|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 20584 |
FusionGeneSummary for MAGI2_VWC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAGI2_VWC2 | Fusion gene ID: 20584 | Hgene | Tgene | Gene symbol | MAGI2 | VWC2 | Gene ID | 9863 | 375567 |
| Gene name | membrane associated guanylate kinase, WW and PDZ domain containing 2 | von Willebrand factor C domain containing 2 | |
| Synonyms | ACVRIP1|AIP-1|AIP1|ARIP1|MAGI-2|SSCAM | PSST739|UNQ739 | |
| Cytomap | 7q21.11 | 7p12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2activin receptor interacting protein 1atrophin-1-interacting protein 1atrophin-1-interacting protein Amembrane-associated guanylate kinase inverted 2 | brorinbrain-specific chordin-like proteinvon Willebrand factor C domain-containing protein 2 | |
| Modification date | 20180522 | 20180329 | |
| UniProtAcc | Q86UL8 | Q2TAL6 | |
| Ensembl transtripts involved in fusion gene | ENST00000419488, ENST00000354212, ENST00000522391, ENST00000536571, ENST00000535697, ENST00000517762, | ENST00000340652, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 2 X 4=40 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAGI2 [Title/Abstract] AND VWC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAGI2 | GO:0002092 | positive regulation of receptor internalization | 11526121 |
| Hgene | MAGI2 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 10760291 |
| Hgene | MAGI2 | GO:0051898 | negative regulation of protein kinase B signaling | 10760291 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-HT-7477-01B | MAGI2 | chr7 | 79082336 | - | VWC2 | chr7 | 49842307 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000419488 | ENST00000340652 | MAGI2 | chr7 | 79082336 | - | VWC2 | chr7 | 49842307 | + |
| In-frame | ENST00000354212 | ENST00000340652 | MAGI2 | chr7 | 79082336 | - | VWC2 | chr7 | 49842307 | + |
| In-frame | ENST00000522391 | ENST00000340652 | MAGI2 | chr7 | 79082336 | - | VWC2 | chr7 | 49842307 | + |
| intron-3CDS | ENST00000536571 | ENST00000340652 | MAGI2 | chr7 | 79082336 | - | VWC2 | chr7 | 49842307 | + |
| intron-3CDS | ENST00000535697 | ENST00000340652 | MAGI2 | chr7 | 79082336 | - | VWC2 | chr7 | 49842307 | + |
| intron-3CDS | ENST00000517762 | ENST00000340652 | MAGI2 | chr7 | 79082336 | - | VWC2 | chr7 | 49842307 | + |
Top |
FusionProtFeatures for MAGI2_VWC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAGI2 | VWC2 |
| BMP antagonist which may play a role in neuraldevelopment. Promotes cell adhesion (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000354212 | - | 1 | 22 | 17_101 | 100 | 1456 | Domain | PDZ 1 |
| Hgene | MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000419488 | - | 1 | 21 | 17_101 | 100 | 1442 | Domain | PDZ 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000354212 | - | 1 | 22 | 1015_1118 | 100 | 1456 | Compositional bias | Note=Pro-rich |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000354212 | - | 1 | 22 | 1340_1430 | 100 | 1456 | Compositional bias | Note=Ala-rich |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000419488 | - | 1 | 21 | 1015_1118 | 100 | 1442 | Compositional bias | Note=Pro-rich |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000419488 | - | 1 | 21 | 1340_1430 | 100 | 1442 | Compositional bias | Note=Ala-rich |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000354212 | - | 1 | 22 | 109_283 | 100 | 1456 | Domain | Guanylate kinase-like |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000354212 | - | 1 | 22 | 1147_1229 | 100 | 1456 | Domain | PDZ 6 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000354212 | - | 1 | 22 | 302_335 | 100 | 1456 | Domain | WW 1 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000354212 | - | 1 | 22 | 348_381 | 100 | 1456 | Domain | WW 2 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000354212 | - | 1 | 22 | 426_510 | 100 | 1456 | Domain | PDZ 2 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000354212 | - | 1 | 22 | 605_683 | 100 | 1456 | Domain | PDZ 3 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000354212 | - | 1 | 22 | 778_860 | 100 | 1456 | Domain | PDZ 4 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000354212 | - | 1 | 22 | 920_1010 | 100 | 1456 | Domain | PDZ 5 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000419488 | - | 1 | 21 | 109_283 | 100 | 1442 | Domain | Guanylate kinase-like |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000419488 | - | 1 | 21 | 1147_1229 | 100 | 1442 | Domain | PDZ 6 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000419488 | - | 1 | 21 | 302_335 | 100 | 1442 | Domain | WW 1 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000419488 | - | 1 | 21 | 348_381 | 100 | 1442 | Domain | WW 2 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000419488 | - | 1 | 21 | 426_510 | 100 | 1442 | Domain | PDZ 2 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000419488 | - | 1 | 21 | 605_683 | 100 | 1442 | Domain | PDZ 3 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000419488 | - | 1 | 21 | 778_860 | 100 | 1442 | Domain | PDZ 4 |
| Hgene | >MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000419488 | - | 1 | 21 | 920_1010 | 100 | 1442 | Domain | PDZ 5 |
| Tgene | VWC2 | chr7:79082336 | chr7:49842307 | ENST00000340652 | + | 1 | 4 | 120_127 | 232 | 326 | Compositional bias | Note=Poly-Ala |
| Tgene | VWC2 | chr7:79082336 | chr7:49842307 | ENST00000340652 | + | 1 | 4 | 153_212 | 232 | 326 | Domain | VWFC 1 |
| Tgene | VWC2 | chr7:79082336 | chr7:49842307 | ENST00000340652 | + | 1 | 4 | 216_274 | 232 | 326 | Domain | VWFC 2 |
| Tgene | VWC2 | chr7:79082336 | chr7:49842307 | ENST00000340652 | + | 1 | 4 | 114_116 | 232 | 326 | Motif | Mediates cell adhesion |
Top |
FusionGeneSequence for MAGI2_VWC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MAGI2_ENST00000419488_chr7_79082336_-_VWC2_ENST00000340652_chr7_49842307_+_194aa MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCK DPLRLKCVKQGVSMREVSLXSQRXGAMHSVSVSPDGVCGPCVRAXSVLSHLQKWSKLLCRNRGDPCWQRSEDXRVHHMPLYLXGRHMENR >In-frame_MAGI2_ENST00000354212_chr7_79082336_-_VWC2_ENST00000340652_chr7_49842307_+_194aa MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCK DPLRLKCVKQGVSMREVSLXSQRXGAMHSVSVSPDGVCGPCVRAXSVLSHLQKWSKLLCRNRGDPCWQRSEDXRVHHMPLYLXGRHMENR >In-frame_MAGI2_ENST00000522391_chr7_79082336_-_VWC2_ENST00000340652_chr7_49842307_+_194aa MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCK DPLRLKCVKQGVSMREVSLXSQRXGAMHSVSVSPDGVCGPCVRAXSVLSHLQKWSKLLCRNRGDPCWQRSEDXRVHHMPLYLXGRHMENR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MAGI2_ENST00000419488_chr7_79082336_-_VWC2_ENST00000340652_chr7_49842307_+_583nt ATGTCCAAAAGCTTGAAAAAGAAAAGCCACTGGACTAGCAAAGTCCATGAGAGTGTCATTGGCAGGAACCCGGAGGGCCAGCTGGGCTTT GAACTGAAGGGGGGCGCCGAGAATGGACAGTTCCCCTACCTGGGGGAGGTGAAGCCCGGCAAGGTGGCCTATGAGAGCGGCAGCAAATTG GTGTCGGAGGAGCTGCTGCTGGAGGTGAACGAGACCCCCGTGGCGGGGCTCACCATCAGGGACGTGCTGGCCGTGATCAAACACTGCAAG GACCCCCTCCGGCTCAAGTGTGTCAAGCAAGGTGTCTCCATGCGAGAGGTGTCGCTGTGAAGCCAACGGTGAGGTGCTATGCACAGTGTC AGCGTGTCCCCAGACGGAGTGTGTGGACCCTGTGTACGAGCCTGATCAGTGCTGTCCCATCTGCAAAAATGGTCCAAACTGCTTTGCAGA AACCGCGGTGATCCCTGCTGGCAGAGAAGTGAAGACTGACGAGTGCACCATATGCCACTGTACTTATGAGGAAGGCACATGGAGAATCGA >In-frame_MAGI2_ENST00000354212_chr7_79082336_-_VWC2_ENST00000340652_chr7_49842307_+_583nt ATGTCCAAAAGCTTGAAAAAGAAAAGCCACTGGACTAGCAAAGTCCATGAGAGTGTCATTGGCAGGAACCCGGAGGGCCAGCTGGGCTTT GAACTGAAGGGGGGCGCCGAGAATGGACAGTTCCCCTACCTGGGGGAGGTGAAGCCCGGCAAGGTGGCCTATGAGAGCGGCAGCAAATTG GTGTCGGAGGAGCTGCTGCTGGAGGTGAACGAGACCCCCGTGGCGGGGCTCACCATCAGGGACGTGCTGGCCGTGATCAAACACTGCAAG GACCCCCTCCGGCTCAAGTGTGTCAAGCAAGGTGTCTCCATGCGAGAGGTGTCGCTGTGAAGCCAACGGTGAGGTGCTATGCACAGTGTC AGCGTGTCCCCAGACGGAGTGTGTGGACCCTGTGTACGAGCCTGATCAGTGCTGTCCCATCTGCAAAAATGGTCCAAACTGCTTTGCAGA AACCGCGGTGATCCCTGCTGGCAGAGAAGTGAAGACTGACGAGTGCACCATATGCCACTGTACTTATGAGGAAGGCACATGGAGAATCGA >In-frame_MAGI2_ENST00000522391_chr7_79082336_-_VWC2_ENST00000340652_chr7_49842307_+_583nt ATGTCCAAAAGCTTGAAAAAGAAAAGCCACTGGACTAGCAAAGTCCATGAGAGTGTCATTGGCAGGAACCCGGAGGGCCAGCTGGGCTTT GAACTGAAGGGGGGCGCCGAGAATGGACAGTTCCCCTACCTGGGGGAGGTGAAGCCCGGCAAGGTGGCCTATGAGAGCGGCAGCAAATTG GTGTCGGAGGAGCTGCTGCTGGAGGTGAACGAGACCCCCGTGGCGGGGCTCACCATCAGGGACGTGCTGGCCGTGATCAAACACTGCAAG GACCCCCTCCGGCTCAAGTGTGTCAAGCAAGGTGTCTCCATGCGAGAGGTGTCGCTGTGAAGCCAACGGTGAGGTGCTATGCACAGTGTC AGCGTGTCCCCAGACGGAGTGTGTGGACCCTGTGTACGAGCCTGATCAGTGCTGTCCCATCTGCAAAAATGGTCCAAACTGCTTTGCAGA AACCGCGGTGATCCCTGCTGGCAGAGAAGTGAAGACTGACGAGTGCACCATATGCCACTGTACTTATGAGGAAGGCACATGGAGAATCGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MAGI2_ENST00000419488_chr7_79082336_-_VWC2_ENST00000340652_chr7_49842307_+_10583nt GGGACAGCACAACCTCATCCAAGCTCTCCTACCTCTGCCCAGCCGTCCCTCTCATCCTCCCCATTCCTCGTCCACACTCCATCCAAAGAA GAGGGAAAGCACCGAATAGAGGGGGGCGAAGGCAAAGTCTGCTGTTCTTCCCCCTGGGCCCCCTTGCTCCTCCATCCTCATTCTCTCACC ACCAGCCCCCCTAACCCCAAGGAGCCCAGGAACTGAGGCGACTCGCCCCACTGCCATGTCCAAAAGCTTGAAAAAGAAAAGCCACTGGAC TAGCAAAGTCCATGAGAGTGTCATTGGCAGGAACCCGGAGGGCCAGCTGGGCTTTGAACTGAAGGGGGGCGCCGAGAATGGACAGTTCCC CTACCTGGGGGAGGTGAAGCCCGGCAAGGTGGCCTATGAGAGCGGCAGCAAATTGGTGTCGGAGGAGCTGCTGCTGGAGGTGAACGAGAC CCCCGTGGCGGGGCTCACCATCAGGGACGTGCTGGCCGTGATCAAACACTGCAAGGACCCCCTCCGGCTCAAGTGTGTCAAGCAAGGTGT CTCCATGCGAGAGGTGTCGCTGTGAAGCCAACGGTGAGGTGCTATGCACAGTGTCAGCGTGTCCCCAGACGGAGTGTGTGGACCCTGTGT ACGAGCCTGATCAGTGCTGTCCCATCTGCAAAAATGGTCCAAACTGCTTTGCAGAAACCGCGGTGATCCCTGCTGGCAGAGAAGTGAAGA CTGACGAGTGCACCATATGCCACTGTACTTATGAGGAAGGCACATGGAGAATCGAGCGGCAGGCCATGTGCACGAGACATGAATGCAGGC AAATGTAGACGCTTCCCAGAACACAAACTCTGACTTTTTCTAGAACATTTTACTGATGTGAACATTCTAGATGACTCTGGGAACTATCAG TCAAAGAAGACTTTTGATGAGGAATAATGGAAAATTGTTGGTACTTTTCCTTTTCTTGATAACAGTTACTACAACAGAAGGAAATGGATA TATTTCAAAACATCAACAAGAACTTTGGGCATAAAATCCTTCTCTAAATAAATGTGCTATTTTCACAGTAAGTACACAAAAGTACACTAT TATATATCAAATGTATTTCTATAATCCCTCCATTAGAGAGCTTATATAAGTGTTTTCTATAGATGCAGATTAAAAATGCTGTGTTGTCAA CCGTCCTCACCGTGTACCTGCATATCTTTTTCAGTTCTGATTCCATCACCCAGGAATGTTCCCCCTGCACATTTTCACAGGGCAGAGTCA CGCATGAATGGATCATAAGATATTAGGACCAATTTCCACTGAAACCCTGTTTAAATTCTATTTAATTACAGACATATCTCTAATGTTGAT GTCTACTTCACATAAATATATTTCCTTTTTATAATAATATATGGCTTTTATCTGCTTCATTCTCAGTCACTTGTGAAATGCAGGTGTAAA GATCACTAACTCACACTTTCTCAGTTCTTTCCCCTAAGCTCCTGTATTGTACACCATAGGTAAGCACATACATATATTTCATTCTTATTT ACATTATTTTCTCTTCTAAGGATAACTTTAATTCATTCCCTAAACTGAGGAATAAAGTAGGCTGGAAAATTTGCATTACTGTTCCATCAA GCTGAAGCAGACAACAAAATAGGGGAGGAGTCCTTCGATTCTCCTAGGATAGTTAAGGAAAATCAAACTCCTAAACAAGTTTATATACCT GAAATCTAAATGTGCTACAGATAACTCAGCTGTCAGTTCAGTGGAATCATATTTGTCATCAGACTTGAGTCATCTATCCTCCATAAACTA CACAGTAAAATCTTGACTGATAACCTTGAATTAGCCACCCTTCACAAGCAGAGTGAGGAAGCAGTTATTTTGTTAAAACAAAGCTGAAGA CCAAGTGCACTCCACAACTTTCCTATAGTTATAATTCCAAACCAACTTCTTTTCTCTTCATTTGAACAGAGAACATAAAAAGCCACTGCA AAGTCCTGCTAATCTAATTAATGCATAATAGAAAATAGTTCTACCTTTATCAATCATATCAGCATGCGGTGTGTTGATGAAAGAGGTAAT TGGAGTCTTAATAGGTGTAGGATAAAAAAAGCAAAACTATAATCACTATTAATGTCTTTAAAGGATTAAAATATATATAATCATTATTTG AAGCCTCTAAAGGTATTTTTCATATTTTTGTTTATTCTGAAATTTTGCATTAAGAACCTATTAAGTACAAAGCATTGACAACAAGGGAAT AAGGCTTGATTTCTTGCCTTCTTGGACTTTCGGTCTCTGGCATAAGAAGTATATGAAATCATAATGTATTGTATTAGGAGCCAAACTAGA GACCAGCAAATGGAGATTAGAAAGCCTTCCTAATGAGAAGATGGAGAACATGAAAAAATCATTATATAAAAAATAATTCAATCATTAAAG ACTGAATAACATTCAAGAAAAATGGATACATCTATCATAATTGAAAAATTAAACTATTGTGAACCTTAGTAAGTATAAAGATGCCACTGA CTGAGTCATCAAAACACTACATATAGTCATTTAATTTTTGTCTTGTTCATAAAGAACACCTTGAGCCAAAGGAACTACCAGTACATAGAT TTCATGAAAATACTCAGGGGAATTATTAGCTAATTGTTCTCAGGTGTAATCAGCTTTCCAAAATTTAACCTTTGTATTAAAGACTGGTAG ACATTGGCCATCCCTCCTTTATTCAAGGATGGATTGTTTGAGACACAGTTATTTAAAGTTGTCGTTTTGCTAATAAATGGCCCTAGCCCC CATGGGTAGGTGGGCCATTAGTAACCTCTTCTCTCTCCATCAGGCATGATGCAGTTAGAGACTCAGTCCATGCAGCTCAAAGTCTTCCTG TTTCCCTTAATAATAATTCCTACCAGAATGGATGATGAGCTCTGAAATAATTGCAATGGTGTTTTCAATGCTGTGAGAATTTCAGAAAAC CTAGTATTTTGTTGCATATAGAGAGAATGAACCCAGTATCATCTTGGGAAGTTAACTGACTCACTTGCTCTAAACTTAGTTTGACCTGCA GGGTCACCAGCACACACTCCTAAGAGCTAAAGCTCAATGGCTGTTATTACACCAAAGTAACTCCCCTCCCCATCTCTGATTTCAACCCCC TCATTCCTCTCTCCTCATAGAAATAATGCATAAACCAAACACATGGAAGAACTTGGATTTTTGACACTGTATATACTCATTAATAATAAT GGCATTATTTGCATTTTTGTCCAAGATCAACTTCTTCTTGCAGTTAGACTTTCACAAATACATAGCTATCTCAGATTGACATTCTATTTT CCTCCCCTCTGTTGTCAGAGAACTCTTTGCTGAGATTGTCAACAACAAACTGTTCTATTCAATAAATAACCTGAATAACTGCCCAATAAA AAAGGAAAGTATAAGTTACTCAATTTCAAAATAATATGGTTTGGAGATAGCACAGAAAAGGGGGCCTCAGAATTCAAGTATAGAAGTTCT GGAAAAGCCATAATCACTAAAATTCAAATAGGCCTGCTCTATAAGTACCTAATAATTGTTAAATGATTTGTTCAAGTTAATAAACTAAAT CGTGCTTACAAATGTATTAATGAATTTATTTCAAATTTTCAACCCATATTTAGATCTGAAAGTATAAAGCTACTTATGTAAGCAATAGAA TGGTTCTGGAAATTATCTGATGTCTTAGAGGTTTTCAAGTTAAATTCATTCTTTCAGTGATAGGATATTTACTTGTTGGGTGGATTAACA ATACTTTTTATTGACATTTCCCAGAAGTCTTGAGAAAAGTCATTTCAAAAACTTGTATTTCATCCCTGCATGCAAGAAGTATTAGATGCA CTCCAGTCCAGGCAAGTCCTGCTATAATGTTGCAGCTAGTGCAGATGGAGAGGCACAGTGTCCTTGACATCAAGGGGTCTGTAAGCCTTG AAACTAATTTAGGTTTGATTATAATACTTTTAATCTTTTGATACTTAGAATTTCATCACCTGCTTTGTGCAGTAAAACATGCTAAGAAGA ATTATCATGCAGTTTTAAGTTCATAACATCAATAATATGTTTAATAAACTTTCTTCCCTCGTTCTCCAACATAAATGTTGCATTTATATA AGGTTAAAAGTCCTAAAAAATCATAAAATTCAGATGTTTAATTTTTGTTTTTAAGCAGTGAAATGGGTTTTTAAATGTATACATTATCTG AAACTTACAAAATATACACTGTTTCAAACAAGCATTGTTGGAAACTAAATCCATTATTTTAAATGTGGACTATTTAAACATGTAGAAAAC AAAATTATAGACATAAACTATGATTTTAAAAATATTAACAATTTGCTAAATTTGCTTCAATGGGCAAGAGATCAATCCTACTTTTCATTG TTATTTTTAATATCATATTTTTCCCCAACATAATGTTATTATGAAGAGTATCAGATGTACAAATAAGCATCATTGGTAAAAACATACATG CTTCTTTGGCCAACATAATTTGTAACTGTCTTACTGAACCTACTTACCTACTATATTTTTTTTCCTCACTAGTAGCATCTGATGGTTGAT ACAGTCAGTAACTATTCTGAAGAATCAGATTAAGAGAGAACAATTTACTTATTCAGGAATAAGTGCATTTTTACAGTACATATTTTTCAC ATTTCAGCTGCAACTTCCAAAGATCAGGTTCTCATTGCTCCGTAGCACAGATTAAACAGCCTACTTATGTCATATCCTCACTTCACACCA ACTTCTTCAGTCTATTATTTTAGTTTTCTAAATGTAGATCTAGTTTTCAACTGAATTCTTTGAGGATCGCAATCACACACAAAATAACAT CCAAACTCCTCAACATGGAAGACTGGTGTCTTCACAATTAGATCATGGACAACACCATGACCCAGGCCCCTGTGGCTGGTGAGACTTCTG GGCCCTGGGTACCACAGACTATACTCTAAACATGGTCTTTACTATCTCAGATCCTGCCCTGAGTGTCCTTTGCAGCATGTTGAGTATTAG CCATTTTCAATGTCCAGTTCAAGTGCCATTGCTGGTAAGGCTTCTGTAGTTCTTATTGGAAGAATTGTCACTCTATGTCCCAGTAATAGT ACTAATTTGGTTTCTTATTTTAACATATCATTTAGGAATCATACCATAGTTTGCATAATGGTTAATTTTATGCCTGCTTCTTCTATTATT TACAAATCCCTTTAGTTTGGGCTGTGAAATATTCAATTCCCAAAACATCACCCAATATCTATATGTTAAAGGCTTGTTGAATTGTATTCC ATCTATTAGTTCAGAGTTATTTGCTATTCTTGTTTAAGGACAATGTATGTATTAAAGAGCAACTAAAAACTCCCATTACTGTTTGCCAAC CCAGTTGTCTTTTGATTTCTCTGTCAACTTACAAGTATCAAATATCTAAGTCACAGAACCCAGAGACACATCAAATACCCCAAATACCCC ATGGTAGTTTTCGGATGAACTCTGACAGCTATTGGCCATTTCTGGTGCAAGTCAGAAAAAAATTGCTTTTAGTGTGAAATTTTTGATGCT GAAGAAAGTTGATTGTATTGAAGAGACACTGGCCCTTTATGATAAAGGAAGTCAAGTTTACAGTTTTGATATTTGTTTACTTTCTTATTT CTAATTTTTGGAAAACAATTTTCTTAGACTTTCATTTGTGATATTGATCATTTCTGTGTGTTTTAATCTTTCTACATAACATAATTAAAC ACCTCAGTAGGTATCTAGTGAACTGATACAATAATGAGCTGAGTCATTTGTACAGAAATATAGTAGCTTCCATAATCTGAATGATAACCA TTTAAAAGTGATGGTTGTTGAAATTTTACTGTAGTGTCAAATTTCACTTTAAATTTTGCAAAGCACCTGCTATTCTAGCCTTAACACAAA GATTTGGCTAATTTTTAAATGAACAAATCCCATTGAATATTAAGTGACACTGACAATCACCCTGAAAAGTATTCAGCCAAAGTTTCAATA GAATTAGGAAACTTAAATGAAAATGTGCTCTCAGTGCTTGGCCCATGAGCAGTTTATGATTTAAGACGTGCATACTGTTTAACTCTTTCC TTTAAAGTTCAGAAAAGTACATAAAACCTCTGGCTGACCTATTATATAGGCACAGAATTATCAAAAGCAATCAAAGTATGTACCTAAAGT CAATTTAGTATATTATGAATACAGCCTGATGACTAAACACAATTGCAAATATTGCGACTTTAGTTTTTAATTCAATTTTCAGCAAGTAGA AATATTTCTCAATTTTATTTGGTATCTAATTATATTAAGACCAACATATACATTAAAGTGTATTTAGATGATTAATATTTAATGATCATT ATTTTATTTAATGATTAATATTTTCTATTATTTGAATTTCTGTAATTTATGTTTTAGAAAGAACTGTTTCCAAACACATTTTATGGAAAG ATTTCATTTTTCCATTCCCTTTACTTTTATATTTACATTGTCAAATAAATACAATTCTATTTTCATTTCTATTAGTTTTCAGGGTTTATT CTTTTCCTAAGCATATAATTCTTATAATGGAAAAAAGTGAAAAGTATCCAGTAAGTAATATACACCTATGAAACTATTAATGTTCTTTAT ACTACCAAGTAGTTTCATAGTTTTAAAAAGCCATTCTTAAGCAGTCGGTGAATGTATATCATCGGCCAAAAGTTATGCTAGGTTTCCTTC ACTTATTATCACATTTAACCTCACAGTTCTCCCAAATTGTGGGTAATGCTATCCCCTTTGTTGCAGAAAAGTAAATATAGGCTCAGGGAA ATTTAAAAACTGCCTTAAGATTCAGTCTAGTGAATGAGAGGCTGAGTTAAGAATCCAAATCTGCTTTATATCAGAGCCCGTGATTTGAAG TCTTATCATTTGTGTTTAGGTCAGGGACCTCTAGAAAATAGACAGAAATTTCCAAAATGGTCTTTTACCCCACTCCCCATAAATAAGATA ATGAATAGCAACACTGATCCCTAATTCTAGAATATCAATCTTGATACTTGTCAAAGTAAATAGTAGCTCGTCACAAAAATGTTGTAGCCT CCCTAGTCTAAATGCTTATGCTATATTTTGTTTCCTAAATCTAGAGATCTCTTTTTAAAAATAGTATTGAAGCATCAGGTTGTTCAGGTA TGATTCTCATATTGAAATTTACAAAATATAACCAAATATTGTGACCCAGTTTTTCTGGAGCCAAGAGAAGTAAACTGCCATTTATTAGGT GATGATTATAGGGCAAACACTACAATTTCAAATTTCATATTCTTTTATCTGATTTATTCATTTTATCAACTCTGCTATATTGATGAAGAA GTCAACATATGGTGGGTAACTTATCCAAATTTCAGTGATGGGCTGGGCGTGGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCTGA GGCAGGTGGATCAGGAGTTTGAGGCCAACCTGACCAACATGTGAAACCCCATCTCTACTAAAAATACAAAAAAATTACCTGGGCATGGTG GCACATGCCTGTAATCTACTCGGGAGGCTGAGGCAGGAGAATCCCTTAAACCGAGGGGGTGGAGGTTGCTTGAGCCGAGATCGCGTCACT GCACTCCAGCCTGGGTAACAGAGCAAGACTCTGTTTAAAAAAAAAAAAAAAATCAGTGATGGAACTGAGGCCAAATCTGTCTGGTTCCAA AGCTATCCTACATGGGGCACAGTCAGGACTGGAATGGATAGCTCTACCTGCTTCCAAATATTCTTCCCTGGGGAGCAGCTGTGAGTCTTA CTGAATCGATTTATTCATTGCATTCTATGTGTCAACTGCAATTTAGACCTGGGTGATAGAGTCATATATGGTCTTTGGACCCATGAAGCT CTGAGTCAAGGATACCAGCAGATATCCTTAAACTAATAAAAAAAGCGATGGCATCACATGCCATTTTGAACTTTTGCATTAAAGTCATAA ACTTACATCAGTATTATGATTTATACTTTTAAGCAAAATTTTGCCATTTTCTGATACATAGTAGCTAGCTAGTGATAAAATTATGAAGTT ACCATTGTATGTTCCAATGACATAAAAAACTAAGTGCCTGCTTGGGCTAGTTATACTCTGCAGTATACCCTGGTTTATTGTGAGGATTAA ATAAAAAATCCTCACAAACCCCAATTTAATTTAATATAGATTAATTATAAAAATAATCTACCCATGTTACATAATGTTAAATCTGTAGTT TCAAGGTGTATGCTATTTCTTAAAACAAAAACAAAGATTGTCCCCACTCCAAACAATAACAGCAATGGTGAAGGTTGTGGGTGGACAGAG GTAGTCCCACTCATCCCCAGGGGGCTCAGCTGCCACCGGCCAGGTCTATCTATTGCTCCCACCTGCTCTGACTGTTTTCTCTCAAGAAAA AGATTTTCATTTTAAGATAGGCATCAGTGCAATAAAGGAGCTTGATACAAAAATCATTATGTTCTATATATGTTTTTGTAGGTTTTAGAT TAATTATGGCCAACTGATACCTTAAAATATTTGTTACAAATAACACTGAAGTGAGATTCAAAATTGTGCCTTCTATTGAAGCCAAGAAAG TAAATGTCTTTAAAATAAACATAATGGTGTTTTTTTTTGGTACAATAAACAGCATACCTACATTTCAGAGGACAAATCATGTTATTATAA TAACCAGGAGAGAAAATAAAAGGAGACATTAATTTGGATATGGAAGCAAAATGGAACAGAGCAATATAGAGCAAAACAGAGGTTTGTCTG AAACATTTAAAATATTAAGAAGTATGACTAAAAAACTCAAACATTTTAATACACGATGAATCCTTTTCTTAAGGAAAAAATGAAAATAAT AAAAGTGGTATTTGGATGAGATAATTTTCCTTTAAATTTATTCCTCAGAATGATGTAAATTTTCCAGCTGGAAGGTCATCTTTCTATACA TGCATGCATCTATACAAATGGTTAAACAGTTACTCTCTCAATTTGCTGTGATAGGAAAGGTGGATATAAATATAAGCAAGGGTCTGATTA AAACAAAACAAAACAAACAAAAGACAAGAGAAGCACTGCATTGTTGGCAAGAAATTCCTTTTAAGTCAGACTTAAGTCCACGGAAAGCTG GACCTAAGCAGTGAAGGATGTAAGGGAACAGAGAGAGACTCTGCTTGGCCGAGTTTGCTATTCTCATTTGTCTATGTCAATACGGCTACA TAAAGTTCACAACTATTTGCACATAGCTATAAATATAGCATGAATAAAACACATATGTATTTAATTGTGTTATTTACTATTTATAATTTG AATTGTTTAAAATAATTTTAAATACTTATTCCATAAACTCAGTATTTGAAAACTTAAAAAAAAAGTCATTTTAAATAACATCATTTACCA AGTCTGTGTGATGCTTTACAAGGTACCTGATGAATGTAAAATTATAGCTTTTTGTCTTCATTTCTAATAGACTGTTATAGGGGAAATGTA CTAAAATGTTGTACTTATTACATTTATGAATTTCTGACAGTTTCTATAGACTGAGAATAATGATATGCTTTTATAAATTATTTGGTGAAA GTTTTCCAGTAAGTGTTCATGTCCTGTACAAATTTATTAAACAACATCAATTTTACCTAACAACTGTAACCACTAATAAATCATCAGTCA CCACCTTTCCTGCATATCTGACAGATGGAGAACACTGTGCTTAGTGTTGAAGATACCAAAGGGAATTCAAGTGAGGGGAAAAGAGGAGAG CAAACTGATCAAAAGGGAATGCCCATGATGCTTTCAGGAAACCAGGGTGAGAACATGCTGGCTGGAGGATGGGTCTGGTTTCCAGCAGAG ATGATAGGAGTTAAAAGGCATAGGTGAGTTGTTCCCATCCCTGGCCTGAGCCTTACTCCATAGCTATAGAGACATAGTCTCTAGAAACAA AGGCCAGAGCATCCTTTTAACATTTATATCATAAGTATTCTCAATAAACGTTTGCAATTTATTTGCTTTAATGTAACTTGGCAGTAAAGA CTTTGGCCTTTGGAGGTCTGATTCTAATCCCAGTTCTACCACTTACTGGTTATTTATCAGGTACACGTTACCTACCTCTCTGTAACTCAG ATTGCTCATCAGTAACATGGGGAGAGTGGTATCAACCACTAAGAGGATTAAATGAGTGAATATTTGTAAAACACGTAGCCTAGAATAGAT ATTTATAAAGCACAAGATCTATGTAAAGTGTTTATAACATAATACATTGGAATATGAGACTTGAACATTTTGAAGATTCTAATAAATGAA TAATTTAATTTAGTGCTCATTTGAAAAATATTTTATCCTCATGTTTACATTTAACACATATAATTTATATCTTAGTTTTTATCCCATTTA TATATATATTTACCAGAAAAATGTTTTGTAATACCTTAATTTTATGTGGAGTTGAATTTAAATAATTAGGCCGAATTTGTATGTATTGTT >In-frame_MAGI2_ENST00000354212_chr7_79082336_-_VWC2_ENST00000340652_chr7_49842307_+_10602nt AGCCTTGAGTGTCATTCAAGGGACAGCACAACCTCATCCAAGCTCTCCTACCTCTGCCCAGCCGTCCCTCTCATCCTCCCCATTCCTCGT CCACACTCCATCCAAAGAAGAGGGAAAGCACCGAATAGAGGGGGGCGAAGGCAAAGTCTGCTGTTCTTCCCCCTGGGCCCCCTTGCTCCT CCATCCTCATTCTCTCACCACCAGCCCCCCTAACCCCAAGGAGCCCAGGAACTGAGGCGACTCGCCCCACTGCCATGTCCAAAAGCTTGA AAAAGAAAAGCCACTGGACTAGCAAAGTCCATGAGAGTGTCATTGGCAGGAACCCGGAGGGCCAGCTGGGCTTTGAACTGAAGGGGGGCG CCGAGAATGGACAGTTCCCCTACCTGGGGGAGGTGAAGCCCGGCAAGGTGGCCTATGAGAGCGGCAGCAAATTGGTGTCGGAGGAGCTGC TGCTGGAGGTGAACGAGACCCCCGTGGCGGGGCTCACCATCAGGGACGTGCTGGCCGTGATCAAACACTGCAAGGACCCCCTCCGGCTCA AGTGTGTCAAGCAAGGTGTCTCCATGCGAGAGGTGTCGCTGTGAAGCCAACGGTGAGGTGCTATGCACAGTGTCAGCGTGTCCCCAGACG GAGTGTGTGGACCCTGTGTACGAGCCTGATCAGTGCTGTCCCATCTGCAAAAATGGTCCAAACTGCTTTGCAGAAACCGCGGTGATCCCT GCTGGCAGAGAAGTGAAGACTGACGAGTGCACCATATGCCACTGTACTTATGAGGAAGGCACATGGAGAATCGAGCGGCAGGCCATGTGC ACGAGACATGAATGCAGGCAAATGTAGACGCTTCCCAGAACACAAACTCTGACTTTTTCTAGAACATTTTACTGATGTGAACATTCTAGA TGACTCTGGGAACTATCAGTCAAAGAAGACTTTTGATGAGGAATAATGGAAAATTGTTGGTACTTTTCCTTTTCTTGATAACAGTTACTA CAACAGAAGGAAATGGATATATTTCAAAACATCAACAAGAACTTTGGGCATAAAATCCTTCTCTAAATAAATGTGCTATTTTCACAGTAA GTACACAAAAGTACACTATTATATATCAAATGTATTTCTATAATCCCTCCATTAGAGAGCTTATATAAGTGTTTTCTATAGATGCAGATT AAAAATGCTGTGTTGTCAACCGTCCTCACCGTGTACCTGCATATCTTTTTCAGTTCTGATTCCATCACCCAGGAATGTTCCCCCTGCACA TTTTCACAGGGCAGAGTCACGCATGAATGGATCATAAGATATTAGGACCAATTTCCACTGAAACCCTGTTTAAATTCTATTTAATTACAG ACATATCTCTAATGTTGATGTCTACTTCACATAAATATATTTCCTTTTTATAATAATATATGGCTTTTATCTGCTTCATTCTCAGTCACT TGTGAAATGCAGGTGTAAAGATCACTAACTCACACTTTCTCAGTTCTTTCCCCTAAGCTCCTGTATTGTACACCATAGGTAAGCACATAC ATATATTTCATTCTTATTTACATTATTTTCTCTTCTAAGGATAACTTTAATTCATTCCCTAAACTGAGGAATAAAGTAGGCTGGAAAATT TGCATTACTGTTCCATCAAGCTGAAGCAGACAACAAAATAGGGGAGGAGTCCTTCGATTCTCCTAGGATAGTTAAGGAAAATCAAACTCC TAAACAAGTTTATATACCTGAAATCTAAATGTGCTACAGATAACTCAGCTGTCAGTTCAGTGGAATCATATTTGTCATCAGACTTGAGTC ATCTATCCTCCATAAACTACACAGTAAAATCTTGACTGATAACCTTGAATTAGCCACCCTTCACAAGCAGAGTGAGGAAGCAGTTATTTT GTTAAAACAAAGCTGAAGACCAAGTGCACTCCACAACTTTCCTATAGTTATAATTCCAAACCAACTTCTTTTCTCTTCATTTGAACAGAG AACATAAAAAGCCACTGCAAAGTCCTGCTAATCTAATTAATGCATAATAGAAAATAGTTCTACCTTTATCAATCATATCAGCATGCGGTG TGTTGATGAAAGAGGTAATTGGAGTCTTAATAGGTGTAGGATAAAAAAAGCAAAACTATAATCACTATTAATGTCTTTAAAGGATTAAAA TATATATAATCATTATTTGAAGCCTCTAAAGGTATTTTTCATATTTTTGTTTATTCTGAAATTTTGCATTAAGAACCTATTAAGTACAAA GCATTGACAACAAGGGAATAAGGCTTGATTTCTTGCCTTCTTGGACTTTCGGTCTCTGGCATAAGAAGTATATGAAATCATAATGTATTG TATTAGGAGCCAAACTAGAGACCAGCAAATGGAGATTAGAAAGCCTTCCTAATGAGAAGATGGAGAACATGAAAAAATCATTATATAAAA AATAATTCAATCATTAAAGACTGAATAACATTCAAGAAAAATGGATACATCTATCATAATTGAAAAATTAAACTATTGTGAACCTTAGTA AGTATAAAGATGCCACTGACTGAGTCATCAAAACACTACATATAGTCATTTAATTTTTGTCTTGTTCATAAAGAACACCTTGAGCCAAAG GAACTACCAGTACATAGATTTCATGAAAATACTCAGGGGAATTATTAGCTAATTGTTCTCAGGTGTAATCAGCTTTCCAAAATTTAACCT TTGTATTAAAGACTGGTAGACATTGGCCATCCCTCCTTTATTCAAGGATGGATTGTTTGAGACACAGTTATTTAAAGTTGTCGTTTTGCT AATAAATGGCCCTAGCCCCCATGGGTAGGTGGGCCATTAGTAACCTCTTCTCTCTCCATCAGGCATGATGCAGTTAGAGACTCAGTCCAT GCAGCTCAAAGTCTTCCTGTTTCCCTTAATAATAATTCCTACCAGAATGGATGATGAGCTCTGAAATAATTGCAATGGTGTTTTCAATGC TGTGAGAATTTCAGAAAACCTAGTATTTTGTTGCATATAGAGAGAATGAACCCAGTATCATCTTGGGAAGTTAACTGACTCACTTGCTCT AAACTTAGTTTGACCTGCAGGGTCACCAGCACACACTCCTAAGAGCTAAAGCTCAATGGCTGTTATTACACCAAAGTAACTCCCCTCCCC ATCTCTGATTTCAACCCCCTCATTCCTCTCTCCTCATAGAAATAATGCATAAACCAAACACATGGAAGAACTTGGATTTTTGACACTGTA TATACTCATTAATAATAATGGCATTATTTGCATTTTTGTCCAAGATCAACTTCTTCTTGCAGTTAGACTTTCACAAATACATAGCTATCT CAGATTGACATTCTATTTTCCTCCCCTCTGTTGTCAGAGAACTCTTTGCTGAGATTGTCAACAACAAACTGTTCTATTCAATAAATAACC TGAATAACTGCCCAATAAAAAAGGAAAGTATAAGTTACTCAATTTCAAAATAATATGGTTTGGAGATAGCACAGAAAAGGGGGCCTCAGA ATTCAAGTATAGAAGTTCTGGAAAAGCCATAATCACTAAAATTCAAATAGGCCTGCTCTATAAGTACCTAATAATTGTTAAATGATTTGT TCAAGTTAATAAACTAAATCGTGCTTACAAATGTATTAATGAATTTATTTCAAATTTTCAACCCATATTTAGATCTGAAAGTATAAAGCT ACTTATGTAAGCAATAGAATGGTTCTGGAAATTATCTGATGTCTTAGAGGTTTTCAAGTTAAATTCATTCTTTCAGTGATAGGATATTTA CTTGTTGGGTGGATTAACAATACTTTTTATTGACATTTCCCAGAAGTCTTGAGAAAAGTCATTTCAAAAACTTGTATTTCATCCCTGCAT GCAAGAAGTATTAGATGCACTCCAGTCCAGGCAAGTCCTGCTATAATGTTGCAGCTAGTGCAGATGGAGAGGCACAGTGTCCTTGACATC AAGGGGTCTGTAAGCCTTGAAACTAATTTAGGTTTGATTATAATACTTTTAATCTTTTGATACTTAGAATTTCATCACCTGCTTTGTGCA GTAAAACATGCTAAGAAGAATTATCATGCAGTTTTAAGTTCATAACATCAATAATATGTTTAATAAACTTTCTTCCCTCGTTCTCCAACA TAAATGTTGCATTTATATAAGGTTAAAAGTCCTAAAAAATCATAAAATTCAGATGTTTAATTTTTGTTTTTAAGCAGTGAAATGGGTTTT TAAATGTATACATTATCTGAAACTTACAAAATATACACTGTTTCAAACAAGCATTGTTGGAAACTAAATCCATTATTTTAAATGTGGACT ATTTAAACATGTAGAAAACAAAATTATAGACATAAACTATGATTTTAAAAATATTAACAATTTGCTAAATTTGCTTCAATGGGCAAGAGA TCAATCCTACTTTTCATTGTTATTTTTAATATCATATTTTTCCCCAACATAATGTTATTATGAAGAGTATCAGATGTACAAATAAGCATC ATTGGTAAAAACATACATGCTTCTTTGGCCAACATAATTTGTAACTGTCTTACTGAACCTACTTACCTACTATATTTTTTTTCCTCACTA GTAGCATCTGATGGTTGATACAGTCAGTAACTATTCTGAAGAATCAGATTAAGAGAGAACAATTTACTTATTCAGGAATAAGTGCATTTT TACAGTACATATTTTTCACATTTCAGCTGCAACTTCCAAAGATCAGGTTCTCATTGCTCCGTAGCACAGATTAAACAGCCTACTTATGTC ATATCCTCACTTCACACCAACTTCTTCAGTCTATTATTTTAGTTTTCTAAATGTAGATCTAGTTTTCAACTGAATTCTTTGAGGATCGCA ATCACACACAAAATAACATCCAAACTCCTCAACATGGAAGACTGGTGTCTTCACAATTAGATCATGGACAACACCATGACCCAGGCCCCT GTGGCTGGTGAGACTTCTGGGCCCTGGGTACCACAGACTATACTCTAAACATGGTCTTTACTATCTCAGATCCTGCCCTGAGTGTCCTTT GCAGCATGTTGAGTATTAGCCATTTTCAATGTCCAGTTCAAGTGCCATTGCTGGTAAGGCTTCTGTAGTTCTTATTGGAAGAATTGTCAC TCTATGTCCCAGTAATAGTACTAATTTGGTTTCTTATTTTAACATATCATTTAGGAATCATACCATAGTTTGCATAATGGTTAATTTTAT GCCTGCTTCTTCTATTATTTACAAATCCCTTTAGTTTGGGCTGTGAAATATTCAATTCCCAAAACATCACCCAATATCTATATGTTAAAG GCTTGTTGAATTGTATTCCATCTATTAGTTCAGAGTTATTTGCTATTCTTGTTTAAGGACAATGTATGTATTAAAGAGCAACTAAAAACT CCCATTACTGTTTGCCAACCCAGTTGTCTTTTGATTTCTCTGTCAACTTACAAGTATCAAATATCTAAGTCACAGAACCCAGAGACACAT CAAATACCCCAAATACCCCATGGTAGTTTTCGGATGAACTCTGACAGCTATTGGCCATTTCTGGTGCAAGTCAGAAAAAAATTGCTTTTA GTGTGAAATTTTTGATGCTGAAGAAAGTTGATTGTATTGAAGAGACACTGGCCCTTTATGATAAAGGAAGTCAAGTTTACAGTTTTGATA TTTGTTTACTTTCTTATTTCTAATTTTTGGAAAACAATTTTCTTAGACTTTCATTTGTGATATTGATCATTTCTGTGTGTTTTAATCTTT CTACATAACATAATTAAACACCTCAGTAGGTATCTAGTGAACTGATACAATAATGAGCTGAGTCATTTGTACAGAAATATAGTAGCTTCC ATAATCTGAATGATAACCATTTAAAAGTGATGGTTGTTGAAATTTTACTGTAGTGTCAAATTTCACTTTAAATTTTGCAAAGCACCTGCT ATTCTAGCCTTAACACAAAGATTTGGCTAATTTTTAAATGAACAAATCCCATTGAATATTAAGTGACACTGACAATCACCCTGAAAAGTA TTCAGCCAAAGTTTCAATAGAATTAGGAAACTTAAATGAAAATGTGCTCTCAGTGCTTGGCCCATGAGCAGTTTATGATTTAAGACGTGC ATACTGTTTAACTCTTTCCTTTAAAGTTCAGAAAAGTACATAAAACCTCTGGCTGACCTATTATATAGGCACAGAATTATCAAAAGCAAT CAAAGTATGTACCTAAAGTCAATTTAGTATATTATGAATACAGCCTGATGACTAAACACAATTGCAAATATTGCGACTTTAGTTTTTAAT TCAATTTTCAGCAAGTAGAAATATTTCTCAATTTTATTTGGTATCTAATTATATTAAGACCAACATATACATTAAAGTGTATTTAGATGA TTAATATTTAATGATCATTATTTTATTTAATGATTAATATTTTCTATTATTTGAATTTCTGTAATTTATGTTTTAGAAAGAACTGTTTCC AAACACATTTTATGGAAAGATTTCATTTTTCCATTCCCTTTACTTTTATATTTACATTGTCAAATAAATACAATTCTATTTTCATTTCTA TTAGTTTTCAGGGTTTATTCTTTTCCTAAGCATATAATTCTTATAATGGAAAAAAGTGAAAAGTATCCAGTAAGTAATATACACCTATGA AACTATTAATGTTCTTTATACTACCAAGTAGTTTCATAGTTTTAAAAAGCCATTCTTAAGCAGTCGGTGAATGTATATCATCGGCCAAAA GTTATGCTAGGTTTCCTTCACTTATTATCACATTTAACCTCACAGTTCTCCCAAATTGTGGGTAATGCTATCCCCTTTGTTGCAGAAAAG TAAATATAGGCTCAGGGAAATTTAAAAACTGCCTTAAGATTCAGTCTAGTGAATGAGAGGCTGAGTTAAGAATCCAAATCTGCTTTATAT CAGAGCCCGTGATTTGAAGTCTTATCATTTGTGTTTAGGTCAGGGACCTCTAGAAAATAGACAGAAATTTCCAAAATGGTCTTTTACCCC ACTCCCCATAAATAAGATAATGAATAGCAACACTGATCCCTAATTCTAGAATATCAATCTTGATACTTGTCAAAGTAAATAGTAGCTCGT CACAAAAATGTTGTAGCCTCCCTAGTCTAAATGCTTATGCTATATTTTGTTTCCTAAATCTAGAGATCTCTTTTTAAAAATAGTATTGAA GCATCAGGTTGTTCAGGTATGATTCTCATATTGAAATTTACAAAATATAACCAAATATTGTGACCCAGTTTTTCTGGAGCCAAGAGAAGT AAACTGCCATTTATTAGGTGATGATTATAGGGCAAACACTACAATTTCAAATTTCATATTCTTTTATCTGATTTATTCATTTTATCAACT CTGCTATATTGATGAAGAAGTCAACATATGGTGGGTAACTTATCCAAATTTCAGTGATGGGCTGGGCGTGGTGGCTCACGCCTATAATCC CAGCACTTTGGGAGGCTGAGGCAGGTGGATCAGGAGTTTGAGGCCAACCTGACCAACATGTGAAACCCCATCTCTACTAAAAATACAAAA AAATTACCTGGGCATGGTGGCACATGCCTGTAATCTACTCGGGAGGCTGAGGCAGGAGAATCCCTTAAACCGAGGGGGTGGAGGTTGCTT GAGCCGAGATCGCGTCACTGCACTCCAGCCTGGGTAACAGAGCAAGACTCTGTTTAAAAAAAAAAAAAAAATCAGTGATGGAACTGAGGC CAAATCTGTCTGGTTCCAAAGCTATCCTACATGGGGCACAGTCAGGACTGGAATGGATAGCTCTACCTGCTTCCAAATATTCTTCCCTGG GGAGCAGCTGTGAGTCTTACTGAATCGATTTATTCATTGCATTCTATGTGTCAACTGCAATTTAGACCTGGGTGATAGAGTCATATATGG TCTTTGGACCCATGAAGCTCTGAGTCAAGGATACCAGCAGATATCCTTAAACTAATAAAAAAAGCGATGGCATCACATGCCATTTTGAAC TTTTGCATTAAAGTCATAAACTTACATCAGTATTATGATTTATACTTTTAAGCAAAATTTTGCCATTTTCTGATACATAGTAGCTAGCTA GTGATAAAATTATGAAGTTACCATTGTATGTTCCAATGACATAAAAAACTAAGTGCCTGCTTGGGCTAGTTATACTCTGCAGTATACCCT GGTTTATTGTGAGGATTAAATAAAAAATCCTCACAAACCCCAATTTAATTTAATATAGATTAATTATAAAAATAATCTACCCATGTTACA TAATGTTAAATCTGTAGTTTCAAGGTGTATGCTATTTCTTAAAACAAAAACAAAGATTGTCCCCACTCCAAACAATAACAGCAATGGTGA AGGTTGTGGGTGGACAGAGGTAGTCCCACTCATCCCCAGGGGGCTCAGCTGCCACCGGCCAGGTCTATCTATTGCTCCCACCTGCTCTGA CTGTTTTCTCTCAAGAAAAAGATTTTCATTTTAAGATAGGCATCAGTGCAATAAAGGAGCTTGATACAAAAATCATTATGTTCTATATAT GTTTTTGTAGGTTTTAGATTAATTATGGCCAACTGATACCTTAAAATATTTGTTACAAATAACACTGAAGTGAGATTCAAAATTGTGCCT TCTATTGAAGCCAAGAAAGTAAATGTCTTTAAAATAAACATAATGGTGTTTTTTTTTGGTACAATAAACAGCATACCTACATTTCAGAGG ACAAATCATGTTATTATAATAACCAGGAGAGAAAATAAAAGGAGACATTAATTTGGATATGGAAGCAAAATGGAACAGAGCAATATAGAG CAAAACAGAGGTTTGTCTGAAACATTTAAAATATTAAGAAGTATGACTAAAAAACTCAAACATTTTAATACACGATGAATCCTTTTCTTA AGGAAAAAATGAAAATAATAAAAGTGGTATTTGGATGAGATAATTTTCCTTTAAATTTATTCCTCAGAATGATGTAAATTTTCCAGCTGG AAGGTCATCTTTCTATACATGCATGCATCTATACAAATGGTTAAACAGTTACTCTCTCAATTTGCTGTGATAGGAAAGGTGGATATAAAT ATAAGCAAGGGTCTGATTAAAACAAAACAAAACAAACAAAAGACAAGAGAAGCACTGCATTGTTGGCAAGAAATTCCTTTTAAGTCAGAC TTAAGTCCACGGAAAGCTGGACCTAAGCAGTGAAGGATGTAAGGGAACAGAGAGAGACTCTGCTTGGCCGAGTTTGCTATTCTCATTTGT CTATGTCAATACGGCTACATAAAGTTCACAACTATTTGCACATAGCTATAAATATAGCATGAATAAAACACATATGTATTTAATTGTGTT ATTTACTATTTATAATTTGAATTGTTTAAAATAATTTTAAATACTTATTCCATAAACTCAGTATTTGAAAACTTAAAAAAAAAGTCATTT TAAATAACATCATTTACCAAGTCTGTGTGATGCTTTACAAGGTACCTGATGAATGTAAAATTATAGCTTTTTGTCTTCATTTCTAATAGA CTGTTATAGGGGAAATGTACTAAAATGTTGTACTTATTACATTTATGAATTTCTGACAGTTTCTATAGACTGAGAATAATGATATGCTTT TATAAATTATTTGGTGAAAGTTTTCCAGTAAGTGTTCATGTCCTGTACAAATTTATTAAACAACATCAATTTTACCTAACAACTGTAACC ACTAATAAATCATCAGTCACCACCTTTCCTGCATATCTGACAGATGGAGAACACTGTGCTTAGTGTTGAAGATACCAAAGGGAATTCAAG TGAGGGGAAAAGAGGAGAGCAAACTGATCAAAAGGGAATGCCCATGATGCTTTCAGGAAACCAGGGTGAGAACATGCTGGCTGGAGGATG GGTCTGGTTTCCAGCAGAGATGATAGGAGTTAAAAGGCATAGGTGAGTTGTTCCCATCCCTGGCCTGAGCCTTACTCCATAGCTATAGAG ACATAGTCTCTAGAAACAAAGGCCAGAGCATCCTTTTAACATTTATATCATAAGTATTCTCAATAAACGTTTGCAATTTATTTGCTTTAA TGTAACTTGGCAGTAAAGACTTTGGCCTTTGGAGGTCTGATTCTAATCCCAGTTCTACCACTTACTGGTTATTTATCAGGTACACGTTAC CTACCTCTCTGTAACTCAGATTGCTCATCAGTAACATGGGGAGAGTGGTATCAACCACTAAGAGGATTAAATGAGTGAATATTTGTAAAA CACGTAGCCTAGAATAGATATTTATAAAGCACAAGATCTATGTAAAGTGTTTATAACATAATACATTGGAATATGAGACTTGAACATTTT GAAGATTCTAATAAATGAATAATTTAATTTAGTGCTCATTTGAAAAATATTTTATCCTCATGTTTACATTTAACACATATAATTTATATC TTAGTTTTTATCCCATTTATATATATATTTACCAGAAAAATGTTTTGTAATACCTTAATTTTATGTGGAGTTGAATTTAAATAATTAGGC >In-frame_MAGI2_ENST00000522391_chr7_79082336_-_VWC2_ENST00000340652_chr7_49842307_+_10498nt AAGAAGAGGGAAAGCACCGAATAGAGGGGGGCGAAGGCAAAGTCTGCTGTTCTTCCCCCTGGGCCCCCTTGCTCCTCCATCCTCATTCTC TCACCACCAGCCCCCCTAACCCCAAGGAGCCCAGGAACTGAGGCGACTCGCCCCACTGCCATGTCCAAAAGCTTGAAAAAGAAAAGCCAC TGGACTAGCAAAGTCCATGAGAGTGTCATTGGCAGGAACCCGGAGGGCCAGCTGGGCTTTGAACTGAAGGGGGGCGCCGAGAATGGACAG TTCCCCTACCTGGGGGAGGTGAAGCCCGGCAAGGTGGCCTATGAGAGCGGCAGCAAATTGGTGTCGGAGGAGCTGCTGCTGGAGGTGAAC GAGACCCCCGTGGCGGGGCTCACCATCAGGGACGTGCTGGCCGTGATCAAACACTGCAAGGACCCCCTCCGGCTCAAGTGTGTCAAGCAA GGTGTCTCCATGCGAGAGGTGTCGCTGTGAAGCCAACGGTGAGGTGCTATGCACAGTGTCAGCGTGTCCCCAGACGGAGTGTGTGGACCC TGTGTACGAGCCTGATCAGTGCTGTCCCATCTGCAAAAATGGTCCAAACTGCTTTGCAGAAACCGCGGTGATCCCTGCTGGCAGAGAAGT GAAGACTGACGAGTGCACCATATGCCACTGTACTTATGAGGAAGGCACATGGAGAATCGAGCGGCAGGCCATGTGCACGAGACATGAATG CAGGCAAATGTAGACGCTTCCCAGAACACAAACTCTGACTTTTTCTAGAACATTTTACTGATGTGAACATTCTAGATGACTCTGGGAACT ATCAGTCAAAGAAGACTTTTGATGAGGAATAATGGAAAATTGTTGGTACTTTTCCTTTTCTTGATAACAGTTACTACAACAGAAGGAAAT GGATATATTTCAAAACATCAACAAGAACTTTGGGCATAAAATCCTTCTCTAAATAAATGTGCTATTTTCACAGTAAGTACACAAAAGTAC ACTATTATATATCAAATGTATTTCTATAATCCCTCCATTAGAGAGCTTATATAAGTGTTTTCTATAGATGCAGATTAAAAATGCTGTGTT GTCAACCGTCCTCACCGTGTACCTGCATATCTTTTTCAGTTCTGATTCCATCACCCAGGAATGTTCCCCCTGCACATTTTCACAGGGCAG AGTCACGCATGAATGGATCATAAGATATTAGGACCAATTTCCACTGAAACCCTGTTTAAATTCTATTTAATTACAGACATATCTCTAATG TTGATGTCTACTTCACATAAATATATTTCCTTTTTATAATAATATATGGCTTTTATCTGCTTCATTCTCAGTCACTTGTGAAATGCAGGT GTAAAGATCACTAACTCACACTTTCTCAGTTCTTTCCCCTAAGCTCCTGTATTGTACACCATAGGTAAGCACATACATATATTTCATTCT TATTTACATTATTTTCTCTTCTAAGGATAACTTTAATTCATTCCCTAAACTGAGGAATAAAGTAGGCTGGAAAATTTGCATTACTGTTCC ATCAAGCTGAAGCAGACAACAAAATAGGGGAGGAGTCCTTCGATTCTCCTAGGATAGTTAAGGAAAATCAAACTCCTAAACAAGTTTATA TACCTGAAATCTAAATGTGCTACAGATAACTCAGCTGTCAGTTCAGTGGAATCATATTTGTCATCAGACTTGAGTCATCTATCCTCCATA AACTACACAGTAAAATCTTGACTGATAACCTTGAATTAGCCACCCTTCACAAGCAGAGTGAGGAAGCAGTTATTTTGTTAAAACAAAGCT GAAGACCAAGTGCACTCCACAACTTTCCTATAGTTATAATTCCAAACCAACTTCTTTTCTCTTCATTTGAACAGAGAACATAAAAAGCCA CTGCAAAGTCCTGCTAATCTAATTAATGCATAATAGAAAATAGTTCTACCTTTATCAATCATATCAGCATGCGGTGTGTTGATGAAAGAG GTAATTGGAGTCTTAATAGGTGTAGGATAAAAAAAGCAAAACTATAATCACTATTAATGTCTTTAAAGGATTAAAATATATATAATCATT ATTTGAAGCCTCTAAAGGTATTTTTCATATTTTTGTTTATTCTGAAATTTTGCATTAAGAACCTATTAAGTACAAAGCATTGACAACAAG GGAATAAGGCTTGATTTCTTGCCTTCTTGGACTTTCGGTCTCTGGCATAAGAAGTATATGAAATCATAATGTATTGTATTAGGAGCCAAA CTAGAGACCAGCAAATGGAGATTAGAAAGCCTTCCTAATGAGAAGATGGAGAACATGAAAAAATCATTATATAAAAAATAATTCAATCAT TAAAGACTGAATAACATTCAAGAAAAATGGATACATCTATCATAATTGAAAAATTAAACTATTGTGAACCTTAGTAAGTATAAAGATGCC ACTGACTGAGTCATCAAAACACTACATATAGTCATTTAATTTTTGTCTTGTTCATAAAGAACACCTTGAGCCAAAGGAACTACCAGTACA TAGATTTCATGAAAATACTCAGGGGAATTATTAGCTAATTGTTCTCAGGTGTAATCAGCTTTCCAAAATTTAACCTTTGTATTAAAGACT GGTAGACATTGGCCATCCCTCCTTTATTCAAGGATGGATTGTTTGAGACACAGTTATTTAAAGTTGTCGTTTTGCTAATAAATGGCCCTA GCCCCCATGGGTAGGTGGGCCATTAGTAACCTCTTCTCTCTCCATCAGGCATGATGCAGTTAGAGACTCAGTCCATGCAGCTCAAAGTCT TCCTGTTTCCCTTAATAATAATTCCTACCAGAATGGATGATGAGCTCTGAAATAATTGCAATGGTGTTTTCAATGCTGTGAGAATTTCAG AAAACCTAGTATTTTGTTGCATATAGAGAGAATGAACCCAGTATCATCTTGGGAAGTTAACTGACTCACTTGCTCTAAACTTAGTTTGAC CTGCAGGGTCACCAGCACACACTCCTAAGAGCTAAAGCTCAATGGCTGTTATTACACCAAAGTAACTCCCCTCCCCATCTCTGATTTCAA CCCCCTCATTCCTCTCTCCTCATAGAAATAATGCATAAACCAAACACATGGAAGAACTTGGATTTTTGACACTGTATATACTCATTAATA ATAATGGCATTATTTGCATTTTTGTCCAAGATCAACTTCTTCTTGCAGTTAGACTTTCACAAATACATAGCTATCTCAGATTGACATTCT ATTTTCCTCCCCTCTGTTGTCAGAGAACTCTTTGCTGAGATTGTCAACAACAAACTGTTCTATTCAATAAATAACCTGAATAACTGCCCA ATAAAAAAGGAAAGTATAAGTTACTCAATTTCAAAATAATATGGTTTGGAGATAGCACAGAAAAGGGGGCCTCAGAATTCAAGTATAGAA GTTCTGGAAAAGCCATAATCACTAAAATTCAAATAGGCCTGCTCTATAAGTACCTAATAATTGTTAAATGATTTGTTCAAGTTAATAAAC TAAATCGTGCTTACAAATGTATTAATGAATTTATTTCAAATTTTCAACCCATATTTAGATCTGAAAGTATAAAGCTACTTATGTAAGCAA TAGAATGGTTCTGGAAATTATCTGATGTCTTAGAGGTTTTCAAGTTAAATTCATTCTTTCAGTGATAGGATATTTACTTGTTGGGTGGAT TAACAATACTTTTTATTGACATTTCCCAGAAGTCTTGAGAAAAGTCATTTCAAAAACTTGTATTTCATCCCTGCATGCAAGAAGTATTAG ATGCACTCCAGTCCAGGCAAGTCCTGCTATAATGTTGCAGCTAGTGCAGATGGAGAGGCACAGTGTCCTTGACATCAAGGGGTCTGTAAG CCTTGAAACTAATTTAGGTTTGATTATAATACTTTTAATCTTTTGATACTTAGAATTTCATCACCTGCTTTGTGCAGTAAAACATGCTAA GAAGAATTATCATGCAGTTTTAAGTTCATAACATCAATAATATGTTTAATAAACTTTCTTCCCTCGTTCTCCAACATAAATGTTGCATTT ATATAAGGTTAAAAGTCCTAAAAAATCATAAAATTCAGATGTTTAATTTTTGTTTTTAAGCAGTGAAATGGGTTTTTAAATGTATACATT ATCTGAAACTTACAAAATATACACTGTTTCAAACAAGCATTGTTGGAAACTAAATCCATTATTTTAAATGTGGACTATTTAAACATGTAG AAAACAAAATTATAGACATAAACTATGATTTTAAAAATATTAACAATTTGCTAAATTTGCTTCAATGGGCAAGAGATCAATCCTACTTTT CATTGTTATTTTTAATATCATATTTTTCCCCAACATAATGTTATTATGAAGAGTATCAGATGTACAAATAAGCATCATTGGTAAAAACAT ACATGCTTCTTTGGCCAACATAATTTGTAACTGTCTTACTGAACCTACTTACCTACTATATTTTTTTTCCTCACTAGTAGCATCTGATGG TTGATACAGTCAGTAACTATTCTGAAGAATCAGATTAAGAGAGAACAATTTACTTATTCAGGAATAAGTGCATTTTTACAGTACATATTT TTCACATTTCAGCTGCAACTTCCAAAGATCAGGTTCTCATTGCTCCGTAGCACAGATTAAACAGCCTACTTATGTCATATCCTCACTTCA CACCAACTTCTTCAGTCTATTATTTTAGTTTTCTAAATGTAGATCTAGTTTTCAACTGAATTCTTTGAGGATCGCAATCACACACAAAAT AACATCCAAACTCCTCAACATGGAAGACTGGTGTCTTCACAATTAGATCATGGACAACACCATGACCCAGGCCCCTGTGGCTGGTGAGAC TTCTGGGCCCTGGGTACCACAGACTATACTCTAAACATGGTCTTTACTATCTCAGATCCTGCCCTGAGTGTCCTTTGCAGCATGTTGAGT ATTAGCCATTTTCAATGTCCAGTTCAAGTGCCATTGCTGGTAAGGCTTCTGTAGTTCTTATTGGAAGAATTGTCACTCTATGTCCCAGTA ATAGTACTAATTTGGTTTCTTATTTTAACATATCATTTAGGAATCATACCATAGTTTGCATAATGGTTAATTTTATGCCTGCTTCTTCTA TTATTTACAAATCCCTTTAGTTTGGGCTGTGAAATATTCAATTCCCAAAACATCACCCAATATCTATATGTTAAAGGCTTGTTGAATTGT ATTCCATCTATTAGTTCAGAGTTATTTGCTATTCTTGTTTAAGGACAATGTATGTATTAAAGAGCAACTAAAAACTCCCATTACTGTTTG CCAACCCAGTTGTCTTTTGATTTCTCTGTCAACTTACAAGTATCAAATATCTAAGTCACAGAACCCAGAGACACATCAAATACCCCAAAT ACCCCATGGTAGTTTTCGGATGAACTCTGACAGCTATTGGCCATTTCTGGTGCAAGTCAGAAAAAAATTGCTTTTAGTGTGAAATTTTTG ATGCTGAAGAAAGTTGATTGTATTGAAGAGACACTGGCCCTTTATGATAAAGGAAGTCAAGTTTACAGTTTTGATATTTGTTTACTTTCT TATTTCTAATTTTTGGAAAACAATTTTCTTAGACTTTCATTTGTGATATTGATCATTTCTGTGTGTTTTAATCTTTCTACATAACATAAT TAAACACCTCAGTAGGTATCTAGTGAACTGATACAATAATGAGCTGAGTCATTTGTACAGAAATATAGTAGCTTCCATAATCTGAATGAT AACCATTTAAAAGTGATGGTTGTTGAAATTTTACTGTAGTGTCAAATTTCACTTTAAATTTTGCAAAGCACCTGCTATTCTAGCCTTAAC ACAAAGATTTGGCTAATTTTTAAATGAACAAATCCCATTGAATATTAAGTGACACTGACAATCACCCTGAAAAGTATTCAGCCAAAGTTT CAATAGAATTAGGAAACTTAAATGAAAATGTGCTCTCAGTGCTTGGCCCATGAGCAGTTTATGATTTAAGACGTGCATACTGTTTAACTC TTTCCTTTAAAGTTCAGAAAAGTACATAAAACCTCTGGCTGACCTATTATATAGGCACAGAATTATCAAAAGCAATCAAAGTATGTACCT AAAGTCAATTTAGTATATTATGAATACAGCCTGATGACTAAACACAATTGCAAATATTGCGACTTTAGTTTTTAATTCAATTTTCAGCAA GTAGAAATATTTCTCAATTTTATTTGGTATCTAATTATATTAAGACCAACATATACATTAAAGTGTATTTAGATGATTAATATTTAATGA TCATTATTTTATTTAATGATTAATATTTTCTATTATTTGAATTTCTGTAATTTATGTTTTAGAAAGAACTGTTTCCAAACACATTTTATG GAAAGATTTCATTTTTCCATTCCCTTTACTTTTATATTTACATTGTCAAATAAATACAATTCTATTTTCATTTCTATTAGTTTTCAGGGT TTATTCTTTTCCTAAGCATATAATTCTTATAATGGAAAAAAGTGAAAAGTATCCAGTAAGTAATATACACCTATGAAACTATTAATGTTC TTTATACTACCAAGTAGTTTCATAGTTTTAAAAAGCCATTCTTAAGCAGTCGGTGAATGTATATCATCGGCCAAAAGTTATGCTAGGTTT CCTTCACTTATTATCACATTTAACCTCACAGTTCTCCCAAATTGTGGGTAATGCTATCCCCTTTGTTGCAGAAAAGTAAATATAGGCTCA GGGAAATTTAAAAACTGCCTTAAGATTCAGTCTAGTGAATGAGAGGCTGAGTTAAGAATCCAAATCTGCTTTATATCAGAGCCCGTGATT TGAAGTCTTATCATTTGTGTTTAGGTCAGGGACCTCTAGAAAATAGACAGAAATTTCCAAAATGGTCTTTTACCCCACTCCCCATAAATA AGATAATGAATAGCAACACTGATCCCTAATTCTAGAATATCAATCTTGATACTTGTCAAAGTAAATAGTAGCTCGTCACAAAAATGTTGT AGCCTCCCTAGTCTAAATGCTTATGCTATATTTTGTTTCCTAAATCTAGAGATCTCTTTTTAAAAATAGTATTGAAGCATCAGGTTGTTC AGGTATGATTCTCATATTGAAATTTACAAAATATAACCAAATATTGTGACCCAGTTTTTCTGGAGCCAAGAGAAGTAAACTGCCATTTAT TAGGTGATGATTATAGGGCAAACACTACAATTTCAAATTTCATATTCTTTTATCTGATTTATTCATTTTATCAACTCTGCTATATTGATG AAGAAGTCAACATATGGTGGGTAACTTATCCAAATTTCAGTGATGGGCTGGGCGTGGTGGCTCACGCCTATAATCCCAGCACTTTGGGAG GCTGAGGCAGGTGGATCAGGAGTTTGAGGCCAACCTGACCAACATGTGAAACCCCATCTCTACTAAAAATACAAAAAAATTACCTGGGCA TGGTGGCACATGCCTGTAATCTACTCGGGAGGCTGAGGCAGGAGAATCCCTTAAACCGAGGGGGTGGAGGTTGCTTGAGCCGAGATCGCG TCACTGCACTCCAGCCTGGGTAACAGAGCAAGACTCTGTTTAAAAAAAAAAAAAAAATCAGTGATGGAACTGAGGCCAAATCTGTCTGGT TCCAAAGCTATCCTACATGGGGCACAGTCAGGACTGGAATGGATAGCTCTACCTGCTTCCAAATATTCTTCCCTGGGGAGCAGCTGTGAG TCTTACTGAATCGATTTATTCATTGCATTCTATGTGTCAACTGCAATTTAGACCTGGGTGATAGAGTCATATATGGTCTTTGGACCCATG AAGCTCTGAGTCAAGGATACCAGCAGATATCCTTAAACTAATAAAAAAAGCGATGGCATCACATGCCATTTTGAACTTTTGCATTAAAGT CATAAACTTACATCAGTATTATGATTTATACTTTTAAGCAAAATTTTGCCATTTTCTGATACATAGTAGCTAGCTAGTGATAAAATTATG AAGTTACCATTGTATGTTCCAATGACATAAAAAACTAAGTGCCTGCTTGGGCTAGTTATACTCTGCAGTATACCCTGGTTTATTGTGAGG ATTAAATAAAAAATCCTCACAAACCCCAATTTAATTTAATATAGATTAATTATAAAAATAATCTACCCATGTTACATAATGTTAAATCTG TAGTTTCAAGGTGTATGCTATTTCTTAAAACAAAAACAAAGATTGTCCCCACTCCAAACAATAACAGCAATGGTGAAGGTTGTGGGTGGA CAGAGGTAGTCCCACTCATCCCCAGGGGGCTCAGCTGCCACCGGCCAGGTCTATCTATTGCTCCCACCTGCTCTGACTGTTTTCTCTCAA GAAAAAGATTTTCATTTTAAGATAGGCATCAGTGCAATAAAGGAGCTTGATACAAAAATCATTATGTTCTATATATGTTTTTGTAGGTTT TAGATTAATTATGGCCAACTGATACCTTAAAATATTTGTTACAAATAACACTGAAGTGAGATTCAAAATTGTGCCTTCTATTGAAGCCAA GAAAGTAAATGTCTTTAAAATAAACATAATGGTGTTTTTTTTTGGTACAATAAACAGCATACCTACATTTCAGAGGACAAATCATGTTAT TATAATAACCAGGAGAGAAAATAAAAGGAGACATTAATTTGGATATGGAAGCAAAATGGAACAGAGCAATATAGAGCAAAACAGAGGTTT GTCTGAAACATTTAAAATATTAAGAAGTATGACTAAAAAACTCAAACATTTTAATACACGATGAATCCTTTTCTTAAGGAAAAAATGAAA ATAATAAAAGTGGTATTTGGATGAGATAATTTTCCTTTAAATTTATTCCTCAGAATGATGTAAATTTTCCAGCTGGAAGGTCATCTTTCT ATACATGCATGCATCTATACAAATGGTTAAACAGTTACTCTCTCAATTTGCTGTGATAGGAAAGGTGGATATAAATATAAGCAAGGGTCT GATTAAAACAAAACAAAACAAACAAAAGACAAGAGAAGCACTGCATTGTTGGCAAGAAATTCCTTTTAAGTCAGACTTAAGTCCACGGAA AGCTGGACCTAAGCAGTGAAGGATGTAAGGGAACAGAGAGAGACTCTGCTTGGCCGAGTTTGCTATTCTCATTTGTCTATGTCAATACGG CTACATAAAGTTCACAACTATTTGCACATAGCTATAAATATAGCATGAATAAAACACATATGTATTTAATTGTGTTATTTACTATTTATA ATTTGAATTGTTTAAAATAATTTTAAATACTTATTCCATAAACTCAGTATTTGAAAACTTAAAAAAAAAGTCATTTTAAATAACATCATT TACCAAGTCTGTGTGATGCTTTACAAGGTACCTGATGAATGTAAAATTATAGCTTTTTGTCTTCATTTCTAATAGACTGTTATAGGGGAA ATGTACTAAAATGTTGTACTTATTACATTTATGAATTTCTGACAGTTTCTATAGACTGAGAATAATGATATGCTTTTATAAATTATTTGG TGAAAGTTTTCCAGTAAGTGTTCATGTCCTGTACAAATTTATTAAACAACATCAATTTTACCTAACAACTGTAACCACTAATAAATCATC AGTCACCACCTTTCCTGCATATCTGACAGATGGAGAACACTGTGCTTAGTGTTGAAGATACCAAAGGGAATTCAAGTGAGGGGAAAAGAG GAGAGCAAACTGATCAAAAGGGAATGCCCATGATGCTTTCAGGAAACCAGGGTGAGAACATGCTGGCTGGAGGATGGGTCTGGTTTCCAG CAGAGATGATAGGAGTTAAAAGGCATAGGTGAGTTGTTCCCATCCCTGGCCTGAGCCTTACTCCATAGCTATAGAGACATAGTCTCTAGA AACAAAGGCCAGAGCATCCTTTTAACATTTATATCATAAGTATTCTCAATAAACGTTTGCAATTTATTTGCTTTAATGTAACTTGGCAGT AAAGACTTTGGCCTTTGGAGGTCTGATTCTAATCCCAGTTCTACCACTTACTGGTTATTTATCAGGTACACGTTACCTACCTCTCTGTAA CTCAGATTGCTCATCAGTAACATGGGGAGAGTGGTATCAACCACTAAGAGGATTAAATGAGTGAATATTTGTAAAACACGTAGCCTAGAA TAGATATTTATAAAGCACAAGATCTATGTAAAGTGTTTATAACATAATACATTGGAATATGAGACTTGAACATTTTGAAGATTCTAATAA ATGAATAATTTAATTTAGTGCTCATTTGAAAAATATTTTATCCTCATGTTTACATTTAACACATATAATTTATATCTTAGTTTTTATCCC ATTTATATATATATTTACCAGAAAAATGTTTTGTAATACCTTAATTTTATGTGGAGTTGAATTTAAATAATTAGGCCGAATTTGTATGTA |
Top |
FusionGenePPI for MAGI2_VWC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAGI2 | ATN1, ACVR2A, DSCAML1, PLXNB3, ADRB1, CTNNB1, ARRDC3, BAI1, TTBK1, RHBDL1 | VWC2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000354212 | - | 1 | 22 | 302_381 | 100 | 1456 | DDN |
| Hgene | MAGI2 | chr7:79082336 | chr7:49842307 | ENST00000419488 | - | 1 | 21 | 302_381 | 100 | 1442 | DDN |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MAGI2_VWC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MAGI2_VWC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MAGI2 | C0036341 | Schizophrenia | 3 | CTD_human;PSYGENET |
| Hgene | MAGI2 | C0003469 | Anxiety Disorders | 1 | CTD_human |
| Hgene | MAGI2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | MAGI2 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | MAGI2 | C0025261 | Memory Disorders | 1 | CTD_human |
| Hgene | MAGI2 | C0525041 | Neurobehavioral Manifestations | 1 | CTD_human |
| Hgene | MAGI2 | C1839839 | MAJOR AFFECTIVE DISORDER 2 | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|