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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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RelatedDiseases

Fusion gene ID: 20700

FusionGeneSummary for MAML2_BCAS4

check button Fusion gene summary
Fusion gene informationFusion gene name: MAML2_BCAS4
Fusion gene ID: 20700
HgeneTgene
Gene symbol

MAML2

BCAS4

Gene ID

84441

55653

Gene namemastermind like transcriptional coactivator 2breast carcinoma amplified sequence 4
SynonymsMAM-3|MAM2|MAM3|MLL-MAML2CNOL
Cytomap

11q21

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionmastermind-like protein 2mam-2mastermind-like 2breast carcinoma-amplified sequence 4BCAS4/BCAS3 fusionbreast carcinoma amplified sequence 4/3 fusion protein
Modification date2018052320180523
UniProtAcc

Q8IZL2

Q8TDM0

Ensembl transtripts involved in fusion geneENST00000524717, ENST00000358791, 
ENST00000262591, ENST00000371608, 
ENST00000609336, ENST00000485049, 
Fusion gene scores* DoF score11 X 8 X 5=4406 X 3 X 6=108
# samples 126
** MAII scorelog2(12/440*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAML2 [Title/Abstract] AND BCAS4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAML2

GO:0007219

Notch signaling pathway

12370315

HgeneMAML2

GO:0045944

positive regulation of transcription by RNA polymerase II

12370315


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPCPGTCGA-WB-A81K-01AMAML2chr11

95825056

-BCAS4chr20

49493023

+
TCGALDPCPGTCGA-WB-A81K-01AMAML2chr11

95825056

-BCAS4chr20

49458303

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000524717ENST00000358791MAML2chr11

95825056

-BCAS4chr20

49493023

+
Frame-shiftENST00000524717ENST00000262591MAML2chr11

95825056

-BCAS4chr20

49493023

+
Frame-shiftENST00000524717ENST00000371608MAML2chr11

95825056

-BCAS4chr20

49493023

+
Frame-shiftENST00000524717ENST00000609336MAML2chr11

95825056

-BCAS4chr20

49493023

+
5CDS-intronENST00000524717ENST00000485049MAML2chr11

95825056

-BCAS4chr20

49493023

+
In-frameENST00000524717ENST00000358791MAML2chr11

95825056

-BCAS4chr20

49458303

+
5CDS-intronENST00000524717ENST00000262591MAML2chr11

95825056

-BCAS4chr20

49458303

+
5CDS-intronENST00000524717ENST00000371608MAML2chr11

95825056

-BCAS4chr20

49458303

+
5CDS-intronENST00000524717ENST00000609336MAML2chr11

95825056

-BCAS4chr20

49458303

+
5CDS-intronENST00000524717ENST00000485049MAML2chr11

95825056

-BCAS4chr20

49458303

+

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FusionProtFeatures for MAML2_BCAS4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAML2

Q8IZL2

BCAS4

Q8TDM0

Acts as a transcriptional coactivator for NOTCHproteins. Has been shown to amplify NOTCH-induced transcription ofHES1. Potentiates activation by NOTCH3 and NOTCH4 more efficientlythan MAML1 or MAML3. {ECO:0000269|PubMed:12370315,ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MAML2_BCAS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MAML2_ENST00000524717_chr11_95825056_-_BCAS4_ENST00000358791_chr20_49493023_+_729aa
MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAG
KHTKATATAATTTAPPPPPAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPG
ETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPME
KIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQ
QHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRS
FINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQ
QQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQKSPAPVP

