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Fusion gene ID: 20763 |
FusionGeneSummary for MAN2B2_TP63 |
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Fusion gene information | Fusion gene name: MAN2B2_TP63 | Fusion gene ID: 20763 | Hgene | Tgene | Gene symbol | MAN2B2 | TP63 | Gene ID | 23324 | 8626 |
Gene name | mannosidase alpha class 2B member 2 | tumor protein p63 | |
Synonyms | - | AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L | |
Cytomap | 4p16.1 | 3q28 | |
Type of gene | protein-coding | protein-coding | |
Description | epididymis-specific alpha-mannosidasecore-specific lysosomal alpha-1,6-Mannosidase | tumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing protein | |
Modification date | 20180523 | 20180521 | |
UniProtAcc | Q9Y2E5 | Q9H3D4 | |
Ensembl transtripts involved in fusion gene | ENST00000285599, ENST00000504248, ENST00000504960, | ENST00000264731, ENST00000382063, ENST00000418709, ENST00000320472, ENST00000392460, ENST00000440651, ENST00000354600, ENST00000437221, ENST00000392463, ENST00000392461, ENST00000456148, ENST00000449992, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 5 X 4=120 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAN2B2 [Title/Abstract] AND TP63 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TP63 | GO:0045747 | positive regulation of Notch signaling pathway | 11641404 |
Tgene | TP63 | GO:0045892 | negative regulation of transcription, DNA-templated | 12446784 |
Tgene | TP63 | GO:0045893 | positive regulation of transcription, DNA-templated | 12446784|16343436 |
Tgene | TP63 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22521434 |
Tgene | TP63 | GO:2000271 | positive regulation of fibroblast apoptotic process | 9774969 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ331863 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000285599 | ENST00000264731 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000285599 | ENST00000382063 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000285599 | ENST00000418709 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000285599 | ENST00000320472 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000285599 | ENST00000392460 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000285599 | ENST00000440651 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000285599 | ENST00000354600 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000285599 | ENST00000437221 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000285599 | ENST00000392463 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000285599 | ENST00000392461 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000285599 | ENST00000456148 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000285599 | ENST00000449992 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504248 | ENST00000264731 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504248 | ENST00000382063 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504248 | ENST00000418709 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504248 | ENST00000320472 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504248 | ENST00000392460 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504248 | ENST00000440651 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504248 | ENST00000354600 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504248 | ENST00000437221 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504248 | ENST00000392463 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504248 | ENST00000392461 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504248 | ENST00000456148 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504248 | ENST00000449992 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504960 | ENST00000264731 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504960 | ENST00000382063 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504960 | ENST00000418709 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504960 | ENST00000320472 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504960 | ENST00000392460 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504960 | ENST00000440651 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504960 | ENST00000354600 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504960 | ENST00000437221 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504960 | ENST00000392463 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504960 | ENST00000392461 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504960 | ENST00000456148 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
intron-intron | ENST00000504960 | ENST00000449992 | MAN2B2 | chr4 | 6594897 | - | TP63 | chr3 | 189578930 | + |
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FusionProtFeatures for MAN2B2_TP63 |
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Hgene | Tgene |
MAN2B2 | TP63 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAN2B2_TP63 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAN2B2_TP63 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAN2B2_TP63 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAN2B2_TP63 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TP63 | C1785148 | RAPP-HODGKIN SYNDROME | 6 | CTD_human;ORPHANET;UNIPROT |
Tgene | TP63 | C1858562 | ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 3 | 5 | CTD_human;UNIPROT |
Tgene | TP63 | C0406709 | Hay-Wells syndrome | 3 | CTD_human;UNIPROT |
Tgene | TP63 | C0024121 | Lung Neoplasms | 2 | CTD_human |
Tgene | TP63 | C1854442 | SPLIT-HAND/FOOT MALFORMATION 4 | 2 | CTD_human;UNIPROT |
Tgene | TP63 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | TP63 | C0006145 | Breast Diseases | 1 | CTD_human |
Tgene | TP63 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Tgene | TP63 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Tgene | TP63 | C0008924 | Cleft Lip | 1 | CTD_human;HPO;ORPHANET |
Tgene | TP63 | C0008925 | Cleft Palate | 1 | CTD_human;HPO |
Tgene | TP63 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | TP63 | C0016508 | Congenital Foot Deformity | 1 | CTD_human |
Tgene | TP63 | C0018566 | Congenital Hand Deformities | 1 | CTD_human |
Tgene | TP63 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | TP63 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
Tgene | TP63 | C0037268 | Skin Abnormalities | 1 | CTD_human |
Tgene | TP63 | C0038987 | Sweat Gland Neoplasms | 1 | CTD_human |
Tgene | TP63 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Tgene | TP63 | C0206720 | Squamous Cell Neoplasms | 1 | CTD_human |
Tgene | TP63 | C0206762 | Limb Deformities, Congenital | 1 | CTD_human |
Tgene | TP63 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Tgene | TP63 | C0406704 | Rudiger syndrome 1 | 1 | CTD_human;ORPHANET |
Tgene | TP63 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Tgene | TP63 | C1720887 | Female Urogenital Diseases | 1 | CTD_human |
Tgene | TP63 | C1863204 | ADULT SYNDROME | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | TP63 | C1863753 | LIMB-MAMMARY SYNDROME | 1 | CTD_human;ORPHANET |