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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 20586

FusionGeneSummary for MAGI3_DENND5A

check button Fusion gene summary
Fusion gene informationFusion gene name: MAGI3_DENND5A
Fusion gene ID: 20586
HgeneTgene
Gene symbol

MAGI3

DENND5A

Gene ID

260425

23258

Gene namemembrane associated guanylate kinase, WW and PDZ domain containing 3DENN domain containing 5A
SynonymsMAGI-3|dJ730K3.2EIEE49|RAB6IP1
Cytomap

1p13.2

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated guanylate kinase, WW and PDZ domain-containing protein 3membrane-associated guanylate kinase inverted 3membrane-associated guanylate kinase-related 3DENN domain-containing protein 5ADENN/MADD domain containing 5ARAB6 interacting protein 1rab6-interacting protein 1
Modification date2018052220180522
UniProtAcc

Q5TCQ9

Q6IQ26

Ensembl transtripts involved in fusion geneENST00000369617, ENST00000307546, 
ENST00000369615, ENST00000369611, 
ENST00000486456, 		ENST00000328194, 
ENST00000530044, ENST00000527700, 
ENST00000526523, 
Fusion gene scores* DoF score5 X 3 X 3=459 X 10 X 5=450
# samples 510
** MAII scorelog2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAGI3 [Title/Abstract] AND DENND5A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-24-1549-01AMAGI3chr1

113933971

+DENND5Achr11

9161401

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000369617ENST00000328194MAGI3chr1

113933971

+DENND5Achr11

9161401

-
Frame-shiftENST00000369617ENST00000530044MAGI3chr1

113933971

+DENND5Achr11

9161401

-
Frame-shiftENST00000369617ENST00000527700MAGI3chr1

113933971

+DENND5Achr11

9161401

-
5CDS-intronENST00000369617ENST00000526523MAGI3chr1

113933971

+DENND5Achr11

9161401

-
In-frameENST00000307546ENST00000328194MAGI3chr1

113933971

+DENND5Achr11

9161401

-
Frame-shiftENST00000307546ENST00000530044MAGI3chr1

113933971

+DENND5Achr11

9161401

-
Frame-shiftENST00000307546ENST00000527700MAGI3chr1

113933971

+DENND5Achr11

9161401

-
5CDS-intronENST00000307546ENST00000526523MAGI3chr1

113933971

+DENND5Achr11

9161401

-
In-frameENST00000369615ENST00000328194MAGI3chr1

113933971

+DENND5Achr11

9161401

-
Frame-shiftENST00000369615ENST00000530044MAGI3chr1

113933971

+DENND5Achr11

9161401

-
Frame-shiftENST00000369615ENST00000527700MAGI3chr1

113933971

+DENND5Achr11

9161401

-
5CDS-intronENST00000369615ENST00000526523MAGI3chr1

113933971

+DENND5Achr11

9161401

-
In-frameENST00000369611ENST00000328194MAGI3chr1

113933971

+DENND5Achr11

9161401

-
Frame-shiftENST00000369611ENST00000530044MAGI3chr1

113933971

+DENND5Achr11

9161401

-
Frame-shiftENST00000369611ENST00000527700MAGI3chr1

113933971

+DENND5Achr11

9161401

-
5CDS-intronENST00000369611ENST00000526523MAGI3chr1

113933971

+DENND5Achr11

9161401

-
3UTR-3CDSENST00000486456ENST00000328194MAGI3chr1

113933971

+DENND5Achr11

9161401

-
3UTR-3CDSENST00000486456ENST00000530044MAGI3chr1

113933971

+DENND5Achr11

9161401

-
3UTR-3CDSENST00000486456ENST00000527700MAGI3chr1

113933971

+DENND5Achr11

9161401

-
3UTR-intronENST00000486456ENST00000526523MAGI3chr1

113933971

+DENND5Achr11

9161401

-

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FusionProtFeatures for MAGI3_DENND5A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAGI3

Q5TCQ9

DENND5A

Q6IQ26

Guanine nucleotide exchange factor (GEF) which mayactivate RAB6A and RAB39A and/or RAB39B. Promotes the exchange ofGDP to GTP, converting inactive GDP-bound Rab proteins into theiractive GTP-bound form. Involved in the negative regulation ofneurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0,ECO:0000269|PubMed:20937701}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAGI3chr1:113933971chr11:9161401ENST00000307546+1216_91051482Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369611+1216_91051126Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369615+1226_91052009Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369617+1226_91051151Compositional biasNote=Poly-Lys

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAGI3chr1:113933971chr11:9161401ENST00000307546+121238_2431051482Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369611+121238_2431051126Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369615+122238_2431052009Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369617+122238_2431051151Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr11:9161401ENST00000307546+1211021_11031051482DomainPDZ 6
HgeneMAGI3chr1:113933971chr11:9161401ENST00000307546+121114_2881051482DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr11:9161401ENST00000307546+121293_3261051482DomainWW 1
HgeneMAGI3chr1:113933971chr11:9161401ENST00000307546+121339_3721051482DomainWW 2
HgeneMAGI3chr1:113933971chr11:9161401ENST00000307546+121578_6541051482DomainPDZ 3
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369611+1211021_11031051126DomainPDZ 6
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369611+121114_2881051126DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369611+121293_3261051126DomainWW 1
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369611+121339_3721051126DomainWW 2
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369611+121578_6541051126DomainPDZ 3
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369615+1221021_11031052009DomainPDZ 6
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369615+122114_2881052009DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369615+122293_3261052009DomainWW 1
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369615+122339_3721052009DomainWW 2
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369615+122578_6541052009DomainPDZ 3
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369617+1221021_11031051151DomainPDZ 6
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369617+122114_2881051151DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369617+122293_3261051151DomainWW 1
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369617+122339_3721051151DomainWW 2
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369617+122578_6541051151DomainPDZ 3
HgeneMAGI3chr1:113933971chr11:9161401ENST00000307546+121121_1281051482Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369611+121121_1281051126Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369615+122121_1281052009Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369617+122121_1281051151Nucleotide bindingATP
TgeneDENND5Achr1:113933971chr11:9161401ENST00000328194-21233_912261288Compositional biasNote=Poly-Gly
TgeneDENND5Achr1:113933971chr11:9161401ENST00000328194-2123593_59812261288Compositional biasNote=Poly-Asp
TgeneDENND5Achr1:113933971chr11:9161401ENST00000530044-21233_912151242Compositional biasNote=Poly-Gly
TgeneDENND5Achr1:113933971chr11:9161401ENST00000530044-2123593_59812151242Compositional biasNote=Poly-Asp
TgeneDENND5Achr1:113933971chr11:9161401ENST00000328194-21231134_128212261288DomainRUN 2
TgeneDENND5Achr1:113933971chr11:9161401ENST00000328194-2123278_41412261288DomaincDENN
TgeneDENND5Achr1:113933971chr11:9161401ENST00000328194-2123416_59812261288DomaindDENN
TgeneDENND5Achr1:113933971chr11:9161401ENST00000328194-212357_25912261288DomainuDENN
TgeneDENND5Achr1:113933971chr11:9161401ENST00000328194-2123787_95012261288DomainRUN 1
TgeneDENND5Achr1:113933971chr11:9161401ENST00000328194-2123954_106212261288DomainPLAT
TgeneDENND5Achr1:113933971chr11:9161401ENST00000530044-21231134_128212151242DomainRUN 2
TgeneDENND5Achr1:113933971chr11:9161401ENST00000530044-2123278_41412151242DomaincDENN
TgeneDENND5Achr1:113933971chr11:9161401ENST00000530044-2123416_59812151242DomaindDENN
TgeneDENND5Achr1:113933971chr11:9161401ENST00000530044-212357_25912151242DomainuDENN
TgeneDENND5Achr1:113933971chr11:9161401ENST00000530044-2123787_95012151242DomainRUN 1
TgeneDENND5Achr1:113933971chr11:9161401ENST00000530044-2123954_106212151242DomainPLAT


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FusionGeneSequence for MAGI3_DENND5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MAGI3_ENST00000369617_chr1_113933971_+_DENND5A_ENST00000328194_chr11_9161401_-_166aa
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV

>In-frame_MAGI3_ENST00000307546_chr1_113933971_+_DENND5A_ENST00000328194_chr11_9161401_-_166aa
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV

>In-frame_MAGI3_ENST00000369615_chr1_113933971_+_DENND5A_ENST00000328194_chr11_9161401_-_166aa
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV

>In-frame_MAGI3_ENST00000369611_chr1_113933971_+_DENND5A_ENST00000328194_chr11_9161401_-_166aa
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MAGI3_ENST00000369617_chr1_113933971_+_DENND5A_ENST00000328194_chr11_9161401_-_500nt
ATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGC
GCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTC
TCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTC
ATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCC
CCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGG

>In-frame_MAGI3_ENST00000307546_chr1_113933971_+_DENND5A_ENST00000328194_chr11_9161401_-_500nt
ATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGC
GCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTC
TCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTC
ATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCC
CCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGG

>In-frame_MAGI3_ENST00000369615_chr1_113933971_+_DENND5A_ENST00000328194_chr11_9161401_-_500nt
ATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGC
GCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTC
TCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTC
ATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCC
CCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGG

>In-frame_MAGI3_ENST00000369611_chr1_113933971_+_DENND5A_ENST00000328194_chr11_9161401_-_500nt
ATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGC
GCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTC
TCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTC
ATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCC
CCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_MAGI3_ENST00000369617_chr1_113933971_+_DENND5A_ENST00000328194_chr11_9161401_-_1631nt
CTCCTGGGGACAATTCCCTTTTCCTTTCTTCAGCCTAACCCGCGGTGGCCCTCGCGGAGTCCGGTCAGCCCCGGGGAGCGCAGCCGGGAG
GGGCGTCCAAGGGGCGTCTCGCGTCTGGGAACGGCCGGGCCCCCAGCGGGCTGTGGTCGCGGGGTGGGGGCCGGAGCGGCGAGGCCCCCC
TTACCGGGCTGCGCGGGCCGCCCAGGGCCCCCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGT
GCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCC
CCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGC
ACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGG
GACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGAGATCACCTCCTACACCACTGGATTGCCC
TGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGC
TGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGG
ACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCAC
TGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTTGCTGATTTGCTTTTTACACACTTTCATGTGAAAG
AGTGATAGGGAGAGGGAGCGAGGCTGGTGCCGCTTATTTTGAAGCTGGTGCCCTCCCTCGCCGTGGCCACATGCTGGAAGCCTGAGGCCT
CCCTGGACTGAGCCTGTGGCACTGCGTGCGGGACAGTTATGTTTCCTTGCCCCGTCGCATTAATGAGGCCCTTCCACATCATTTTTAAAC
TAATGTTTTTCTATATTAACATTATTATGGATATTTGGCTTTCATAGGCCACACACAGGTGTGCTGCGCGGGAAGCCCCATGCTCCAATC
AAAGGGATTTTTAGTAGTGCCTCTAAGCAAGCACCGATGAGTCAGTCCCACGTATTTTCTTTTTTGTCAGTATTGTTTGGGAAGGAGACA
TGCCGGGATGTGTCATCGTGCCAAATACCACATTTCCTGTTGGCACAGTTTCACAGAAGTAAACATAAGCATGTTTTAACAGGTTTTTCT
TTTCTTTTTTCTTTTTTAAAATGTTTTATTTATTTAACCCGCCATTGTGTGTTTTTAAGTATTTTCTTTTTTTAAGGAAAGGAAAAGCTT
GTCACAATCTAACTGGCTATGTTATTATTATTAAATTTATGTTTTGCAACTTAGAAACCAGCTACAGTATGGCCCACTTAATAAAACACC

>In-frame_MAGI3_ENST00000307546_chr1_113933971_+_DENND5A_ENST00000328194_chr11_9161401_-_1421nt
CCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTG
AAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGT
GGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCC
AGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGC
GAGCCCATCCGTCTCAAGACTGTGAAACCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACA
TGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGC
TGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGAC
CTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAA
TAAATAATCTATTTTAGAGTTTATTTGCTGATTTGCTTTTTACACACTTTCATGTGAAAGAGTGATAGGGAGAGGGAGCGAGGCTGGTGC
CGCTTATTTTGAAGCTGGTGCCCTCCCTCGCCGTGGCCACATGCTGGAAGCCTGAGGCCTCCCTGGACTGAGCCTGTGGCACTGCGTGCG
GGACAGTTATGTTTCCTTGCCCCGTCGCATTAATGAGGCCCTTCCACATCATTTTTAAACTAATGTTTTTCTATATTAACATTATTATGG
ATATTTGGCTTTCATAGGCCACACACAGGTGTGCTGCGCGGGAAGCCCCATGCTCCAATCAAAGGGATTTTTAGTAGTGCCTCTAAGCAA
GCACCGATGAGTCAGTCCCACGTATTTTCTTTTTTGTCAGTATTGTTTGGGAAGGAGACATGCCGGGATGTGTCATCGTGCCAAATACCA
CATTTCCTGTTGGCACAGTTTCACAGAAGTAAACATAAGCATGTTTTAACAGGTTTTTCTTTTCTTTTTTCTTTTTTAAAATGTTTTATT
TATTTAACCCGCCATTGTGTGTTTTTAAGTATTTTCTTTTTTTAAGGAAAGGAAAAGCTTGTCACAATCTAACTGGCTATGTTATTATTA

>In-frame_MAGI3_ENST00000369615_chr1_113933971_+_DENND5A_ENST00000328194_chr11_9161401_-_1408nt
GGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGC
ACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTG
GCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATG
TGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTC
TCAAGACTGTGAAACCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGT
GGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCT
TGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAA
GGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTATT
TTAGAGTTTATTTGCTGATTTGCTTTTTACACACTTTCATGTGAAAGAGTGATAGGGAGAGGGAGCGAGGCTGGTGCCGCTTATTTTGAA
GCTGGTGCCCTCCCTCGCCGTGGCCACATGCTGGAAGCCTGAGGCCTCCCTGGACTGAGCCTGTGGCACTGCGTGCGGGACAGTTATGTT
TCCTTGCCCCGTCGCATTAATGAGGCCCTTCCACATCATTTTTAAACTAATGTTTTTCTATATTAACATTATTATGGATATTTGGCTTTC
ATAGGCCACACACAGGTGTGCTGCGCGGGAAGCCCCATGCTCCAATCAAAGGGATTTTTAGTAGTGCCTCTAAGCAAGCACCGATGAGTC
AGTCCCACGTATTTTCTTTTTTGTCAGTATTGTTTGGGAAGGAGACATGCCGGGATGTGTCATCGTGCCAAATACCACATTTCCTGTTGG
CACAGTTTCACAGAAGTAAACATAAGCATGTTTTAACAGGTTTTTCTTTTCTTTTTTCTTTTTTAAAATGTTTTATTTATTTAACCCGCC
ATTGTGTGTTTTTAAGTATTTTCTTTTTTTAAGGAAAGGAAAAGCTTGTCACAATCTAACTGGCTATGTTATTATTATTAAATTTATGTT

>In-frame_MAGI3_ENST00000369611_chr1_113933971_+_DENND5A_ENST00000328194_chr11_9161401_-_1391nt
CGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTG
CAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTG
GGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAAC
GGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCA
GAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACC
ATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACA
TCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGT
GCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTTGCTG
ATTTGCTTTTTACACACTTTCATGTGAAAGAGTGATAGGGAGAGGGAGCGAGGCTGGTGCCGCTTATTTTGAAGCTGGTGCCCTCCCTCG
CCGTGGCCACATGCTGGAAGCCTGAGGCCTCCCTGGACTGAGCCTGTGGCACTGCGTGCGGGACAGTTATGTTTCCTTGCCCCGTCGCAT
TAATGAGGCCCTTCCACATCATTTTTAAACTAATGTTTTTCTATATTAACATTATTATGGATATTTGGCTTTCATAGGCCACACACAGGT
GTGCTGCGCGGGAAGCCCCATGCTCCAATCAAAGGGATTTTTAGTAGTGCCTCTAAGCAAGCACCGATGAGTCAGTCCCACGTATTTTCT
TTTTTGTCAGTATTGTTTGGGAAGGAGACATGCCGGGATGTGTCATCGTGCCAAATACCACATTTCCTGTTGGCACAGTTTCACAGAAGT
AAACATAAGCATGTTTTAACAGGTTTTTCTTTTCTTTTTTCTTTTTTAAAATGTTTTATTTATTTAACCCGCCATTGTGTGTTTTTAAGT
ATTTTCTTTTTTTAAGGAAAGGAAAAGCTTGTCACAATCTAACTGGCTATGTTATTATTATTAAATTTATGTTTTGCAACTTAGAAACCA


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FusionGenePPI for MAGI3_DENND5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAGI3PTPRB, BAI1, PTEN, USP43, TNK2, SSTR3, NRCAM, DSCAML1, PLXNB3, MED28, RAPGEF2, LATS1, RHBDL1, TCL1B, LDLRAD4, PCBP2, RPE, CDH1, PTRF, PTPN14, FERMT1DENND5AAR, CSNK2B, PRKCZ, ELAVL1, XRN2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMAGI3chr1:113933971chr11:9161401ENST00000307546+12118_1061051482ADRB1 and TGFA
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369611+12118_1061051126ADRB1 and TGFA
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369615+12218_1061052009ADRB1 and TGFA
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369617+12218_1061051151ADRB1 and TGFA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMAGI3chr1:113933971chr11:9161401ENST00000307546+121726_8081051482ADGRB1
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369611+121726_8081051126ADGRB1
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369615+122726_8081052009ADGRB1
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369617+122726_8081051151ADGRB1
HgeneMAGI3chr1:113933971chr11:9161401ENST00000307546+121851_9381051482LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369611+121851_9381051126LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369615+122851_9381052009LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369617+122851_9381051151LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr11:9161401ENST00000307546+121410_4921051482PTEN
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369611+121410_4921051126PTEN
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369615+122410_4921052009PTEN
HgeneMAGI3chr1:113933971chr11:9161401ENST00000369617+122410_4921051151PTEN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAGI3_DENND5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAGI3_DENND5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource