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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20763

FusionGeneSummary for MAN2B2_TP63

check button Fusion gene summary
Fusion gene informationFusion gene name: MAN2B2_TP63
Fusion gene ID: 20763
HgeneTgene
Gene symbol

MAN2B2

TP63

Gene ID

23324

8626

Gene namemannosidase alpha class 2B member 2tumor protein p63
Synonyms-AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L
Cytomap

4p16.1

3q28

Type of geneprotein-codingprotein-coding
Descriptionepididymis-specific alpha-mannosidasecore-specific lysosomal alpha-1,6-Mannosidasetumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing protein
Modification date2018052320180521
UniProtAcc

Q9Y2E5

Q9H3D4

Ensembl transtripts involved in fusion geneENST00000285599, ENST00000504248, 
ENST00000504960, 		ENST00000264731, 
ENST00000382063, ENST00000418709, 
ENST00000320472, ENST00000392460, 
ENST00000440651, ENST00000354600, 
ENST00000437221, ENST00000392463, 
ENST00000392461, ENST00000456148, 
ENST00000449992, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 5 X 4=120
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAN2B2 [Title/Abstract] AND TP63 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTP63

GO:0045747

positive regulation of Notch signaling pathway

11641404

TgeneTP63

GO:0045892

negative regulation of transcription, DNA-templated

12446784

TgeneTP63

GO:0045893

positive regulation of transcription, DNA-templated

12446784|16343436

TgeneTP63

GO:0045944

positive regulation of transcription by RNA polymerase II

22521434

TgeneTP63

GO:2000271

positive regulation of fibroblast apoptotic process

9774969


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ331863MAN2B2chr4

6594897

-TP63chr3

189578930

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000285599ENST00000264731MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000285599ENST00000382063MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000285599ENST00000418709MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000285599ENST00000320472MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000285599ENST00000392460MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000285599ENST00000440651MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000285599ENST00000354600MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000285599ENST00000437221MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000285599ENST00000392463MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000285599ENST00000392461MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000285599ENST00000456148MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000285599ENST00000449992MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504248ENST00000264731MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504248ENST00000382063MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504248ENST00000418709MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504248ENST00000320472MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504248ENST00000392460MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504248ENST00000440651MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504248ENST00000354600MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504248ENST00000437221MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504248ENST00000392463MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504248ENST00000392461MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504248ENST00000456148MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504248ENST00000449992MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504960ENST00000264731MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504960ENST00000382063MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504960ENST00000418709MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504960ENST00000320472MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504960ENST00000392460MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504960ENST00000440651MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504960ENST00000354600MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504960ENST00000437221MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504960ENST00000392463MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504960ENST00000392461MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504960ENST00000456148MAN2B2chr4

6594897

-TP63chr3

189578930

+
intron-intronENST00000504960ENST00000449992MAN2B2chr4

6594897

-TP63chr3

189578930

+

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FusionProtFeatures for MAN2B2_TP63


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAN2B2

Q9Y2E5

TP63

Q9H3D4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAN2B2_TP63


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAN2B2_TP63


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAN2B2_TP63


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAN2B2_TP63


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTP63C1785148RAPP-HODGKIN SYNDROME6CTD_human;ORPHANET;UNIPROT
TgeneTP63C1858562ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 35CTD_human;UNIPROT
TgeneTP63C0406709Hay-Wells syndrome3CTD_human;UNIPROT
TgeneTP63C0024121Lung Neoplasms2CTD_human
TgeneTP63C1854442SPLIT-HAND/FOOT MALFORMATION 42CTD_human;UNIPROT
TgeneTP63C0001418Adenocarcinoma1CTD_human
TgeneTP63C0006145Breast Diseases1CTD_human
TgeneTP63C0007137Squamous cell carcinoma1CTD_human
TgeneTP63C0007621Neoplastic Cell Transformation1CTD_human
TgeneTP63C0008924Cleft Lip1CTD_human;HPO;ORPHANET
TgeneTP63C0008925Cleft Palate1CTD_human;HPO
TgeneTP63C0009404Colorectal Neoplasms1CTD_human
TgeneTP63C0016508Congenital Foot Deformity1CTD_human
TgeneTP63C0018566Congenital Hand Deformities1CTD_human
TgeneTP63C0027627Neoplasm Metastasis1CTD_human
TgeneTP63C0030297Pancreatic Neoplasm1CTD_human
TgeneTP63C0037268Skin Abnormalities1CTD_human
TgeneTP63C0038987Sweat Gland Neoplasms1CTD_human
TgeneTP63C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneTP63C0206720Squamous Cell Neoplasms1CTD_human
TgeneTP63C0206762Limb Deformities, Congenital1CTD_human
TgeneTP63C0376634Craniofacial Abnormalities1CTD_human
TgeneTP63C0406704Rudiger syndrome 11CTD_human;ORPHANET
TgeneTP63C0919267ovarian neoplasm1CTD_human
TgeneTP63C1720887Female Urogenital Diseases1CTD_human
TgeneTP63C1863204ADULT SYNDROME1CTD_human;ORPHANET;UNIPROT
TgeneTP63C1863753LIMB-MAMMARY SYNDROME1CTD_human;ORPHANET