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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 2070

FusionGeneSummary for AP2B1_RAB20

check button Fusion gene summary
Fusion gene informationFusion gene name: AP2B1_RAB20
Fusion gene ID: 2070
HgeneTgene
Gene symbol

AP2B1

RAB20

Gene ID

163

55647

Gene nameadaptor related protein complex 2 subunit beta 1RAB20, member RAS oncogene family
SynonymsADTB2|AP105B|AP2-BETA|CLAPB1-
Cytomap

17q12

13q34

Type of geneprotein-codingprotein-coding
DescriptionAP-2 complex subunit betaadapter-related protein complex 2 beta subunitadapter-related protein complex 2 subunit betaadaptin, beta 2 (beta)adaptor protein complex AP-2 subunit betaadaptor related protein complex 2 beta 1 subunitadaptor-related proteras-related protein Rab-20
Modification date2018052220180523
UniProtAcc

P63010

Q9NX57

Ensembl transtripts involved in fusion geneENST00000262325, ENST00000592545, 
ENST00000538556, ENST00000312678, 
ENST00000589344, ENST00000537622, 
ENST00000545922, 
ENST00000267328, 
Fusion gene scores* DoF score7 X 7 X 4=1963 X 1 X 3=9
# samples 73
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AP2B1 [Title/Abstract] AND RAB20 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-CQ-6225-01AAP2B1chr17

33921086

+RAB20chr13

111176544

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262325ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-
In-frameENST00000592545ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-
5UTR-3CDSENST00000538556ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-
In-frameENST00000312678ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-
In-frameENST00000589344ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-
In-frameENST00000537622ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-
intron-3CDSENST00000545922ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-

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FusionProtFeatures for AP2B1_RAB20


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AP2B1

P63010

RAB20

Q9NX57

Component of the adaptor protein complex 2 (AP-2).Adaptor protein complexes function in protein transport viatransport vesicles in different membrane traffic pathways. Adaptorprotein complexes are vesicle coat components and appear to beinvolved in cargo selection and vesicle formation. AP-2 isinvolved in clathrin-dependent endocytosis in which cargo proteinsare incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with theearly endosome. The clathrin lattice serves as a mechanicalscaffold but is itself unable to bind directly to membranecomponents. Clathrin-associated adaptor protein (AP) complexeswhich can bind directly to both the clathrin lattice and to thelipid and protein components of membranes are considered to be themajor clathrin adaptors contributing the CCV formation. AP-2 alsoserves as a cargo receptor to selectively sort the membraneproteins involved in receptor-mediated endocytosis. AP-2 seems toplay a role in the recycling of synaptic vesicle membranes fromthe presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi)and [ED]-X-X-X-L-[LI] endocytosis signal motifs within thecytosolic tails of transmembrane cargo molecules. AP-2 may alsoplay a role in maintaining normal post-endocytic traffickingthrough the ARF6-regulated, non-clathrin pathway. The AP-2 betasubunit acts via its C-terminal appendage domain as a scaffoldingplatform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds toclathrin heavy chain, promoting clathrin lattice assembly;clathrin displaces at least some CLASPs from AP2B1 which probablythen can be positioned for further coat assembly.{ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334,ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387}. Plays a role in apical endocytosis/recycling. Plays arole in the maturation and acidification of phagosomes that engulfpathogens, such as S.aureus and M.tuberculosis. Plays a role inthe fusion of phagosomes with lysosomes.{ECO:0000269|PubMed:21255211}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAB20chr17:33921086chr13:111176544ENST00000267328-02113_11657235Nucleotide bindingGTP
TgeneRAB20chr17:33921086chr13:111176544ENST00000267328-0255_5957235Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAP2B1chr17:33921086chr13:111176544ENST00000262325+221576_71612938Compositional biasNote=Pro-rich (stalk region)
HgeneAP2B1chr17:33921086chr13:111176544ENST00000312678+222576_71612952Compositional biasNote=Pro-rich (stalk region)
HgeneAP2B1chr17:33921086chr13:111176544ENST00000537622+222576_71612952Compositional biasNote=Pro-rich (stalk region)
HgeneAP2B1chr17:33921086chr13:111176544ENST00000538556+222576_716-74881Compositional biasNote=Pro-rich (stalk region)
HgeneAP2B1chr17:33921086chr13:111176544ENST00000589344+222576_71612952Compositional biasNote=Pro-rich (stalk region)
TgeneRAB20chr17:33921086chr13:111176544ENST00000267328-0233_4157235MotifEffector region
TgeneRAB20chr17:33921086chr13:111176544ENST00000267328-0212_1957235Nucleotide bindingGTP


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FusionGeneSequence for AP2B1_RAB20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AP2B1_ENST00000262325_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_190aa
MTDSKYFTTNKKGREQFHGLGSMYCRGAAAIILTYDVNHRQSLVELEDRFLGLTDTASKDCLFAIVGNKVDLTEEGALAGQEKEECSPNM
DAGDRVSPRAPKQVQLEDAVALYKKILKYKMLDEQDVPAAEQMCFETSAKTGYNVDLLFETLFDLVVPMILQQRAERPSHTVDISSHKPP

>In-frame_AP2B1_ENST00000592545_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_190aa
MTDSKYFTTNKKGREQFHGLGSMYCRGAAAIILTYDVNHRQSLVELEDRFLGLTDTASKDCLFAIVGNKVDLTEEGALAGQEKEECSPNM
DAGDRVSPRAPKQVQLEDAVALYKKILKYKMLDEQDVPAAEQMCFETSAKTGYNVDLLFETLFDLVVPMILQQRAERPSHTVDISSHKPP

>In-frame_AP2B1_ENST00000312678_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_190aa
MTDSKYFTTNKKGREQFHGLGSMYCRGAAAIILTYDVNHRQSLVELEDRFLGLTDTASKDCLFAIVGNKVDLTEEGALAGQEKEECSPNM
DAGDRVSPRAPKQVQLEDAVALYKKILKYKMLDEQDVPAAEQMCFETSAKTGYNVDLLFETLFDLVVPMILQQRAERPSHTVDISSHKPP

>In-frame_AP2B1_ENST00000589344_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_190aa
MTDSKYFTTNKKGREQFHGLGSMYCRGAAAIILTYDVNHRQSLVELEDRFLGLTDTASKDCLFAIVGNKVDLTEEGALAGQEKEECSPNM
DAGDRVSPRAPKQVQLEDAVALYKKILKYKMLDEQDVPAAEQMCFETSAKTGYNVDLLFETLFDLVVPMILQQRAERPSHTVDISSHKPP

>In-frame_AP2B1_ENST00000537622_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_190aa
MTDSKYFTTNKKGREQFHGLGSMYCRGAAAIILTYDVNHRQSLVELEDRFLGLTDTASKDCLFAIVGNKVDLTEEGALAGQEKEECSPNM
DAGDRVSPRAPKQVQLEDAVALYKKILKYKMLDEQDVPAAEQMCFETSAKTGYNVDLLFETLFDLVVPMILQQRAERPSHTVDISSHKPP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AP2B1_ENST00000262325_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_570nt
ATGACTGACTCCAAGTATTTCACAACCAATAAAAAAGGGCGGGAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCC
ATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGAC
TGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATG
GACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAG
ATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAG
ACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCC

>In-frame_AP2B1_ENST00000592545_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_570nt
ATGACTGACTCCAAGTATTTCACAACCAATAAAAAAGGGCGGGAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCC
ATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGAC
TGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATG
GACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAG
ATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAG
ACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCC

>In-frame_AP2B1_ENST00000312678_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_570nt
ATGACTGACTCCAAGTATTTCACAACCAATAAAAAAGGGCGGGAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCC
ATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGAC
TGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATG
GACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAG
ATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAG
ACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCC

>In-frame_AP2B1_ENST00000589344_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_570nt
ATGACTGACTCCAAGTATTTCACAACCAATAAAAAAGGGCGGGAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCC
ATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGAC
TGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATG
GACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAG
ATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAG
ACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCC

>In-frame_AP2B1_ENST00000537622_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_570nt
ATGACTGACTCCAAGTATTTCACAACCAATAAAAAAGGGCGGGAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCC
ATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGAC
TGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATG
GACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAG
ATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAG
ACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_AP2B1_ENST00000262325_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_1718nt
TTTTACGTGCAGCACTATCCTCTAGCCCCACTGCCCGTATATAGGCCTGGGCTATATCACCATTGTCCGCCCTTGAGCCTGGAAGGAAAA
TGAGCTGAGGGGTTTTGTTTTTTCAGAAAGGAACAGGATATTTCATCATCTCTATGTTTACGTTTTTCAGAGAATTTCTGTGCGAGGAAA
CAAATCCATTGTCAGCTTTTTAAAATATATCCCTTTGGAGTAGCCACTTAACATCCTCTGAGGCCCAGATGGGCTAGCTTGCCGGGACCA
AAGGAAATCTTTGGGTCTGGAAGGCGACAAGAGATCACAGGCTTTCTAGGTCTACCGCGCACCCCGATGACGTCACGCGGCGACGTTCTC
TGACGTCAGAGTTTCCTGCCCACCATCTTTGTCCCTGGCAAAGTGGGTTTTGCGCAGTGGCTTAGACCTAGAAAAGAATCGTGACGGGCA
GGAAACCATTACACCACCACCTGGGCTGTGCTCTCCGGCTCCCGCCGCCACCCCCGCCCTCGCCTTCGCCTCCGCCTCCGGTGCACATTA
AAGATCCAAAGTCATGACTGACTCCAAGTATTTCACAACCAATAAAAAAGGGCGGGAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCG
GGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTGGGCCTGACAGACAC
AGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTG
CAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGAT
CCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACCGGCTACAATGTGGA
CCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACAGTGGATATATCCAG
TCATAAGCCACCCAAGAGGACCAGATCTGGGTGTTGTGCCTGACTTTCGAGGGCCTCCTGGACTCAGACTGTGCATGTTGGGAAGGGGTC
TGACCAGGCAAGCTGTGATCTGAAAGGAGCAAGGAACAGCAAGGAATTATTTTCCAGAATGACACCCGCAGCAGAATGTTGGAGTGGAAA
TGATGGCTGGCTATGAAGAGGAGGTCAACGTGTGTGGTCTCCTCAGTCTCTGTCAGAGGGGTGGGGAGGTGGGAAACAGGAATCCTCTGC
AAAGCCCAATCTGCAGAGTCGAGACCCCTGGTGCTCTCTGCCCCGCTGCCTGGCACTGGTCCTTTGCAGCCAGCCACCAACGGCCCCCTT
GCCCTTGCAGAGGCAGAAGCCTGCGTCTGCACCTGCACCTCTGACCGTTTCAGCACCCTGGGTTGTTACCACGTCCTACAACTCTGACAT
TTCTTGTTCTCAAGCGTTTCTCTTCACTGTGAGTTGTCTTTGGTCCTCCCACTTGGTACTTGTATCTTGATGCTTTATAATCCTGACTCT
CGACGTGTTCATTTATACAAAATCAGGAATAACTTTGTTTTTATACTGATTGCAGCAATGTTGGCTACATGTATTATTAAAGAGGATTTT

>In-frame_AP2B1_ENST00000592545_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_1303nt
AGTGGCTTAGACCTAGAAAAGAATCGTGACGGGCAGGAAACCATTACACCACCACCTGGGCTGTGCTCTCCGGCTCCCGCCGCCACCCCC
GCCCTCGCCTTCGCCTCCGCCTCCGGTGCACATTAAAGATCCAAAGTCATGACTGACTCCAAGTATTTCACAACCAATAAAAAAGGGCGG
GAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTG
GAGCTGGAGGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAG
GAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTG
CAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGC
TTTGAGACCAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGA
GCTGAGAGGCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCCAAGAGGACCAGATCTGGGTGTTGTGCCTGACTTTCGAGGGCC
TCCTGGACTCAGACTGTGCATGTTGGGAAGGGGTCTGACCAGGCAAGCTGTGATCTGAAAGGAGCAAGGAACAGCAAGGAATTATTTTCC
AGAATGACACCCGCAGCAGAATGTTGGAGTGGAAATGATGGCTGGCTATGAAGAGGAGGTCAACGTGTGTGGTCTCCTCAGTCTCTGTCA
GAGGGGTGGGGAGGTGGGAAACAGGAATCCTCTGCAAAGCCCAATCTGCAGAGTCGAGACCCCTGGTGCTCTCTGCCCCGCTGCCTGGCA
CTGGTCCTTTGCAGCCAGCCACCAACGGCCCCCTTGCCCTTGCAGAGGCAGAAGCCTGCGTCTGCACCTGCACCTCTGACCGTTTCAGCA
CCCTGGGTTGTTACCACGTCCTACAACTCTGACATTTCTTGTTCTCAAGCGTTTCTCTTCACTGTGAGTTGTCTTTGGTCCTCCCACTTG
GTACTTGTATCTTGATGCTTTATAATCCTGACTCTCGACGTGTTCATTTATACAAAATCAGGAATAACTTTGTTTTTATACTGATTGCAG

>In-frame_AP2B1_ENST00000312678_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_1295nt
AGACCTAGAAAAGAATCGTGACGGGCAGGAAACCATTACACCACCACCTGGGCTGTGCTCTCCGGCTCCCGCCGCCACCCCCGCCCTCGC
CTTCGCCTCCGCCTCCGGTGCACATTAAAGATCCAAAGTCATGACTGACTCCAAGTATTTCACAACCAATAAAAAAGGGCGGGAGCAGTT
CCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGA
GGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGC
CTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGA
GGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGAC
CAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAG
GCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCCAAGAGGACCAGATCTGGGTGTTGTGCCTGACTTTCGAGGGCCTCCTGGAC
TCAGACTGTGCATGTTGGGAAGGGGTCTGACCAGGCAAGCTGTGATCTGAAAGGAGCAAGGAACAGCAAGGAATTATTTTCCAGAATGAC
ACCCGCAGCAGAATGTTGGAGTGGAAATGATGGCTGGCTATGAAGAGGAGGTCAACGTGTGTGGTCTCCTCAGTCTCTGTCAGAGGGGTG
GGGAGGTGGGAAACAGGAATCCTCTGCAAAGCCCAATCTGCAGAGTCGAGACCCCTGGTGCTCTCTGCCCCGCTGCCTGGCACTGGTCCT
TTGCAGCCAGCCACCAACGGCCCCCTTGCCCTTGCAGAGGCAGAAGCCTGCGTCTGCACCTGCACCTCTGACCGTTTCAGCACCCTGGGT
TGTTACCACGTCCTACAACTCTGACATTTCTTGTTCTCAAGCGTTTCTCTTCACTGTGAGTTGTCTTTGGTCCTCCCACTTGGTACTTGT
ATCTTGATGCTTTATAATCCTGACTCTCGACGTGTTCATTTATACAAAATCAGGAATAACTTTGTTTTTATACTGATTGCAGCAATGTTG

>In-frame_AP2B1_ENST00000589344_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_1419nt
ACCTGGGCTGTGCTCTCCGGCTCCCGCCGCCACCCCCGCCCTCGCCTTCGCCTCCGCCTCCGGTGAGTTCAGGGCGGTTGCCTTTAGGGT
GTGTCCCTAATTGACGGGGTCGGGGACGGAGAGAAGGGTAACACCAGGCTGGGTCGGAGACCGGCGGAGGCGAGGAAATCCTAAGAGCGT
GACCGTTGATGATGCAGGGAACCGTCGGGTGTGACCATTGAGAGGGAAAAGGTGCACATTAAAGATCCAAAGTCATGACTGACTCCAAGT
ATTTCACAACCAATAAAAAAGGGCGGGAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATG
ATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCG
TGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTG
TCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGG
ATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGG
TGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCCAAGAGGACCAGATCTG
GGTGTTGTGCCTGACTTTCGAGGGCCTCCTGGACTCAGACTGTGCATGTTGGGAAGGGGTCTGACCAGGCAAGCTGTGATCTGAAAGGAG
CAAGGAACAGCAAGGAATTATTTTCCAGAATGACACCCGCAGCAGAATGTTGGAGTGGAAATGATGGCTGGCTATGAAGAGGAGGTCAAC
GTGTGTGGTCTCCTCAGTCTCTGTCAGAGGGGTGGGGAGGTGGGAAACAGGAATCCTCTGCAAAGCCCAATCTGCAGAGTCGAGACCCCT
GGTGCTCTCTGCCCCGCTGCCTGGCACTGGTCCTTTGCAGCCAGCCACCAACGGCCCCCTTGCCCTTGCAGAGGCAGAAGCCTGCGTCTG
CACCTGCACCTCTGACCGTTTCAGCACCCTGGGTTGTTACCACGTCCTACAACTCTGACATTTCTTGTTCTCAAGCGTTTCTCTTCACTG
TGAGTTGTCTTTGGTCCTCCCACTTGGTACTTGTATCTTGATGCTTTATAATCCTGACTCTCGACGTGTTCATTTATACAAAATCAGGAA