>In-frame_MAML2_ENST00000524717_chr11_95825056_-_BCAS4_ENST00000358791_chr20_49458303_+_807aa
MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAG
KHTKATATAATTTAPPPPPAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPG
ETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPME
KIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQ
QHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRS
FINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQ
QQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQAFVKMVG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MAML2_ENST00000524717_chr11_95825056_-_BCAS4_ENST00000358791_chr20_49493023_+_2189nt
ATGGGGGACACAGCGCCCCCGCAGGCCCCCGCAGGAGGGCTAGGGGGGGCCTCTGGGGCGGGGCTCCTTGGAGGGGGCTCAGTCACCCCG
AGAGTGCACAGTGCTATCGTGGAGCGCCTCCGGGCTCGGATCGCTGTCTGCCGCCAACACCACCTGAGCTGTGAAGGACGATATGAACGA
GGTAGGGCCGAGAGCTCAGACCGGGAAAGAGAAAGCACCTTGCAGCTCCTGAGCCTTGTACAGCATGGCCAGGGGGCAAGGAAAGCTGGC
AAACACACCAAGGCCACCGCCACTGCTGCCACCACTACAGCCCCTCCACCGCCCCCTGCTGCCCCTCCTGCGGCCTCCCAAGCAGCAGCA
ACAGCAGCCCCACCGCCCCCACCAGACTATCACCATCACCACCAGCAGCACCTGCTGAACAGTAGCAATAATGGTGGCAGTGGTGGGATA
AACGGAGAGCAGCAGCCGCCCGCTTCAACCCCAGGGGACCAGAGGAACTCAGCCCTGATTGCGCTCCAGGGTTCCTTGAAAAGAAAACAG
GTAGTTAACCTATCTCCTGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTTCTTGATATCAAAAGAATTCGTGTTGGGGAG
AATCTCTCTGCAGGACAAGGTGGCCTCCAAATAAACAATGGACAAAGTCAGATTATGTCAGGGACCTTGCCTATGAGCCAAGCACCCCTG
CGAAAGACTAACACTCTGCCATCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATGGGCTTAAAGGAGGTAAAGAAGGAGCCAGGA
GAGACTCTGTCTTGCAGTAAGCACATGGATGGCCAAATGACCCAAGAGAATATTTTTCCTAATAGGTACGGAGACGACCCTGGAGAACAA
CTGATGGATCCTGAGCTGCAGGAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCCATGAGTGACCTTGAACTGGAGAACATGATC
AATGCCACCATAAAGCAGGATGACCCATTTAACATTGACTTGGGTCAGCAAAGCCAGAGGAGCACACCTAGGCCCTCCTTACCCATGGAG
AAAATAGTGATCAAAAGTGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCTCAGCTGAGGCCCCCATCAGCTGGCCCCGCA
TTCTCCATGGCCAACTCTGCCCTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGCTCAGCCTCAGACAGGCTCCGGAGCA
AGCCGGGCCTTGCCAAGCTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCTGCTAATCGTCAGCAGCATGCCCGGATGCAG
CAGCACCAGCAGCAGCACCAGCCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGACCATCACCAGGTCCATTTGGGCAGGAGAAAATC
CCCAGCCCTTCTTTTGGTCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTAGCTGGCGGCAGCGGCCAGTCGAAAGTAATG
GCTAACTACATGTACAAGGCCGGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCAAAAGCCTCAGGATCTCAGTCGAAGT
TTTATTAACAACCCGCACCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTTCATTTTAACTCAGATCAAGCGAACCAGCAG
ATGCCTTCTGTTTTGCCTTCCCAGAACAAGCCTTCTCTCCTACACTACACCCAACAGCAACAGCAGCAACAGCAGCAGCAGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAGTTCAATTTCAGCTCAACAACAGCAA
CAGCAGCAGAGCTCAATTTCAGCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAGCAGCAGCAACAACAACAGCAACAACAGCAGCAG
CAGCAGCAGCAACAACCATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTCACCTTTGCCACTTCAGCAAAAGCTC
CTACTTCAGCAAATGCAGAATCAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAACAACAGAGACAGAAGTCACCTGCACCGGTGCCC

