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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 20588

FusionGeneSummary for MAGI3_NOTCH2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAGI3_NOTCH2
Fusion gene ID: 20588
HgeneTgene
Gene symbol

MAGI3

NOTCH2

Gene ID

260425

4853

Gene namemembrane associated guanylate kinase, WW and PDZ domain containing 3notch 2
SynonymsMAGI-3|dJ730K3.2AGS2|HJCYS|hN2
Cytomap

1p13.2

1p12

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated guanylate kinase, WW and PDZ domain-containing protein 3membrane-associated guanylate kinase inverted 3membrane-associated guanylate kinase-related 3neurogenic locus notch homolog protein 2Notch homolog 2
Modification date2018052220180519
UniProtAcc

Q5TCQ9

Q04721

Ensembl transtripts involved in fusion geneENST00000369617, ENST00000307546, 
ENST00000369615, ENST00000369611, 
ENST00000486456, 
ENST00000256646, 
ENST00000602566, ENST00000493703, 
Fusion gene scores* DoF score5 X 3 X 3=459 X 7 X 3=189
# samples 59
** MAII scorelog2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/189*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAGI3 [Title/Abstract] AND NOTCH2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNOTCH2

GO:0007050

cell cycle arrest

11306509

TgeneNOTCH2

GO:0007219

Notch signaling pathway

11306509|25985737

TgeneNOTCH2

GO:0010629

negative regulation of gene expression

11306509

TgeneNOTCH2

GO:0045967

negative regulation of growth rate

11306509

TgeneNOTCH2

GO:0046579

positive regulation of Ras protein signal transduction

11306509

TgeneNOTCH2

GO:0070374

positive regulation of ERK1 and ERK2 cascade

11306509


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0W3-01AMAGI3chr1

113933971

+NOTCH2chr1

120539955

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000369617ENST00000256646MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
In-frameENST00000369617ENST00000602566MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
5CDS-intronENST00000369617ENST00000493703MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
In-frameENST00000307546ENST00000256646MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
In-frameENST00000307546ENST00000602566MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
5CDS-intronENST00000307546ENST00000493703MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
In-frameENST00000369615ENST00000256646MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
In-frameENST00000369615ENST00000602566MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
5CDS-intronENST00000369615ENST00000493703MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
In-frameENST00000369611ENST00000256646MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
In-frameENST00000369611ENST00000602566MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
5CDS-intronENST00000369611ENST00000493703MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
3UTR-3CDSENST00000486456ENST00000256646MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
3UTR-3CDSENST00000486456ENST00000602566MAGI3chr1

113933971

+NOTCH2chr1

120539955

-
3UTR-intronENST00000486456ENST00000493703MAGI3chr1

113933971

+NOTCH2chr1

120539955

-

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FusionProtFeatures for MAGI3_NOTCH2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAGI3

Q5TCQ9

NOTCH2

Q04721

Functions as a receptor for membrane-bound ligandsJagged1, Jagged2 and Delta1 to regulate cell-fate determination.Upon ligand activation through the released notch intracellulardomain (NICD) it forms a transcriptional activator complex withRBPJ/RBPSUH and activates genes of the enhancer of split locus.Affects the implementation of differentiation, proliferation andapoptotic programs (By similarity). Involved in bone remodelingand homeostasis. In collaboration with RELA/p65 enhances NFATc1promoter activity and positively regulates RANKL-inducedosteoclast differentiation (PubMed:29149593). Positively regulatesself-renewal of liver cancer cells (PubMed:25985737).{ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985,ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737,ECO:0000269|PubMed:29149593}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+1216_91051482Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+1216_91051126Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+1226_91052009Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+1226_91051151Compositional biasNote=Poly-Lys
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341645_16481382472Compositional biasNote=Poly-Ala
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341994_19971382472Compositional biasNote=Poly-Leu
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2342426_24291382472Compositional biasNote=Poly-Ser
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341025_10611382472DomainEGF-like 27%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341063_10991382472DomainEGF-like 28
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341101_11471382472DomainEGF-like 29
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341149_11851382472DomainEGF-like 30%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341187_12231382472DomainEGF-like 31%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341225_12621382472DomainEGF-like 32%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341264_13021382472DomainEGF-like 33
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341304_13431382472DomainEGF-like 34
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341374_14121382472DomainEGF-like 35
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234144_1801382472DomainEGF-like 4
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234182_2191382472DomainEGF-like 5%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234221_2581382472DomainEGF-like 6
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234260_2961382472DomainEGF-like 7%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234298_3361382472DomainEGF-like 8%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234338_3741382472DomainEGF-like 9%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234375_4131382472DomainEGF-like 10
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234415_4541382472DomainEGF-like 11%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234456_4921382472DomainEGF-like 12%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234494_5301382472DomainEGF-like 13%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234532_5681382472DomainEGF-like 14%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234570_6051382472DomainEGF-like 15%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234607_6431382472DomainEGF-like 16%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234645_6801382472DomainEGF-like 17%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234682_7181382472DomainEGF-like 18%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234720_7551382472DomainEGF-like 19
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234757_7931382472DomainEGF-like 20%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234795_8311382472DomainEGF-like 21%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234833_8711382472DomainEGF-like 22
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234873_9091382472DomainEGF-like 23%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234911_9471382472DomainEGF-like 24%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234949_9851382472DomainEGF-like 25%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234987_10231382472DomainEGF-like 26%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341425_16771382472RegionNote=Negative regulatory region (NRR)
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341425_14651382472RepeatNote=LNR 1
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341466_15021382472RepeatNote=LNR 2
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341503_15441382472RepeatNote=LNR 3
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341827_18711382472RepeatNote=ANK 1
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341876_19051382472RepeatNote=ANK 2
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341909_19391382472RepeatNote=ANK 3
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341943_19721382472RepeatNote=ANK 4
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341976_20051382472RepeatNote=ANK 5
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2342009_20381382472RepeatNote=ANK 6
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341699_24711382472Topological domainCytoplasmic
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-2341678_16981382472TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121238_2431051482Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121238_2431051126Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122238_2431052009Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122238_2431051151Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+1211021_11031051482DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121114_2881051482DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121293_3261051482DomainWW 1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121339_3721051482DomainWW 2
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121578_6541051482DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+1211021_11031051126DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121114_2881051126DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121293_3261051126DomainWW 1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121339_3721051126DomainWW 2
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121578_6541051126DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+1221021_11031052009DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122114_2881052009DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122293_3261052009DomainWW 1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122339_3721052009DomainWW 2
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122578_6541052009DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+1221021_11031051151DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122114_2881051151DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122293_3261051151DomainWW 1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122339_3721051151DomainWW 2
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122578_6541051151DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121121_1281051482Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121121_1281051126Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122121_1281052009Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122121_1281051151Nucleotide bindingATP
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-234105_1431382472DomainEGF-like 3
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-23426_631382472DomainEGF-like 1
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-23464_1021382472DomainEGF-like 2
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646-23426_16771382472Topological domainExtracellular


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FusionGeneSequence for MAGI3_NOTCH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MAGI3_ENST00000369617_chr1_113933971_+_NOTCH2_ENST00000256646_chr1_120539955_-_2439aa
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF
TGQYCDSLTVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECL
LQPNACQNGGTCANRNGGTGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTN
PLNGQTICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGTAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCM
PGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGTECQCATGFTGVLCEENIDN
CDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGI
NRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGTKCLCDAGWVGIN
CEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGTNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCE
NAAVCKESPNFESTTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTF
SCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCL
HEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGATCDVPNVSCDIAASRRG
VLVEHLCQHSGVCINAGNTHYCQCPLGTTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGTQGVNCETEVDECQNQPCQNGGTCI
DLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCR
SAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPC
QHGGSCHPQRQPPTYSCQCAPPFSGSRCELYTAPPSTPPATCLSQTCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCW
DTINNQCDELCNTVECLFDNFECQGNSKTCKTDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDAR
SFLRALGTLLHTNLRIKRDSQGELMVYPTTGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASH
AIQGTLSYPLVSVVSESLTPERTQLLTLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQ
VSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLM
LASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQ
GVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETP
LFLAAREGSTEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKS
RRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTTVSDTTSSPMITSPGILQASPNPMLATAAPPAPV
HAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIA
PQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAT
HPFPASVGKYPTPPSQHSTASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPP

>In-frame_MAGI3_ENST00000369617_chr1_113933971_+_NOTCH2_ENST00000602566_chr1_120539955_-_242aa
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF

>In-frame_MAGI3_ENST00000307546_chr1_113933971_+_NOTCH2_ENST00000256646_chr1_120539955_-_2439aa
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF
TGQYCDSLTVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECL
LQPNACQNGGTCANRNGGTGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTN
PLNGQTICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGTAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCM
PGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGTECQCATGFTGVLCEENIDN
CDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGI
NRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGTKCLCDAGWVGIN
CEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGTNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCE
NAAVCKESPNFESTTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTF
SCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCL
HEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGATCDVPNVSCDIAASRRG
VLVEHLCQHSGVCINAGNTHYCQCPLGTTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGTQGVNCETEVDECQNQPCQNGGTCI
DLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCR
SAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPC
QHGGSCHPQRQPPTYSCQCAPPFSGSRCELYTAPPSTPPATCLSQTCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCW
DTINNQCDELCNTVECLFDNFECQGNSKTCKTDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDAR
SFLRALGTLLHTNLRIKRDSQGELMVYPTTGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASH
AIQGTLSYPLVSVVSESLTPERTQLLTLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQ
VSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLM
LASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQ
GVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETP
LFLAAREGSTEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKS
RRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTTVSDTTSSPMITSPGILQASPNPMLATAAPPAPV
HAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIA
PQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAT
HPFPASVGKYPTPPSQHSTASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPP

>In-frame_MAGI3_ENST00000307546_chr1_113933971_+_NOTCH2_ENST00000602566_chr1_120539955_-_242aa
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF

>In-frame_MAGI3_ENST00000369615_chr1_113933971_+_NOTCH2_ENST00000256646_chr1_120539955_-_2439aa
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF
TGQYCDSLTVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECL
LQPNACQNGGTCANRNGGTGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTN
PLNGQTICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGTAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCM
PGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGTECQCATGFTGVLCEENIDN
CDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGI
NRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGTKCLCDAGWVGIN
CEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGTNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCE
NAAVCKESPNFESTTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTF
SCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCL
HEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGATCDVPNVSCDIAASRRG
VLVEHLCQHSGVCINAGNTHYCQCPLGTTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGTQGVNCETEVDECQNQPCQNGGTCI
DLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCR
SAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPC
QHGGSCHPQRQPPTYSCQCAPPFSGSRCELYTAPPSTPPATCLSQTCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCW
DTINNQCDELCNTVECLFDNFECQGNSKTCKTDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDAR
SFLRALGTLLHTNLRIKRDSQGELMVYPTTGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASH
AIQGTLSYPLVSVVSESLTPERTQLLTLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQ
VSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLM
LASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQ
GVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETP
LFLAAREGSTEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKS
RRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTTVSDTTSSPMITSPGILQASPNPMLATAAPPAPV
HAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIA
PQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAT
HPFPASVGKYPTPPSQHSTASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPP

>In-frame_MAGI3_ENST00000369615_chr1_113933971_+_NOTCH2_ENST00000602566_chr1_120539955_-_242aa
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF

>In-frame_MAGI3_ENST00000369611_chr1_113933971_+_NOTCH2_ENST00000256646_chr1_120539955_-_2439aa
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF
TGQYCDSLTVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECL
LQPNACQNGGTCANRNGGTGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTN
PLNGQTICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGTAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCM
PGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGTECQCATGFTGVLCEENIDN
CDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGI
NRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGTKCLCDAGWVGIN
CEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGTNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCE
NAAVCKESPNFESTTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTF
SCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCL
HEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGATCDVPNVSCDIAASRRG
VLVEHLCQHSGVCINAGNTHYCQCPLGTTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGTQGVNCETEVDECQNQPCQNGGTCI
DLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCR
SAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPC
QHGGSCHPQRQPPTYSCQCAPPFSGSRCELYTAPPSTPPATCLSQTCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCW
DTINNQCDELCNTVECLFDNFECQGNSKTCKTDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDAR
SFLRALGTLLHTNLRIKRDSQGELMVYPTTGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASH
AIQGTLSYPLVSVVSESLTPERTQLLTLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQ
VSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLM
LASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQ
GVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETP
LFLAAREGSTEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKS
RRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTTVSDTTSSPMITSPGILQASPNPMLATAAPPAPV
HAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIA
PQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAT
HPFPASVGKYPTPPSQHSTASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPP

>In-frame_MAGI3_ENST00000369611_chr1_113933971_+_NOTCH2_ENST00000602566_chr1_120539955_-_242aa
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MAGI3_ENST00000369617_chr1_113933971_+_NOTCH2_ENST00000256646_chr1_120539955_-_7317nt
ATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGC
GCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTC
TCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTC
ATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGT
GCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTC
AATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTC
ACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACT
TTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTGTGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAGAATGGAGGG
GTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCCCCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTG
CTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAACCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGAT
GACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTGTACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATG
TGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGATGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAAC
CCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTACAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAAT
AGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGATGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGT
GAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAATGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATG
CCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGAATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTC
AATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCCAGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAAT
GGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCAGTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAAC
TGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGGTATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATC
TGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCTGAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGC
CAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGATGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATT
AATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCAGAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAG
GGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTATATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAA
TGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGGTCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAAC
TGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCAGAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGC
AAGAAGGGCTTTAAAGGCTATAACTGCCAGGTGAATATTGATGAATGTGCCTCAAATCCATGCCTGAACCAAGGAACCTGCTTTGATGAC
ATAAGTGGCTACACTTGCCACTGTGTGCTGCCATACACAGGCAAGAATTGTCAGACAGTATTGGCTCCCTGTTCCCCAAACCCTTGTGAG
AATGCTGCTGTTTGCAAAGAGTCACCAAATTTTGAGAGTTATACTTGCTTGTGTGCTCCTGGCTGGCAAGGTCAGCGGTGTACCATTGAC
ATTGACGAGTGTATCTCCAAGCCCTGCATGAACCATGGTCTCTGCCATAACACCCAGGGCAGCTACATGTGTGAATGTCCACCAGGCTTC
AGTGGTATGGACTGTGAGGAGGACATTGATGACTGCCTTGCCAATCCTTGCCAGAATGGAGGTTCCTGTATGGATGGAGTGAATACTTTC
TCCTGCCTCTGCCTTCCGGGTTTCACTGGGGATAAGTGCCAGACAGACATGAATGAGTGTCTGAGTGAACCCTGTAAGAATGGAGGGACC
TGCTCTGACTACGTCAACAGTTACACTTGCAAGTGCCAGGCAGGATTTGATGGAGTCCATTGTGAGAACAACATCAATGAGTGCACTGAG
AGCTCCTGTTTCAATGGTGGCACATGTGTTGATGGGATTAACTCCTTCTCTTGCTTGTGCCCTGTGGGTTTCACTGGATCCTTCTGCCTC
CATGAGATCAATGAATGCAGCTCTCATCCATGCCTGAATGAGGGAACGTGTGTTGATGGCCTGGGTACCTACCGCTGCAGCTGCCCCCTG
GGCTACACTGGGAAAAACTGTCAGACCCTGGTGAATCTCTGCAGTCGGTCTCCATGTAAAAACAAAGGTACTTGCGTTCAGAAAAAAGCA
GAGTCCCAGTGCCTATGTCCATCTGGATGGGCTGGTGCCTATTGTGACGTGCCCAATGTCTCTTGTGACATAGCAGCCTCCAGGAGAGGT
GTGCTTGTTGAACACTTGTGCCAGCACTCAGGTGTCTGCATCAATGCTGGCAACACGCATTACTGTCAGTGCCCCCTGGGCTATACTGGG
AGCTACTGTGAGGAGCAACTCGATGAGTGTGCGTCCAACCCCTGCCAGCACGGGGCAACATGCAGTGACTTCATTGGTGGATACAGATGC
GAGTGTGTCCCAGGCTATCAGGGTGTCAACTGTGAGTATGAAGTGGATGAGTGCCAGAATCAGCCCTGCCAGAATGGAGGCACCTGTATT
GACCTTGTGAACCATTTCAAGTGCTCTTGCCCACCAGGCACTCGGGGCCTACTCTGTGAAGAGAACATTGATGACTGTGCCCGGGGTCCC
CATTGCCTTAATGGTGGTCAGTGCATGGATAGGATTGGAGGCTACAGTTGTCGCTGCTTGCCTGGCTTTGCTGGGGAGCGTTGTGAGGGA
GACATCAACGAGTGCCTCTCCAACCCCTGCAGCTCTGAGGGCAGCCTGGACTGTATACAGCTCACCAATGACTACCTGTGTGTTTGCCGT
AGTGCCTTTACTGGCCGGCACTGTGAAACCTTCGTCGATGTGTGTCCCCAGATGCCCTGCCTGAATGGAGGGACTTGTGCTGTGGCCAGT
AACATGCCTGATGGTTTCATTTGCCGTTGTCCCCCGGGATTTTCCGGGGCAAGGTGCCAGAGCAGCTGTGGACAAGTGAAATGTAGGAAG
GGGGAGCAGTGTGTGCACACCGCCTCTGGACCCCGCTGCTTCTGCCCCAGTCCCCGGGACTGCGAGTCAGGCTGTGCCAGTAGCCCCTGC
CAGCACGGGGGCAGCTGCCACCCTCAGCGCCAGCCTCCTTATTACTCCTGCCAGTGTGCCCCACCATTCTCGGGTAGCCGCTGTGAACTC
TACACGGCACCCCCCAGCACCCCTCCTGCCACCTGTCTGAGCCAGTATTGTGCCGACAAAGCTCGGGATGGCGTCTGTGATGAGGCCTGC
AACAGCCATGCCTGCCAGTGGGATGGGGGTGACTGTTCTCTCACCATGGAGAACCCCTGGGCCAACTGCTCCTCCCCACTTCCCTGCTGG
GATTATATCAACAACCAGTGTGATGAGCTGTGCAACACGGTCGAGTGCCTGTTTGACAACTTTGAATGCCAGGGGAACAGCAAGACATGC
AAGTATGACAAATACTGTGCAGACCACTTCAAAGACAACCACTGTGACCAGGGGTGCAACAGTGAGGAGTGTGGTTGGGATGGGCTGGAC
TGTGCTGCTGACCAACCTGAGAACCTGGCAGAAGGTACCCTGGTTATTGTGGTATTGATGCCACCTGAACAACTGCTCCAGGATGCTCGC
AGCTTCTTGCGGGCACTGGGTACCCTGCTCCACACCAACCTGCGCATTAAGCGGGACTCCCAGGGGGAACTCATGGTGTACCCCTATTAT
GGTGAGAAGTCAGCTGCTATGAAGAAACAGAGGATGACACGCAGATCCCTTCCTGGTGAACAAGAACAGGAGGTGGCTGGCTCTAAAGTC
TTTCTGGAAATTGACAACCGCCAGTGTGTTCAAGACTCAGACCACTGCTTCAAGAACACGGATGCAGCAGCAGCTCTCCTGGCCTCTCAC
GCCATACAGGGGACCCTGTCATACCCTCTTGTGTCTGTCGTCAGTGAATCCCTGACTCCAGAACGCACTCAGCTCCTCTATCTCCTTGCT
GTTGCTGTTGTCATCATTCTGTTTATTATTCTGCTGGGGGTAATCATGGCAAAACGAAAGCGTAAGCATGGCTCTCTCTGGCTGCCTGAA
GGTTTCACTCTTCGCCGAGATGCAAGCAATCACAAGCGTCGTGAGCCAGTGGGACAGGATGCTGTGGGGCTGAAAAATCTCTCAGTGCAA
GTCTCAGAAGCTAACCTAATTGGTACTGGAACAAGTGAACACTGGGTCGATGATGAAGGGCCCCAGCCAAAGAAAGTAAAGGCTGAAGAT
GAGGCCTTACTCTCAGAAGAAGATGACCCCATTGATCGACGGCCATGGACACAGCAGCACCTTGAAGCTGCAGACATCCGTAGGACACCA
TCGCTGGCTCTCACCCCTCCTCAGGCAGAGCAGGAGGTGGATGTGTTAGATGTGAATGTCCGTGGCCCAGATGGCTGCACCCCATTGATG
TTGGCTTCTCTCCGAGGAGGCAGCTCAGATTTGAGTGATGAAGATGAAGATGCAGAGGACTCTTCTGCTAACATCATCACAGACTTGGTC
TACCAGGGTGCCAGCCTCCAGGCCCAGACAGACCGGACTGGTGAGATGGCCCTGCACCTTGCAGCCCGCTACTCACGGGCTGATGCTGCC
AAGCGTCTCCTGGATGCAGGTGCAGATGCCAATGCCCAGGACAACATGGGCCGCTGTCCACTCCATGCTGCAGTGGCAGCTGATGCCCAA
GGTGTCTTCCAGATTCTGATTCGCAACCGAGTAACTGATCTAGATGCCAGGATGAATGATGGTACTACACCCCTGATCCTGGCTGCCCGC
CTGGCTGTGGAGGGAATGGTGGCAGAACTGATCAACTGCCAAGCGGATGTGAATGCAGTGGATGACCATGGAAAATCTGCTCTTCACTGG
GCAGCTGCTGTCAATAATGTGGAGGCAACTCTTTTGTTGTTGAAAAATGGGGCCAACCGAGACATGCAGGACAACAAGGAAGAGACACCT
CTGTTTCTTGCTGCCCGGGAGGGGAGCTATGAAGCAGCCAAGATCCTGTTAGACCATTTTGCCAATCGAGACATCACAGACCATATGGAT
CGTCTTCCCCGGGATGTGGCTCGGGATCGCATGCACCATGACATTGTGCGCCTTCTGGATGAATACAATGTGACCCCAAGCCCTCCAGGC
ACCGTGTTGACTTCTGCTCTCTCACCTGTCATCTGTGGGCCCAACAGATCTTTCCTCAGCCTGAAGCACACCCCAATGGGCAAGAAGTCT
AGACGGCCCAGTGCCAAGAGTACCATGCCTACTAGCCTCCCTAACCTTGCCAAGGAGGCAAAGGATGCCAAGGGTAGTAGGAGGAAGAAG
TCTCTGAGTGAGAAGGTCCAACTGTCTGAGAGTTCAGTAACTTTATCCCCTGTTGATTCCCTAGAATCTCCTCACACGTATGTTTCCGAC
ACCACATCCTCTCCAATGATTACATCCCCTGGGATCTTACAGGCCTCACCCAACCCTATGTTGGCCACTGCCGCCCCTCCTGCCCCAGTC
CATGCCCAGCATGCACTATCTTTTTCTAACCTTCATGAAATGCAGCCTTTGGCACATGGGGCCAGCACTGTGCTTCCCTCAGTGAGCCAG
TTGCTATCCCACCACCACATTGTGTCTCCAGGCAGTGGCAGTGCTGGAAGCTTGAGTAGGCTCCATCCAGTCCCAGTCCCAGCAGATTGG
ATGAACCGCATGGAGGTGAATGAGACCCAGTACAATGAGATGTTTGGTATGGTCCTGGCTCCAGCTGAGGGCACCCATCCTGGCATAGCT
CCCCAGAGCAGGCCACCTGAAGGGAAGCACATAACCACCCCTCGGGAGCCCTTGCCCCCCATTGTGACTTTCCAGCTCATCCCTAAAGGC
AGTATTGCCCAACCAGCGGGGGCTCCCCAGCCTCAGTCCACCTGCCCTCCAGCTGTTGCGGGCCCCCTGCCCACCATGTACCAGATTCCA
GAAATGGCCCGTTTGCCCAGTGTGGCTTTCCCCACTGCCATGATGCCCCAGCAGGACGGGCAGGTAGCTCAGACCATTCTCCCAGCCTAT
CATCCTTTCCCAGCCTCTGTGGGCAAGTACCCCACACCCCCTTCACAGCACAGTTATGCTTCCTCAAATGCTGCTGAGCGAACACCCAGT
CACAGTGGTCACCTCCAGGGTGAGCATCCCTACCTGACACCATCCCCAGAGTCTCCTGACCAGTGGTCAAGTTCATCACCCCACTCTGCT
TCTGACTGGTCAGATGTGACCACCAGCCCTACCCCTGGGGGTGCTGGAGGAGGTCAGCGGGGACCTGGGACACACATGTCTGAGCCACCA

