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Fusion gene ID: 20667 |
FusionGeneSummary for MALAT1_SPRED1 |
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Fusion gene information | Fusion gene name: MALAT1_SPRED1 | Fusion gene ID: 20667 | Hgene | Tgene | Gene symbol | MALAT1 | SPRED1 | Gene ID | 378938 | 161742 |
Gene name | metastasis associated lung adenocarcinoma transcript 1 | sprouty related EVH1 domain containing 1 | |
Synonyms | HCN|LINC00047|NCRNA00047|NEAT2|PRO2853 | NFLS|PPP1R147|hSpred1|spred-1 | |
Cytomap | 11q13.1 | 15q14 | |
Type of gene | ncRNA | protein-coding | |
Description | hepcarcinlong intergenic non-protein coding RNA 47metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)nuclear enriched abundant transcript 2nuclear paraspeckle assembly transcript 2 (non-protein coding) | sprouty-related, EVH1 domain-containing protein 1protein phosphatase 1, regulatory subunit 147suppressor of Ras/MAPK activation | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | Q7Z699 | ||
Ensembl transtripts involved in fusion gene | ENST00000534336, | ENST00000299084, ENST00000561205, | |
Fusion gene scores | * DoF score | 83 X 128 X 5=53120 | 5 X 5 X 2=50 |
# samples | 141 | 6 | |
** MAII score | log2(141/53120*10)=-5.23548807894813 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MALAT1 [Title/Abstract] AND SPRED1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SPRED1 | GO:0006469 | negative regulation of protein kinase activity | 18216281 |
Tgene | SPRED1 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA774258 | MALAT1 | chr11 | 65269819 | + | SPRED1 | chr15 | 38643887 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000534336 | ENST00000299084 | MALAT1 | chr11 | 65269819 | + | SPRED1 | chr15 | 38643887 | + |
3UTR-intron | ENST00000534336 | ENST00000561205 | MALAT1 | chr11 | 65269819 | + | SPRED1 | chr15 | 38643887 | + |
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FusionProtFeatures for MALAT1_SPRED1 |
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Hgene | Tgene |
MALAT1 | SPRED1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulateshematopoiesis of bone marrow (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MALAT1_SPRED1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MALAT1_SPRED1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MALAT1_SPRED1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MALAT1_SPRED1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MALAT1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | MALAT1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | MALAT1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | MALAT1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | MALAT1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Hgene | MALAT1 | C0236663 | Alcohol withdrawal syndrome | 1 | PSYGENET |
Hgene | MALAT1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Tgene | SPRED1 | C1969623 | NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | SPRED1 | C0027831 | Neurofibromatosis 1 | 1 | CTD_human |
Tgene | SPRED1 | C0221263 | Cafe-au-Lait Spots | 1 | CTD_human |
Tgene | SPRED1 | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |