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Fusion gene ID: 20686 |
FusionGeneSummary for MALSU1_MALSU1 |
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Fusion gene information | Fusion gene name: MALSU1_MALSU1 | Fusion gene ID: 20686 | Hgene | Tgene | Gene symbol | MALSU1 | MALSU1 | Gene ID | 115416 | 115416 |
Gene name | mitochondrial assembly of ribosomal large subunit 1 | mitochondrial assembly of ribosomal large subunit 1 | |
Synonyms | C7orf30|mtRsfA | C7orf30|mtRsfA | |
Cytomap | 7p15.3 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | mitochondrial assembly of ribosomal large subunit protein 1 | mitochondrial assembly of ribosomal large subunit protein 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96EH3 | Q96EH3 | |
Ensembl transtripts involved in fusion gene | ENST00000479974, ENST00000466681, | ENST00000479974, ENST00000466681, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: MALSU1 [Title/Abstract] AND MALSU1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MALSU1 | GO:0070130 | negative regulation of mitochondrial translation | 22829778 |
Tgene | MALSU1 | GO:0070130 | negative regulation of mitochondrial translation | 22829778 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI571420 | MALSU1 | chr7 | 23347270 | - | MALSU1 | chr7 | 23348832 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000479974 | ENST00000479974 | MALSU1 | chr7 | 23347270 | - | MALSU1 | chr7 | 23348832 | - |
intron-intron | ENST00000479974 | ENST00000466681 | MALSU1 | chr7 | 23347270 | - | MALSU1 | chr7 | 23348832 | - |
intron-intron | ENST00000466681 | ENST00000479974 | MALSU1 | chr7 | 23347270 | - | MALSU1 | chr7 | 23348832 | - |
intron-intron | ENST00000466681 | ENST00000466681 | MALSU1 | chr7 | 23347270 | - | MALSU1 | chr7 | 23348832 | - |
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FusionProtFeatures for MALSU1_MALSU1 |
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Hgene | Tgene |
MALSU1 | MALSU1 |
May function as a ribosomal silencing factor. Additionto isolated mitochondrial ribosomal subunits partially inhibitstranslation. Interacts with mitochondrial ribosomal protein L14(MRPL14), probably blocking formation of intersubunit bridge B8,preventing association of the 28S and 39S ribosomal subunits andthe formation of functional ribosomes, thus repressingtranslation. May also participate in the assembly and/orregulation of the stability of the large subunit of themitochondrial ribosome. {ECO:0000269|PubMed:22238376}. | May function as a ribosomal silencing factor. Additionto isolated mitochondrial ribosomal subunits partially inhibitstranslation. Interacts with mitochondrial ribosomal protein L14(MRPL14), probably blocking formation of intersubunit bridge B8,preventing association of the 28S and 39S ribosomal subunits andthe formation of functional ribosomes, thus repressingtranslation. May also participate in the assembly and/orregulation of the stability of the large subunit of themitochondrial ribosome. {ECO:0000269|PubMed:22238376}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MALSU1_MALSU1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MALSU1_MALSU1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MALSU1_MALSU1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MALSU1_MALSU1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |