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Fusion gene ID: 20726 |
FusionGeneSummary for MAMSTR_RASIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAMSTR_RASIP1 | Fusion gene ID: 20726 | Hgene | Tgene | Gene symbol | MAMSTR | RASIP1 | Gene ID | 284358 | 54922 |
| Gene name | MEF2 activating motif and SAP domain containing transcriptional regulator | Ras interacting protein 1 | |
| Synonyms | MASTR | RAIN | |
| Cytomap | 19q13.33 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MEF2-activating motif and SAP domain-containing transcriptional regulatorMEF2-activating SAP transcriptional regulatory proteinlikely ortholog of MEF2-activating SAP transcriptional regulator | ras-interacting protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6ZN01 | Q5U651 | |
| Ensembl transtripts involved in fusion gene | ENST00000318083, ENST00000356751, ENST00000594582, ENST00000377367, ENST00000419611, | ENST00000222145, ENST00000594232, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 3=27 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/27*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAMSTR [Title/Abstract] AND RASIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-13-1489-01A | MAMSTR | chr19 | 49222231 | - | RASIP1 | chr19 | 49230687 | - |
| TCGA | RV | OV | TCGA-13-1489-02A | MAMSTR | chr19 | 49222231 | - | RASIP1 | chr19 | 49230687 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000318083 | ENST00000222145 | MAMSTR | chr19 | 49222231 | - | RASIP1 | chr19 | 49230687 | - |
| 5CDS-intron | ENST00000318083 | ENST00000594232 | MAMSTR | chr19 | 49222231 | - | RASIP1 | chr19 | 49230687 | - |
| intron-3CDS | ENST00000356751 | ENST00000222145 | MAMSTR | chr19 | 49222231 | - | RASIP1 | chr19 | 49230687 | - |
| intron-intron | ENST00000356751 | ENST00000594232 | MAMSTR | chr19 | 49222231 | - | RASIP1 | chr19 | 49230687 | - |
| intron-3CDS | ENST00000594582 | ENST00000222145 | MAMSTR | chr19 | 49222231 | - | RASIP1 | chr19 | 49230687 | - |
| intron-intron | ENST00000594582 | ENST00000594232 | MAMSTR | chr19 | 49222231 | - | RASIP1 | chr19 | 49230687 | - |
| 5UTR-3CDS | ENST00000377367 | ENST00000222145 | MAMSTR | chr19 | 49222231 | - | RASIP1 | chr19 | 49230687 | - |
| 5UTR-intron | ENST00000377367 | ENST00000594232 | MAMSTR | chr19 | 49222231 | - | RASIP1 | chr19 | 49230687 | - |
| 5UTR-3CDS | ENST00000419611 | ENST00000222145 | MAMSTR | chr19 | 49222231 | - | RASIP1 | chr19 | 49230687 | - |
| 5UTR-intron | ENST00000419611 | ENST00000594232 | MAMSTR | chr19 | 49222231 | - | RASIP1 | chr19 | 49230687 | - |
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FusionProtFeatures for MAMSTR_RASIP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAMSTR | RASIP1 |
| Transcriptional coactivator. Stimulates thetranscriptional activity of MEF2C. Stimulates MYOD1 activity inpart via MEF2, resulting in an enhancement of skeletal muscledifferentiation (By similarity). {ECO:0000250}. | Required for the proper formation of vascular structuresthat develop via both vasculogenesis and angiogenesis. Acts as acritical and vascular-specific regulator of GTPase signaling, cellarchitecture, and adhesion, which is essential for endothelialcell morphogenesis and blood vessel tubulogenesis. Regulates theactivity of Rho GTPases in part by recruiting ARHGAP29 andsuppressing RhoA signaling and dampening ROCK and MYH9 activitiesin endothelial cells (By similarity). May act as effector forGolgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acidstarvation-induced autophagy. {ECO:0000250,ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAMSTR_RASIP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAMSTR_RASIP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAMSTR | RASIP1 | HRAS, ARFGAP1, LDB2, PPP1R18, CDC42, HNRNPD, BUB3, BAG3, RNF41, ZWINT, FGFR1OP2, RACGAP1, SIKE1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAMSTR_RASIP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAMSTR_RASIP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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