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Fusion gene ID: 20610 |
FusionGeneSummary for MALAT1_CLGN |
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Fusion gene information | Fusion gene name: MALAT1_CLGN | Fusion gene ID: 20610 | Hgene | Tgene | Gene symbol | MALAT1 | CLGN | Gene ID | 378938 | 4312 |
Gene name | metastasis associated lung adenocarcinoma transcript 1 | matrix metallopeptidase 1 | |
Synonyms | HCN|LINC00047|NCRNA00047|NEAT2|PRO2853 | CLG|CLGN | |
Cytomap | 11q13.1 | 11q22.2 | |
Type of gene | ncRNA | protein-coding | |
Description | hepcarcinlong intergenic non-protein coding RNA 47metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)nuclear enriched abundant transcript 2nuclear paraspeckle assembly transcript 2 (non-protein coding) | interstitial collagenasefibroblast collagenasematrix metallopeptidase 1 (interstitial collagenase)matrix metalloprotease 1matrix metalloproteinase 1 | |
Modification date | 20180527 | 20180522 | |
UniProtAcc | O14967 | ||
Ensembl transtripts involved in fusion gene | ENST00000534336, | ENST00000414773, ENST00000325617, ENST00000537281, | |
Fusion gene scores | * DoF score | 83 X 128 X 5=53120 | 2 X 2 X 2=8 |
# samples | 141 | 2 | |
** MAII score | log2(141/53120*10)=-5.23548807894813 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: MALAT1 [Title/Abstract] AND CLGN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CLGN | GO:0006508 | proteolysis | 15863497|19022250 |
Tgene | CLGN | GO:0032461 | positive regulation of protein oligomerization | 19022250 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU568984 | MALAT1 | chr11 | 65267423 | + | CLGN | chr4 | 141313408 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000534336 | ENST00000414773 | MALAT1 | chr11 | 65267423 | + | CLGN | chr4 | 141313408 | - |
3UTR-3CDS | ENST00000534336 | ENST00000325617 | MALAT1 | chr11 | 65267423 | + | CLGN | chr4 | 141313408 | - |
3UTR-3CDS | ENST00000534336 | ENST00000537281 | MALAT1 | chr11 | 65267423 | + | CLGN | chr4 | 141313408 | - |
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FusionProtFeatures for MALAT1_CLGN |
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Hgene | Tgene |
MALAT1 | CLGN |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Functions during spermatogenesis as a chaperone for arange of client proteins that are important for sperm adhesiononto the egg zona pellucida and for subsequent penetration of thezona pellucida. Required for normal sperm migration from theuterus into the oviduct. Required for normal male fertility. Bindscalcium ions (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MALAT1_CLGN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MALAT1_CLGN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MALAT1_CLGN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MALAT1_CLGN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MALAT1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | MALAT1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | MALAT1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | MALAT1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | MALAT1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Hgene | MALAT1 | C0236663 | Alcohol withdrawal syndrome | 1 | PSYGENET |
Hgene | MALAT1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |