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Fusion gene ID: 20703 |
FusionGeneSummary for MAML2_EPHB2 |
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Fusion gene information | Fusion gene name: MAML2_EPHB2 | Fusion gene ID: 20703 | Hgene | Tgene | Gene symbol | MAML2 | EPHB2 | Gene ID | 84441 | 2048 |
Gene name | mastermind like transcriptional coactivator 2 | EPH receptor B2 | |
Synonyms | MAM-3|MAM2|MAM3|MLL-MAML2 | CAPB|DRT|EK5|EPHT3|ERK|Hek5|PCBC|Tyro5 | |
Cytomap | 11q21 | 1p36.12 | |
Type of gene | protein-coding | protein-coding | |
Description | mastermind-like protein 2mam-2mastermind-like 2 | ephrin type-B receptor 2EPH-like kinase 5developmentally-regulated Eph-related tyrosine kinaseelk-related tyrosine kinaseeph tyrosine kinase 3protein-tyrosine kinase HEK5renal carcinoma antigen NY-REN-47tyrosine-protein kinase TYRO5tyrosine-protei | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8IZL2 | P29323 | |
Ensembl transtripts involved in fusion gene | ENST00000524717, | ENST00000544305, ENST00000374630, ENST00000400191, ENST00000374632, ENST00000374627, ENST00000465676, | |
Fusion gene scores | * DoF score | 11 X 8 X 5=440 | 9 X 8 X 4=288 |
# samples | 12 | 11 | |
** MAII score | log2(12/440*10)=-1.87446911791614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/288*10)=-1.38856528791765 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAML2 [Title/Abstract] AND EPHB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MAML2 | GO:0007219 | Notch signaling pathway | 12370315 |
Hgene | MAML2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12370315 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF929677 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000524717 | ENST00000544305 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
intron-intron | ENST00000524717 | ENST00000374630 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
intron-intron | ENST00000524717 | ENST00000400191 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
intron-intron | ENST00000524717 | ENST00000374632 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
intron-intron | ENST00000524717 | ENST00000374627 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
intron-intron | ENST00000524717 | ENST00000465676 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
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FusionProtFeatures for MAML2_EPHB2 |
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Hgene | Tgene |
MAML2 | EPHB2 |
Acts as a transcriptional coactivator for NOTCHproteins. Has been shown to amplify NOTCH-induced transcription ofHES1. Potentiates activation by NOTCH3 and NOTCH4 more efficientlythan MAML1 or MAML3. {ECO:0000269|PubMed:12370315,ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}. | Receptor tyrosine kinase which binds promiscuouslytransmembrane ephrin-B family ligands residing on adjacent cells,leading to contact-dependent bidirectional signaling intoneighboring cells. The signaling pathway downstream of thereceptor is referred to as forward signaling while the signalingpathway downstream of the ephrin ligand is referred to as reversesignaling. Functions in axon guidance during development. Involvedin the guidance of commissural axons, that form a majorinterhemispheric connection between the 2 temporal lobes of thecerebral cortex. Also involved in guidance of contralateral innerear efferent growth cones at the midline and of retinal ganglioncell axons to the optic disk. In addition to axon guidance, alsoregulates dendritic spines development and maturation andstimulates the formation of excitatory synapses. Upon activationby EFNB1, abolishes the ARHGEF15-mediated negative regulation onexcitatory synapse formation. Controls other aspects ofdevelopment including angiogenesis, palate development and ininner ear development through regulation of endolymph production.Forward and reverse signaling through the EFNB2/EPHB2 complexregulate movement and adhesion of cells that tubularize theurethra and septate the cloaca. May function as a tumorsuppressor. {ECO:0000269|PubMed:15300251}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAML2_EPHB2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAML2_EPHB2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAML2_EPHB2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAML2_EPHB2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MAML2 | C3495559 | Juvenile arthritis | 1 | CTD_human |
Tgene | EPHB2 | C0376358 | Malignant neoplasm of prostate | 3 | UNIPROT |
Tgene | EPHB2 | C0014474 | Ependymoma | 1 | CTD_human |