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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20582

FusionGeneSummary for MAGI2_CTNNA2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAGI2_CTNNA2
Fusion gene ID: 20582
HgeneTgene
Gene symbol

MAGI2

CTNNA2

Gene ID

9863

1496

Gene namemembrane associated guanylate kinase, WW and PDZ domain containing 2catenin alpha 2
SynonymsACVRIP1|AIP-1|AIP1|ARIP1|MAGI-2|SSCAMCAP-R|CAPR|CT114|CTNR
Cytomap

7q21.11

2p12

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated guanylate kinase, WW and PDZ domain-containing protein 2activin receptor interacting protein 1atrophin-1-interacting protein 1atrophin-1-interacting protein Amembrane-associated guanylate kinase inverted 2catenin alpha-2alpha-N-cateninalpha-catenin-related proteincadherin-associated protein, relatedcancer/testis antigen 114catenin (cadherin-associated protein), alpha 2
Modification date2018052220180522
UniProtAcc

Q86UL8

P26232

Ensembl transtripts involved in fusion geneENST00000419488, ENST00000354212, 
ENST00000522391, ENST00000536571, 
ENST00000535697, ENST00000517762, 
ENST00000466387, ENST00000496558, 
ENST00000361291, ENST00000402739, 
ENST00000540488, ENST00000541047, 
ENST00000343114, ENST00000496251, 
ENST00000409266, 
Fusion gene scores* DoF score3 X 3 X 2=1815 X 12 X 9=1620
# samples 315
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/1620*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAGI2 [Title/Abstract] AND CTNNA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAGI2

GO:0002092

positive regulation of receptor internalization

11526121

HgeneMAGI2

GO:0032516

positive regulation of phosphoprotein phosphatase activity

10760291

HgeneMAGI2

GO:0051898

negative regulation of protein kinase B signaling

10760291


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA202182MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000419488ENST00000466387MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000419488ENST00000496558MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000419488ENST00000361291MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000419488ENST00000402739MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000419488ENST00000540488MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000419488ENST00000541047MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000419488ENST00000343114MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-intronENST00000419488ENST00000496251MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-intronENST00000419488ENST00000409266MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000354212ENST00000466387MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000354212ENST00000496558MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000354212ENST00000361291MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000354212ENST00000402739MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000354212ENST00000540488MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000354212ENST00000541047MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000354212ENST00000343114MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-intronENST00000354212ENST00000496251MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-intronENST00000354212ENST00000409266MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000522391ENST00000466387MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000522391ENST00000496558MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000522391ENST00000361291MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000522391ENST00000402739MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000522391ENST00000540488MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000522391ENST00000541047MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000522391ENST00000343114MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-intronENST00000522391ENST00000496251MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-intronENST00000522391ENST00000409266MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000536571ENST00000466387MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000536571ENST00000496558MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000536571ENST00000361291MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000536571ENST00000402739MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000536571ENST00000540488MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000536571ENST00000541047MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000536571ENST00000343114MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-intronENST00000536571ENST00000496251MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-intronENST00000536571ENST00000409266MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000535697ENST00000466387MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000535697ENST00000496558MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000535697ENST00000361291MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000535697ENST00000402739MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000535697ENST00000540488MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000535697ENST00000541047MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-3CDSENST00000535697ENST00000343114MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-intronENST00000535697ENST00000496251MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
5UTR-intronENST00000535697ENST00000409266MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000517762ENST00000466387MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000517762ENST00000496558MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000517762ENST00000361291MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000517762ENST00000402739MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000517762ENST00000540488MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000517762ENST00000541047MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-3CDSENST00000517762ENST00000343114MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-intronENST00000517762ENST00000496251MAGI2chr7

78400167

-CTNNA2chr2

80620333

+
intron-intronENST00000517762ENST00000409266MAGI2chr7

78400167

-CTNNA2chr2

80620333

+

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FusionProtFeatures for MAGI2_CTNNA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAGI2

Q86UL8

CTNNA2

P26232


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAGI2_CTNNA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAGI2_CTNNA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MAGI2_CTNNA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAGI2_CTNNA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAGI2C0036341Schizophrenia3CTD_human;PSYGENET
HgeneMAGI2C0003469Anxiety Disorders1CTD_human
HgeneMAGI2C0005586Bipolar Disorder1PSYGENET
HgeneMAGI2C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneMAGI2C0025261Memory Disorders1CTD_human
HgeneMAGI2C0525041Neurobehavioral Manifestations1CTD_human
HgeneMAGI2C1839839MAJOR AFFECTIVE DISORDER 21PSYGENET
TgeneCTNNA2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneCTNNA2C0036341Schizophrenia1PSYGENET
TgeneCTNNA2C0038356Stomach Neoplasms1CTD_human