>In-frame_AP2B1_ENST00000537622_chr17_33921086_+_RAB20_ENST00000267328_chr13_111176544_-_1400nt
AGGGTGTGTCCCTAATTGACGGGGTCGGGGACGGAGAGAAGGGTAACACCAGGCTGGGTCGGAGACCGGCGGAGGCGAGGAAATCCTAAG
AGCGTGACCGTTGATGATGCAGGGAACCGTCGGGTGTGACCATTGAGAGGGAAAAGGTTGGAGAAAGGGTCTCTACCATGATGCCTGTGG
TGCGGTGAGGGAATCCTCGGGTGTGGCAGCAGGTGCACATTAAAGATCCAAAGTCATGACTGACTCCAAGTATTTCACAACCAATAAAAA
AGGGCGGGAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAG
CCTGGTGGAGCTGGAGGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCT
CACTGAGGAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAA
GCAGGTGCAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCA
AATGTGCTTTGAGACCAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACA
GCAGAGAGCTGAGAGGCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCCAAGAGGACCAGATCTGGGTGTTGTGCCTGACTTTC
GAGGGCCTCCTGGACTCAGACTGTGCATGTTGGGAAGGGGTCTGACCAGGCAAGCTGTGATCTGAAAGGAGCAAGGAACAGCAAGGAATT
ATTTTCCAGAATGACACCCGCAGCAGAATGTTGGAGTGGAAATGATGGCTGGCTATGAAGAGGAGGTCAACGTGTGTGGTCTCCTCAGTC
TCTGTCAGAGGGGTGGGGAGGTGGGAAACAGGAATCCTCTGCAAAGCCCAATCTGCAGAGTCGAGACCCCTGGTGCTCTCTGCCCCGCTG
CCTGGCACTGGTCCTTTGCAGCCAGCCACCAACGGCCCCCTTGCCCTTGCAGAGGCAGAAGCCTGCGTCTGCACCTGCACCTCTGACCGT
TTCAGCACCCTGGGTTGTTACCACGTCCTACAACTCTGACATTTCTTGTTCTCAAGCGTTTCTCTTCACTGTGAGTTGTCTTTGGTCCTC
CCACTTGGTACTTGTATCTTGATGCTTTATAATCCTGACTCTCGACGTGTTCATTTATACAAAATCAGGAATAACTTTGTTTTTATACTG


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FusionGenePPI for AP2B1_RAB20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AP2B1KIAA0408, DHX58, MLH1, AP1M1, MEA1, TUBGCP4, LDLRAP1, THAP1, POM121, NECAP2, ATP6V1G1, NUP54, TERF2IP, FAM46C, RIBC2, AP1M2, AP2M1, RNPS1, TGFBR1, TGFBR2, BUB1B, CLINT1, ARRB2, OSBPL10, APC, ITSN1, SIRT7, CLTC, AMPH, CUL3, ABL1, SHC1, CRK, EPS15, ERBB2, FN1, VCAM1, DAB2, ITGA4, MMS19, RNF11, EGFR, GRB2, PLOD2, EPN1, LNPEP, NUSAP1, SEC24C, XPO7, RPA3, RPA2, RPA1, EPHA2, GTF2I, PIP5K1C, SLC25A6, KPNA2, U2AF1, RAPGEF3, TXN2, AFF4, XRCC6BP1, NEU4, AAK1, HSPB1, AP1S1, AP1S2, AP1G1, AP2A1, AP2A2, CAB39, AP2S1, COX5B, NUP50, TOMM40, VAPA, NTRK1, CEP128, ODF2, XPO1, CLTB, DBN1, FLNA, GAK, MYH9, PICALM, LIMA1, GTSE1, ANLN, MYO19, TFRC, MCM2, MEX3C, TFAP2A, DIEXF, MYO6, ARFGAP1, RUNDC3A, SNX9, UBC, OCRL, TRIM25, BRCA1, SLC2A8RAB20NXF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAP2B1chr17:33921086chr13:111176544ENST00000262325+221841_93712938ARRB1
HgeneAP2B1chr17:33921086chr13:111176544ENST00000312678+222841_93712952ARRB1
HgeneAP2B1chr17:33921086chr13:111176544ENST00000537622+222841_93712952ARRB1
HgeneAP2B1chr17:33921086chr13:111176544ENST00000538556+222841_937-74881ARRB1
HgeneAP2B1chr17:33921086chr13:111176544ENST00000589344+222841_93712952ARRB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AP2B1_RAB20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AP2B1_RAB20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAP2B1C0086132Depressive Symptoms1PSYGENET