MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399629MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399597MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000327702MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399621MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399649MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399637MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000402845MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399591MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399641MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000347598MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399606MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399595MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399601MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399603MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399634MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000399617MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000406454MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-
intron-intronENST00000504183ENST00000491104MAP1Bchr5

71490371

+CACNA1Cchr12

2801390

-

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FusionProtFeatures for MAP1B_CACNA1C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP1B

P46821

CACNA1C

Q13936

Facilitates tyrosination of alpha-tubulin in neuronalmicrotubules (By similarity). Phosphorylated MAP1B may play a rolein the cytoskeletal changes that accompany neurite extension.Possibly MAP1B binds to at least two tubulin subunits in thepolymer, and this bridging of subunits might be involved innucleating microtubule polymerization and in stabilizingmicrotubules. Acts as a positive cofactor in DAPK1-mediatedautophagic vesicle formation and membrane blebbing. {ECO:0000250,ECO:0000269|PubMed:18195017}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP1B_CACNA1C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP1B_CACNA1C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP1B_CACNA1C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCACNA1CQ13936DB00308IbutilideVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB00401NisoldipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB00898EthanolVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB04855DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB09089TrimebutineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB09227BarnidipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB00270IsradipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB00393NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB00568CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB00622NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB01023FelodipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB01054NitrendipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB04920ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB06712NilvadipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB06751DrotaverineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB09231BenidipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB09232CilnidipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB09236LacidipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB09238ManidipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB11633IsavuconazoleVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational|vet_approved
TgeneCACNA1CQ13936DB01373CalciumVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|nutraceutical

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RelatedDiseases for MAP1B_CACNA1C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCACNA1CC0005586Bipolar Disorder8CTD_human;PSYGENET
TgeneCACNA1CC1832916Timothy syndrome6CTD_human;ORPHANET;UNIPROT
TgeneCACNA1CC0011570Mental Depression5PSYGENET
TgeneCACNA1CC0011581Depressive disorder5PSYGENET
TgeneCACNA1CC0041696Unipolar Depression5PSYGENET
TgeneCACNA1CC0525045Mood Disorders5PSYGENET
TgeneCACNA1CC1269683Major Depressive Disorder5PSYGENET
TgeneCACNA1CC0036341Schizophrenia4PSYGENET
TgeneCACNA1CC0033975Psychotic Disorders3PSYGENET
TgeneCACNA1CC0178417Anhedonia2PSYGENET
TgeneCACNA1CC0003811Cardiac Arrhythmia1CTD_human
TgeneCACNA1CC0004352Autistic Disorder1CTD_human
TgeneCACNA1CC0020538Hypertensive disease1CTD_human
TgeneCACNA1CC0020615Hypoglycemia1CTD_human
TgeneCACNA1CC0021051Immunologic Deficiency Syndromes1CTD_human
TgeneCACNA1CC0206762Limb Deformities, Congenital1CTD_human
TgeneCACNA1CC0349204Nonorganic psychosis1PSYGENET
TgeneCACNA1CC2678478Brugada Syndrome 31CTD_human;UNIPROT