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Fusion gene ID: 20753 |
FusionGeneSummary for MAN2A1_HSPA4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAN2A1_HSPA4 | Fusion gene ID: 20753 | Hgene | Tgene | Gene symbol | MAN2A1 | HSPA4 | Gene ID | 4124 | 3308 |
| Gene name | mannosidase alpha class 2A member 1 | heat shock protein family A (Hsp70) member 4 | |
| Synonyms | AMan II|GOLIM7|MANA2|MANII | APG-2|HEL-S-5a|HS24/P52|HSPH2|RY|hsp70|hsp70RY | |
| Cytomap | 5q21.3 | 5q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-mannosidase 2Golgi alpha-mannosidase IIgolgi integral membrane protein 7mannosidase, alpha type IImannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase | heat shock 70 kDa protein 4epididymis secretory sperm binding protein Li 5aheat shock 70-related protein APG-2heat shock 70kD protein 4heat shock 70kDa protein 4heat shock protein, 110 kDahsp70 RY | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q16706 | P34932 | |
| Ensembl transtripts involved in fusion gene | ENST00000261483, ENST00000505313, | ENST00000304858, ENST00000504328, | |
| Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 3 X 5 X 2=30 |
| # samples | 6 | 6 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAN2A1 [Title/Abstract] AND HSPA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HSPA4 | GO:0045040 | protein import into mitochondrial outer membrane | 15644312 |
| Tgene | HSPA4 | GO:0051131 | chaperone-mediated protein complex assembly | 15644312 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-4Z-AA84-01A | MAN2A1 | chr5 | 109117299 | + | HSPA4 | chr5 | 132435237 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000261483 | ENST00000304858 | MAN2A1 | chr5 | 109117299 | + | HSPA4 | chr5 | 132435237 | + |
| 5CDS-intron | ENST00000261483 | ENST00000504328 | MAN2A1 | chr5 | 109117299 | + | HSPA4 | chr5 | 132435237 | + |
| intron-3CDS | ENST00000505313 | ENST00000304858 | MAN2A1 | chr5 | 109117299 | + | HSPA4 | chr5 | 132435237 | + |
| intron-intron | ENST00000505313 | ENST00000504328 | MAN2A1 | chr5 | 109117299 | + | HSPA4 | chr5 | 132435237 | + |
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FusionProtFeatures for MAN2A1_HSPA4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAN2A1 | HSPA4 |
| Catalyzes the first committed step in the biosynthesisof complex N-glycans. It controls conversion of high mannose tocomplex N-glycans; the final hydrolytic step in the N-glycanmaturation pathway. {ECO:0000250|UniProtKB:P28494}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAN2A1_HSPA4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAN2A1_HSPA4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAN2A1 | CD55, FLOT1, TMED9, SEC23B, PLAUR, PTCH1, PTPRK, NAAA, CAPN1, NUDT9, FUT8, SCGB2A2, MGAT4C, LYZL2, EDEM3, TRIM25 | HSPA4 | MAP3K3, VIMP, MARK4, BAG4, NCOR1, DNMBP, TTC1, HSPBP1, DNAJB1, CHTF18, HCFC1, HDAC2, HDAC1, HDAC3, ESR1, FES, HSF1, CDC73, PRSS23, NQO1, SGTA, APAF1, STIP1, KRT18, DNAJC3, IRS4, STUB1, HSBP1, BAG1, HNRNPD, PARK2, TP53, GUCY1A2, H2AFY, ZMYM2, LIMK1, PRKCB, BCOR, PCGF1, ISG15, EGFR, VCP, HIF1A, HSP90AA1, RPS3, BAG2, AIMP2, KAT6A, PARK7, SUV420H2, NOS1, PPP5C, SOD1, CDK11B, RCOR1, MEN1, TELO2, TTI1, TTI2, TRAF6, MRGBP, MAPT, ENDOG, ABL1, TSSK6, BAG3, AKT1, VEGFA, AIRE, YY1, CTNNBL1, ERBB2, MORF4L1, MORF4L2, THRA, THRB, HES1, BCL3, WDR82, PPP1R10, TOX4, FANCC, DNMT1, BCL2L12, TERF1, TERF2, CDK5RAP3, TGFBR1, CUL5, COMMD1, APP, CBL, FGFR3, ERG, PRKAA1, APOBEC3G, MME, KCNQ1, HDAC5, FAM175A, MYOCD, MDM2, UBE3A, TERF2IP, PARD6G, RICTOR, SIRT1, SIRT3, EPAS1, FBXW8, RBBP6, AMFR, GBA, HAP1, CALM1, KPNA1, NTRK1, CD40, BAG5, SNCA, MAP3K5, PSMC2, TRIAP1, ATR, NBN, ZAP70, SSTR3, RELA, REL, NFKB1, KDM4B, LIN37, CTU1, TLR4, SIRT7, BLNK, ZFP36, NHLRC1, MKKS, ATXN1, DNAJB2, SGK1, CFTR, PINK1, FAF1, BCL2L11, MCL1, HUWE1, CUL1, CUL3, PSMD4, ASB9, KCNH2, PPP1CA, PPP1CB, PPP1CC, CRYAB, GSK3B, CSNK1A1, CSNK2A1, HOPX, CDK2, COPS5, NEDD8, PRNP, DNAJC5, MET, HDAC8, IKBKG, BRMS1, MYOC, IRAK1, RPTOR, TYRP1, ATG16L1, XIAP, SUGT1, DDIT4, WT1, FKBP5, DNAJC7, BAX, RHO, TARDBP, AIPL1, HSPA8, NUB1, LRRK2, PHLDA1, OPRD1, TUBG1, PIM1, GRK5, SMAD2, SMAD3, NOX5, PACRG, GPR37, TCP1, HSPA5, RPSA, HNRNPK, NLRP12, APTX, DUSP1, OLA1, CFAP52, GATA1, PLK1, GZMB, NOS2, METTL18, METTL21A, UBL4A, MTOR, NPM1, SMG1, RUVBL1, MAPK7, SQSTM1, UBE2L3, RAF1, RAD52, HDAC6, MGRN1, BCR, TOMM40, TERT, PPP6R1, CDKN2A, GZMA, CAND1, CRMP1, CARS, FAM114A1, GART, JMJD6, PPAT, SEC23A, XRCC5, HSPH1, JUP, KARS, PPM1G, RANBP6, TROVE2, WWOX, NDRG1, PA2G4, USP19, PRKCG, PRKCD, SIK2, VHL, MAP3K11, UIMC1, PSMD10, CDK1, CDC25C, ERLIN2, APPBP2, AGTRAP, SHMT2, MOV10, NXF1, KAT2B, TRAF3IP2, CCDC8, FKBP4, ST13, CCDC117, DENND2D, CDK3, CUEDC2, TP53BP2, NF2, TEAD3, YAP1, HSPB1, UNK, PTGS2, CCT2, DNAJA1, DNAJA2, DNAJA4, DNAJB4, DNAJB5, DNAJC10, CPS1, EZR, GRPEL1, HSP90AB1, HSPA9, HSPD1, HSPE1, MSN, PREP, RDX, SEC23IP, ZW10, TAGLN2, TAGLN3, TUBB, USP39, RAP1A, SCLT1, OFD1, HIST1H3E, CLTC, MBOAT1, OTUB1, BARD1, NR3C1, DDIAS, ABCC2, TCAP, TRMT12, SLC27A3, SNX20, KCNJ10, TTC9B, SLC9A1, DNAJB8, CYLD, RPAP3, DLD, DNM1L, SDHA, SNRPE, TRIM25, G3BP1, BRCA1, TRIM32, TRIM63, RRM2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAN2A1_HSPA4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAN2A1_HSPA4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | HSPA4 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Tgene | HSPA4 | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
| Tgene | HSPA4 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | HSPA4 | C0238288 | Muscular Dystrophy, Facioscapulohumeral | 1 | CTD_human |
| Tgene | HSPA4 | C0338831 | Manic | 1 | PSYGENET |
| Tgene | HSPA4 | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | HSPA4 | C0564408 | Manic mood | 1 | PSYGENET |
| Tgene | HSPA4 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | HSPA4 | C3496069 | cocaine use | 1 | PSYGENET |
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