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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20594

FusionGeneSummary for MAG_NMNAT3

check button Fusion gene summary
Fusion gene informationFusion gene name: MAG_NMNAT3
Fusion gene ID: 20594
HgeneTgene
Gene symbol

MAG

NMNAT3

Gene ID

4099

349565

Gene namemyelin associated glycoproteinnicotinamide nucleotide adenylyltransferase 3
SynonymsGMA|S-MAG|SIGLEC-4A|SIGLEC4A|SPG75FKSG76|PNAT-3|PNAT3
Cytomap

19q13.12

3q23

Type of geneprotein-codingprotein-coding
Descriptionmyelin-associated glycoproteinsialic acid binding Ig-like lectin 4Asialic acid-binding immunoglobulin-like lectin 4Anicotinamide/nicotinic acid mononucleotide adenylyltransferase 3NMN adenylyltransferase 3NMN/NaMN adenylyltransferase 3NaMN adenylyltransferase 3nicotinamide mononucleotide adenylyltransferase 3nicotinate-nucleotide adenylyltransferase 3pyridine nuc
Modification date2018052220180523
UniProtAcc

P20916

Q96T66

Ensembl transtripts involved in fusion geneENST00000392213, ENST00000361922, 
ENST00000597035, ENST00000537831, 
ENST00000593348, 		ENST00000406164, 
ENST00000406824, ENST00000339837, 
ENST00000413939, ENST00000296202, 
ENST00000511444, ENST00000512391, 
ENST00000514703, ENST00000507242, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 4 X 4=96
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAG [Title/Abstract] AND NMNAT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM544763MAGchr19

35786353

+NMNAT3chr3

139396595

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000392213ENST00000406164MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000392213ENST00000406824MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000392213ENST00000339837MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000392213ENST00000413939MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000392213ENST00000296202MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000392213ENST00000511444MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000392213ENST00000512391MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000392213ENST00000514703MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000392213ENST00000507242MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000361922ENST00000406164MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000361922ENST00000406824MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000361922ENST00000339837MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000361922ENST00000413939MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000361922ENST00000296202MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000361922ENST00000511444MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000361922ENST00000512391MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000361922ENST00000514703MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000361922ENST00000507242MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000597035ENST00000406164MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000597035ENST00000406824MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000597035ENST00000339837MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000597035ENST00000413939MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000597035ENST00000296202MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000597035ENST00000511444MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000597035ENST00000512391MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000597035ENST00000514703MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000597035ENST00000507242MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000537831ENST00000406164MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000537831ENST00000406824MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000537831ENST00000339837MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000537831ENST00000413939MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000537831ENST00000296202MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-intronENST00000537831ENST00000511444MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000537831ENST00000512391MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-intronENST00000537831ENST00000514703MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-intronENST00000537831ENST00000507242MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000593348ENST00000406164MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000593348ENST00000406824MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000593348ENST00000339837MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000593348ENST00000413939MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000593348ENST00000296202MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-intronENST00000593348ENST00000511444MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000593348ENST00000512391MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-intronENST00000593348ENST00000514703MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-intronENST00000593348ENST00000507242MAGchr19

35786353

+NMNAT3chr3

139396595

-

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FusionProtFeatures for MAG_NMNAT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAG

P20916

NMNAT3

Q96T66

Adhesion molecule that mediates interactions betweenmyelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2(By similarity). Not required for initial myelination, but seemsto play a role in the maintenance of normal axon myelination.Protects motoneurons against apoptosis, also after injury;protection against apoptosis is probably mediated via interactionwith neuronal RTN4R and RTN4RL2. Required to prevent degenerationof myelinated axons in adults; this probably depends on binding togangliosides on the axon cell membrane (By similarity). Negativeregulator of neurite outgrowth; in dorsal root ganglion neuronsthe inhibition is mediated primarily via binding to neuronal RTN4Ror RTN4RL2 and to a lesser degree via binding to neuronalgangliosides. In cerebellar granule cells the inhibition ismediated primarily via binding to neuronal gangliosides. Insensory neurons, inhibition of neurite extension depends onlypartially on RTN4R, RTN4RL2 and gangliosides. Inhibits axonlongitudinal growth (By similarity). Inhibits axon outgrowth bybinding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity).{ECO:0000250|UniProtKB:P07722, ECO:0000250|UniProtKB:P20917}. Catalyzes the formation of NAD(+) from nicotinamidemononucleotide (NMN) and ATP. Can also use the deamidated form;nicotinic acid mononucleotide (NaMN) as substrate with the sameefficiency. Can use triazofurin monophosphate (TrMP) as substrate.Can also use GTP and ITP as nucleotide donors. Also catalyzes thereverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+).For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD,nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamideguanine dinucleotide (NGD) as substrates. Fails to cleavephosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protectsagainst axonal degeneration following injury.{ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAG_NMNAT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAG_NMNAT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAG_NMNAT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAG_NMNAT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAGC0036341Schizophrenia5PSYGENET
HgeneMAGC0030567Parkinson Disease1CTD_human
HgeneMAGC0752347Lewy Body Disease1CTD_human
HgeneMAGC4225250SPASTIC PARAPLEGIA 75, AUTOSOMAL RECESSIVE1ORPHANET;UNIPROT
TgeneNMNAT3C0032460Polycystic Ovary Syndrome1CTD_human