>In-frame_MAGI3_ENST00000369617_chr1_113933971_+_NOTCH2_ENST00000602566_chr1_120539955_-_726nt
ATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGC
GCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTC
TCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTC
ATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGT
GCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTC
AATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTC
ACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACT
TTTGAGTGCAACTGCCTTCCAGAAACAGTGAGAAATAAGAGGAACAGAGCTCTGGGAAAGGGACAGGCAAGTCTGGAATGGAAAAGAACA

>In-frame_MAGI3_ENST00000307546_chr1_113933971_+_NOTCH2_ENST00000256646_chr1_120539955_-_7317nt
ATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGC
GCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTC
TCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTC
ATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGT
GCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTC
AATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTC
ACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACT
TTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTGTGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAGAATGGAGGG
GTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCCCCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTG
CTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAACCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGAT
GACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTGTACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATG
TGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGATGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAAC
CCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTACAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAAT
AGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGATGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGT
GAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAATGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATG
CCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGAATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTC
AATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCCAGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAAT
GGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCAGTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAAC
TGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGGTATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATC
TGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCTGAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGC
CAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGATGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATT
AATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCAGAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAG
GGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTATATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAA
TGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGGTCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAAC
TGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCAGAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGC
AAGAAGGGCTTTAAAGGCTATAACTGCCAGGTGAATATTGATGAATGTGCCTCAAATCCATGCCTGAACCAAGGAACCTGCTTTGATGAC
ATAAGTGGCTACACTTGCCACTGTGTGCTGCCATACACAGGCAAGAATTGTCAGACAGTATTGGCTCCCTGTTCCCCAAACCCTTGTGAG
AATGCTGCTGTTTGCAAAGAGTCACCAAATTTTGAGAGTTATACTTGCTTGTGTGCTCCTGGCTGGCAAGGTCAGCGGTGTACCATTGAC
ATTGACGAGTGTATCTCCAAGCCCTGCATGAACCATGGTCTCTGCCATAACACCCAGGGCAGCTACATGTGTGAATGTCCACCAGGCTTC
AGTGGTATGGACTGTGAGGAGGACATTGATGACTGCCTTGCCAATCCTTGCCAGAATGGAGGTTCCTGTATGGATGGAGTGAATACTTTC
TCCTGCCTCTGCCTTCCGGGTTTCACTGGGGATAAGTGCCAGACAGACATGAATGAGTGTCTGAGTGAACCCTGTAAGAATGGAGGGACC
TGCTCTGACTACGTCAACAGTTACACTTGCAAGTGCCAGGCAGGATTTGATGGAGTCCATTGTGAGAACAACATCAATGAGTGCACTGAG
AGCTCCTGTTTCAATGGTGGCACATGTGTTGATGGGATTAACTCCTTCTCTTGCTTGTGCCCTGTGGGTTTCACTGGATCCTTCTGCCTC
CATGAGATCAATGAATGCAGCTCTCATCCATGCCTGAATGAGGGAACGTGTGTTGATGGCCTGGGTACCTACCGCTGCAGCTGCCCCCTG
GGCTACACTGGGAAAAACTGTCAGACCCTGGTGAATCTCTGCAGTCGGTCTCCATGTAAAAACAAAGGTACTTGCGTTCAGAAAAAAGCA
GAGTCCCAGTGCCTATGTCCATCTGGATGGGCTGGTGCCTATTGTGACGTGCCCAATGTCTCTTGTGACATAGCAGCCTCCAGGAGAGGT
GTGCTTGTTGAACACTTGTGCCAGCACTCAGGTGTCTGCATCAATGCTGGCAACACGCATTACTGTCAGTGCCCCCTGGGCTATACTGGG
AGCTACTGTGAGGAGCAACTCGATGAGTGTGCGTCCAACCCCTGCCAGCACGGGGCAACATGCAGTGACTTCATTGGTGGATACAGATGC
GAGTGTGTCCCAGGCTATCAGGGTGTCAACTGTGAGTATGAAGTGGATGAGTGCCAGAATCAGCCCTGCCAGAATGGAGGCACCTGTATT
GACCTTGTGAACCATTTCAAGTGCTCTTGCCCACCAGGCACTCGGGGCCTACTCTGTGAAGAGAACATTGATGACTGTGCCCGGGGTCCC
CATTGCCTTAATGGTGGTCAGTGCATGGATAGGATTGGAGGCTACAGTTGTCGCTGCTTGCCTGGCTTTGCTGGGGAGCGTTGTGAGGGA
GACATCAACGAGTGCCTCTCCAACCCCTGCAGCTCTGAGGGCAGCCTGGACTGTATACAGCTCACCAATGACTACCTGTGTGTTTGCCGT
AGTGCCTTTACTGGCCGGCACTGTGAAACCTTCGTCGATGTGTGTCCCCAGATGCCCTGCCTGAATGGAGGGACTTGTGCTGTGGCCAGT
AACATGCCTGATGGTTTCATTTGCCGTTGTCCCCCGGGATTTTCCGGGGCAAGGTGCCAGAGCAGCTGTGGACAAGTGAAATGTAGGAAG
GGGGAGCAGTGTGTGCACACCGCCTCTGGACCCCGCTGCTTCTGCCCCAGTCCCCGGGACTGCGAGTCAGGCTGTGCCAGTAGCCCCTGC
CAGCACGGGGGCAGCTGCCACCCTCAGCGCCAGCCTCCTTATTACTCCTGCCAGTGTGCCCCACCATTCTCGGGTAGCCGCTGTGAACTC
TACACGGCACCCCCCAGCACCCCTCCTGCCACCTGTCTGAGCCAGTATTGTGCCGACAAAGCTCGGGATGGCGTCTGTGATGAGGCCTGC
AACAGCCATGCCTGCCAGTGGGATGGGGGTGACTGTTCTCTCACCATGGAGAACCCCTGGGCCAACTGCTCCTCCCCACTTCCCTGCTGG
GATTATATCAACAACCAGTGTGATGAGCTGTGCAACACGGTCGAGTGCCTGTTTGACAACTTTGAATGCCAGGGGAACAGCAAGACATGC
AAGTATGACAAATACTGTGCAGACCACTTCAAAGACAACCACTGTGACCAGGGGTGCAACAGTGAGGAGTGTGGTTGGGATGGGCTGGAC
TGTGCTGCTGACCAACCTGAGAACCTGGCAGAAGGTACCCTGGTTATTGTGGTATTGATGCCACCTGAACAACTGCTCCAGGATGCTCGC
AGCTTCTTGCGGGCACTGGGTACCCTGCTCCACACCAACCTGCGCATTAAGCGGGACTCCCAGGGGGAACTCATGGTGTACCCCTATTAT
GGTGAGAAGTCAGCTGCTATGAAGAAACAGAGGATGACACGCAGATCCCTTCCTGGTGAACAAGAACAGGAGGTGGCTGGCTCTAAAGTC
TTTCTGGAAATTGACAACCGCCAGTGTGTTCAAGACTCAGACCACTGCTTCAAGAACACGGATGCAGCAGCAGCTCTCCTGGCCTCTCAC
GCCATACAGGGGACCCTGTCATACCCTCTTGTGTCTGTCGTCAGTGAATCCCTGACTCCAGAACGCACTCAGCTCCTCTATCTCCTTGCT
GTTGCTGTTGTCATCATTCTGTTTATTATTCTGCTGGGGGTAATCATGGCAAAACGAAAGCGTAAGCATGGCTCTCTCTGGCTGCCTGAA
GGTTTCACTCTTCGCCGAGATGCAAGCAATCACAAGCGTCGTGAGCCAGTGGGACAGGATGCTGTGGGGCTGAAAAATCTCTCAGTGCAA
GTCTCAGAAGCTAACCTAATTGGTACTGGAACAAGTGAACACTGGGTCGATGATGAAGGGCCCCAGCCAAAGAAAGTAAAGGCTGAAGAT
GAGGCCTTACTCTCAGAAGAAGATGACCCCATTGATCGACGGCCATGGACACAGCAGCACCTTGAAGCTGCAGACATCCGTAGGACACCA
TCGCTGGCTCTCACCCCTCCTCAGGCAGAGCAGGAGGTGGATGTGTTAGATGTGAATGTCCGTGGCCCAGATGGCTGCACCCCATTGATG
TTGGCTTCTCTCCGAGGAGGCAGCTCAGATTTGAGTGATGAAGATGAAGATGCAGAGGACTCTTCTGCTAACATCATCACAGACTTGGTC
TACCAGGGTGCCAGCCTCCAGGCCCAGACAGACCGGACTGGTGAGATGGCCCTGCACCTTGCAGCCCGCTACTCACGGGCTGATGCTGCC
AAGCGTCTCCTGGATGCAGGTGCAGATGCCAATGCCCAGGACAACATGGGCCGCTGTCCACTCCATGCTGCAGTGGCAGCTGATGCCCAA
GGTGTCTTCCAGATTCTGATTCGCAACCGAGTAACTGATCTAGATGCCAGGATGAATGATGGTACTACACCCCTGATCCTGGCTGCCCGC
CTGGCTGTGGAGGGAATGGTGGCAGAACTGATCAACTGCCAAGCGGATGTGAATGCAGTGGATGACCATGGAAAATCTGCTCTTCACTGG
GCAGCTGCTGTCAATAATGTGGAGGCAACTCTTTTGTTGTTGAAAAATGGGGCCAACCGAGACATGCAGGACAACAAGGAAGAGACACCT
CTGTTTCTTGCTGCCCGGGAGGGGAGCTATGAAGCAGCCAAGATCCTGTTAGACCATTTTGCCAATCGAGACATCACAGACCATATGGAT
CGTCTTCCCCGGGATGTGGCTCGGGATCGCATGCACCATGACATTGTGCGCCTTCTGGATGAATACAATGTGACCCCAAGCCCTCCAGGC
ACCGTGTTGACTTCTGCTCTCTCACCTGTCATCTGTGGGCCCAACAGATCTTTCCTCAGCCTGAAGCACACCCCAATGGGCAAGAAGTCT
AGACGGCCCAGTGCCAAGAGTACCATGCCTACTAGCCTCCCTAACCTTGCCAAGGAGGCAAAGGATGCCAAGGGTAGTAGGAGGAAGAAG
TCTCTGAGTGAGAAGGTCCAACTGTCTGAGAGTTCAGTAACTTTATCCCCTGTTGATTCCCTAGAATCTCCTCACACGTATGTTTCCGAC
ACCACATCCTCTCCAATGATTACATCCCCTGGGATCTTACAGGCCTCACCCAACCCTATGTTGGCCACTGCCGCCCCTCCTGCCCCAGTC
CATGCCCAGCATGCACTATCTTTTTCTAACCTTCATGAAATGCAGCCTTTGGCACATGGGGCCAGCACTGTGCTTCCCTCAGTGAGCCAG
TTGCTATCCCACCACCACATTGTGTCTCCAGGCAGTGGCAGTGCTGGAAGCTTGAGTAGGCTCCATCCAGTCCCAGTCCCAGCAGATTGG
ATGAACCGCATGGAGGTGAATGAGACCCAGTACAATGAGATGTTTGGTATGGTCCTGGCTCCAGCTGAGGGCACCCATCCTGGCATAGCT
CCCCAGAGCAGGCCACCTGAAGGGAAGCACATAACCACCCCTCGGGAGCCCTTGCCCCCCATTGTGACTTTCCAGCTCATCCCTAAAGGC
AGTATTGCCCAACCAGCGGGGGCTCCCCAGCCTCAGTCCACCTGCCCTCCAGCTGTTGCGGGCCCCCTGCCCACCATGTACCAGATTCCA
GAAATGGCCCGTTTGCCCAGTGTGGCTTTCCCCACTGCCATGATGCCCCAGCAGGACGGGCAGGTAGCTCAGACCATTCTCCCAGCCTAT
CATCCTTTCCCAGCCTCTGTGGGCAAGTACCCCACACCCCCTTCACAGCACAGTTATGCTTCCTCAAATGCTGCTGAGCGAACACCCAGT
CACAGTGGTCACCTCCAGGGTGAGCATCCCTACCTGACACCATCCCCAGAGTCTCCTGACCAGTGGTCAAGTTCATCACCCCACTCTGCT
TCTGACTGGTCAGATGTGACCACCAGCCCTACCCCTGGGGGTGCTGGAGGAGGTCAGCGGGGACCTGGGACACACATGTCTGAGCCACCA

>In-frame_MAGI3_ENST00000307546_chr1_113933971_+_NOTCH2_ENST00000602566_chr1_120539955_-_726nt
ATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGC
GCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTC
TCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTC
ATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGT
GCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTC
AATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTC
ACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACT
TTTGAGTGCAACTGCCTTCCAGAAACAGTGAGAAATAAGAGGAACAGAGCTCTGGGAAAGGGACAGGCAAGTCTGGAATGGAAAAGAACA

>In-frame_MAGI3_ENST00000369615_chr1_113933971_+_NOTCH2_ENST00000256646_chr1_120539955_-_7317nt
ATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGC
GCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTC
TCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTC
ATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGT
GCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTC
AATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTC
ACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACT
TTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTGTGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAGAATGGAGGG
GTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCCCCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTG
CTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAACCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGAT
GACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTGTACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATG
TGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGATGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAAC
CCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTACAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAAT
AGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGATGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGT
GAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAATGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATG
CCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGAATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTC
AATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCCAGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAAT
GGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCAGTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAAC
TGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGGTATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATC
TGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCTGAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGC
CAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGATGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATT
AATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCAGAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAG
GGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTATATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAA
TGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGGTCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAAC
TGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCAGAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGC
AAGAAGGGCTTTAAAGGCTATAACTGCCAGGTGAATATTGATGAATGTGCCTCAAATCCATGCCTGAACCAAGGAACCTGCTTTGATGAC
ATAAGTGGCTACACTTGCCACTGTGTGCTGCCATACACAGGCAAGAATTGTCAGACAGTATTGGCTCCCTGTTCCCCAAACCCTTGTGAG
AATGCTGCTGTTTGCAAAGAGTCACCAAATTTTGAGAGTTATACTTGCTTGTGTGCTCCTGGCTGGCAAGGTCAGCGGTGTACCATTGAC
ATTGACGAGTGTATCTCCAAGCCCTGCATGAACCATGGTCTCTGCCATAACACCCAGGGCAGCTACATGTGTGAATGTCCACCAGGCTTC
AGTGGTATGGACTGTGAGGAGGACATTGATGACTGCCTTGCCAATCCTTGCCAGAATGGAGGTTCCTGTATGGATGGAGTGAATACTTTC
TCCTGCCTCTGCCTTCCGGGTTTCACTGGGGATAAGTGCCAGACAGACATGAATGAGTGTCTGAGTGAACCCTGTAAGAATGGAGGGACC
TGCTCTGACTACGTCAACAGTTACACTTGCAAGTGCCAGGCAGGATTTGATGGAGTCCATTGTGAGAACAACATCAATGAGTGCACTGAG
AGCTCCTGTTTCAATGGTGGCACATGTGTTGATGGGATTAACTCCTTCTCTTGCTTGTGCCCTGTGGGTTTCACTGGATCCTTCTGCCTC
CATGAGATCAATGAATGCAGCTCTCATCCATGCCTGAATGAGGGAACGTGTGTTGATGGCCTGGGTACCTACCGCTGCAGCTGCCCCCTG
GGCTACACTGGGAAAAACTGTCAGACCCTGGTGAATCTCTGCAGTCGGTCTCCATGTAAAAACAAAGGTACTTGCGTTCAGAAAAAAGCA
GAGTCCCAGTGCCTATGTCCATCTGGATGGGCTGGTGCCTATTGTGACGTGCCCAATGTCTCTTGTGACATAGCAGCCTCCAGGAGAGGT
GTGCTTGTTGAACACTTGTGCCAGCACTCAGGTGTCTGCATCAATGCTGGCAACACGCATTACTGTCAGTGCCCCCTGGGCTATACTGGG
AGCTACTGTGAGGAGCAACTCGATGAGTGTGCGTCCAACCCCTGCCAGCACGGGGCAACATGCAGTGACTTCATTGGTGGATACAGATGC
GAGTGTGTCCCAGGCTATCAGGGTGTCAACTGTGAGTATGAAGTGGATGAGTGCCAGAATCAGCCCTGCCAGAATGGAGGCACCTGTATT
GACCTTGTGAACCATTTCAAGTGCTCTTGCCCACCAGGCACTCGGGGCCTACTCTGTGAAGAGAACATTGATGACTGTGCCCGGGGTCCC
CATTGCCTTAATGGTGGTCAGTGCATGGATAGGATTGGAGGCTACAGTTGTCGCTGCTTGCCTGGCTTTGCTGGGGAGCGTTGTGAGGGA
GACATCAACGAGTGCCTCTCCAACCCCTGCAGCTCTGAGGGCAGCCTGGACTGTATACAGCTCACCAATGACTACCTGTGTGTTTGCCGT
AGTGCCTTTACTGGCCGGCACTGTGAAACCTTCGTCGATGTGTGTCCCCAGATGCCCTGCCTGAATGGAGGGACTTGTGCTGTGGCCAGT
AACATGCCTGATGGTTTCATTTGCCGTTGTCCCCCGGGATTTTCCGGGGCAAGGTGCCAGAGCAGCTGTGGACAAGTGAAATGTAGGAAG
GGGGAGCAGTGTGTGCACACCGCCTCTGGACCCCGCTGCTTCTGCCCCAGTCCCCGGGACTGCGAGTCAGGCTGTGCCAGTAGCCCCTGC
CAGCACGGGGGCAGCTGCCACCCTCAGCGCCAGCCTCCTTATTACTCCTGCCAGTGTGCCCCACCATTCTCGGGTAGCCGCTGTGAACTC
TACACGGCACCCCCCAGCACCCCTCCTGCCACCTGTCTGAGCCAGTATTGTGCCGACAAAGCTCGGGATGGCGTCTGTGATGAGGCCTGC
AACAGCCATGCCTGCCAGTGGGATGGGGGTGACTGTTCTCTCACCATGGAGAACCCCTGGGCCAACTGCTCCTCCCCACTTCCCTGCTGG
GATTATATCAACAACCAGTGTGATGAGCTGTGCAACACGGTCGAGTGCCTGTTTGACAACTTTGAATGCCAGGGGAACAGCAAGACATGC
AAGTATGACAAATACTGTGCAGACCACTTCAAAGACAACCACTGTGACCAGGGGTGCAACAGTGAGGAGTGTGGTTGGGATGGGCTGGAC
TGTGCTGCTGACCAACCTGAGAACCTGGCAGAAGGTACCCTGGTTATTGTGGTATTGATGCCACCTGAACAACTGCTCCAGGATGCTCGC
AGCTTCTTGCGGGCACTGGGTACCCTGCTCCACACCAACCTGCGCATTAAGCGGGACTCCCAGGGGGAACTCATGGTGTACCCCTATTAT
GGTGAGAAGTCAGCTGCTATGAAGAAACAGAGGATGACACGCAGATCCCTTCCTGGTGAACAAGAACAGGAGGTGGCTGGCTCTAAAGTC
TTTCTGGAAATTGACAACCGCCAGTGTGTTCAAGACTCAGACCACTGCTTCAAGAACACGGATGCAGCAGCAGCTCTCCTGGCCTCTCAC
GCCATACAGGGGACCCTGTCATACCCTCTTGTGTCTGTCGTCAGTGAATCCCTGACTCCAGAACGCACTCAGCTCCTCTATCTCCTTGCT
GTTGCTGTTGTCATCATTCTGTTTATTATTCTGCTGGGGGTAATCATGGCAAAACGAAAGCGTAAGCATGGCTCTCTCTGGCTGCCTGAA
GGTTTCACTCTTCGCCGAGATGCAAGCAATCACAAGCGTCGTGAGCCAGTGGGACAGGATGCTGTGGGGCTGAAAAATCTCTCAGTGCAA
GTCTCAGAAGCTAACCTAATTGGTACTGGAACAAGTGAACACTGGGTCGATGATGAAGGGCCCCAGCCAAAGAAAGTAAAGGCTGAAGAT
GAGGCCTTACTCTCAGAAGAAGATGACCCCATTGATCGACGGCCATGGACACAGCAGCACCTTGAAGCTGCAGACATCCGTAGGACACCA
TCGCTGGCTCTCACCCCTCCTCAGGCAGAGCAGGAGGTGGATGTGTTAGATGTGAATGTCCGTGGCCCAGATGGCTGCACCCCATTGATG
TTGGCTTCTCTCCGAGGAGGCAGCTCAGATTTGAGTGATGAAGATGAAGATGCAGAGGACTCTTCTGCTAACATCATCACAGACTTGGTC
TACCAGGGTGCCAGCCTCCAGGCCCAGACAGACCGGACTGGTGAGATGGCCCTGCACCTTGCAGCCCGCTACTCACGGGCTGATGCTGCC
AAGCGTCTCCTGGATGCAGGTGCAGATGCCAATGCCCAGGACAACATGGGCCGCTGTCCACTCCATGCTGCAGTGGCAGCTGATGCCCAA
GGTGTCTTCCAGATTCTGATTCGCAACCGAGTAACTGATCTAGATGCCAGGATGAATGATGGTACTACACCCCTGATCCTGGCTGCCCGC
CTGGCTGTGGAGGGAATGGTGGCAGAACTGATCAACTGCCAAGCGGATGTGAATGCAGTGGATGACCATGGAAAATCTGCTCTTCACTGG
GCAGCTGCTGTCAATAATGTGGAGGCAACTCTTTTGTTGTTGAAAAATGGGGCCAACCGAGACATGCAGGACAACAAGGAAGAGACACCT
CTGTTTCTTGCTGCCCGGGAGGGGAGCTATGAAGCAGCCAAGATCCTGTTAGACCATTTTGCCAATCGAGACATCACAGACCATATGGAT
CGTCTTCCCCGGGATGTGGCTCGGGATCGCATGCACCATGACATTGTGCGCCTTCTGGATGAATACAATGTGACCCCAAGCCCTCCAGGC
ACCGTGTTGACTTCTGCTCTCTCACCTGTCATCTGTGGGCCCAACAGATCTTTCCTCAGCCTGAAGCACACCCCAATGGGCAAGAAGTCT
AGACGGCCCAGTGCCAAGAGTACCATGCCTACTAGCCTCCCTAACCTTGCCAAGGAGGCAAAGGATGCCAAGGGTAGTAGGAGGAAGAAG
TCTCTGAGTGAGAAGGTCCAACTGTCTGAGAGTTCAGTAACTTTATCCCCTGTTGATTCCCTAGAATCTCCTCACACGTATGTTTCCGAC
ACCACATCCTCTCCAATGATTACATCCCCTGGGATCTTACAGGCCTCACCCAACCCTATGTTGGCCACTGCCGCCCCTCCTGCCCCAGTC
CATGCCCAGCATGCACTATCTTTTTCTAACCTTCATGAAATGCAGCCTTTGGCACATGGGGCCAGCACTGTGCTTCCCTCAGTGAGCCAG
TTGCTATCCCACCACCACATTGTGTCTCCAGGCAGTGGCAGTGCTGGAAGCTTGAGTAGGCTCCATCCAGTCCCAGTCCCAGCAGATTGG
ATGAACCGCATGGAGGTGAATGAGACCCAGTACAATGAGATGTTTGGTATGGTCCTGGCTCCAGCTGAGGGCACCCATCCTGGCATAGCT
CCCCAGAGCAGGCCACCTGAAGGGAAGCACATAACCACCCCTCGGGAGCCCTTGCCCCCCATTGTGACTTTCCAGCTCATCCCTAAAGGC
AGTATTGCCCAACCAGCGGGGGCTCCCCAGCCTCAGTCCACCTGCCCTCCAGCTGTTGCGGGCCCCCTGCCCACCATGTACCAGATTCCA
GAAATGGCCCGTTTGCCCAGTGTGGCTTTCCCCACTGCCATGATGCCCCAGCAGGACGGGCAGGTAGCTCAGACCATTCTCCCAGCCTAT
CATCCTTTCCCAGCCTCTGTGGGCAAGTACCCCACACCCCCTTCACAGCACAGTTATGCTTCCTCAAATGCTGCTGAGCGAACACCCAGT
CACAGTGGTCACCTCCAGGGTGAGCATCCCTACCTGACACCATCCCCAGAGTCTCCTGACCAGTGGTCAAGTTCATCACCCCACTCTGCT
TCTGACTGGTCAGATGTGACCACCAGCCCTACCCCTGGGGGTGCTGGAGGAGGTCAGCGGGGACCTGGGACACACATGTCTGAGCCACCA

>In-frame_MAGI3_ENST00000369615_chr1_113933971_+_NOTCH2_ENST00000602566_chr1_120539955_-_726nt
ATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGC
GCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTC
TCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTC
ATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGT
GCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTC
AATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTC
ACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACT
TTTGAGTGCAACTGCCTTCCAGAAACAGTGAGAAATAAGAGGAACAGAGCTCTGGGAAAGGGACAGGCAAGTCTGGAATGGAAAAGAACA

>In-frame_MAGI3_ENST00000369611_chr1_113933971_+_NOTCH2_ENST00000256646_chr1_120539955_-_7317nt
ATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGC
GCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTC
TCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTC
ATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGT
GCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTC
AATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTC
ACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACT
TTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTGTGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAGAATGGAGGG
GTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCCCCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTG
CTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAACCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGAT
GACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTGTACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATG
TGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGATGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAAC
CCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTACAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAAT
AGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGATGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGT
GAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAATGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATG
CCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGAATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTC
AATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCCAGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAAT
GGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCAGTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAAC
TGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGGTATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATC
TGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCTGAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGC
CAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGATGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATT
AATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCAGAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAG
GGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTATATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAA
TGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGGTCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAAC
TGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCAGAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGC
AAGAAGGGCTTTAAAGGCTATAACTGCCAGGTGAATATTGATGAATGTGCCTCAAATCCATGCCTGAACCAAGGAACCTGCTTTGATGAC
ATAAGTGGCTACACTTGCCACTGTGTGCTGCCATACACAGGCAAGAATTGTCAGACAGTATTGGCTCCCTGTTCCCCAAACCCTTGTGAG
AATGCTGCTGTTTGCAAAGAGTCACCAAATTTTGAGAGTTATACTTGCTTGTGTGCTCCTGGCTGGCAAGGTCAGCGGTGTACCATTGAC
ATTGACGAGTGTATCTCCAAGCCCTGCATGAACCATGGTCTCTGCCATAACACCCAGGGCAGCTACATGTGTGAATGTCCACCAGGCTTC
AGTGGTATGGACTGTGAGGAGGACATTGATGACTGCCTTGCCAATCCTTGCCAGAATGGAGGTTCCTGTATGGATGGAGTGAATACTTTC
TCCTGCCTCTGCCTTCCGGGTTTCACTGGGGATAAGTGCCAGACAGACATGAATGAGTGTCTGAGTGAACCCTGTAAGAATGGAGGGACC
TGCTCTGACTACGTCAACAGTTACACTTGCAAGTGCCAGGCAGGATTTGATGGAGTCCATTGTGAGAACAACATCAATGAGTGCACTGAG
AGCTCCTGTTTCAATGGTGGCACATGTGTTGATGGGATTAACTCCTTCTCTTGCTTGTGCCCTGTGGGTTTCACTGGATCCTTCTGCCTC
CATGAGATCAATGAATGCAGCTCTCATCCATGCCTGAATGAGGGAACGTGTGTTGATGGCCTGGGTACCTACCGCTGCAGCTGCCCCCTG
GGCTACACTGGGAAAAACTGTCAGACCCTGGTGAATCTCTGCAGTCGGTCTCCATGTAAAAACAAAGGTACTTGCGTTCAGAAAAAAGCA
GAGTCCCAGTGCCTATGTCCATCTGGATGGGCTGGTGCCTATTGTGACGTGCCCAATGTCTCTTGTGACATAGCAGCCTCCAGGAGAGGT
GTGCTTGTTGAACACTTGTGCCAGCACTCAGGTGTCTGCATCAATGCTGGCAACACGCATTACTGTCAGTGCCCCCTGGGCTATACTGGG
AGCTACTGTGAGGAGCAACTCGATGAGTGTGCGTCCAACCCCTGCCAGCACGGGGCAACATGCAGTGACTTCATTGGTGGATACAGATGC
GAGTGTGTCCCAGGCTATCAGGGTGTCAACTGTGAGTATGAAGTGGATGAGTGCCAGAATCAGCCCTGCCAGAATGGAGGCACCTGTATT
GACCTTGTGAACCATTTCAAGTGCTCTTGCCCACCAGGCACTCGGGGCCTACTCTGTGAAGAGAACATTGATGACTGTGCCCGGGGTCCC
CATTGCCTTAATGGTGGTCAGTGCATGGATAGGATTGGAGGCTACAGTTGTCGCTGCTTGCCTGGCTTTGCTGGGGAGCGTTGTGAGGGA
GACATCAACGAGTGCCTCTCCAACCCCTGCAGCTCTGAGGGCAGCCTGGACTGTATACAGCTCACCAATGACTACCTGTGTGTTTGCCGT
AGTGCCTTTACTGGCCGGCACTGTGAAACCTTCGTCGATGTGTGTCCCCAGATGCCCTGCCTGAATGGAGGGACTTGTGCTGTGGCCAGT
AACATGCCTGATGGTTTCATTTGCCGTTGTCCCCCGGGATTTTCCGGGGCAAGGTGCCAGAGCAGCTGTGGACAAGTGAAATGTAGGAAG
GGGGAGCAGTGTGTGCACACCGCCTCTGGACCCCGCTGCTTCTGCCCCAGTCCCCGGGACTGCGAGTCAGGCTGTGCCAGTAGCCCCTGC
CAGCACGGGGGCAGCTGCCACCCTCAGCGCCAGCCTCCTTATTACTCCTGCCAGTGTGCCCCACCATTCTCGGGTAGCCGCTGTGAACTC
TACACGGCACCCCCCAGCACCCCTCCTGCCACCTGTCTGAGCCAGTATTGTGCCGACAAAGCTCGGGATGGCGTCTGTGATGAGGCCTGC
AACAGCCATGCCTGCCAGTGGGATGGGGGTGACTGTTCTCTCACCATGGAGAACCCCTGGGCCAACTGCTCCTCCCCACTTCCCTGCTGG
GATTATATCAACAACCAGTGTGATGAGCTGTGCAACACGGTCGAGTGCCTGTTTGACAACTTTGAATGCCAGGGGAACAGCAAGACATGC
AAGTATGACAAATACTGTGCAGACCACTTCAAAGACAACCACTGTGACCAGGGGTGCAACAGTGAGGAGTGTGGTTGGGATGGGCTGGAC
TGTGCTGCTGACCAACCTGAGAACCTGGCAGAAGGTACCCTGGTTATTGTGGTATTGATGCCACCTGAACAACTGCTCCAGGATGCTCGC
AGCTTCTTGCGGGCACTGGGTACCCTGCTCCACACCAACCTGCGCATTAAGCGGGACTCCCAGGGGGAACTCATGGTGTACCCCTATTAT
GGTGAGAAGTCAGCTGCTATGAAGAAACAGAGGATGACACGCAGATCCCTTCCTGGTGAACAAGAACAGGAGGTGGCTGGCTCTAAAGTC
TTTCTGGAAATTGACAACCGCCAGTGTGTTCAAGACTCAGACCACTGCTTCAAGAACACGGATGCAGCAGCAGCTCTCCTGGCCTCTCAC
GCCATACAGGGGACCCTGTCATACCCTCTTGTGTCTGTCGTCAGTGAATCCCTGACTCCAGAACGCACTCAGCTCCTCTATCTCCTTGCT
GTTGCTGTTGTCATCATTCTGTTTATTATTCTGCTGGGGGTAATCATGGCAAAACGAAAGCGTAAGCATGGCTCTCTCTGGCTGCCTGAA
GGTTTCACTCTTCGCCGAGATGCAAGCAATCACAAGCGTCGTGAGCCAGTGGGACAGGATGCTGTGGGGCTGAAAAATCTCTCAGTGCAA
GTCTCAGAAGCTAACCTAATTGGTACTGGAACAAGTGAACACTGGGTCGATGATGAAGGGCCCCAGCCAAAGAAAGTAAAGGCTGAAGAT
GAGGCCTTACTCTCAGAAGAAGATGACCCCATTGATCGACGGCCATGGACACAGCAGCACCTTGAAGCTGCAGACATCCGTAGGACACCA
TCGCTGGCTCTCACCCCTCCTCAGGCAGAGCAGGAGGTGGATGTGTTAGATGTGAATGTCCGTGGCCCAGATGGCTGCACCCCATTGATG
TTGGCTTCTCTCCGAGGAGGCAGCTCAGATTTGAGTGATGAAGATGAAGATGCAGAGGACTCTTCTGCTAACATCATCACAGACTTGGTC
TACCAGGGTGCCAGCCTCCAGGCCCAGACAGACCGGACTGGTGAGATGGCCCTGCACCTTGCAGCCCGCTACTCACGGGCTGATGCTGCC
AAGCGTCTCCTGGATGCAGGTGCAGATGCCAATGCCCAGGACAACATGGGCCGCTGTCCACTCCATGCTGCAGTGGCAGCTGATGCCCAA
GGTGTCTTCCAGATTCTGATTCGCAACCGAGTAACTGATCTAGATGCCAGGATGAATGATGGTACTACACCCCTGATCCTGGCTGCCCGC
CTGGCTGTGGAGGGAATGGTGGCAGAACTGATCAACTGCCAAGCGGATGTGAATGCAGTGGATGACCATGGAAAATCTGCTCTTCACTGG
GCAGCTGCTGTCAATAATGTGGAGGCAACTCTTTTGTTGTTGAAAAATGGGGCCAACCGAGACATGCAGGACAACAAGGAAGAGACACCT
CTGTTTCTTGCTGCCCGGGAGGGGAGCTATGAAGCAGCCAAGATCCTGTTAGACCATTTTGCCAATCGAGACATCACAGACCATATGGAT
CGTCTTCCCCGGGATGTGGCTCGGGATCGCATGCACCATGACATTGTGCGCCTTCTGGATGAATACAATGTGACCCCAAGCCCTCCAGGC
ACCGTGTTGACTTCTGCTCTCTCACCTGTCATCTGTGGGCCCAACAGATCTTTCCTCAGCCTGAAGCACACCCCAATGGGCAAGAAGTCT
AGACGGCCCAGTGCCAAGAGTACCATGCCTACTAGCCTCCCTAACCTTGCCAAGGAGGCAAAGGATGCCAAGGGTAGTAGGAGGAAGAAG
TCTCTGAGTGAGAAGGTCCAACTGTCTGAGAGTTCAGTAACTTTATCCCCTGTTGATTCCCTAGAATCTCCTCACACGTATGTTTCCGAC
ACCACATCCTCTCCAATGATTACATCCCCTGGGATCTTACAGGCCTCACCCAACCCTATGTTGGCCACTGCCGCCCCTCCTGCCCCAGTC
CATGCCCAGCATGCACTATCTTTTTCTAACCTTCATGAAATGCAGCCTTTGGCACATGGGGCCAGCACTGTGCTTCCCTCAGTGAGCCAG
TTGCTATCCCACCACCACATTGTGTCTCCAGGCAGTGGCAGTGCTGGAAGCTTGAGTAGGCTCCATCCAGTCCCAGTCCCAGCAGATTGG
ATGAACCGCATGGAGGTGAATGAGACCCAGTACAATGAGATGTTTGGTATGGTCCTGGCTCCAGCTGAGGGCACCCATCCTGGCATAGCT
CCCCAGAGCAGGCCACCTGAAGGGAAGCACATAACCACCCCTCGGGAGCCCTTGCCCCCCATTGTGACTTTCCAGCTCATCCCTAAAGGC
AGTATTGCCCAACCAGCGGGGGCTCCCCAGCCTCAGTCCACCTGCCCTCCAGCTGTTGCGGGCCCCCTGCCCACCATGTACCAGATTCCA
GAAATGGCCCGTTTGCCCAGTGTGGCTTTCCCCACTGCCATGATGCCCCAGCAGGACGGGCAGGTAGCTCAGACCATTCTCCCAGCCTAT
CATCCTTTCCCAGCCTCTGTGGGCAAGTACCCCACACCCCCTTCACAGCACAGTTATGCTTCCTCAAATGCTGCTGAGCGAACACCCAGT
CACAGTGGTCACCTCCAGGGTGAGCATCCCTACCTGACACCATCCCCAGAGTCTCCTGACCAGTGGTCAAGTTCATCACCCCACTCTGCT
TCTGACTGGTCAGATGTGACCACCAGCCCTACCCCTGGGGGTGCTGGAGGAGGTCAGCGGGGACCTGGGACACACATGTCTGAGCCACCA

>In-frame_MAGI3_ENST00000369611_chr1_113933971_+_NOTCH2_ENST00000602566_chr1_120539955_-_726nt
ATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGC
GCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTC
TCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTC
ATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGT
GCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTC
AATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTC
ACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACT
TTTGAGTGCAACTGCCTTCCAGAAACAGTGAGAAATAAGAGGAACAGAGCTCTGGGAAAGGGACAGGCAAGTCTGGAATGGAAAAGAACA