>In-frame_MAML2_ENST00000524717_chr11_95825056_-_BCAS4_ENST00000358791_chr20_49458303_+_2421nt
ATGGGGGACACAGCGCCCCCGCAGGCCCCCGCAGGAGGGCTAGGGGGGGCCTCTGGGGCGGGGCTCCTTGGAGGGGGCTCAGTCACCCCG
AGAGTGCACAGTGCTATCGTGGAGCGCCTCCGGGCTCGGATCGCTGTCTGCCGCCAACACCACCTGAGCTGTGAAGGACGATATGAACGA
GGTAGGGCCGAGAGCTCAGACCGGGAAAGAGAAAGCACCTTGCAGCTCCTGAGCCTTGTACAGCATGGCCAGGGGGCAAGGAAAGCTGGC
AAACACACCAAGGCCACCGCCACTGCTGCCACCACTACAGCCCCTCCACCGCCCCCTGCTGCCCCTCCTGCGGCCTCCCAAGCAGCAGCA
ACAGCAGCCCCACCGCCCCCACCAGACTATCACCATCACCACCAGCAGCACCTGCTGAACAGTAGCAATAATGGTGGCAGTGGTGGGATA
AACGGAGAGCAGCAGCCGCCCGCTTCAACCCCAGGGGACCAGAGGAACTCAGCCCTGATTGCGCTCCAGGGTTCCTTGAAAAGAAAACAG
GTAGTTAACCTATCTCCTGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTTCTTGATATCAAAAGAATTCGTGTTGGGGAG
AATCTCTCTGCAGGACAAGGTGGCCTCCAAATAAACAATGGACAAAGTCAGATTATGTCAGGGACCTTGCCTATGAGCCAAGCACCCCTG
CGAAAGACTAACACTCTGCCATCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATGGGCTTAAAGGAGGTAAAGAAGGAGCCAGGA
GAGACTCTGTCTTGCAGTAAGCACATGGATGGCCAAATGACCCAAGAGAATATTTTTCCTAATAGGTACGGAGACGACCCTGGAGAACAA
CTGATGGATCCTGAGCTGCAGGAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCCATGAGTGACCTTGAACTGGAGAACATGATC
AATGCCACCATAAAGCAGGATGACCCATTTAACATTGACTTGGGTCAGCAAAGCCAGAGGAGCACACCTAGGCCCTCCTTACCCATGGAG
AAAATAGTGATCAAAAGTGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCTCAGCTGAGGCCCCCATCAGCTGGCCCCGCA
TTCTCCATGGCCAACTCTGCCCTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGCTCAGCCTCAGACAGGCTCCGGAGCA
AGCCGGGCCTTGCCAAGCTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCTGCTAATCGTCAGCAGCATGCCCGGATGCAG
CAGCACCAGCAGCAGCACCAGCCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGACCATCACCAGGTCCATTTGGGCAGGAGAAAATC
CCCAGCCCTTCTTTTGGTCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTAGCTGGCGGCAGCGGCCAGTCGAAAGTAATG
GCTAACTACATGTACAAGGCCGGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCAAAAGCCTCAGGATCTCAGTCGAAGT
TTTATTAACAACCCGCACCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTTCATTTTAACTCAGATCAAGCGAACCAGCAG
ATGCCTTCTGTTTTGCCTTCCCAGAACAAGCCTTCTCTCCTACACTACACCCAACAGCAACAGCAGCAACAGCAGCAGCAGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAGTTCAATTTCAGCTCAACAACAGCAA
CAGCAGCAGAGCTCAATTTCAGCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAGCAGCAGCAACAACAACAGCAACAACAGCAGCAG
CAGCAGCAGCAACAACCATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTCACCTTTGCCACTTCAGCAAAAGCTC
CTACTTCAGCAAATGCAGAATCAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAACAACAGAGACAGGCCTTCGTCAAGATGGTTGGA
CACCACGTCGCCTTCCTGGAAGCAGACGTGCTTCAGGCTGAGCGGGACCATGGGGCCTTCCCTCAGGCCCTGCGGAGGTGGCTGGGATCC
GCAGGGCTCCCCTCCTTCAGGAACGTGGAGTGCAGTGGCACAATCCCAGCTCGCTGCAACCTCCGCCTCCCGGGTTCAAGTGATTCTCCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_MAML2_ENST00000524717_chr11_95825056_-_BCAS4_ENST00000358791_chr20_49493023_+_4116nt
CTCCCTCTCCTATCGGAGCACAATGAAAGCCTGTGTATCGCCGTGACTCCGGGCGCGAGCCAGTGTCAGCAAAGCGGCTAACAACAGACG
AGAAAGAGAAAGGAAAATACAAGCTACTTTTTTTTTCCATCTATAAAGCGGAGCAAATACAGGAGATAGAACCAGATTGCTTATTGCGAG
TCCAGACCCTCAGATCCACTGGCCGGGGATGGAATGTACAAAAGTGGACAGAAAAGTGGCTGGACATGACTCGGTGCAATTTGCTGGAAG
TTTGTAAGTTTGACCATCGTTTGTAAATTACTCTCGGAAGAGTTTGTCTCTCTTGATACTGTATTAGAATAGAGCCGGGGGTGAGGAATA
GAAACGTAAGCGGGAAAGAAAAAAATGTGTTGAAGGATCTCTCTCAGTGGCTAGCGACTTAAGATTGCTTTTCATTTAAGGCTAGGAAAC
CTTAGAGGGAGTGAGGATTTTACCGGTGATTGGATTAGCTGAAGAAAAAAGCATGGTCCAAAAGTCCAATTACTGACATTGTTAACAGTT
GAAAAGCTGTCTCCCTCTTTTGGGAGAAGACAACATCCTACAGTACCCCAAAGAGGAGAAAACACCGGAGCGAAAGGAAAGGGAGGAAAA
ATTAAAAGCCAAAAGACAGTCTCCCTTGATTTTTGCACATTTTGAACAGTGACTTAAACATCTTCTGAAACAGCACTGTTTTGTTTTGTT
TTGGTTTTTTATTTAACCTGAGGAAAAGTCAAGGCTGCTGGTTACATAGACATGGTAGAAATGTGTTTCTCTGCAGAAACATCCCCATAA
AGAATTGTCGGAAACAACTAGGTGAGGGGGAGTCCTCTCTATTAATACCTCTCTCAATACCTTTTGCTGTGTGTTTCTGTCTCTTGCTGG
ACAATCCCTGAATTCTTGATCTAACCCCCAGATCGTGTGTTTACAAAGTACCTAGTGGCTCTTGTCAGCTTGGTGGAGGAAAAAAAATCC
ACCAACTCTGTCCAACTTCTCCAGAGCTGTCAAATGCAATTAGAGTAAGTTAATCAGGGTTTGTTTCCAACTTATCCTCCCCCCAGTTGG
TTTCTATTCTTTCTCCCCACCCTCTTTTTACTAACTCCCCTCCCCCACAACTTCTCCACGGCTCCCCCACAACCTCTGAAGACCTCTATT
CATGTGGCCCTGAACACTGAGCTCACATTGTCAAAAACAGACTTGCCTGCAATAGCCAGCAGTAGCCTCTTTCCACCTCACCATCCCAGA
GGCAGCAATCATTGTGTCCGGTAAGATGGGGGACACAGCGCCCCCGCAGGCCCCCGCAGGAGGGCTAGGGGGGGCCTCTGGGGCGGGGCT
CCTTGGAGGGGGCTCAGTCACCCCGAGAGTGCACAGTGCTATCGTGGAGCGCCTCCGGGCTCGGATCGCTGTCTGCCGCCAACACCACCT
GAGCTGTGAAGGACGATATGAACGAGGTAGGGCCGAGAGCTCAGACCGGGAAAGAGAAAGCACCTTGCAGCTCCTGAGCCTTGTACAGCA
TGGCCAGGGGGCAAGGAAAGCTGGCAAACACACCAAGGCCACCGCCACTGCTGCCACCACTACAGCCCCTCCACCGCCCCCTGCTGCCCC
TCCTGCGGCCTCCCAAGCAGCAGCAACAGCAGCCCCACCGCCCCCACCAGACTATCACCATCACCACCAGCAGCACCTGCTGAACAGTAG
CAATAATGGTGGCAGTGGTGGGATAAACGGAGAGCAGCAGCCGCCCGCTTCAACCCCAGGGGACCAGAGGAACTCAGCCCTGATTGCGCT
CCAGGGTTCCTTGAAAAGAAAACAGGTAGTTAACCTATCTCCTGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTTCTTGA
TATCAAAAGAATTCGTGTTGGGGAGAATCTCTCTGCAGGACAAGGTGGCCTCCAAATAAACAATGGACAAAGTCAGATTATGTCAGGGAC
CTTGCCTATGAGCCAAGCACCCCTGCGAAAGACTAACACTCTGCCATCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATGGGCTT
AAAGGAGGTAAAGAAGGAGCCAGGAGAGACTCTGTCTTGCAGTAAGCACATGGATGGCCAAATGACCCAAGAGAATATTTTTCCTAATAG
GTACGGAGACGACCCTGGAGAACAACTGATGGATCCTGAGCTGCAGGAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCCATGAG
TGACCTTGAACTGGAGAACATGATCAATGCCACCATAAAGCAGGATGACCCATTTAACATTGACTTGGGTCAGCAAAGCCAGAGGAGCAC
ACCTAGGCCCTCCTTACCCATGGAGAAAATAGTGATCAAAAGTGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCTCAGCT
GAGGCCCCCATCAGCTGGCCCCGCATTCTCCATGGCCAACTCTGCCCTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGC
TCAGCCTCAGACAGGCTCCGGAGCAAGCCGGGCCTTGCCAAGCTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCTGCTAA
TCGTCAGCAGCATGCCCGGATGCAGCAGCACCAGCAGCAGCACCAGCCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGACCATCACC
AGGTCCATTTGGGCAGGAGAAAATCCCCAGCCCTTCTTTTGGTCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTAGCTGG
CGGCAGCGGCCAGTCGAAAGTAATGGCTAACTACATGTACAAGGCCGGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCA
AAAGCCTCAGGATCTCAGTCGAAGTTTTATTAACAACCCGCACCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTTCATTT
TAACTCAGATCAAGCGAACCAGCAGATGCCTTCTGTTTTGCCTTCCCAGAACAAGCCTTCTCTCCTACACTACACCCAACAGCAACAGCA
GCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAG
TTCAATTTCAGCTCAACAACAGCAACAGCAGCAGAGCTCAATTTCAGCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAGCAGCAGCA
ACAACAACAGCAACAACAGCAGCAGCAGCAGCAGCAACAACCATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTC
ACCTTTGCCACTTCAGCAAAAGCTCCTACTTCAGCAAATGCAGAATCAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAACAACAGAG
ACAGAAGTCACCTGCACCGGTGCCCGTGACGTACGAGCTGCCCACACTGTATAGGACGGAGGACTATTTTCCTGTGGACGCCGGGGAAGC
ACAGCACCACCCCCGCACCTGCCCTCGGCCTTTGTGAGCTTTGTGGTCTTCCCATCAGGAACGCTGGAAAGTGACATTGTGTACACACTG
CAGCTTGGGGGTTTTTTCTTTGTATTGCTGTTTATTTTATATTTTAAAAATATTTAAAAAAATGTCGAGATGGGGTCTCACTATGTTGTC
CAGACTGATCTCAAACTCCTGGGCTCAAGTGATCCACCCACCTTGGCCTTCCAAAGTGGTGGGATTATGGGCAGGAGCCTCCGTGCCCAG
GCTGCTGCCATTTTCAAATTTCCTCCCTGCCTCATGTGAGACCACAGGGTTTGGAGAAGCAGTTGGAACCCACGTGTGGTGATGCCTCCC
ACATCGGCCTGCTTGGGGTTCTACAGGGGTTGAGGGACCAGGCCTGGCCGGGGCTGATGGACAGTGGGGACTTTCCTTCTCTCCATGATG
GCTTTGCAGGGGCTCCATGGTCCTTCTCTCTGTGATGGGTTTTTGCACGGGGTGTGCTCTGCCACTGTGGTGGGTGGGTGGATGCTGCTT

>In-frame_MAML2_ENST00000524717_chr11_95825056_-_BCAS4_ENST00000358791_chr20_49458303_+_4348nt
CTCCCTCTCCTATCGGAGCACAATGAAAGCCTGTGTATCGCCGTGACTCCGGGCGCGAGCCAGTGTCAGCAAAGCGGCTAACAACAGACG
AGAAAGAGAAAGGAAAATACAAGCTACTTTTTTTTTCCATCTATAAAGCGGAGCAAATACAGGAGATAGAACCAGATTGCTTATTGCGAG
TCCAGACCCTCAGATCCACTGGCCGGGGATGGAATGTACAAAAGTGGACAGAAAAGTGGCTGGACATGACTCGGTGCAATTTGCTGGAAG
TTTGTAAGTTTGACCATCGTTTGTAAATTACTCTCGGAAGAGTTTGTCTCTCTTGATACTGTATTAGAATAGAGCCGGGGGTGAGGAATA
GAAACGTAAGCGGGAAAGAAAAAAATGTGTTGAAGGATCTCTCTCAGTGGCTAGCGACTTAAGATTGCTTTTCATTTAAGGCTAGGAAAC
CTTAGAGGGAGTGAGGATTTTACCGGTGATTGGATTAGCTGAAGAAAAAAGCATGGTCCAAAAGTCCAATTACTGACATTGTTAACAGTT
GAAAAGCTGTCTCCCTCTTTTGGGAGAAGACAACATCCTACAGTACCCCAAAGAGGAGAAAACACCGGAGCGAAAGGAAAGGGAGGAAAA
ATTAAAAGCCAAAAGACAGTCTCCCTTGATTTTTGCACATTTTGAACAGTGACTTAAACATCTTCTGAAACAGCACTGTTTTGTTTTGTT
TTGGTTTTTTATTTAACCTGAGGAAAAGTCAAGGCTGCTGGTTACATAGACATGGTAGAAATGTGTTTCTCTGCAGAAACATCCCCATAA
AGAATTGTCGGAAACAACTAGGTGAGGGGGAGTCCTCTCTATTAATACCTCTCTCAATACCTTTTGCTGTGTGTTTCTGTCTCTTGCTGG
ACAATCCCTGAATTCTTGATCTAACCCCCAGATCGTGTGTTTACAAAGTACCTAGTGGCTCTTGTCAGCTTGGTGGAGGAAAAAAAATCC
ACCAACTCTGTCCAACTTCTCCAGAGCTGTCAAATGCAATTAGAGTAAGTTAATCAGGGTTTGTTTCCAACTTATCCTCCCCCCAGTTGG
TTTCTATTCTTTCTCCCCACCCTCTTTTTACTAACTCCCCTCCCCCACAACTTCTCCACGGCTCCCCCACAACCTCTGAAGACCTCTATT
CATGTGGCCCTGAACACTGAGCTCACATTGTCAAAAACAGACTTGCCTGCAATAGCCAGCAGTAGCCTCTTTCCACCTCACCATCCCAGA
GGCAGCAATCATTGTGTCCGGTAAGATGGGGGACACAGCGCCCCCGCAGGCCCCCGCAGGAGGGCTAGGGGGGGCCTCTGGGGCGGGGCT
CCTTGGAGGGGGCTCAGTCACCCCGAGAGTGCACAGTGCTATCGTGGAGCGCCTCCGGGCTCGGATCGCTGTCTGCCGCCAACACCACCT
GAGCTGTGAAGGACGATATGAACGAGGTAGGGCCGAGAGCTCAGACCGGGAAAGAGAAAGCACCTTGCAGCTCCTGAGCCTTGTACAGCA
TGGCCAGGGGGCAAGGAAAGCTGGCAAACACACCAAGGCCACCGCCACTGCTGCCACCACTACAGCCCCTCCACCGCCCCCTGCTGCCCC
TCCTGCGGCCTCCCAAGCAGCAGCAACAGCAGCCCCACCGCCCCCACCAGACTATCACCATCACCACCAGCAGCACCTGCTGAACAGTAG
CAATAATGGTGGCAGTGGTGGGATAAACGGAGAGCAGCAGCCGCCCGCTTCAACCCCAGGGGACCAGAGGAACTCAGCCCTGATTGCGCT
CCAGGGTTCCTTGAAAAGAAAACAGGTAGTTAACCTATCTCCTGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTTCTTGA
TATCAAAAGAATTCGTGTTGGGGAGAATCTCTCTGCAGGACAAGGTGGCCTCCAAATAAACAATGGACAAAGTCAGATTATGTCAGGGAC
CTTGCCTATGAGCCAAGCACCCCTGCGAAAGACTAACACTCTGCCATCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATGGGCTT
AAAGGAGGTAAAGAAGGAGCCAGGAGAGACTCTGTCTTGCAGTAAGCACATGGATGGCCAAATGACCCAAGAGAATATTTTTCCTAATAG
GTACGGAGACGACCCTGGAGAACAACTGATGGATCCTGAGCTGCAGGAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCCATGAG
TGACCTTGAACTGGAGAACATGATCAATGCCACCATAAAGCAGGATGACCCATTTAACATTGACTTGGGTCAGCAAAGCCAGAGGAGCAC
ACCTAGGCCCTCCTTACCCATGGAGAAAATAGTGATCAAAAGTGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCTCAGCT
GAGGCCCCCATCAGCTGGCCCCGCATTCTCCATGGCCAACTCTGCCCTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGC
TCAGCCTCAGACAGGCTCCGGAGCAAGCCGGGCCTTGCCAAGCTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCTGCTAA
TCGTCAGCAGCATGCCCGGATGCAGCAGCACCAGCAGCAGCACCAGCCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGACCATCACC
AGGTCCATTTGGGCAGGAGAAAATCCCCAGCCCTTCTTTTGGTCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTAGCTGG
CGGCAGCGGCCAGTCGAAAGTAATGGCTAACTACATGTACAAGGCCGGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCA
AAAGCCTCAGGATCTCAGTCGAAGTTTTATTAACAACCCGCACCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTTCATTT
TAACTCAGATCAAGCGAACCAGCAGATGCCTTCTGTTTTGCCTTCCCAGAACAAGCCTTCTCTCCTACACTACACCCAACAGCAACAGCA
GCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAG
TTCAATTTCAGCTCAACAACAGCAACAGCAGCAGAGCTCAATTTCAGCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAGCAGCAGCA
ACAACAACAGCAACAACAGCAGCAGCAGCAGCAGCAACAACCATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTC
ACCTTTGCCACTTCAGCAAAAGCTCCTACTTCAGCAAATGCAGAATCAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAACAACAGAG
ACAGGCCTTCGTCAAGATGGTTGGACACCACGTCGCCTTCCTGGAAGCAGACGTGCTTCAGGCTGAGCGGGACCATGGGGCCTTCCCTCA
GGCCCTGCGGAGGTGGCTGGGATCCGCAGGGCTCCCCTCCTTCAGGAACGTGGAGTGCAGTGGCACAATCCCAGCTCGCTGCAACCTCCG
CCTCCCGGGTTCAAGTGATTCTCCTGCCTCCGCCTCCCAAGTAGCTGGGATTACAGAAGTCACCTGCACCGGTGCCCGTGACGTACGAGC
TGCCCACACTGTATAGGACGGAGGACTATTTTCCTGTGGACGCCGGGGAAGCACAGCACCACCCCCGCACCTGCCCTCGGCCTTTGTGAG
CTTTGTGGTCTTCCCATCAGGAACGCTGGAAAGTGACATTGTGTACACACTGCAGCTTGGGGGTTTTTTCTTTGTATTGCTGTTTATTTT
ATATTTTAAAAATATTTAAAAAAATGTCGAGATGGGGTCTCACTATGTTGTCCAGACTGATCTCAAACTCCTGGGCTCAAGTGATCCACC
CACCTTGGCCTTCCAAAGTGGTGGGATTATGGGCAGGAGCCTCCGTGCCCAGGCTGCTGCCATTTTCAAATTTCCTCCCTGCCTCATGTG
AGACCACAGGGTTTGGAGAAGCAGTTGGAACCCACGTGTGGTGATGCCTCCCACATCGGCCTGCTTGGGGTTCTACAGGGGTTGAGGGAC
CAGGCCTGGCCGGGGCTGATGGACAGTGGGGACTTTCCTTCTCTCCATGATGGCTTTGCAGGGGCTCCATGGTCCTTCTCTCTGTGATGG
GTTTTTGCACGGGGTGTGCTCTGCCACTGTGGTGGGTGGGTGGATGCTGCTTCTGTTGCCTCCAGACCTCGGTGCCCACAGCCTTGAGGA


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FusionGenePPI for MAML2_BCAS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAML2MAML1, NOTCH1, DIABLO, CREBBP, EP300, RBPJBCAS4DTNBP1, PKD2, BLOC1S6, BLOC1S2, BLOC1S5, BLOC1S1, LOH12CR1, ATG4A, SNAPIN, BLOC1S3, SRCIN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAML2_BCAS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAML2_BCAS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAML2C3495559Juvenile arthritis1CTD_human