* Fusion transcript sequences (Full-length transcript).
>In-frame_MAGI3_ENST00000369617_chr1_113933971_+_NOTCH2_ENST00000256646_chr1_120539955_-_11355nt
CTCCTGGGGACAATTCCCTTTTCCTTTCTTCAGCCTAACCCGCGGTGGCCCTCGCGGAGTCCGGTCAGCCCCGGGGAGCGCAGCCGGGAG
GGGCGTCCAAGGGGCGTCTCGCGTCTGGGAACGGCCGGGCCCCCAGCGGGCTGTGGTCGCGGGGTGGGGGCCGGAGCGGCGAGGCCCCCC
TTACCGGGCTGCGCGGGCCGCCCAGGGCCCCCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGT
GCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCC
CCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGC
ACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGG
GACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGC
CTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAA
TGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAG
TGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAG
ACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTGTGAGAGGAATATTGATGACTGCCCTAACCACAGG
TGTCAGAATGGAGGGGTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCCCCCACAATGGACAGGACAGTTCTGCACAGAGGAT
GTGGATGAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAACCGCAATGGAGGCTATGGCTGTGTATGTGTCAAC
GGCTGGAGTGGAGATGACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTGTACTCCAGGCTCCACCTGCATCGACCGTGTGGCC
TCCTTCTCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGATGCATGCATCAGCAATCCTTGCCACAAGGGGGCA
CTGTGTGACACCAACCCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTACAAAGGGGCTGACTGCACAGAAGATGTGGATGAA
TGTGCCATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGATGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTAT
GCAGGACCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAATGATGCTACCTGTCTGGATAAGATTGGAGGCTTC
ACATGTCTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGAATGTCAGAGCAACCCTTGTGTGAACAATGGGCAG
TGTGTGGATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCCAGTTTGCCAGATTGATATTGATGACTGTTCCAGT
ACTCCGTGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCAGTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAG
GAGAACATTGACAACTGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGGTATTGATTCCTACACCTGCATCTGCAATCCCGGG
TACATGGGCGCCATCTGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCTGAACGATGGTCGCTGCATTGACCTGGTCAATGGC
TACCAGTGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGATGACTGTGCAAGTAACCCTTGTATCCATGGAATC
TGTATGGATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCAGAGATGTAACATTGACATTGATGAGTGTGCCTCC
AATCCCTGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTATATGCCCCGAGGGACCCCATCACCCCAGCTGCTAC
TCACAGGTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGGTCTCAGTGGATATAAGTGTCTCTGTGATGCAGGC
TGGGTTGGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCAGAATGGAGGAACTTGTGACAATCTGGTGAATGGA
TACAGGTGTACTTGCAAGAAGGGCTTTAAAGGCTATAACTGCCAGGTGAATATTGATGAATGTGCCTCAAATCCATGCCTGAACCAAGGA
ACCTGCTTTGATGACATAAGTGGCTACACTTGCCACTGTGTGCTGCCATACACAGGCAAGAATTGTCAGACAGTATTGGCTCCCTGTTCC
CCAAACCCTTGTGAGAATGCTGCTGTTTGCAAAGAGTCACCAAATTTTGAGAGTTATACTTGCTTGTGTGCTCCTGGCTGGCAAGGTCAG
CGGTGTACCATTGACATTGACGAGTGTATCTCCAAGCCCTGCATGAACCATGGTCTCTGCCATAACACCCAGGGCAGCTACATGTGTGAA
TGTCCACCAGGCTTCAGTGGTATGGACTGTGAGGAGGACATTGATGACTGCCTTGCCAATCCTTGCCAGAATGGAGGTTCCTGTATGGAT
GGAGTGAATACTTTCTCCTGCCTCTGCCTTCCGGGTTTCACTGGGGATAAGTGCCAGACAGACATGAATGAGTGTCTGAGTGAACCCTGT
AAGAATGGAGGGACCTGCTCTGACTACGTCAACAGTTACACTTGCAAGTGCCAGGCAGGATTTGATGGAGTCCATTGTGAGAACAACATC
AATGAGTGCACTGAGAGCTCCTGTTTCAATGGTGGCACATGTGTTGATGGGATTAACTCCTTCTCTTGCTTGTGCCCTGTGGGTTTCACT
GGATCCTTCTGCCTCCATGAGATCAATGAATGCAGCTCTCATCCATGCCTGAATGAGGGAACGTGTGTTGATGGCCTGGGTACCTACCGC
TGCAGCTGCCCCCTGGGCTACACTGGGAAAAACTGTCAGACCCTGGTGAATCTCTGCAGTCGGTCTCCATGTAAAAACAAAGGTACTTGC
GTTCAGAAAAAAGCAGAGTCCCAGTGCCTATGTCCATCTGGATGGGCTGGTGCCTATTGTGACGTGCCCAATGTCTCTTGTGACATAGCA
GCCTCCAGGAGAGGTGTGCTTGTTGAACACTTGTGCCAGCACTCAGGTGTCTGCATCAATGCTGGCAACACGCATTACTGTCAGTGCCCC
CTGGGCTATACTGGGAGCTACTGTGAGGAGCAACTCGATGAGTGTGCGTCCAACCCCTGCCAGCACGGGGCAACATGCAGTGACTTCATT
GGTGGATACAGATGCGAGTGTGTCCCAGGCTATCAGGGTGTCAACTGTGAGTATGAAGTGGATGAGTGCCAGAATCAGCCCTGCCAGAAT
GGAGGCACCTGTATTGACCTTGTGAACCATTTCAAGTGCTCTTGCCCACCAGGCACTCGGGGCCTACTCTGTGAAGAGAACATTGATGAC
TGTGCCCGGGGTCCCCATTGCCTTAATGGTGGTCAGTGCATGGATAGGATTGGAGGCTACAGTTGTCGCTGCTTGCCTGGCTTTGCTGGG
GAGCGTTGTGAGGGAGACATCAACGAGTGCCTCTCCAACCCCTGCAGCTCTGAGGGCAGCCTGGACTGTATACAGCTCACCAATGACTAC
CTGTGTGTTTGCCGTAGTGCCTTTACTGGCCGGCACTGTGAAACCTTCGTCGATGTGTGTCCCCAGATGCCCTGCCTGAATGGAGGGACT
TGTGCTGTGGCCAGTAACATGCCTGATGGTTTCATTTGCCGTTGTCCCCCGGGATTTTCCGGGGCAAGGTGCCAGAGCAGCTGTGGACAA
GTGAAATGTAGGAAGGGGGAGCAGTGTGTGCACACCGCCTCTGGACCCCGCTGCTTCTGCCCCAGTCCCCGGGACTGCGAGTCAGGCTGT
GCCAGTAGCCCCTGCCAGCACGGGGGCAGCTGCCACCCTCAGCGCCAGCCTCCTTATTACTCCTGCCAGTGTGCCCCACCATTCTCGGGT
AGCCGCTGTGAACTCTACACGGCACCCCCCAGCACCCCTCCTGCCACCTGTCTGAGCCAGTATTGTGCCGACAAAGCTCGGGATGGCGTC
TGTGATGAGGCCTGCAACAGCCATGCCTGCCAGTGGGATGGGGGTGACTGTTCTCTCACCATGGAGAACCCCTGGGCCAACTGCTCCTCC
CCACTTCCCTGCTGGGATTATATCAACAACCAGTGTGATGAGCTGTGCAACACGGTCGAGTGCCTGTTTGACAACTTTGAATGCCAGGGG
AACAGCAAGACATGCAAGTATGACAAATACTGTGCAGACCACTTCAAAGACAACCACTGTGACCAGGGGTGCAACAGTGAGGAGTGTGGT
TGGGATGGGCTGGACTGTGCTGCTGACCAACCTGAGAACCTGGCAGAAGGTACCCTGGTTATTGTGGTATTGATGCCACCTGAACAACTG
CTCCAGGATGCTCGCAGCTTCTTGCGGGCACTGGGTACCCTGCTCCACACCAACCTGCGCATTAAGCGGGACTCCCAGGGGGAACTCATG
GTGTACCCCTATTATGGTGAGAAGTCAGCTGCTATGAAGAAACAGAGGATGACACGCAGATCCCTTCCTGGTGAACAAGAACAGGAGGTG
GCTGGCTCTAAAGTCTTTCTGGAAATTGACAACCGCCAGTGTGTTCAAGACTCAGACCACTGCTTCAAGAACACGGATGCAGCAGCAGCT
CTCCTGGCCTCTCACGCCATACAGGGGACCCTGTCATACCCTCTTGTGTCTGTCGTCAGTGAATCCCTGACTCCAGAACGCACTCAGCTC
CTCTATCTCCTTGCTGTTGCTGTTGTCATCATTCTGTTTATTATTCTGCTGGGGGTAATCATGGCAAAACGAAAGCGTAAGCATGGCTCT
CTCTGGCTGCCTGAAGGTTTCACTCTTCGCCGAGATGCAAGCAATCACAAGCGTCGTGAGCCAGTGGGACAGGATGCTGTGGGGCTGAAA
AATCTCTCAGTGCAAGTCTCAGAAGCTAACCTAATTGGTACTGGAACAAGTGAACACTGGGTCGATGATGAAGGGCCCCAGCCAAAGAAA
GTAAAGGCTGAAGATGAGGCCTTACTCTCAGAAGAAGATGACCCCATTGATCGACGGCCATGGACACAGCAGCACCTTGAAGCTGCAGAC
ATCCGTAGGACACCATCGCTGGCTCTCACCCCTCCTCAGGCAGAGCAGGAGGTGGATGTGTTAGATGTGAATGTCCGTGGCCCAGATGGC
TGCACCCCATTGATGTTGGCTTCTCTCCGAGGAGGCAGCTCAGATTTGAGTGATGAAGATGAAGATGCAGAGGACTCTTCTGCTAACATC
ATCACAGACTTGGTCTACCAGGGTGCCAGCCTCCAGGCCCAGACAGACCGGACTGGTGAGATGGCCCTGCACCTTGCAGCCCGCTACTCA
CGGGCTGATGCTGCCAAGCGTCTCCTGGATGCAGGTGCAGATGCCAATGCCCAGGACAACATGGGCCGCTGTCCACTCCATGCTGCAGTG
GCAGCTGATGCCCAAGGTGTCTTCCAGATTCTGATTCGCAACCGAGTAACTGATCTAGATGCCAGGATGAATGATGGTACTACACCCCTG
ATCCTGGCTGCCCGCCTGGCTGTGGAGGGAATGGTGGCAGAACTGATCAACTGCCAAGCGGATGTGAATGCAGTGGATGACCATGGAAAA
TCTGCTCTTCACTGGGCAGCTGCTGTCAATAATGTGGAGGCAACTCTTTTGTTGTTGAAAAATGGGGCCAACCGAGACATGCAGGACAAC
AAGGAAGAGACACCTCTGTTTCTTGCTGCCCGGGAGGGGAGCTATGAAGCAGCCAAGATCCTGTTAGACCATTTTGCCAATCGAGACATC
ACAGACCATATGGATCGTCTTCCCCGGGATGTGGCTCGGGATCGCATGCACCATGACATTGTGCGCCTTCTGGATGAATACAATGTGACC
CCAAGCCCTCCAGGCACCGTGTTGACTTCTGCTCTCTCACCTGTCATCTGTGGGCCCAACAGATCTTTCCTCAGCCTGAAGCACACCCCA
ATGGGCAAGAAGTCTAGACGGCCCAGTGCCAAGAGTACCATGCCTACTAGCCTCCCTAACCTTGCCAAGGAGGCAAAGGATGCCAAGGGT
AGTAGGAGGAAGAAGTCTCTGAGTGAGAAGGTCCAACTGTCTGAGAGTTCAGTAACTTTATCCCCTGTTGATTCCCTAGAATCTCCTCAC
ACGTATGTTTCCGACACCACATCCTCTCCAATGATTACATCCCCTGGGATCTTACAGGCCTCACCCAACCCTATGTTGGCCACTGCCGCC
CCTCCTGCCCCAGTCCATGCCCAGCATGCACTATCTTTTTCTAACCTTCATGAAATGCAGCCTTTGGCACATGGGGCCAGCACTGTGCTT
CCCTCAGTGAGCCAGTTGCTATCCCACCACCACATTGTGTCTCCAGGCAGTGGCAGTGCTGGAAGCTTGAGTAGGCTCCATCCAGTCCCA
GTCCCAGCAGATTGGATGAACCGCATGGAGGTGAATGAGACCCAGTACAATGAGATGTTTGGTATGGTCCTGGCTCCAGCTGAGGGCACC
CATCCTGGCATAGCTCCCCAGAGCAGGCCACCTGAAGGGAAGCACATAACCACCCCTCGGGAGCCCTTGCCCCCCATTGTGACTTTCCAG
CTCATCCCTAAAGGCAGTATTGCCCAACCAGCGGGGGCTCCCCAGCCTCAGTCCACCTGCCCTCCAGCTGTTGCGGGCCCCCTGCCCACC
ATGTACCAGATTCCAGAAATGGCCCGTTTGCCCAGTGTGGCTTTCCCCACTGCCATGATGCCCCAGCAGGACGGGCAGGTAGCTCAGACC
ATTCTCCCAGCCTATCATCCTTTCCCAGCCTCTGTGGGCAAGTACCCCACACCCCCTTCACAGCACAGTTATGCTTCCTCAAATGCTGCT
GAGCGAACACCCAGTCACAGTGGTCACCTCCAGGGTGAGCATCCCTACCTGACACCATCCCCAGAGTCTCCTGACCAGTGGTCAAGTTCA
TCACCCCACTCTGCTTCTGACTGGTCAGATGTGACCACCAGCCCTACCCCTGGGGGTGCTGGAGGAGGTCAGCGGGGACCTGGGACACAC
ATGTCTGAGCCACCACACAACAACATGCAGGTTTATGCGTGAGAGAGTCCACCTCCAGTGTAGAGACATAACTGACTTTTGTAAATGCTG
CTGAGGAACAAATGAAGGTCATCCGGGAGAGAAATGAAGAAATCTCTGGAGCCAGCTTCTAGAGGTAGGAAAGAGAAGATGTTCTTATTC
AGATAATGCAAGAGAAGCAATTCGTCAGTTTCACTGGGTATCTGCAAGGCTTATTGATTATTCTAATCTAATAAGACAAGTTTGTGGAAA
TGCAAGATGAATACAAGCCTTGGGTCCATGTTTACTCTCTTCTATTTGGAGAATAAGATGGATGCTTATTGAAGCCCAGACATTCTTGCA
GCTTGGACTGCATTTTAAGCCCTGCAGGCTTCTGCCATATCCATGAGAAGATTCTACACTAGCGTCCTGTTGGGAATTATGCCCTGGAAT
TCTGCCTGAATTGACCTACGCATCTCCTCCTCCTTGGACATTCTTTTGTCTTCATTTGGTGCTTTTGGTTTTGCACCTCTCCGTGATTGT
AGCCCTACCAGCATGTTATAGGGCAAGACCTTTGTGCTTTTGATCATTCTGGCCCATGAAAGCAACTTTGGTCTCCTTTCCCCTCCTGTC
TTCCCGGTATCCCTTGGAGTCTCACAAGGTTTACTTTGGTATGGTTCTCAGCACAAACCTTTCAAGTATGTTGTTTCTTTGGAAAATGGA
CATACTGTATTGTGTTCTCCTGCATATATCATTCCTGGAGAGAGAAGGGGAGAAGAATACTTTTCTTCAACAAATTTTGGGGGCAGGAGA
TCCCTTCAAGAGGCTGCACCTTAATTTTTCTTGTCTGTGTGCAGGTCTTCATATAAACTTTACCAGGAAGAAGGGTGTGAGTTTGTTGTT
TTTCTGTGTATGGGCCTGGTCAGTGTAAAGTTTTATCCTTGATAGTCTAGTTACTATGACCCTCCCCACTTTTTTAAAACCAGAAAAAGG
TTTGGAATGTTGGAATGACCAAGAGACAAGTTAACTCGTGCAAGAGCCAGTTACCCACCCACAGGTCCCCCTACTTCCTGCCAAGCATTC
CATTGACTGCCTGTATGGAACACATTTGTCCCAGATCTGAGCATTCTAGGCCTGTTTCACTCACTCACCCAGCATATGAAACTAGTCTTA
ACTGTTGAGCCTTTCCTTTCATATCCACAGAAGACACTGTCTCAAATGTTGTACCCTTGCCATTTAGGACTGAACTTTCCTTAGCCCAAG
GGACCCAGTGACAGTTGTCTTCCGTTTGTCAGATGATCAGTCTCTACTGATTATCTTGCTGCTTAAAGGCCTGCTCACCAATCTTTCTTT
CACACCGTGTGGTCCGTGTTACTGGTATACCCAGTATGTTCTCACTGAAGACATGGACTTTATATGTTCAAGTGCAGGAATTGGAAAGTT
GGACTTGTTTTCTATGATCCAAAACAGCCCTATAAGAAGGTTGGAAAAGGAGGAACTATATAGCAGCCTTTGCTATTTTCTGCTACCATT
TCTTTTCCTCTGAAGCGGCCATGACATTCCCTTTGGCAACTAACGTAGAAACTCAACAGAACATTTTCCTTTCCTAGAGTCACCTTTTAG
ATGATAATGGACAACTATAGACTTGCTCATTGTTCAGACTGATTGCCCCTCACCTGAATCCACTCTCTGTATTCATGCTCTTGGCAATTT
CTTTGACTTTCTTTTAAGGGCAGAAGCATTTTAGTTAATTGTAGATAAAGAATAGTTTTCTTCCTCTTCTCCTTGGGCCAGTTAATAATT
GGTCCATGGCTACACTGCAACTTCCGTCCAGTGCTGTGATGCCCATGACACCTGCAAAATAAGTTCTGCCTGGGCATTTTGTAGATATTA
ACAGGTGAATTCCCGACTCTTTTGGTTTGAATGACAGTTCTCATTCCTTCTATGGCTGCAAGTATGCATCAGTGCTTCCCACTTACCTGA
TTTGTCTGTCGGTGGCCCCATATGGAAACCCTGCGTGTCTGTTGGCATAATAGTTTACAAATGGTTTTTTCAGTCCTATCCAAATTTATT
GAACCAACAAAAATAATTACTTCTGCCCTGAGATAAGCAGATTAAGTTTGTTCATTCTCTGCTTTATTCTCTCCATGTGGCAACATTCTG
TCAGCCTCTTTCATAGTGTGCAAACATTTTATCATTCTAAATGGTGACTCTCTGCCCTTGGACCCATTTATTATTCACAGATGGGGAGAA
CCTATCTGCATGGACCTCTGTGGACCACAGCGTACCTGCCCCTTTCTGCCCTCCTGCTCCAGCCCCACTTCTGAAAGTATCAGCTACTGA
TCCAGCCACTGGATATTTTATATCCTCCCTTTTCCTTAAGCACAATGTCAGACCAAATTGCTTGTTTCTTTTTCTTGGACTACTTTAATT
TGGATCCTTTGGGTTTGGAGAAAGGGAATGTGAAAGCTGTCATTACAGACAACAGGTTTCAGTGATGAGGAGGACAACACTGCCTTTCAA
ACTTTTTACTGATCTCTTAGATTTTAAGAACTCTTGAATTGTGTGGTATCTAATAAAAGGGAAGGTAAGATGGATAATCACTTTCTCATT
TGGGTTCTGAATTGGAGACTCAGTTTTTATGAGACACATCTTTTATGCCATGTATAGATCCTCCCCTGCTATTTTTGGTTTATTTTTATT
GTTATAAATGCTTTCTTTCTTTGACTCCTCTTCTGCCTGCCTTTGGGGATAGGTTTTTTTGTTTGTTTATTTGCTTCCTCTGTTTTGTTT
TAAGCATCATTTTCTTATGTGAGGTGGGGAAGGGAAAGGTATGAGGGAAAGAGAGTCTGAGAATTAAAATATTTTAGTATAAGCAATTGG
CTGTGATGCTCAAATCCATTGCATCCTCTTATTGAATTTGCCAATTTGTAATTTTTGCATAATAAAGAACCAAAGGTGTAATGTTTTGTT
GAGAGGTGGTTTAGGGATTTTGGCCCTAACCAATACATTGAATGTATGATGACTATTTGGGAGGACACATTTATGTACCCAGAGGCCCCC
ACTAATAAGTGGTACTATGGTTACTTCCTTGTGTACATTTCTCTTAAAAGTGATATTATATCTGTTTGTATGAGAAACCCAGTAACCAAT
AAAATGACCGCATATTCCTGACTAAACGTAGTAAGGAAAATGCACACTTTGTTTTTACTTTTCCGTTTCATTCTAAAGGTAGTTAAGATG
AAATTTATATGAAAGCATTTTTATCACAAAATAAAAAAGGTTTGCCAAGCTCAGTGGTGTTGTATTTTTTATTTTCCAATACTGCATCCA
TGGCCTGGCAGTGTTACCTCATGATGTCATAATTTGCTGAGAGAGCAAATTTTCTTTTCTTTCTGAATCCCACAAAGCCTAGCACCAAAC
TTCTTTTTTTCTTCCTTTAATTAGATCATAAATAAATGATCCTGGGGAAAAAGCATCTGTCAAATAGGAAACATCACAAAACTGAGCACT
CTTCTGTGCACTAGCCATAGCTGGTGACAAACAGATGGTTGCTCAGGGACAAGGTGCCTTCCAATGGAAATGCGAAGTAGTTGCTATAGC
AAGAATTGGGAACTGGGATATAAGTCATAATATTAATTATGCTGTTATGTAAATGATTGGTTTGTAACATTCCTTAAGTGAAATTTGTGT
AGAACTTAATATACAGGATTATAAAATAATATTTTGTGTATAAATTTGTTATAAGTTCACATTCATACATTTATTTATAAAGTCAGTGAG

>In-frame_MAGI3_ENST00000369617_chr1_113933971_+_NOTCH2_ENST00000602566_chr1_120539955_-_4903nt
CTCCTGGGGACAATTCCCTTTTCCTTTCTTCAGCCTAACCCGCGGTGGCCCTCGCGGAGTCCGGTCAGCCCCGGGGAGCGCAGCCGGGAG
GGGCGTCCAAGGGGCGTCTCGCGTCTGGGAACGGCCGGGCCCCCAGCGGGCTGTGGTCGCGGGGTGGGGGCCGGAGCGGCGAGGCCCCCC
TTACCGGGCTGCGCGGGCCGCCCAGGGCCCCCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGT
GCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCC
CCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGC
ACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGG
GACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGC
CTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAA
TGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAG
TGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAG
ACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGAAACAGTGAGAAATAAGAGGAACAGAGCTCTGGGAAAGGGACAGGCAAGTCTG
GAATGGAAAAGAACACGATGAGAATTAGACACTGGAAAATATGTATGTGTGGTTAATAAAGTGCTTTAAACTGAATTGACATTAACAGTA
GGTGATCAACTTTCCTATGTGCTTGTGCTTTTGCTTTTGATGGAGTAATTCATTGTTTTCTTATCCACCTAAATGCACCCAGCTGCCCTT
GATTTTCTCTGGGCTACTGGCCTTCACAACCCTCTCCCATGTACCCTCTCTGACTTTGGGGTAACCCTCCCCTAACTTAAAGCTAGAGAA
TTCTGAAACTGAGGAGGGGATCCTCTGTTAATCAGTGAGCACTTTTTGATGAGCTGATAGATGATATATGAGAGACTATGCGTGGCACAA
TACTTTGTTACACTCTTCACTGATACAAGTGTTCTAGAGTGCACACACAACCCAAAGATAGAAACAAAAAGAGGAGCAGTGTCGGGGAGC
TTGGGGCCTGGTGTTCCATGGAGAGGGAGAAAGGAACAAGCCTGGCCAATTCATTCAACTCCTTATAAAAATGATGAGGAGGCTGAAAAC
CAAGAATTTTGATTGGGAACAGAATACAAGCAGCTGGAGCAGATGAATTACTAAGCAACAAAGATCCTGTTTTTATACAAATATCCTTAG
TACAAAAACAAAAGAAGGAAAACTGTAGGGGGGAGTAATGTGCTAAGTAAGCAGAATTGCCTCAAAAAGAAGTTGTTCTAGTTACTCTTT
CAGAGTGGGAATCTTAGATTCTGGTATTGTGGATATGGTTCACATATAATGGGATTGTGTGTTTTATTTTGGAGAGATTAAAGGTCATAG
GTTGGTCCTCAGTATAAAATCAACTGGTAATTTATTCATTTCATTTGGTAAAAATGTATTGACTGCCTGCTATGTTCTAGGCACCATGCT
ATGTATTTGGAATACAGCTATACAAAGCATTGTCACATAATTGAAATGAAAACTTTATATTATTTAAGTCACAAGAACAAGCTATTTAAT
TATATTACTTTTAGTTTCTCTTTTAATAAAGAATAGATAATGCTATCATTCTAGATACTAAATAAGTGTTTTCTTAACATAATATTACTA
TTCACTTTATCTTGTAGAAGAAATAACTAAAATACGTCTGTCTTCACTCCTGCATTTGTTTGCATTTTAAGGGTTAAAGACAGAAATAGA
AATGTAAACAACTTTATTTTGAAAATATTTCAATATTGCAAATATCTCTGGGTCTGATATTCTAGTAATCTAATTGGCTAGTAATTGATG
TTAGTGTGATTTATTGTTGAAGGCTAAATGTGTTTTTCAGTTTCAAGAAAATTGCTTTTAATAATTGCCTAGAACAAGAGGTTGATTTGG
CAGCAAGATGTTGACGGGAAGTTAGAGAAGTCAATAAAGGAAGTTTTTAGCTGAGAGAGAGTGATTATTCACTCCCATAGCCTCTGCATT
GTTATCCATTAGCCACGATAAGAACCTTAGGGAATTCTGAGAGTGTGTCCAGGAAAGGATCTGTCAAACTAGAATAGTATCTCCTCCTTG
AGAAAGGAAATAACCAAGGATTCCGCAGCTGAGAGGCTGCCAGGGCTAGTGAAATAGAGTAAGGAAATCTTGGCTGTCTCTTATTCTCTG
GTTGTAGTTTAACGCAAGACACTTATTTACTCACTGATGGTGTGTGTGTATGTGGGAGGGGAGATTAGCATGAGGGGTGGGAATGGGGAG
ATTTGATGAAGAGAAAACTAACATTTTTTTGGTGACTCAGGAACTGTGCCAGGTACTTCCATGCTTATTAGCTCAATTACACAAAAATCT
TGGGACCAGGTATTATTTTTCAAGTCTTCCCACATGAAGTAACTGAAGTTTGGAGATGTTAAGTGATTCACCCAAAGTTGTACAGCTAAT
ATGTGGTTAGGCTGGGTCCTGAAACCGAGGCAGTTTATTTTCAAAGCCTTTGCTTTGTGCATCTTACTGCGCCACATTGCACTGCACATC
TGCTTCCTGAAAGCACTTTGTAGGTGTGTAAAACTTTTCGTTAAATGCTTTAAGCTGTTTGGGTTAAAAATATATGTTCATGTTATAAGA
AAACCAAGACACTCCTAATTATAATCAAATAGTACTTGTTACATATCAATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
GTGTATATATATATGGCATTGTGCAGATGTTTAAAAGTAGTTACATAGACTAGTTCTTGCTTTTCAGGGTCCCATAATCTAAACCAGATG
ACTTCAGCTTTGGATAAATATATAGAAGGAAATTTAAAGAGAATTCAAAACAATAGATGATGCAGTGACACTGTGAATAAATGTTATTTA
TACAGTTTGTAAGATTTCATGCTCATTGTTCGTATGTCCCAGGTGGAGTTCAGAAAATATTCACTTCATTTCCACAAAGGGAAATAGTGC
CTAGAGATGGTTTTCTTTTAAAAAGTCCTTTTCATAATGCAGTGCCCTTCCTTCCATTGCCCTTCATTCCATTGCTTCCCATGCTTGTCA
AGAGACTAAAATGTTACTTATAGTAATAGTCACTATCTCAATGTAAATAGCACCCTTATTTGATGAGAATTATTATTTCAGTTCTAAAAA
TGGGGAAACAAAGTCAGCAGGAGGCAAAGTAGCTTGTTAAAGTATTCTGCAACTTTCAAATGGTTGCTTCCACTGCATTTCACGTCTTGG
CACTTCTAATTGAGGGTTACTCTAACCACCCTATTTAAAATTGTAACTGTCCCCCACCCCCTTAATTACTAACCCTGGTCTACTTTTTGT
TTTCTTTTTCTGTAACTCTTATCTTCTTACTATATAATTTATACTATATAATTTACTTCATTATGTCTATTGTTTATTGTCTGTCTTTTC
CAAATTCTACTGCCTCTTACCCTCTCCAGAATGAAAACTAGTATCTTTGTTTTTGTTTACTGATGTAACCCAAACACCTACAAACAGTGC
CCAGTATATACTAGGCCCGCAAATATATATTGGCTGACTGACTGTATGGTTTAGTATCATGTCATAGTATTGAGACTGTAACTTTGGTCT
TCTCATTTTCTTCTTTGTATTGTGCGTCCTAGACTTAGTTTGGCCTCTCCTTTTGTCCTTGTATACTCTAATACTGGATAAGAATTTTGG
AGTCTTTTTCAACTCTGAGTCAGTGAATGCCACATAACTTAGTGACTATATTTAAATGGTTAATTTACAATTTTTTCCCTGCAAAGGATA
CTGTAGTCACTGTGAGTATTTTAGTATTATTGTAGGACTCAAGAGGGAATTAAAACTACAAAAATGACTCGTCTTGTATGACACAGAAAG
AAATGTTTCTTCACAGAGGGAGGAGAAAAATATCTTCAAGAGAGAACTAATTGAATCAAATCAATGAACCATGTCTCATCTTTTTGGATA
AGTAACTGTTAGTAATCCAGACACTTCATGAGCTTTCATTATGTAAAGTCTTTAGCAGAAGCTAAAGGAGGGGCACCAACCACAGTAATT
TTAACTTAAGAACAAAATGGAGCATGAAAATAAATTATTAAATCATTTACTCCCACTATTTTTGGGTTAGGGCCAATAATGGGGAGAGAA
AGAGGTAGACTAGTTTTGTGTTTGTGGCTATTTTAATAGAGTAGCACAAGTAATCAAAAAACAGTAGGCTGTTTTGAATTTACTGGCTGT
CCCTTATGAGTTCACAGTTAGATTGGACTGTCCTCAATGTACTTTCTTTTTTTTCTTTCTTTCCCACATCTCTTTATTTCTCTGATTTTG
TTTAAACTTCATAAAGAGCTCTCTGATCTTTCCTTTCCAAACAATGAAGGTTTATCCTTTGTAAACTACCTCTGTACTCCACAGGCTGAT

>In-frame_MAGI3_ENST00000307546_chr1_113933971_+_NOTCH2_ENST00000256646_chr1_120539955_-_11145nt
CCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTG
AAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGT
GGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCC
AGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGC
GAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACC
TGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATT
CCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGT
GACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGC
CTTCCAGGTTTTGAAGGGAGCACCTGTGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAGAATGGAGGGGTTTGTGTGGATGGG
GTCAACACTTACAACTGCCGCTGTCCCCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTGCTGCAGCCCAATGCC
TGTCAAAATGGGGGCACCTGTGCCAACCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGATGACTGCAGTGAGAAC
ATTGATGATTGTGCCTTCGCCTCCTGTACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATGTGCCCAGAGGGGAAG
GCAGGTCTCCTGTGTCATCTGGATGATGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAACCCCCTAAATGGGCAA
TATATTTGCACCTGCCCACAAGGCTACAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAATAGCAATCCTTGTGAG
CATGCAGGAAAATGTGTGAACACGGATGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGTGAGATGGACATCAAT
GAGTGCCATTCAGACCCCTGCCAGAATGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATGCCAGGTTTCAAAGGT
GTGCATTGTGAATTAGAAATAAATGAATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTCAATCGTTTCCAGTGC
CTGTGTCCTCCTGGTTTCACTGGGCCAGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAATGGGGCAAAGTGTATC
GATCACCCGAATGGCTATGAATGCCAGTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAACTGTGACCCCGATCCT
TGCCACCATGGTCAGTGTCAGGATGGTATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATCTGCAGTGACCAGATT
GATGAATGTTACAGCAGCCCTTGCCTGAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGCCAGCCAGGCACGTCA
GGGGTTAATTGTGAAATTAATTTTGATGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATTAATCGCTACAGTTGT
GTCTGCTCACCAGGATTCACAGGGCAGAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAGGGTGCAACATGTATC
AACGGTGTGAATGGTTTCCGCTGTATATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAATGCCTGAGCAATCCC
TGCATCCATGGAAACTGTACTGGAGGTCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAACTGTGAAGTGGACAAA
AATGAATGCCTTTCGAATCCATGCCAGAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGCAAGAAGGGCTTTAAA
GGCTATAACTGCCAGGTGAATATTGATGAATGTGCCTCAAATCCATGCCTGAACCAAGGAACCTGCTTTGATGACATAAGTGGCTACACT
TGCCACTGTGTGCTGCCATACACAGGCAAGAATTGTCAGACAGTATTGGCTCCCTGTTCCCCAAACCCTTGTGAGAATGCTGCTGTTTGC
AAAGAGTCACCAAATTTTGAGAGTTATACTTGCTTGTGTGCTCCTGGCTGGCAAGGTCAGCGGTGTACCATTGACATTGACGAGTGTATC
TCCAAGCCCTGCATGAACCATGGTCTCTGCCATAACACCCAGGGCAGCTACATGTGTGAATGTCCACCAGGCTTCAGTGGTATGGACTGT
GAGGAGGACATTGATGACTGCCTTGCCAATCCTTGCCAGAATGGAGGTTCCTGTATGGATGGAGTGAATACTTTCTCCTGCCTCTGCCTT
CCGGGTTTCACTGGGGATAAGTGCCAGACAGACATGAATGAGTGTCTGAGTGAACCCTGTAAGAATGGAGGGACCTGCTCTGACTACGTC
AACAGTTACACTTGCAAGTGCCAGGCAGGATTTGATGGAGTCCATTGTGAGAACAACATCAATGAGTGCACTGAGAGCTCCTGTTTCAAT
GGTGGCACATGTGTTGATGGGATTAACTCCTTCTCTTGCTTGTGCCCTGTGGGTTTCACTGGATCCTTCTGCCTCCATGAGATCAATGAA
TGCAGCTCTCATCCATGCCTGAATGAGGGAACGTGTGTTGATGGCCTGGGTACCTACCGCTGCAGCTGCCCCCTGGGCTACACTGGGAAA
AACTGTCAGACCCTGGTGAATCTCTGCAGTCGGTCTCCATGTAAAAACAAAGGTACTTGCGTTCAGAAAAAAGCAGAGTCCCAGTGCCTA
TGTCCATCTGGATGGGCTGGTGCCTATTGTGACGTGCCCAATGTCTCTTGTGACATAGCAGCCTCCAGGAGAGGTGTGCTTGTTGAACAC
TTGTGCCAGCACTCAGGTGTCTGCATCAATGCTGGCAACACGCATTACTGTCAGTGCCCCCTGGGCTATACTGGGAGCTACTGTGAGGAG
CAACTCGATGAGTGTGCGTCCAACCCCTGCCAGCACGGGGCAACATGCAGTGACTTCATTGGTGGATACAGATGCGAGTGTGTCCCAGGC
TATCAGGGTGTCAACTGTGAGTATGAAGTGGATGAGTGCCAGAATCAGCCCTGCCAGAATGGAGGCACCTGTATTGACCTTGTGAACCAT
TTCAAGTGCTCTTGCCCACCAGGCACTCGGGGCCTACTCTGTGAAGAGAACATTGATGACTGTGCCCGGGGTCCCCATTGCCTTAATGGT
GGTCAGTGCATGGATAGGATTGGAGGCTACAGTTGTCGCTGCTTGCCTGGCTTTGCTGGGGAGCGTTGTGAGGGAGACATCAACGAGTGC
CTCTCCAACCCCTGCAGCTCTGAGGGCAGCCTGGACTGTATACAGCTCACCAATGACTACCTGTGTGTTTGCCGTAGTGCCTTTACTGGC
CGGCACTGTGAAACCTTCGTCGATGTGTGTCCCCAGATGCCCTGCCTGAATGGAGGGACTTGTGCTGTGGCCAGTAACATGCCTGATGGT
TTCATTTGCCGTTGTCCCCCGGGATTTTCCGGGGCAAGGTGCCAGAGCAGCTGTGGACAAGTGAAATGTAGGAAGGGGGAGCAGTGTGTG
CACACCGCCTCTGGACCCCGCTGCTTCTGCCCCAGTCCCCGGGACTGCGAGTCAGGCTGTGCCAGTAGCCCCTGCCAGCACGGGGGCAGC
TGCCACCCTCAGCGCCAGCCTCCTTATTACTCCTGCCAGTGTGCCCCACCATTCTCGGGTAGCCGCTGTGAACTCTACACGGCACCCCCC
AGCACCCCTCCTGCCACCTGTCTGAGCCAGTATTGTGCCGACAAAGCTCGGGATGGCGTCTGTGATGAGGCCTGCAACAGCCATGCCTGC
CAGTGGGATGGGGGTGACTGTTCTCTCACCATGGAGAACCCCTGGGCCAACTGCTCCTCCCCACTTCCCTGCTGGGATTATATCAACAAC
CAGTGTGATGAGCTGTGCAACACGGTCGAGTGCCTGTTTGACAACTTTGAATGCCAGGGGAACAGCAAGACATGCAAGTATGACAAATAC
TGTGCAGACCACTTCAAAGACAACCACTGTGACCAGGGGTGCAACAGTGAGGAGTGTGGTTGGGATGGGCTGGACTGTGCTGCTGACCAA
CCTGAGAACCTGGCAGAAGGTACCCTGGTTATTGTGGTATTGATGCCACCTGAACAACTGCTCCAGGATGCTCGCAGCTTCTTGCGGGCA
CTGGGTACCCTGCTCCACACCAACCTGCGCATTAAGCGGGACTCCCAGGGGGAACTCATGGTGTACCCCTATTATGGTGAGAAGTCAGCT
GCTATGAAGAAACAGAGGATGACACGCAGATCCCTTCCTGGTGAACAAGAACAGGAGGTGGCTGGCTCTAAAGTCTTTCTGGAAATTGAC
AACCGCCAGTGTGTTCAAGACTCAGACCACTGCTTCAAGAACACGGATGCAGCAGCAGCTCTCCTGGCCTCTCACGCCATACAGGGGACC
CTGTCATACCCTCTTGTGTCTGTCGTCAGTGAATCCCTGACTCCAGAACGCACTCAGCTCCTCTATCTCCTTGCTGTTGCTGTTGTCATC
ATTCTGTTTATTATTCTGCTGGGGGTAATCATGGCAAAACGAAAGCGTAAGCATGGCTCTCTCTGGCTGCCTGAAGGTTTCACTCTTCGC
CGAGATGCAAGCAATCACAAGCGTCGTGAGCCAGTGGGACAGGATGCTGTGGGGCTGAAAAATCTCTCAGTGCAAGTCTCAGAAGCTAAC
CTAATTGGTACTGGAACAAGTGAACACTGGGTCGATGATGAAGGGCCCCAGCCAAAGAAAGTAAAGGCTGAAGATGAGGCCTTACTCTCA
GAAGAAGATGACCCCATTGATCGACGGCCATGGACACAGCAGCACCTTGAAGCTGCAGACATCCGTAGGACACCATCGCTGGCTCTCACC
CCTCCTCAGGCAGAGCAGGAGGTGGATGTGTTAGATGTGAATGTCCGTGGCCCAGATGGCTGCACCCCATTGATGTTGGCTTCTCTCCGA
GGAGGCAGCTCAGATTTGAGTGATGAAGATGAAGATGCAGAGGACTCTTCTGCTAACATCATCACAGACTTGGTCTACCAGGGTGCCAGC
CTCCAGGCCCAGACAGACCGGACTGGTGAGATGGCCCTGCACCTTGCAGCCCGCTACTCACGGGCTGATGCTGCCAAGCGTCTCCTGGAT
GCAGGTGCAGATGCCAATGCCCAGGACAACATGGGCCGCTGTCCACTCCATGCTGCAGTGGCAGCTGATGCCCAAGGTGTCTTCCAGATT
CTGATTCGCAACCGAGTAACTGATCTAGATGCCAGGATGAATGATGGTACTACACCCCTGATCCTGGCTGCCCGCCTGGCTGTGGAGGGA
ATGGTGGCAGAACTGATCAACTGCCAAGCGGATGTGAATGCAGTGGATGACCATGGAAAATCTGCTCTTCACTGGGCAGCTGCTGTCAAT
AATGTGGAGGCAACTCTTTTGTTGTTGAAAAATGGGGCCAACCGAGACATGCAGGACAACAAGGAAGAGACACCTCTGTTTCTTGCTGCC
CGGGAGGGGAGCTATGAAGCAGCCAAGATCCTGTTAGACCATTTTGCCAATCGAGACATCACAGACCATATGGATCGTCTTCCCCGGGAT
GTGGCTCGGGATCGCATGCACCATGACATTGTGCGCCTTCTGGATGAATACAATGTGACCCCAAGCCCTCCAGGCACCGTGTTGACTTCT
GCTCTCTCACCTGTCATCTGTGGGCCCAACAGATCTTTCCTCAGCCTGAAGCACACCCCAATGGGCAAGAAGTCTAGACGGCCCAGTGCC
AAGAGTACCATGCCTACTAGCCTCCCTAACCTTGCCAAGGAGGCAAAGGATGCCAAGGGTAGTAGGAGGAAGAAGTCTCTGAGTGAGAAG
GTCCAACTGTCTGAGAGTTCAGTAACTTTATCCCCTGTTGATTCCCTAGAATCTCCTCACACGTATGTTTCCGACACCACATCCTCTCCA
ATGATTACATCCCCTGGGATCTTACAGGCCTCACCCAACCCTATGTTGGCCACTGCCGCCCCTCCTGCCCCAGTCCATGCCCAGCATGCA
CTATCTTTTTCTAACCTTCATGAAATGCAGCCTTTGGCACATGGGGCCAGCACTGTGCTTCCCTCAGTGAGCCAGTTGCTATCCCACCAC
CACATTGTGTCTCCAGGCAGTGGCAGTGCTGGAAGCTTGAGTAGGCTCCATCCAGTCCCAGTCCCAGCAGATTGGATGAACCGCATGGAG
GTGAATGAGACCCAGTACAATGAGATGTTTGGTATGGTCCTGGCTCCAGCTGAGGGCACCCATCCTGGCATAGCTCCCCAGAGCAGGCCA
CCTGAAGGGAAGCACATAACCACCCCTCGGGAGCCCTTGCCCCCCATTGTGACTTTCCAGCTCATCCCTAAAGGCAGTATTGCCCAACCA
GCGGGGGCTCCCCAGCCTCAGTCCACCTGCCCTCCAGCTGTTGCGGGCCCCCTGCCCACCATGTACCAGATTCCAGAAATGGCCCGTTTG
CCCAGTGTGGCTTTCCCCACTGCCATGATGCCCCAGCAGGACGGGCAGGTAGCTCAGACCATTCTCCCAGCCTATCATCCTTTCCCAGCC
TCTGTGGGCAAGTACCCCACACCCCCTTCACAGCACAGTTATGCTTCCTCAAATGCTGCTGAGCGAACACCCAGTCACAGTGGTCACCTC
CAGGGTGAGCATCCCTACCTGACACCATCCCCAGAGTCTCCTGACCAGTGGTCAAGTTCATCACCCCACTCTGCTTCTGACTGGTCAGAT
GTGACCACCAGCCCTACCCCTGGGGGTGCTGGAGGAGGTCAGCGGGGACCTGGGACACACATGTCTGAGCCACCACACAACAACATGCAG
GTTTATGCGTGAGAGAGTCCACCTCCAGTGTAGAGACATAACTGACTTTTGTAAATGCTGCTGAGGAACAAATGAAGGTCATCCGGGAGA
GAAATGAAGAAATCTCTGGAGCCAGCTTCTAGAGGTAGGAAAGAGAAGATGTTCTTATTCAGATAATGCAAGAGAAGCAATTCGTCAGTT
TCACTGGGTATCTGCAAGGCTTATTGATTATTCTAATCTAATAAGACAAGTTTGTGGAAATGCAAGATGAATACAAGCCTTGGGTCCATG
TTTACTCTCTTCTATTTGGAGAATAAGATGGATGCTTATTGAAGCCCAGACATTCTTGCAGCTTGGACTGCATTTTAAGCCCTGCAGGCT
TCTGCCATATCCATGAGAAGATTCTACACTAGCGTCCTGTTGGGAATTATGCCCTGGAATTCTGCCTGAATTGACCTACGCATCTCCTCC
TCCTTGGACATTCTTTTGTCTTCATTTGGTGCTTTTGGTTTTGCACCTCTCCGTGATTGTAGCCCTACCAGCATGTTATAGGGCAAGACC
TTTGTGCTTTTGATCATTCTGGCCCATGAAAGCAACTTTGGTCTCCTTTCCCCTCCTGTCTTCCCGGTATCCCTTGGAGTCTCACAAGGT
TTACTTTGGTATGGTTCTCAGCACAAACCTTTCAAGTATGTTGTTTCTTTGGAAAATGGACATACTGTATTGTGTTCTCCTGCATATATC
ATTCCTGGAGAGAGAAGGGGAGAAGAATACTTTTCTTCAACAAATTTTGGGGGCAGGAGATCCCTTCAAGAGGCTGCACCTTAATTTTTC
TTGTCTGTGTGCAGGTCTTCATATAAACTTTACCAGGAAGAAGGGTGTGAGTTTGTTGTTTTTCTGTGTATGGGCCTGGTCAGTGTAAAG
TTTTATCCTTGATAGTCTAGTTACTATGACCCTCCCCACTTTTTTAAAACCAGAAAAAGGTTTGGAATGTTGGAATGACCAAGAGACAAG
TTAACTCGTGCAAGAGCCAGTTACCCACCCACAGGTCCCCCTACTTCCTGCCAAGCATTCCATTGACTGCCTGTATGGAACACATTTGTC
CCAGATCTGAGCATTCTAGGCCTGTTTCACTCACTCACCCAGCATATGAAACTAGTCTTAACTGTTGAGCCTTTCCTTTCATATCCACAG
AAGACACTGTCTCAAATGTTGTACCCTTGCCATTTAGGACTGAACTTTCCTTAGCCCAAGGGACCCAGTGACAGTTGTCTTCCGTTTGTC
AGATGATCAGTCTCTACTGATTATCTTGCTGCTTAAAGGCCTGCTCACCAATCTTTCTTTCACACCGTGTGGTCCGTGTTACTGGTATAC
CCAGTATGTTCTCACTGAAGACATGGACTTTATATGTTCAAGTGCAGGAATTGGAAAGTTGGACTTGTTTTCTATGATCCAAAACAGCCC
TATAAGAAGGTTGGAAAAGGAGGAACTATATAGCAGCCTTTGCTATTTTCTGCTACCATTTCTTTTCCTCTGAAGCGGCCATGACATTCC
CTTTGGCAACTAACGTAGAAACTCAACAGAACATTTTCCTTTCCTAGAGTCACCTTTTAGATGATAATGGACAACTATAGACTTGCTCAT
TGTTCAGACTGATTGCCCCTCACCTGAATCCACTCTCTGTATTCATGCTCTTGGCAATTTCTTTGACTTTCTTTTAAGGGCAGAAGCATT
TTAGTTAATTGTAGATAAAGAATAGTTTTCTTCCTCTTCTCCTTGGGCCAGTTAATAATTGGTCCATGGCTACACTGCAACTTCCGTCCA
GTGCTGTGATGCCCATGACACCTGCAAAATAAGTTCTGCCTGGGCATTTTGTAGATATTAACAGGTGAATTCCCGACTCTTTTGGTTTGA
ATGACAGTTCTCATTCCTTCTATGGCTGCAAGTATGCATCAGTGCTTCCCACTTACCTGATTTGTCTGTCGGTGGCCCCATATGGAAACC
CTGCGTGTCTGTTGGCATAATAGTTTACAAATGGTTTTTTCAGTCCTATCCAAATTTATTGAACCAACAAAAATAATTACTTCTGCCCTG
AGATAAGCAGATTAAGTTTGTTCATTCTCTGCTTTATTCTCTCCATGTGGCAACATTCTGTCAGCCTCTTTCATAGTGTGCAAACATTTT
ATCATTCTAAATGGTGACTCTCTGCCCTTGGACCCATTTATTATTCACAGATGGGGAGAACCTATCTGCATGGACCTCTGTGGACCACAG
CGTACCTGCCCCTTTCTGCCCTCCTGCTCCAGCCCCACTTCTGAAAGTATCAGCTACTGATCCAGCCACTGGATATTTTATATCCTCCCT
TTTCCTTAAGCACAATGTCAGACCAAATTGCTTGTTTCTTTTTCTTGGACTACTTTAATTTGGATCCTTTGGGTTTGGAGAAAGGGAATG
TGAAAGCTGTCATTACAGACAACAGGTTTCAGTGATGAGGAGGACAACACTGCCTTTCAAACTTTTTACTGATCTCTTAGATTTTAAGAA
CTCTTGAATTGTGTGGTATCTAATAAAAGGGAAGGTAAGATGGATAATCACTTTCTCATTTGGGTTCTGAATTGGAGACTCAGTTTTTAT
GAGACACATCTTTTATGCCATGTATAGATCCTCCCCTGCTATTTTTGGTTTATTTTTATTGTTATAAATGCTTTCTTTCTTTGACTCCTC
TTCTGCCTGCCTTTGGGGATAGGTTTTTTTGTTTGTTTATTTGCTTCCTCTGTTTTGTTTTAAGCATCATTTTCTTATGTGAGGTGGGGA
AGGGAAAGGTATGAGGGAAAGAGAGTCTGAGAATTAAAATATTTTAGTATAAGCAATTGGCTGTGATGCTCAAATCCATTGCATCCTCTT
ATTGAATTTGCCAATTTGTAATTTTTGCATAATAAAGAACCAAAGGTGTAATGTTTTGTTGAGAGGTGGTTTAGGGATTTTGGCCCTAAC
CAATACATTGAATGTATGATGACTATTTGGGAGGACACATTTATGTACCCAGAGGCCCCCACTAATAAGTGGTACTATGGTTACTTCCTT
GTGTACATTTCTCTTAAAAGTGATATTATATCTGTTTGTATGAGAAACCCAGTAACCAATAAAATGACCGCATATTCCTGACTAAACGTA
GTAAGGAAAATGCACACTTTGTTTTTACTTTTCCGTTTCATTCTAAAGGTAGTTAAGATGAAATTTATATGAAAGCATTTTTATCACAAA
ATAAAAAAGGTTTGCCAAGCTCAGTGGTGTTGTATTTTTTATTTTCCAATACTGCATCCATGGCCTGGCAGTGTTACCTCATGATGTCAT
AATTTGCTGAGAGAGCAAATTTTCTTTTCTTTCTGAATCCCACAAAGCCTAGCACCAAACTTCTTTTTTTCTTCCTTTAATTAGATCATA
AATAAATGATCCTGGGGAAAAAGCATCTGTCAAATAGGAAACATCACAAAACTGAGCACTCTTCTGTGCACTAGCCATAGCTGGTGACAA
ACAGATGGTTGCTCAGGGACAAGGTGCCTTCCAATGGAAATGCGAAGTAGTTGCTATAGCAAGAATTGGGAACTGGGATATAAGTCATAA
TATTAATTATGCTGTTATGTAAATGATTGGTTTGTAACATTCCTTAAGTGAAATTTGTGTAGAACTTAATATACAGGATTATAAAATAAT

>In-frame_MAGI3_ENST00000307546_chr1_113933971_+_NOTCH2_ENST00000602566_chr1_120539955_-_4693nt
CCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTG
AAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGT
GGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCC
AGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGC
GAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACC
TGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATT
CCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGT
GACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGC
CTTCCAGAAACAGTGAGAAATAAGAGGAACAGAGCTCTGGGAAAGGGACAGGCAAGTCTGGAATGGAAAAGAACACGATGAGAATTAGAC
ACTGGAAAATATGTATGTGTGGTTAATAAAGTGCTTTAAACTGAATTGACATTAACAGTAGGTGATCAACTTTCCTATGTGCTTGTGCTT
TTGCTTTTGATGGAGTAATTCATTGTTTTCTTATCCACCTAAATGCACCCAGCTGCCCTTGATTTTCTCTGGGCTACTGGCCTTCACAAC
CCTCTCCCATGTACCCTCTCTGACTTTGGGGTAACCCTCCCCTAACTTAAAGCTAGAGAATTCTGAAACTGAGGAGGGGATCCTCTGTTA
ATCAGTGAGCACTTTTTGATGAGCTGATAGATGATATATGAGAGACTATGCGTGGCACAATACTTTGTTACACTCTTCACTGATACAAGT
GTTCTAGAGTGCACACACAACCCAAAGATAGAAACAAAAAGAGGAGCAGTGTCGGGGAGCTTGGGGCCTGGTGTTCCATGGAGAGGGAGA
AAGGAACAAGCCTGGCCAATTCATTCAACTCCTTATAAAAATGATGAGGAGGCTGAAAACCAAGAATTTTGATTGGGAACAGAATACAAG
CAGCTGGAGCAGATGAATTACTAAGCAACAAAGATCCTGTTTTTATACAAATATCCTTAGTACAAAAACAAAAGAAGGAAAACTGTAGGG
GGGAGTAATGTGCTAAGTAAGCAGAATTGCCTCAAAAAGAAGTTGTTCTAGTTACTCTTTCAGAGTGGGAATCTTAGATTCTGGTATTGT
GGATATGGTTCACATATAATGGGATTGTGTGTTTTATTTTGGAGAGATTAAAGGTCATAGGTTGGTCCTCAGTATAAAATCAACTGGTAA
TTTATTCATTTCATTTGGTAAAAATGTATTGACTGCCTGCTATGTTCTAGGCACCATGCTATGTATTTGGAATACAGCTATACAAAGCAT
TGTCACATAATTGAAATGAAAACTTTATATTATTTAAGTCACAAGAACAAGCTATTTAATTATATTACTTTTAGTTTCTCTTTTAATAAA
GAATAGATAATGCTATCATTCTAGATACTAAATAAGTGTTTTCTTAACATAATATTACTATTCACTTTATCTTGTAGAAGAAATAACTAA
AATACGTCTGTCTTCACTCCTGCATTTGTTTGCATTTTAAGGGTTAAAGACAGAAATAGAAATGTAAACAACTTTATTTTGAAAATATTT
CAATATTGCAAATATCTCTGGGTCTGATATTCTAGTAATCTAATTGGCTAGTAATTGATGTTAGTGTGATTTATTGTTGAAGGCTAAATG
TGTTTTTCAGTTTCAAGAAAATTGCTTTTAATAATTGCCTAGAACAAGAGGTTGATTTGGCAGCAAGATGTTGACGGGAAGTTAGAGAAG
TCAATAAAGGAAGTTTTTAGCTGAGAGAGAGTGATTATTCACTCCCATAGCCTCTGCATTGTTATCCATTAGCCACGATAAGAACCTTAG
GGAATTCTGAGAGTGTGTCCAGGAAAGGATCTGTCAAACTAGAATAGTATCTCCTCCTTGAGAAAGGAAATAACCAAGGATTCCGCAGCT
GAGAGGCTGCCAGGGCTAGTGAAATAGAGTAAGGAAATCTTGGCTGTCTCTTATTCTCTGGTTGTAGTTTAACGCAAGACACTTATTTAC
TCACTGATGGTGTGTGTGTATGTGGGAGGGGAGATTAGCATGAGGGGTGGGAATGGGGAGATTTGATGAAGAGAAAACTAACATTTTTTT
GGTGACTCAGGAACTGTGCCAGGTACTTCCATGCTTATTAGCTCAATTACACAAAAATCTTGGGACCAGGTATTATTTTTCAAGTCTTCC
CACATGAAGTAACTGAAGTTTGGAGATGTTAAGTGATTCACCCAAAGTTGTACAGCTAATATGTGGTTAGGCTGGGTCCTGAAACCGAGG
CAGTTTATTTTCAAAGCCTTTGCTTTGTGCATCTTACTGCGCCACATTGCACTGCACATCTGCTTCCTGAAAGCACTTTGTAGGTGTGTA
AAACTTTTCGTTAAATGCTTTAAGCTGTTTGGGTTAAAAATATATGTTCATGTTATAAGAAAACCAAGACACTCCTAATTATAATCAAAT
AGTACTTGTTACATATCAATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATATATGGCATTGTGCAGATGT
TTAAAAGTAGTTACATAGACTAGTTCTTGCTTTTCAGGGTCCCATAATCTAAACCAGATGACTTCAGCTTTGGATAAATATATAGAAGGA
AATTTAAAGAGAATTCAAAACAATAGATGATGCAGTGACACTGTGAATAAATGTTATTTATACAGTTTGTAAGATTTCATGCTCATTGTT
CGTATGTCCCAGGTGGAGTTCAGAAAATATTCACTTCATTTCCACAAAGGGAAATAGTGCCTAGAGATGGTTTTCTTTTAAAAAGTCCTT
TTCATAATGCAGTGCCCTTCCTTCCATTGCCCTTCATTCCATTGCTTCCCATGCTTGTCAAGAGACTAAAATGTTACTTATAGTAATAGT
CACTATCTCAATGTAAATAGCACCCTTATTTGATGAGAATTATTATTTCAGTTCTAAAAATGGGGAAACAAAGTCAGCAGGAGGCAAAGT
AGCTTGTTAAAGTATTCTGCAACTTTCAAATGGTTGCTTCCACTGCATTTCACGTCTTGGCACTTCTAATTGAGGGTTACTCTAACCACC
CTATTTAAAATTGTAACTGTCCCCCACCCCCTTAATTACTAACCCTGGTCTACTTTTTGTTTTCTTTTTCTGTAACTCTTATCTTCTTAC
TATATAATTTATACTATATAATTTACTTCATTATGTCTATTGTTTATTGTCTGTCTTTTCCAAATTCTACTGCCTCTTACCCTCTCCAGA
ATGAAAACTAGTATCTTTGTTTTTGTTTACTGATGTAACCCAAACACCTACAAACAGTGCCCAGTATATACTAGGCCCGCAAATATATAT
TGGCTGACTGACTGTATGGTTTAGTATCATGTCATAGTATTGAGACTGTAACTTTGGTCTTCTCATTTTCTTCTTTGTATTGTGCGTCCT
AGACTTAGTTTGGCCTCTCCTTTTGTCCTTGTATACTCTAATACTGGATAAGAATTTTGGAGTCTTTTTCAACTCTGAGTCAGTGAATGC
CACATAACTTAGTGACTATATTTAAATGGTTAATTTACAATTTTTTCCCTGCAAAGGATACTGTAGTCACTGTGAGTATTTTAGTATTAT
TGTAGGACTCAAGAGGGAATTAAAACTACAAAAATGACTCGTCTTGTATGACACAGAAAGAAATGTTTCTTCACAGAGGGAGGAGAAAAA
TATCTTCAAGAGAGAACTAATTGAATCAAATCAATGAACCATGTCTCATCTTTTTGGATAAGTAACTGTTAGTAATCCAGACACTTCATG
AGCTTTCATTATGTAAAGTCTTTAGCAGAAGCTAAAGGAGGGGCACCAACCACAGTAATTTTAACTTAAGAACAAAATGGAGCATGAAAA
TAAATTATTAAATCATTTACTCCCACTATTTTTGGGTTAGGGCCAATAATGGGGAGAGAAAGAGGTAGACTAGTTTTGTGTTTGTGGCTA
TTTTAATAGAGTAGCACAAGTAATCAAAAAACAGTAGGCTGTTTTGAATTTACTGGCTGTCCCTTATGAGTTCACAGTTAGATTGGACTG
TCCTCAATGTACTTTCTTTTTTTTCTTTCTTTCCCACATCTCTTTATTTCTCTGATTTTGTTTAAACTTCATAAAGAGCTCTCTGATCTT
TCCTTTCCAAACAATGAAGGTTTATCCTTTGTAAACTACCTCTGTACTCCACAGGCTGATGATATATGATATCCCTATATCATTAAAGTA

>In-frame_MAGI3_ENST00000369615_chr1_113933971_+_NOTCH2_ENST00000256646_chr1_120539955_-_11132nt
GGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGC
ACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTG
GCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATG
TGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTC
TCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGG
CCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCC
AGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATG
TGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGGTTTTG
AAGGGAGCACCTGTGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAGAATGGAGGGGTTTGTGTGGATGGGGTCAACACTTACA
ACTGCCGCTGTCCCCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGG
GCACCTGTGCCAACCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGATGACTGCAGTGAGAACATTGATGATTGTG
CCTTCGCCTCCTGTACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGT
GTCATCTGGATGATGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAACCCCCTAAATGGGCAATATATTTGCACCT
GCCCACAAGGCTACAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAAT
GTGTGAACACGGATGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAG
ACCCCTGCCAGAATGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAAT
TAGAAATAAATGAATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTG
GTTTCACTGGGCCAGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATG
GCTATGAATGCCAGTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAACTGTGACCCCGATCCTTGCCACCATGGTC
AGTGTCAGGATGGTATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATCTGCAGTGACCAGATTGATGAATGTTACA
GCAGCCCTTGCCTGAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTG
AAATTAATTTTGATGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAG
GATTCACAGGGCAGAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATG
GTTTCCGCTGTATATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAA
ACTGTACTGGAGGTCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTT
CGAATCCATGCCAGAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGCAAGAAGGGCTTTAAAGGCTATAACTGCC
AGGTGAATATTGATGAATGTGCCTCAAATCCATGCCTGAACCAAGGAACCTGCTTTGATGACATAAGTGGCTACACTTGCCACTGTGTGC
TGCCATACACAGGCAAGAATTGTCAGACAGTATTGGCTCCCTGTTCCCCAAACCCTTGTGAGAATGCTGCTGTTTGCAAAGAGTCACCAA
ATTTTGAGAGTTATACTTGCTTGTGTGCTCCTGGCTGGCAAGGTCAGCGGTGTACCATTGACATTGACGAGTGTATCTCCAAGCCCTGCA
TGAACCATGGTCTCTGCCATAACACCCAGGGCAGCTACATGTGTGAATGTCCACCAGGCTTCAGTGGTATGGACTGTGAGGAGGACATTG
ATGACTGCCTTGCCAATCCTTGCCAGAATGGAGGTTCCTGTATGGATGGAGTGAATACTTTCTCCTGCCTCTGCCTTCCGGGTTTCACTG
GGGATAAGTGCCAGACAGACATGAATGAGTGTCTGAGTGAACCCTGTAAGAATGGAGGGACCTGCTCTGACTACGTCAACAGTTACACTT
GCAAGTGCCAGGCAGGATTTGATGGAGTCCATTGTGAGAACAACATCAATGAGTGCACTGAGAGCTCCTGTTTCAATGGTGGCACATGTG
TTGATGGGATTAACTCCTTCTCTTGCTTGTGCCCTGTGGGTTTCACTGGATCCTTCTGCCTCCATGAGATCAATGAATGCAGCTCTCATC
CATGCCTGAATGAGGGAACGTGTGTTGATGGCCTGGGTACCTACCGCTGCAGCTGCCCCCTGGGCTACACTGGGAAAAACTGTCAGACCC
TGGTGAATCTCTGCAGTCGGTCTCCATGTAAAAACAAAGGTACTTGCGTTCAGAAAAAAGCAGAGTCCCAGTGCCTATGTCCATCTGGAT
GGGCTGGTGCCTATTGTGACGTGCCCAATGTCTCTTGTGACATAGCAGCCTCCAGGAGAGGTGTGCTTGTTGAACACTTGTGCCAGCACT
CAGGTGTCTGCATCAATGCTGGCAACACGCATTACTGTCAGTGCCCCCTGGGCTATACTGGGAGCTACTGTGAGGAGCAACTCGATGAGT
GTGCGTCCAACCCCTGCCAGCACGGGGCAACATGCAGTGACTTCATTGGTGGATACAGATGCGAGTGTGTCCCAGGCTATCAGGGTGTCA
ACTGTGAGTATGAAGTGGATGAGTGCCAGAATCAGCCCTGCCAGAATGGAGGCACCTGTATTGACCTTGTGAACCATTTCAAGTGCTCTT
GCCCACCAGGCACTCGGGGCCTACTCTGTGAAGAGAACATTGATGACTGTGCCCGGGGTCCCCATTGCCTTAATGGTGGTCAGTGCATGG
ATAGGATTGGAGGCTACAGTTGTCGCTGCTTGCCTGGCTTTGCTGGGGAGCGTTGTGAGGGAGACATCAACGAGTGCCTCTCCAACCCCT
GCAGCTCTGAGGGCAGCCTGGACTGTATACAGCTCACCAATGACTACCTGTGTGTTTGCCGTAGTGCCTTTACTGGCCGGCACTGTGAAA
CCTTCGTCGATGTGTGTCCCCAGATGCCCTGCCTGAATGGAGGGACTTGTGCTGTGGCCAGTAACATGCCTGATGGTTTCATTTGCCGTT
GTCCCCCGGGATTTTCCGGGGCAAGGTGCCAGAGCAGCTGTGGACAAGTGAAATGTAGGAAGGGGGAGCAGTGTGTGCACACCGCCTCTG
GACCCCGCTGCTTCTGCCCCAGTCCCCGGGACTGCGAGTCAGGCTGTGCCAGTAGCCCCTGCCAGCACGGGGGCAGCTGCCACCCTCAGC
GCCAGCCTCCTTATTACTCCTGCCAGTGTGCCCCACCATTCTCGGGTAGCCGCTGTGAACTCTACACGGCACCCCCCAGCACCCCTCCTG
CCACCTGTCTGAGCCAGTATTGTGCCGACAAAGCTCGGGATGGCGTCTGTGATGAGGCCTGCAACAGCCATGCCTGCCAGTGGGATGGGG
GTGACTGTTCTCTCACCATGGAGAACCCCTGGGCCAACTGCTCCTCCCCACTTCCCTGCTGGGATTATATCAACAACCAGTGTGATGAGC
TGTGCAACACGGTCGAGTGCCTGTTTGACAACTTTGAATGCCAGGGGAACAGCAAGACATGCAAGTATGACAAATACTGTGCAGACCACT
TCAAAGACAACCACTGTGACCAGGGGTGCAACAGTGAGGAGTGTGGTTGGGATGGGCTGGACTGTGCTGCTGACCAACCTGAGAACCTGG
CAGAAGGTACCCTGGTTATTGTGGTATTGATGCCACCTGAACAACTGCTCCAGGATGCTCGCAGCTTCTTGCGGGCACTGGGTACCCTGC
TCCACACCAACCTGCGCATTAAGCGGGACTCCCAGGGGGAACTCATGGTGTACCCCTATTATGGTGAGAAGTCAGCTGCTATGAAGAAAC
AGAGGATGACACGCAGATCCCTTCCTGGTGAACAAGAACAGGAGGTGGCTGGCTCTAAAGTCTTTCTGGAAATTGACAACCGCCAGTGTG
TTCAAGACTCAGACCACTGCTTCAAGAACACGGATGCAGCAGCAGCTCTCCTGGCCTCTCACGCCATACAGGGGACCCTGTCATACCCTC
TTGTGTCTGTCGTCAGTGAATCCCTGACTCCAGAACGCACTCAGCTCCTCTATCTCCTTGCTGTTGCTGTTGTCATCATTCTGTTTATTA
TTCTGCTGGGGGTAATCATGGCAAAACGAAAGCGTAAGCATGGCTCTCTCTGGCTGCCTGAAGGTTTCACTCTTCGCCGAGATGCAAGCA
ATCACAAGCGTCGTGAGCCAGTGGGACAGGATGCTGTGGGGCTGAAAAATCTCTCAGTGCAAGTCTCAGAAGCTAACCTAATTGGTACTG
GAACAAGTGAACACTGGGTCGATGATGAAGGGCCCCAGCCAAAGAAAGTAAAGGCTGAAGATGAGGCCTTACTCTCAGAAGAAGATGACC
CCATTGATCGACGGCCATGGACACAGCAGCACCTTGAAGCTGCAGACATCCGTAGGACACCATCGCTGGCTCTCACCCCTCCTCAGGCAG
AGCAGGAGGTGGATGTGTTAGATGTGAATGTCCGTGGCCCAGATGGCTGCACCCCATTGATGTTGGCTTCTCTCCGAGGAGGCAGCTCAG
ATTTGAGTGATGAAGATGAAGATGCAGAGGACTCTTCTGCTAACATCATCACAGACTTGGTCTACCAGGGTGCCAGCCTCCAGGCCCAGA
CAGACCGGACTGGTGAGATGGCCCTGCACCTTGCAGCCCGCTACTCACGGGCTGATGCTGCCAAGCGTCTCCTGGATGCAGGTGCAGATG
CCAATGCCCAGGACAACATGGGCCGCTGTCCACTCCATGCTGCAGTGGCAGCTGATGCCCAAGGTGTCTTCCAGATTCTGATTCGCAACC
GAGTAACTGATCTAGATGCCAGGATGAATGATGGTACTACACCCCTGATCCTGGCTGCCCGCCTGGCTGTGGAGGGAATGGTGGCAGAAC
TGATCAACTGCCAAGCGGATGTGAATGCAGTGGATGACCATGGAAAATCTGCTCTTCACTGGGCAGCTGCTGTCAATAATGTGGAGGCAA
CTCTTTTGTTGTTGAAAAATGGGGCCAACCGAGACATGCAGGACAACAAGGAAGAGACACCTCTGTTTCTTGCTGCCCGGGAGGGGAGCT
ATGAAGCAGCCAAGATCCTGTTAGACCATTTTGCCAATCGAGACATCACAGACCATATGGATCGTCTTCCCCGGGATGTGGCTCGGGATC
GCATGCACCATGACATTGTGCGCCTTCTGGATGAATACAATGTGACCCCAAGCCCTCCAGGCACCGTGTTGACTTCTGCTCTCTCACCTG
TCATCTGTGGGCCCAACAGATCTTTCCTCAGCCTGAAGCACACCCCAATGGGCAAGAAGTCTAGACGGCCCAGTGCCAAGAGTACCATGC
CTACTAGCCTCCCTAACCTTGCCAAGGAGGCAAAGGATGCCAAGGGTAGTAGGAGGAAGAAGTCTCTGAGTGAGAAGGTCCAACTGTCTG
AGAGTTCAGTAACTTTATCCCCTGTTGATTCCCTAGAATCTCCTCACACGTATGTTTCCGACACCACATCCTCTCCAATGATTACATCCC
CTGGGATCTTACAGGCCTCACCCAACCCTATGTTGGCCACTGCCGCCCCTCCTGCCCCAGTCCATGCCCAGCATGCACTATCTTTTTCTA
ACCTTCATGAAATGCAGCCTTTGGCACATGGGGCCAGCACTGTGCTTCCCTCAGTGAGCCAGTTGCTATCCCACCACCACATTGTGTCTC
CAGGCAGTGGCAGTGCTGGAAGCTTGAGTAGGCTCCATCCAGTCCCAGTCCCAGCAGATTGGATGAACCGCATGGAGGTGAATGAGACCC
AGTACAATGAGATGTTTGGTATGGTCCTGGCTCCAGCTGAGGGCACCCATCCTGGCATAGCTCCCCAGAGCAGGCCACCTGAAGGGAAGC
ACATAACCACCCCTCGGGAGCCCTTGCCCCCCATTGTGACTTTCCAGCTCATCCCTAAAGGCAGTATTGCCCAACCAGCGGGGGCTCCCC
AGCCTCAGTCCACCTGCCCTCCAGCTGTTGCGGGCCCCCTGCCCACCATGTACCAGATTCCAGAAATGGCCCGTTTGCCCAGTGTGGCTT
TCCCCACTGCCATGATGCCCCAGCAGGACGGGCAGGTAGCTCAGACCATTCTCCCAGCCTATCATCCTTTCCCAGCCTCTGTGGGCAAGT
ACCCCACACCCCCTTCACAGCACAGTTATGCTTCCTCAAATGCTGCTGAGCGAACACCCAGTCACAGTGGTCACCTCCAGGGTGAGCATC
CCTACCTGACACCATCCCCAGAGTCTCCTGACCAGTGGTCAAGTTCATCACCCCACTCTGCTTCTGACTGGTCAGATGTGACCACCAGCC
CTACCCCTGGGGGTGCTGGAGGAGGTCAGCGGGGACCTGGGACACACATGTCTGAGCCACCACACAACAACATGCAGGTTTATGCGTGAG
AGAGTCCACCTCCAGTGTAGAGACATAACTGACTTTTGTAAATGCTGCTGAGGAACAAATGAAGGTCATCCGGGAGAGAAATGAAGAAAT
CTCTGGAGCCAGCTTCTAGAGGTAGGAAAGAGAAGATGTTCTTATTCAGATAATGCAAGAGAAGCAATTCGTCAGTTTCACTGGGTATCT
GCAAGGCTTATTGATTATTCTAATCTAATAAGACAAGTTTGTGGAAATGCAAGATGAATACAAGCCTTGGGTCCATGTTTACTCTCTTCT
ATTTGGAGAATAAGATGGATGCTTATTGAAGCCCAGACATTCTTGCAGCTTGGACTGCATTTTAAGCCCTGCAGGCTTCTGCCATATCCA
TGAGAAGATTCTACACTAGCGTCCTGTTGGGAATTATGCCCTGGAATTCTGCCTGAATTGACCTACGCATCTCCTCCTCCTTGGACATTC
TTTTGTCTTCATTTGGTGCTTTTGGTTTTGCACCTCTCCGTGATTGTAGCCCTACCAGCATGTTATAGGGCAAGACCTTTGTGCTTTTGA
TCATTCTGGCCCATGAAAGCAACTTTGGTCTCCTTTCCCCTCCTGTCTTCCCGGTATCCCTTGGAGTCTCACAAGGTTTACTTTGGTATG
GTTCTCAGCACAAACCTTTCAAGTATGTTGTTTCTTTGGAAAATGGACATACTGTATTGTGTTCTCCTGCATATATCATTCCTGGAGAGA
GAAGGGGAGAAGAATACTTTTCTTCAACAAATTTTGGGGGCAGGAGATCCCTTCAAGAGGCTGCACCTTAATTTTTCTTGTCTGTGTGCA
GGTCTTCATATAAACTTTACCAGGAAGAAGGGTGTGAGTTTGTTGTTTTTCTGTGTATGGGCCTGGTCAGTGTAAAGTTTTATCCTTGAT
AGTCTAGTTACTATGACCCTCCCCACTTTTTTAAAACCAGAAAAAGGTTTGGAATGTTGGAATGACCAAGAGACAAGTTAACTCGTGCAA
GAGCCAGTTACCCACCCACAGGTCCCCCTACTTCCTGCCAAGCATTCCATTGACTGCCTGTATGGAACACATTTGTCCCAGATCTGAGCA
TTCTAGGCCTGTTTCACTCACTCACCCAGCATATGAAACTAGTCTTAACTGTTGAGCCTTTCCTTTCATATCCACAGAAGACACTGTCTC
AAATGTTGTACCCTTGCCATTTAGGACTGAACTTTCCTTAGCCCAAGGGACCCAGTGACAGTTGTCTTCCGTTTGTCAGATGATCAGTCT
CTACTGATTATCTTGCTGCTTAAAGGCCTGCTCACCAATCTTTCTTTCACACCGTGTGGTCCGTGTTACTGGTATACCCAGTATGTTCTC
ACTGAAGACATGGACTTTATATGTTCAAGTGCAGGAATTGGAAAGTTGGACTTGTTTTCTATGATCCAAAACAGCCCTATAAGAAGGTTG
GAAAAGGAGGAACTATATAGCAGCCTTTGCTATTTTCTGCTACCATTTCTTTTCCTCTGAAGCGGCCATGACATTCCCTTTGGCAACTAA
CGTAGAAACTCAACAGAACATTTTCCTTTCCTAGAGTCACCTTTTAGATGATAATGGACAACTATAGACTTGCTCATTGTTCAGACTGAT
TGCCCCTCACCTGAATCCACTCTCTGTATTCATGCTCTTGGCAATTTCTTTGACTTTCTTTTAAGGGCAGAAGCATTTTAGTTAATTGTA
GATAAAGAATAGTTTTCTTCCTCTTCTCCTTGGGCCAGTTAATAATTGGTCCATGGCTACACTGCAACTTCCGTCCAGTGCTGTGATGCC
CATGACACCTGCAAAATAAGTTCTGCCTGGGCATTTTGTAGATATTAACAGGTGAATTCCCGACTCTTTTGGTTTGAATGACAGTTCTCA
TTCCTTCTATGGCTGCAAGTATGCATCAGTGCTTCCCACTTACCTGATTTGTCTGTCGGTGGCCCCATATGGAAACCCTGCGTGTCTGTT
GGCATAATAGTTTACAAATGGTTTTTTCAGTCCTATCCAAATTTATTGAACCAACAAAAATAATTACTTCTGCCCTGAGATAAGCAGATT
AAGTTTGTTCATTCTCTGCTTTATTCTCTCCATGTGGCAACATTCTGTCAGCCTCTTTCATAGTGTGCAAACATTTTATCATTCTAAATG
GTGACTCTCTGCCCTTGGACCCATTTATTATTCACAGATGGGGAGAACCTATCTGCATGGACCTCTGTGGACCACAGCGTACCTGCCCCT
TTCTGCCCTCCTGCTCCAGCCCCACTTCTGAAAGTATCAGCTACTGATCCAGCCACTGGATATTTTATATCCTCCCTTTTCCTTAAGCAC
AATGTCAGACCAAATTGCTTGTTTCTTTTTCTTGGACTACTTTAATTTGGATCCTTTGGGTTTGGAGAAAGGGAATGTGAAAGCTGTCAT
TACAGACAACAGGTTTCAGTGATGAGGAGGACAACACTGCCTTTCAAACTTTTTACTGATCTCTTAGATTTTAAGAACTCTTGAATTGTG
TGGTATCTAATAAAAGGGAAGGTAAGATGGATAATCACTTTCTCATTTGGGTTCTGAATTGGAGACTCAGTTTTTATGAGACACATCTTT
TATGCCATGTATAGATCCTCCCCTGCTATTTTTGGTTTATTTTTATTGTTATAAATGCTTTCTTTCTTTGACTCCTCTTCTGCCTGCCTT
TGGGGATAGGTTTTTTTGTTTGTTTATTTGCTTCCTCTGTTTTGTTTTAAGCATCATTTTCTTATGTGAGGTGGGGAAGGGAAAGGTATG
AGGGAAAGAGAGTCTGAGAATTAAAATATTTTAGTATAAGCAATTGGCTGTGATGCTCAAATCCATTGCATCCTCTTATTGAATTTGCCA
ATTTGTAATTTTTGCATAATAAAGAACCAAAGGTGTAATGTTTTGTTGAGAGGTGGTTTAGGGATTTTGGCCCTAACCAATACATTGAAT
GTATGATGACTATTTGGGAGGACACATTTATGTACCCAGAGGCCCCCACTAATAAGTGGTACTATGGTTACTTCCTTGTGTACATTTCTC
TTAAAAGTGATATTATATCTGTTTGTATGAGAAACCCAGTAACCAATAAAATGACCGCATATTCCTGACTAAACGTAGTAAGGAAAATGC
ACACTTTGTTTTTACTTTTCCGTTTCATTCTAAAGGTAGTTAAGATGAAATTTATATGAAAGCATTTTTATCACAAAATAAAAAAGGTTT
GCCAAGCTCAGTGGTGTTGTATTTTTTATTTTCCAATACTGCATCCATGGCCTGGCAGTGTTACCTCATGATGTCATAATTTGCTGAGAG
AGCAAATTTTCTTTTCTTTCTGAATCCCACAAAGCCTAGCACCAAACTTCTTTTTTTCTTCCTTTAATTAGATCATAAATAAATGATCCT
GGGGAAAAAGCATCTGTCAAATAGGAAACATCACAAAACTGAGCACTCTTCTGTGCACTAGCCATAGCTGGTGACAAACAGATGGTTGCT
CAGGGACAAGGTGCCTTCCAATGGAAATGCGAAGTAGTTGCTATAGCAAGAATTGGGAACTGGGATATAAGTCATAATATTAATTATGCT
GTTATGTAAATGATTGGTTTGTAACATTCCTTAAGTGAAATTTGTGTAGAACTTAATATACAGGATTATAAAATAATATTTTGTGTATAA

>In-frame_MAGI3_ENST00000369615_chr1_113933971_+_NOTCH2_ENST00000602566_chr1_120539955_-_4680nt
GGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGC
ACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTG
GCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATG
TGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTC
TCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGG
CCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCC
AGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATG
TGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGAAACAG
TGAGAAATAAGAGGAACAGAGCTCTGGGAAAGGGACAGGCAAGTCTGGAATGGAAAAGAACACGATGAGAATTAGACACTGGAAAATATG
TATGTGTGGTTAATAAAGTGCTTTAAACTGAATTGACATTAACAGTAGGTGATCAACTTTCCTATGTGCTTGTGCTTTTGCTTTTGATGG
AGTAATTCATTGTTTTCTTATCCACCTAAATGCACCCAGCTGCCCTTGATTTTCTCTGGGCTACTGGCCTTCACAACCCTCTCCCATGTA
CCCTCTCTGACTTTGGGGTAACCCTCCCCTAACTTAAAGCTAGAGAATTCTGAAACTGAGGAGGGGATCCTCTGTTAATCAGTGAGCACT
TTTTGATGAGCTGATAGATGATATATGAGAGACTATGCGTGGCACAATACTTTGTTACACTCTTCACTGATACAAGTGTTCTAGAGTGCA
CACACAACCCAAAGATAGAAACAAAAAGAGGAGCAGTGTCGGGGAGCTTGGGGCCTGGTGTTCCATGGAGAGGGAGAAAGGAACAAGCCT
GGCCAATTCATTCAACTCCTTATAAAAATGATGAGGAGGCTGAAAACCAAGAATTTTGATTGGGAACAGAATACAAGCAGCTGGAGCAGA
TGAATTACTAAGCAACAAAGATCCTGTTTTTATACAAATATCCTTAGTACAAAAACAAAAGAAGGAAAACTGTAGGGGGGAGTAATGTGC
TAAGTAAGCAGAATTGCCTCAAAAAGAAGTTGTTCTAGTTACTCTTTCAGAGTGGGAATCTTAGATTCTGGTATTGTGGATATGGTTCAC
ATATAATGGGATTGTGTGTTTTATTTTGGAGAGATTAAAGGTCATAGGTTGGTCCTCAGTATAAAATCAACTGGTAATTTATTCATTTCA
TTTGGTAAAAATGTATTGACTGCCTGCTATGTTCTAGGCACCATGCTATGTATTTGGAATACAGCTATACAAAGCATTGTCACATAATTG
AAATGAAAACTTTATATTATTTAAGTCACAAGAACAAGCTATTTAATTATATTACTTTTAGTTTCTCTTTTAATAAAGAATAGATAATGC
TATCATTCTAGATACTAAATAAGTGTTTTCTTAACATAATATTACTATTCACTTTATCTTGTAGAAGAAATAACTAAAATACGTCTGTCT
TCACTCCTGCATTTGTTTGCATTTTAAGGGTTAAAGACAGAAATAGAAATGTAAACAACTTTATTTTGAAAATATTTCAATATTGCAAAT
ATCTCTGGGTCTGATATTCTAGTAATCTAATTGGCTAGTAATTGATGTTAGTGTGATTTATTGTTGAAGGCTAAATGTGTTTTTCAGTTT
CAAGAAAATTGCTTTTAATAATTGCCTAGAACAAGAGGTTGATTTGGCAGCAAGATGTTGACGGGAAGTTAGAGAAGTCAATAAAGGAAG
TTTTTAGCTGAGAGAGAGTGATTATTCACTCCCATAGCCTCTGCATTGTTATCCATTAGCCACGATAAGAACCTTAGGGAATTCTGAGAG
TGTGTCCAGGAAAGGATCTGTCAAACTAGAATAGTATCTCCTCCTTGAGAAAGGAAATAACCAAGGATTCCGCAGCTGAGAGGCTGCCAG
GGCTAGTGAAATAGAGTAAGGAAATCTTGGCTGTCTCTTATTCTCTGGTTGTAGTTTAACGCAAGACACTTATTTACTCACTGATGGTGT
GTGTGTATGTGGGAGGGGAGATTAGCATGAGGGGTGGGAATGGGGAGATTTGATGAAGAGAAAACTAACATTTTTTTGGTGACTCAGGAA
CTGTGCCAGGTACTTCCATGCTTATTAGCTCAATTACACAAAAATCTTGGGACCAGGTATTATTTTTCAAGTCTTCCCACATGAAGTAAC
TGAAGTTTGGAGATGTTAAGTGATTCACCCAAAGTTGTACAGCTAATATGTGGTTAGGCTGGGTCCTGAAACCGAGGCAGTTTATTTTCA
AAGCCTTTGCTTTGTGCATCTTACTGCGCCACATTGCACTGCACATCTGCTTCCTGAAAGCACTTTGTAGGTGTGTAAAACTTTTCGTTA
AATGCTTTAAGCTGTTTGGGTTAAAAATATATGTTCATGTTATAAGAAAACCAAGACACTCCTAATTATAATCAAATAGTACTTGTTACA
TATCAATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATATATGGCATTGTGCAGATGTTTAAAAGTAGTTA
CATAGACTAGTTCTTGCTTTTCAGGGTCCCATAATCTAAACCAGATGACTTCAGCTTTGGATAAATATATAGAAGGAAATTTAAAGAGAA
TTCAAAACAATAGATGATGCAGTGACACTGTGAATAAATGTTATTTATACAGTTTGTAAGATTTCATGCTCATTGTTCGTATGTCCCAGG
TGGAGTTCAGAAAATATTCACTTCATTTCCACAAAGGGAAATAGTGCCTAGAGATGGTTTTCTTTTAAAAAGTCCTTTTCATAATGCAGT
GCCCTTCCTTCCATTGCCCTTCATTCCATTGCTTCCCATGCTTGTCAAGAGACTAAAATGTTACTTATAGTAATAGTCACTATCTCAATG
TAAATAGCACCCTTATTTGATGAGAATTATTATTTCAGTTCTAAAAATGGGGAAACAAAGTCAGCAGGAGGCAAAGTAGCTTGTTAAAGT
ATTCTGCAACTTTCAAATGGTTGCTTCCACTGCATTTCACGTCTTGGCACTTCTAATTGAGGGTTACTCTAACCACCCTATTTAAAATTG
TAACTGTCCCCCACCCCCTTAATTACTAACCCTGGTCTACTTTTTGTTTTCTTTTTCTGTAACTCTTATCTTCTTACTATATAATTTATA
CTATATAATTTACTTCATTATGTCTATTGTTTATTGTCTGTCTTTTCCAAATTCTACTGCCTCTTACCCTCTCCAGAATGAAAACTAGTA
TCTTTGTTTTTGTTTACTGATGTAACCCAAACACCTACAAACAGTGCCCAGTATATACTAGGCCCGCAAATATATATTGGCTGACTGACT
GTATGGTTTAGTATCATGTCATAGTATTGAGACTGTAACTTTGGTCTTCTCATTTTCTTCTTTGTATTGTGCGTCCTAGACTTAGTTTGG
CCTCTCCTTTTGTCCTTGTATACTCTAATACTGGATAAGAATTTTGGAGTCTTTTTCAACTCTGAGTCAGTGAATGCCACATAACTTAGT
GACTATATTTAAATGGTTAATTTACAATTTTTTCCCTGCAAAGGATACTGTAGTCACTGTGAGTATTTTAGTATTATTGTAGGACTCAAG
AGGGAATTAAAACTACAAAAATGACTCGTCTTGTATGACACAGAAAGAAATGTTTCTTCACAGAGGGAGGAGAAAAATATCTTCAAGAGA
GAACTAATTGAATCAAATCAATGAACCATGTCTCATCTTTTTGGATAAGTAACTGTTAGTAATCCAGACACTTCATGAGCTTTCATTATG
TAAAGTCTTTAGCAGAAGCTAAAGGAGGGGCACCAACCACAGTAATTTTAACTTAAGAACAAAATGGAGCATGAAAATAAATTATTAAAT
CATTTACTCCCACTATTTTTGGGTTAGGGCCAATAATGGGGAGAGAAAGAGGTAGACTAGTTTTGTGTTTGTGGCTATTTTAATAGAGTA
GCACAAGTAATCAAAAAACAGTAGGCTGTTTTGAATTTACTGGCTGTCCCTTATGAGTTCACAGTTAGATTGGACTGTCCTCAATGTACT
TTCTTTTTTTTCTTTCTTTCCCACATCTCTTTATTTCTCTGATTTTGTTTAAACTTCATAAAGAGCTCTCTGATCTTTCCTTTCCAAACA
ATGAAGGTTTATCCTTTGTAAACTACCTCTGTACTCCACAGGCTGATGATATATGATATCCCTATATCATTAAAGTAAAGCCTAAGCACA

>In-frame_MAGI3_ENST00000369611_chr1_113933971_+_NOTCH2_ENST00000256646_chr1_120539955_-_11115nt
CGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTG
CAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTG
GGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAAC
GGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCA
GGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGC
AAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGC
CTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCA
CCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTGTGAG
AGGAATATTGATGACTGCCCTAACCACAGGTGTCAGAATGGAGGGGTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCCCCCA
CAATGGACAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAACCGC
AATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGATGACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTGTACT
CCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGATGCA
TGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAACCCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTACAAA
GGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGATGGC
GCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAATGAT
GCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGAATGT
CAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCCAGTT
TGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCAGTGT
GCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAACTGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGGTATT
GATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATCTGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCTGAAC
GATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGATGAC
TGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCAGAGA
TGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTATATGC
CCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGGTCTC
AGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCAGAAT
GGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGCAAGAAGGGCTTTAAAGGCTATAACTGCCAGGTGAATATTGATGAA
TGTGCCTCAAATCCATGCCTGAACCAAGGAACCTGCTTTGATGACATAAGTGGCTACACTTGCCACTGTGTGCTGCCATACACAGGCAAG
AATTGTCAGACAGTATTGGCTCCCTGTTCCCCAAACCCTTGTGAGAATGCTGCTGTTTGCAAAGAGTCACCAAATTTTGAGAGTTATACT
TGCTTGTGTGCTCCTGGCTGGCAAGGTCAGCGGTGTACCATTGACATTGACGAGTGTATCTCCAAGCCCTGCATGAACCATGGTCTCTGC
CATAACACCCAGGGCAGCTACATGTGTGAATGTCCACCAGGCTTCAGTGGTATGGACTGTGAGGAGGACATTGATGACTGCCTTGCCAAT
CCTTGCCAGAATGGAGGTTCCTGTATGGATGGAGTGAATACTTTCTCCTGCCTCTGCCTTCCGGGTTTCACTGGGGATAAGTGCCAGACA
GACATGAATGAGTGTCTGAGTGAACCCTGTAAGAATGGAGGGACCTGCTCTGACTACGTCAACAGTTACACTTGCAAGTGCCAGGCAGGA
TTTGATGGAGTCCATTGTGAGAACAACATCAATGAGTGCACTGAGAGCTCCTGTTTCAATGGTGGCACATGTGTTGATGGGATTAACTCC
TTCTCTTGCTTGTGCCCTGTGGGTTTCACTGGATCCTTCTGCCTCCATGAGATCAATGAATGCAGCTCTCATCCATGCCTGAATGAGGGA
ACGTGTGTTGATGGCCTGGGTACCTACCGCTGCAGCTGCCCCCTGGGCTACACTGGGAAAAACTGTCAGACCCTGGTGAATCTCTGCAGT
CGGTCTCCATGTAAAAACAAAGGTACTTGCGTTCAGAAAAAAGCAGAGTCCCAGTGCCTATGTCCATCTGGATGGGCTGGTGCCTATTGT
GACGTGCCCAATGTCTCTTGTGACATAGCAGCCTCCAGGAGAGGTGTGCTTGTTGAACACTTGTGCCAGCACTCAGGTGTCTGCATCAAT
GCTGGCAACACGCATTACTGTCAGTGCCCCCTGGGCTATACTGGGAGCTACTGTGAGGAGCAACTCGATGAGTGTGCGTCCAACCCCTGC
CAGCACGGGGCAACATGCAGTGACTTCATTGGTGGATACAGATGCGAGTGTGTCCCAGGCTATCAGGGTGTCAACTGTGAGTATGAAGTG
GATGAGTGCCAGAATCAGCCCTGCCAGAATGGAGGCACCTGTATTGACCTTGTGAACCATTTCAAGTGCTCTTGCCCACCAGGCACTCGG
GGCCTACTCTGTGAAGAGAACATTGATGACTGTGCCCGGGGTCCCCATTGCCTTAATGGTGGTCAGTGCATGGATAGGATTGGAGGCTAC
AGTTGTCGCTGCTTGCCTGGCTTTGCTGGGGAGCGTTGTGAGGGAGACATCAACGAGTGCCTCTCCAACCCCTGCAGCTCTGAGGGCAGC
CTGGACTGTATACAGCTCACCAATGACTACCTGTGTGTTTGCCGTAGTGCCTTTACTGGCCGGCACTGTGAAACCTTCGTCGATGTGTGT
CCCCAGATGCCCTGCCTGAATGGAGGGACTTGTGCTGTGGCCAGTAACATGCCTGATGGTTTCATTTGCCGTTGTCCCCCGGGATTTTCC
GGGGCAAGGTGCCAGAGCAGCTGTGGACAAGTGAAATGTAGGAAGGGGGAGCAGTGTGTGCACACCGCCTCTGGACCCCGCTGCTTCTGC
CCCAGTCCCCGGGACTGCGAGTCAGGCTGTGCCAGTAGCCCCTGCCAGCACGGGGGCAGCTGCCACCCTCAGCGCCAGCCTCCTTATTAC
TCCTGCCAGTGTGCCCCACCATTCTCGGGTAGCCGCTGTGAACTCTACACGGCACCCCCCAGCACCCCTCCTGCCACCTGTCTGAGCCAG
TATTGTGCCGACAAAGCTCGGGATGGCGTCTGTGATGAGGCCTGCAACAGCCATGCCTGCCAGTGGGATGGGGGTGACTGTTCTCTCACC
ATGGAGAACCCCTGGGCCAACTGCTCCTCCCCACTTCCCTGCTGGGATTATATCAACAACCAGTGTGATGAGCTGTGCAACACGGTCGAG
TGCCTGTTTGACAACTTTGAATGCCAGGGGAACAGCAAGACATGCAAGTATGACAAATACTGTGCAGACCACTTCAAAGACAACCACTGT
GACCAGGGGTGCAACAGTGAGGAGTGTGGTTGGGATGGGCTGGACTGTGCTGCTGACCAACCTGAGAACCTGGCAGAAGGTACCCTGGTT
ATTGTGGTATTGATGCCACCTGAACAACTGCTCCAGGATGCTCGCAGCTTCTTGCGGGCACTGGGTACCCTGCTCCACACCAACCTGCGC
ATTAAGCGGGACTCCCAGGGGGAACTCATGGTGTACCCCTATTATGGTGAGAAGTCAGCTGCTATGAAGAAACAGAGGATGACACGCAGA
TCCCTTCCTGGTGAACAAGAACAGGAGGTGGCTGGCTCTAAAGTCTTTCTGGAAATTGACAACCGCCAGTGTGTTCAAGACTCAGACCAC
TGCTTCAAGAACACGGATGCAGCAGCAGCTCTCCTGGCCTCTCACGCCATACAGGGGACCCTGTCATACCCTCTTGTGTCTGTCGTCAGT
GAATCCCTGACTCCAGAACGCACTCAGCTCCTCTATCTCCTTGCTGTTGCTGTTGTCATCATTCTGTTTATTATTCTGCTGGGGGTAATC
ATGGCAAAACGAAAGCGTAAGCATGGCTCTCTCTGGCTGCCTGAAGGTTTCACTCTTCGCCGAGATGCAAGCAATCACAAGCGTCGTGAG
CCAGTGGGACAGGATGCTGTGGGGCTGAAAAATCTCTCAGTGCAAGTCTCAGAAGCTAACCTAATTGGTACTGGAACAAGTGAACACTGG
GTCGATGATGAAGGGCCCCAGCCAAAGAAAGTAAAGGCTGAAGATGAGGCCTTACTCTCAGAAGAAGATGACCCCATTGATCGACGGCCA
TGGACACAGCAGCACCTTGAAGCTGCAGACATCCGTAGGACACCATCGCTGGCTCTCACCCCTCCTCAGGCAGAGCAGGAGGTGGATGTG
TTAGATGTGAATGTCCGTGGCCCAGATGGCTGCACCCCATTGATGTTGGCTTCTCTCCGAGGAGGCAGCTCAGATTTGAGTGATGAAGAT
GAAGATGCAGAGGACTCTTCTGCTAACATCATCACAGACTTGGTCTACCAGGGTGCCAGCCTCCAGGCCCAGACAGACCGGACTGGTGAG
ATGGCCCTGCACCTTGCAGCCCGCTACTCACGGGCTGATGCTGCCAAGCGTCTCCTGGATGCAGGTGCAGATGCCAATGCCCAGGACAAC
ATGGGCCGCTGTCCACTCCATGCTGCAGTGGCAGCTGATGCCCAAGGTGTCTTCCAGATTCTGATTCGCAACCGAGTAACTGATCTAGAT
GCCAGGATGAATGATGGTACTACACCCCTGATCCTGGCTGCCCGCCTGGCTGTGGAGGGAATGGTGGCAGAACTGATCAACTGCCAAGCG
GATGTGAATGCAGTGGATGACCATGGAAAATCTGCTCTTCACTGGGCAGCTGCTGTCAATAATGTGGAGGCAACTCTTTTGTTGTTGAAA
AATGGGGCCAACCGAGACATGCAGGACAACAAGGAAGAGACACCTCTGTTTCTTGCTGCCCGGGAGGGGAGCTATGAAGCAGCCAAGATC
CTGTTAGACCATTTTGCCAATCGAGACATCACAGACCATATGGATCGTCTTCCCCGGGATGTGGCTCGGGATCGCATGCACCATGACATT
GTGCGCCTTCTGGATGAATACAATGTGACCCCAAGCCCTCCAGGCACCGTGTTGACTTCTGCTCTCTCACCTGTCATCTGTGGGCCCAAC
AGATCTTTCCTCAGCCTGAAGCACACCCCAATGGGCAAGAAGTCTAGACGGCCCAGTGCCAAGAGTACCATGCCTACTAGCCTCCCTAAC
CTTGCCAAGGAGGCAAAGGATGCCAAGGGTAGTAGGAGGAAGAAGTCTCTGAGTGAGAAGGTCCAACTGTCTGAGAGTTCAGTAACTTTA
TCCCCTGTTGATTCCCTAGAATCTCCTCACACGTATGTTTCCGACACCACATCCTCTCCAATGATTACATCCCCTGGGATCTTACAGGCC
TCACCCAACCCTATGTTGGCCACTGCCGCCCCTCCTGCCCCAGTCCATGCCCAGCATGCACTATCTTTTTCTAACCTTCATGAAATGCAG
CCTTTGGCACATGGGGCCAGCACTGTGCTTCCCTCAGTGAGCCAGTTGCTATCCCACCACCACATTGTGTCTCCAGGCAGTGGCAGTGCT
GGAAGCTTGAGTAGGCTCCATCCAGTCCCAGTCCCAGCAGATTGGATGAACCGCATGGAGGTGAATGAGACCCAGTACAATGAGATGTTT
GGTATGGTCCTGGCTCCAGCTGAGGGCACCCATCCTGGCATAGCTCCCCAGAGCAGGCCACCTGAAGGGAAGCACATAACCACCCCTCGG
GAGCCCTTGCCCCCCATTGTGACTTTCCAGCTCATCCCTAAAGGCAGTATTGCCCAACCAGCGGGGGCTCCCCAGCCTCAGTCCACCTGC
CCTCCAGCTGTTGCGGGCCCCCTGCCCACCATGTACCAGATTCCAGAAATGGCCCGTTTGCCCAGTGTGGCTTTCCCCACTGCCATGATG
CCCCAGCAGGACGGGCAGGTAGCTCAGACCATTCTCCCAGCCTATCATCCTTTCCCAGCCTCTGTGGGCAAGTACCCCACACCCCCTTCA
CAGCACAGTTATGCTTCCTCAAATGCTGCTGAGCGAACACCCAGTCACAGTGGTCACCTCCAGGGTGAGCATCCCTACCTGACACCATCC
CCAGAGTCTCCTGACCAGTGGTCAAGTTCATCACCCCACTCTGCTTCTGACTGGTCAGATGTGACCACCAGCCCTACCCCTGGGGGTGCT
GGAGGAGGTCAGCGGGGACCTGGGACACACATGTCTGAGCCACCACACAACAACATGCAGGTTTATGCGTGAGAGAGTCCACCTCCAGTG
TAGAGACATAACTGACTTTTGTAAATGCTGCTGAGGAACAAATGAAGGTCATCCGGGAGAGAAATGAAGAAATCTCTGGAGCCAGCTTCT
AGAGGTAGGAAAGAGAAGATGTTCTTATTCAGATAATGCAAGAGAAGCAATTCGTCAGTTTCACTGGGTATCTGCAAGGCTTATTGATTA
TTCTAATCTAATAAGACAAGTTTGTGGAAATGCAAGATGAATACAAGCCTTGGGTCCATGTTTACTCTCTTCTATTTGGAGAATAAGATG
GATGCTTATTGAAGCCCAGACATTCTTGCAGCTTGGACTGCATTTTAAGCCCTGCAGGCTTCTGCCATATCCATGAGAAGATTCTACACT
AGCGTCCTGTTGGGAATTATGCCCTGGAATTCTGCCTGAATTGACCTACGCATCTCCTCCTCCTTGGACATTCTTTTGTCTTCATTTGGT
GCTTTTGGTTTTGCACCTCTCCGTGATTGTAGCCCTACCAGCATGTTATAGGGCAAGACCTTTGTGCTTTTGATCATTCTGGCCCATGAA
AGCAACTTTGGTCTCCTTTCCCCTCCTGTCTTCCCGGTATCCCTTGGAGTCTCACAAGGTTTACTTTGGTATGGTTCTCAGCACAAACCT
TTCAAGTATGTTGTTTCTTTGGAAAATGGACATACTGTATTGTGTTCTCCTGCATATATCATTCCTGGAGAGAGAAGGGGAGAAGAATAC
TTTTCTTCAACAAATTTTGGGGGCAGGAGATCCCTTCAAGAGGCTGCACCTTAATTTTTCTTGTCTGTGTGCAGGTCTTCATATAAACTT
TACCAGGAAGAAGGGTGTGAGTTTGTTGTTTTTCTGTGTATGGGCCTGGTCAGTGTAAAGTTTTATCCTTGATAGTCTAGTTACTATGAC
CCTCCCCACTTTTTTAAAACCAGAAAAAGGTTTGGAATGTTGGAATGACCAAGAGACAAGTTAACTCGTGCAAGAGCCAGTTACCCACCC
ACAGGTCCCCCTACTTCCTGCCAAGCATTCCATTGACTGCCTGTATGGAACACATTTGTCCCAGATCTGAGCATTCTAGGCCTGTTTCAC
TCACTCACCCAGCATATGAAACTAGTCTTAACTGTTGAGCCTTTCCTTTCATATCCACAGAAGACACTGTCTCAAATGTTGTACCCTTGC
CATTTAGGACTGAACTTTCCTTAGCCCAAGGGACCCAGTGACAGTTGTCTTCCGTTTGTCAGATGATCAGTCTCTACTGATTATCTTGCT
GCTTAAAGGCCTGCTCACCAATCTTTCTTTCACACCGTGTGGTCCGTGTTACTGGTATACCCAGTATGTTCTCACTGAAGACATGGACTT
TATATGTTCAAGTGCAGGAATTGGAAAGTTGGACTTGTTTTCTATGATCCAAAACAGCCCTATAAGAAGGTTGGAAAAGGAGGAACTATA
TAGCAGCCTTTGCTATTTTCTGCTACCATTTCTTTTCCTCTGAAGCGGCCATGACATTCCCTTTGGCAACTAACGTAGAAACTCAACAGA
ACATTTTCCTTTCCTAGAGTCACCTTTTAGATGATAATGGACAACTATAGACTTGCTCATTGTTCAGACTGATTGCCCCTCACCTGAATC
CACTCTCTGTATTCATGCTCTTGGCAATTTCTTTGACTTTCTTTTAAGGGCAGAAGCATTTTAGTTAATTGTAGATAAAGAATAGTTTTC
TTCCTCTTCTCCTTGGGCCAGTTAATAATTGGTCCATGGCTACACTGCAACTTCCGTCCAGTGCTGTGATGCCCATGACACCTGCAAAAT
AAGTTCTGCCTGGGCATTTTGTAGATATTAACAGGTGAATTCCCGACTCTTTTGGTTTGAATGACAGTTCTCATTCCTTCTATGGCTGCA
AGTATGCATCAGTGCTTCCCACTTACCTGATTTGTCTGTCGGTGGCCCCATATGGAAACCCTGCGTGTCTGTTGGCATAATAGTTTACAA
ATGGTTTTTTCAGTCCTATCCAAATTTATTGAACCAACAAAAATAATTACTTCTGCCCTGAGATAAGCAGATTAAGTTTGTTCATTCTCT
GCTTTATTCTCTCCATGTGGCAACATTCTGTCAGCCTCTTTCATAGTGTGCAAACATTTTATCATTCTAAATGGTGACTCTCTGCCCTTG
GACCCATTTATTATTCACAGATGGGGAGAACCTATCTGCATGGACCTCTGTGGACCACAGCGTACCTGCCCCTTTCTGCCCTCCTGCTCC
AGCCCCACTTCTGAAAGTATCAGCTACTGATCCAGCCACTGGATATTTTATATCCTCCCTTTTCCTTAAGCACAATGTCAGACCAAATTG
CTTGTTTCTTTTTCTTGGACTACTTTAATTTGGATCCTTTGGGTTTGGAGAAAGGGAATGTGAAAGCTGTCATTACAGACAACAGGTTTC
AGTGATGAGGAGGACAACACTGCCTTTCAAACTTTTTACTGATCTCTTAGATTTTAAGAACTCTTGAATTGTGTGGTATCTAATAAAAGG
GAAGGTAAGATGGATAATCACTTTCTCATTTGGGTTCTGAATTGGAGACTCAGTTTTTATGAGACACATCTTTTATGCCATGTATAGATC
CTCCCCTGCTATTTTTGGTTTATTTTTATTGTTATAAATGCTTTCTTTCTTTGACTCCTCTTCTGCCTGCCTTTGGGGATAGGTTTTTTT
GTTTGTTTATTTGCTTCCTCTGTTTTGTTTTAAGCATCATTTTCTTATGTGAGGTGGGGAAGGGAAAGGTATGAGGGAAAGAGAGTCTGA
GAATTAAAATATTTTAGTATAAGCAATTGGCTGTGATGCTCAAATCCATTGCATCCTCTTATTGAATTTGCCAATTTGTAATTTTTGCAT
AATAAAGAACCAAAGGTGTAATGTTTTGTTGAGAGGTGGTTTAGGGATTTTGGCCCTAACCAATACATTGAATGTATGATGACTATTTGG
GAGGACACATTTATGTACCCAGAGGCCCCCACTAATAAGTGGTACTATGGTTACTTCCTTGTGTACATTTCTCTTAAAAGTGATATTATA
TCTGTTTGTATGAGAAACCCAGTAACCAATAAAATGACCGCATATTCCTGACTAAACGTAGTAAGGAAAATGCACACTTTGTTTTTACTT
TTCCGTTTCATTCTAAAGGTAGTTAAGATGAAATTTATATGAAAGCATTTTTATCACAAAATAAAAAAGGTTTGCCAAGCTCAGTGGTGT
TGTATTTTTTATTTTCCAATACTGCATCCATGGCCTGGCAGTGTTACCTCATGATGTCATAATTTGCTGAGAGAGCAAATTTTCTTTTCT
TTCTGAATCCCACAAAGCCTAGCACCAAACTTCTTTTTTTCTTCCTTTAATTAGATCATAAATAAATGATCCTGGGGAAAAAGCATCTGT
CAAATAGGAAACATCACAAAACTGAGCACTCTTCTGTGCACTAGCCATAGCTGGTGACAAACAGATGGTTGCTCAGGGACAAGGTGCCTT
CCAATGGAAATGCGAAGTAGTTGCTATAGCAAGAATTGGGAACTGGGATATAAGTCATAATATTAATTATGCTGTTATGTAAATGATTGG
TTTGTAACATTCCTTAAGTGAAATTTGTGTAGAACTTAATATACAGGATTATAAAATAATATTTTGTGTATAAATTTGTTATAAGTTCAC

>In-frame_MAGI3_ENST00000369611_chr1_113933971_+_NOTCH2_ENST00000602566_chr1_120539955_-_4663nt
CGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTG
CAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTG
GGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAAC
GGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCA
GGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGC
AAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGC
CTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCA
CCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGAAACAGTGAGAAATAAGAGGAAC
AGAGCTCTGGGAAAGGGACAGGCAAGTCTGGAATGGAAAAGAACACGATGAGAATTAGACACTGGAAAATATGTATGTGTGGTTAATAAA
GTGCTTTAAACTGAATTGACATTAACAGTAGGTGATCAACTTTCCTATGTGCTTGTGCTTTTGCTTTTGATGGAGTAATTCATTGTTTTC
TTATCCACCTAAATGCACCCAGCTGCCCTTGATTTTCTCTGGGCTACTGGCCTTCACAACCCTCTCCCATGTACCCTCTCTGACTTTGGG
GTAACCCTCCCCTAACTTAAAGCTAGAGAATTCTGAAACTGAGGAGGGGATCCTCTGTTAATCAGTGAGCACTTTTTGATGAGCTGATAG
ATGATATATGAGAGACTATGCGTGGCACAATACTTTGTTACACTCTTCACTGATACAAGTGTTCTAGAGTGCACACACAACCCAAAGATA
GAAACAAAAAGAGGAGCAGTGTCGGGGAGCTTGGGGCCTGGTGTTCCATGGAGAGGGAGAAAGGAACAAGCCTGGCCAATTCATTCAACT
CCTTATAAAAATGATGAGGAGGCTGAAAACCAAGAATTTTGATTGGGAACAGAATACAAGCAGCTGGAGCAGATGAATTACTAAGCAACA
AAGATCCTGTTTTTATACAAATATCCTTAGTACAAAAACAAAAGAAGGAAAACTGTAGGGGGGAGTAATGTGCTAAGTAAGCAGAATTGC
CTCAAAAAGAAGTTGTTCTAGTTACTCTTTCAGAGTGGGAATCTTAGATTCTGGTATTGTGGATATGGTTCACATATAATGGGATTGTGT
GTTTTATTTTGGAGAGATTAAAGGTCATAGGTTGGTCCTCAGTATAAAATCAACTGGTAATTTATTCATTTCATTTGGTAAAAATGTATT
GACTGCCTGCTATGTTCTAGGCACCATGCTATGTATTTGGAATACAGCTATACAAAGCATTGTCACATAATTGAAATGAAAACTTTATAT
TATTTAAGTCACAAGAACAAGCTATTTAATTATATTACTTTTAGTTTCTCTTTTAATAAAGAATAGATAATGCTATCATTCTAGATACTA
AATAAGTGTTTTCTTAACATAATATTACTATTCACTTTATCTTGTAGAAGAAATAACTAAAATACGTCTGTCTTCACTCCTGCATTTGTT
TGCATTTTAAGGGTTAAAGACAGAAATAGAAATGTAAACAACTTTATTTTGAAAATATTTCAATATTGCAAATATCTCTGGGTCTGATAT
TCTAGTAATCTAATTGGCTAGTAATTGATGTTAGTGTGATTTATTGTTGAAGGCTAAATGTGTTTTTCAGTTTCAAGAAAATTGCTTTTA
ATAATTGCCTAGAACAAGAGGTTGATTTGGCAGCAAGATGTTGACGGGAAGTTAGAGAAGTCAATAAAGGAAGTTTTTAGCTGAGAGAGA
GTGATTATTCACTCCCATAGCCTCTGCATTGTTATCCATTAGCCACGATAAGAACCTTAGGGAATTCTGAGAGTGTGTCCAGGAAAGGAT
CTGTCAAACTAGAATAGTATCTCCTCCTTGAGAAAGGAAATAACCAAGGATTCCGCAGCTGAGAGGCTGCCAGGGCTAGTGAAATAGAGT
AAGGAAATCTTGGCTGTCTCTTATTCTCTGGTTGTAGTTTAACGCAAGACACTTATTTACTCACTGATGGTGTGTGTGTATGTGGGAGGG
GAGATTAGCATGAGGGGTGGGAATGGGGAGATTTGATGAAGAGAAAACTAACATTTTTTTGGTGACTCAGGAACTGTGCCAGGTACTTCC
ATGCTTATTAGCTCAATTACACAAAAATCTTGGGACCAGGTATTATTTTTCAAGTCTTCCCACATGAAGTAACTGAAGTTTGGAGATGTT
AAGTGATTCACCCAAAGTTGTACAGCTAATATGTGGTTAGGCTGGGTCCTGAAACCGAGGCAGTTTATTTTCAAAGCCTTTGCTTTGTGC
ATCTTACTGCGCCACATTGCACTGCACATCTGCTTCCTGAAAGCACTTTGTAGGTGTGTAAAACTTTTCGTTAAATGCTTTAAGCTGTTT
GGGTTAAAAATATATGTTCATGTTATAAGAAAACCAAGACACTCCTAATTATAATCAAATAGTACTTGTTACATATCAATATGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATATATGGCATTGTGCAGATGTTTAAAAGTAGTTACATAGACTAGTTCTTGC
TTTTCAGGGTCCCATAATCTAAACCAGATGACTTCAGCTTTGGATAAATATATAGAAGGAAATTTAAAGAGAATTCAAAACAATAGATGA
TGCAGTGACACTGTGAATAAATGTTATTTATACAGTTTGTAAGATTTCATGCTCATTGTTCGTATGTCCCAGGTGGAGTTCAGAAAATAT
TCACTTCATTTCCACAAAGGGAAATAGTGCCTAGAGATGGTTTTCTTTTAAAAAGTCCTTTTCATAATGCAGTGCCCTTCCTTCCATTGC
CCTTCATTCCATTGCTTCCCATGCTTGTCAAGAGACTAAAATGTTACTTATAGTAATAGTCACTATCTCAATGTAAATAGCACCCTTATT
TGATGAGAATTATTATTTCAGTTCTAAAAATGGGGAAACAAAGTCAGCAGGAGGCAAAGTAGCTTGTTAAAGTATTCTGCAACTTTCAAA
TGGTTGCTTCCACTGCATTTCACGTCTTGGCACTTCTAATTGAGGGTTACTCTAACCACCCTATTTAAAATTGTAACTGTCCCCCACCCC
CTTAATTACTAACCCTGGTCTACTTTTTGTTTTCTTTTTCTGTAACTCTTATCTTCTTACTATATAATTTATACTATATAATTTACTTCA
TTATGTCTATTGTTTATTGTCTGTCTTTTCCAAATTCTACTGCCTCTTACCCTCTCCAGAATGAAAACTAGTATCTTTGTTTTTGTTTAC
TGATGTAACCCAAACACCTACAAACAGTGCCCAGTATATACTAGGCCCGCAAATATATATTGGCTGACTGACTGTATGGTTTAGTATCAT
GTCATAGTATTGAGACTGTAACTTTGGTCTTCTCATTTTCTTCTTTGTATTGTGCGTCCTAGACTTAGTTTGGCCTCTCCTTTTGTCCTT
GTATACTCTAATACTGGATAAGAATTTTGGAGTCTTTTTCAACTCTGAGTCAGTGAATGCCACATAACTTAGTGACTATATTTAAATGGT
TAATTTACAATTTTTTCCCTGCAAAGGATACTGTAGTCACTGTGAGTATTTTAGTATTATTGTAGGACTCAAGAGGGAATTAAAACTACA
AAAATGACTCGTCTTGTATGACACAGAAAGAAATGTTTCTTCACAGAGGGAGGAGAAAAATATCTTCAAGAGAGAACTAATTGAATCAAA
TCAATGAACCATGTCTCATCTTTTTGGATAAGTAACTGTTAGTAATCCAGACACTTCATGAGCTTTCATTATGTAAAGTCTTTAGCAGAA
GCTAAAGGAGGGGCACCAACCACAGTAATTTTAACTTAAGAACAAAATGGAGCATGAAAATAAATTATTAAATCATTTACTCCCACTATT
TTTGGGTTAGGGCCAATAATGGGGAGAGAAAGAGGTAGACTAGTTTTGTGTTTGTGGCTATTTTAATAGAGTAGCACAAGTAATCAAAAA
ACAGTAGGCTGTTTTGAATTTACTGGCTGTCCCTTATGAGTTCACAGTTAGATTGGACTGTCCTCAATGTACTTTCTTTTTTTTCTTTCT
TTCCCACATCTCTTTATTTCTCTGATTTTGTTTAAACTTCATAAAGAGCTCTCTGATCTTTCCTTTCCAAACAATGAAGGTTTATCCTTT


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FusionGenePPI for MAGI3_NOTCH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAGI3PTPRB, BAI1, PTEN, USP43, TNK2, SSTR3, NRCAM, DSCAML1, PLXNB3, MED28, RAPGEF2, LATS1, RHBDL1, TCL1B, LDLRAD4, PCBP2, RPE, CDH1, PTRF, PTPN14, FERMT1NOTCH2CNTN1, GSK3B, JAG1, DLL1, RBPJ, MAML1, JAG2, CRKL, MYOC, SPEN, NDUFV2, NDUFV1, SEC24C, PCMT1, PSMB1, TJP1, SIN3A, PLAUR, NOTCH1, SMAD1, EGFL7, ANKRD28, LATS2, ASB14, ANKRD44, RABGGTB, ZFP41, EEF2, MLLT4, ATP2A2, CDC42, MSN, RDX, PDIA6, CST6, EPSTI1, FAM84B, IL13RA2, IL24, ITIH5, KLK5, MTA3, PSMC3IP, ST14, TMEM17, FBXL17, CDH1, VASN, LRRIQ1, AGRP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+12118_1061051482ADRB1 and TGFA
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+12118_1061051126ADRB1 and TGFA
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+12218_1061052009ADRB1 and TGFA
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+12218_1061051151ADRB1 and TGFA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121726_8081051482ADGRB1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121726_8081051126ADGRB1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122726_8081052009ADGRB1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122726_8081051151ADGRB1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121851_9381051482LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121851_9381051126LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122851_9381052009LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122851_9381051151LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121410_4921051482PTEN
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121410_4921051126PTEN
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122410_4921052009PTEN
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122410_4921051151PTEN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAGI3_NOTCH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAGI3_NOTCH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNOTCH2C0917715Hajdu-Cheney Syndrome2CTD_human;ORPHANET
TgeneNOTCH2C0004114Astrocytoma1CTD_human
TgeneNOTCH2C0007873Uterine Cervical Neoplasm1CTD_human
TgeneNOTCH2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneNOTCH2C0017636Glioblastoma1CTD_human
TgeneNOTCH2C0024121Lung Neoplasms1CTD_human
TgeneNOTCH2C0206663Neuroectodermal Tumor, Primitive1CTD_human
TgeneNOTCH2C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneNOTCH2C1458155Mammary Neoplasms1CTD_human
TgeneNOTCH2C1857761Alagille Syndrome 21ORPHANET;UNIPROT