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Fusion gene ID: 20566 |
FusionGeneSummary for MAGED2_HNRNPDL |
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Fusion gene information | Fusion gene name: MAGED2_HNRNPDL | Fusion gene ID: 20566 | Hgene | Tgene | Gene symbol | MAGED2 | HNRNPDL | Gene ID | 10916 | 9987 |
Gene name | MAGE family member D2 | heterogeneous nuclear ribonucleoprotein D like | |
Synonyms | 11B6|BARTS5|BCG-1|BCG1|HCA10|MAGE-D2 | HNRNP|HNRPDL|JKTBP|JKTBP2|LGMD1G|laAUF1 | |
Cytomap | Xp11.21 | 4q21.22 | |
Type of gene | protein-coding | protein-coding | |
Description | melanoma-associated antigen D2MAGE-D2 antigenbreast cancer-associated gene 1 proteinhepatocellular carcinoma-associated protein JCL-1melanoma antigen family D, 2melanoma antigen family D2 | heterogeneous nuclear ribonucleoprotein D-likeA+U-rich element RNA binding factorAU-rich element RNA-binding factorJKT41-binding proteinhnRNP D-likehnRNP DLprotein laAUF1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9UNF1 | O14979 | |
Ensembl transtripts involved in fusion gene | ENST00000375068, ENST00000375053, ENST00000347546, ENST00000375062, ENST00000218439, ENST00000375058, ENST00000375060, ENST00000396224, ENST00000497484, | ENST00000295470, ENST00000349655, ENST00000602300, ENST00000502762, ENST00000514511, | |
Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 7 X 7 X 3=147 |
# samples | 5 | 9 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/147*10)=-0.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAGED2 [Title/Abstract] AND HNRNPDL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF376806 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000375068 | ENST00000295470 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375068 | ENST00000349655 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375068 | ENST00000602300 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375068 | ENST00000502762 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-5UTR | ENST00000375068 | ENST00000514511 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-3CDS | ENST00000375053 | ENST00000295470 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375053 | ENST00000349655 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375053 | ENST00000602300 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375053 | ENST00000502762 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-5UTR | ENST00000375053 | ENST00000514511 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-3CDS | ENST00000347546 | ENST00000295470 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000347546 | ENST00000349655 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000347546 | ENST00000602300 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000347546 | ENST00000502762 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-5UTR | ENST00000347546 | ENST00000514511 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-3CDS | ENST00000375062 | ENST00000295470 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375062 | ENST00000349655 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375062 | ENST00000602300 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375062 | ENST00000502762 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-5UTR | ENST00000375062 | ENST00000514511 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-3CDS | ENST00000218439 | ENST00000295470 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000218439 | ENST00000349655 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000218439 | ENST00000602300 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000218439 | ENST00000502762 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-5UTR | ENST00000218439 | ENST00000514511 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-3CDS | ENST00000375058 | ENST00000295470 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375058 | ENST00000349655 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375058 | ENST00000602300 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375058 | ENST00000502762 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-5UTR | ENST00000375058 | ENST00000514511 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-3CDS | ENST00000375060 | ENST00000295470 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375060 | ENST00000349655 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375060 | ENST00000602300 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000375060 | ENST00000502762 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-5UTR | ENST00000375060 | ENST00000514511 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-3CDS | ENST00000396224 | ENST00000295470 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000396224 | ENST00000349655 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000396224 | ENST00000602300 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000396224 | ENST00000502762 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-5UTR | ENST00000396224 | ENST00000514511 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-3CDS | ENST00000497484 | ENST00000295470 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000497484 | ENST00000349655 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000497484 | ENST00000602300 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-intron | ENST00000497484 | ENST00000502762 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
intron-5UTR | ENST00000497484 | ENST00000514511 | MAGED2 | chrX | 54839755 | - | HNRNPDL | chr4 | 83347785 | - |
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FusionProtFeatures for MAGED2_HNRNPDL |
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Hgene | Tgene |
MAGED2 | HNRNPDL |
Regulates the expression, localization to the plasmamembrane and function of the sodium chloride cotransportersSLC12A1 and SLC12A3, two key components of salt reabsorption inthe distal renal tubule. {ECO:0000269|PubMed:27120771}. | Acts as a transcriptional regulator. Promotestranscription repression. Promotes transcription activation indifferentiated myotubes (By similarity). Binds to double- andsingle-stranded DNA sequences. Binds to the transcriptionsuppressor CATR sequence of the COX5B promoter (By similarity).Binds with high affinity to RNA molecules that contain AU-richelements (AREs) found within the 3'-UTR of many proto-oncogenesand cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A)mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C)RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensussequence. {ECO:0000250, ECO:0000269|PubMed:9538234}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAGED2_HNRNPDL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAGED2_HNRNPDL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAGED2 | MEPCE, RPAP1, TCEA2, ATG2A, PCK1, CUL3, COPS5, TP53, LAGE3, NSMCE4A, EID3, EID1, EID2, MMS19, SOX2, CDK18, CDK20, FKBP5, HSP90AB1, ACLY, HSP90AA1, MCM5, MGEA5, OGFR, SRRT, TPM3, USP7, TRAP1, IRS4, SPRTN, CEP250, TPGS1, C1QBP, TUBB, GIGYF2, HNRNPU, HSPA5, MAGED1, LGALS3BP, TUBG1, TUBGCP3, NAP1L1, NAP1L4, PIK3C2A, PJA2, TUBA1A, TUBA1C, TUBA4A, TUBB4B, UBB, XRN2, RNF2, JAK3, GNAS, RPS6KB2, NTRK1, XPO1, PRKCI, NCSTN, ZNF281, TMEM63B, TIGD6, ARMC6, TGS1, MCM2, SNW1, OTUB1, DNAJB1, NCL, ZNF746, EGFR, GNAL, RIC8B, INTU, CYLD, DLST, TRIM25, G3BP1, TES | HNRNPDL | ATIC, HGS, KHDRBS2, HNRNPA1, H2AFX, ICT1, VHL, ELAVL1, ERG, LRP1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, HNRNPA3, HNRNPH1, HNRNPM, DDX3X, HNRNPUL1, SRSF2, SNRNP70, HNRNPA2B1, U2AF2, SRSF3, PTBP1, HNRNPR, HNRNPF, SRSF9, SRSF1, EEF1A1, HNRNPH3, HNRNPL, ATP6V1B1, HNRNPH2, RPL36, EIF4H, LSM14A, HNRNPD, WIPF2, HNRNPA0, RMDN3, PDHA1, MRPS16, RPS7, PICALM, EEF2, UBE2S, BARD1, FN1, CSNK2A1, IFIT2, IFIT3, IL7R, ITGA4, HMGA1, FBXO6, TARDBP, PARK2, RPA3, RPA2, RPA1, HSPA5, SPRTN, CUL7, OBSL1, EED, RNF2, MARK3, FBXW11, PABPC4, YARS2, MTERF3, MRPL32, ERAL1, LARP1, MRPS9, NGRN, SUPV3L1, MRPL55, MALSU1, MRPL19, PAIP1, MCAT, MKRN2, CDKN2AIP, MRPL14, UNK, AHNAK, APMAP, ARMC1, FUS, NAA50, UBAP2L, UBE2G2, WDR12, STIP1, NTRK1, EWSR1, HNRNPU, MATR3, CRY2, NANOG, MRPS35, NR3C1, CYLD, COX15, DNM1L, HSD17B10, PARK7, VDAC1, UBE2A, BRCA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAGED2_HNRNPDL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAGED2_HNRNPDL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | HNRNPDL | C1836765 | LIMB-GIRDLE MUSCULAR DYSTROPHY, TYPE 1G (disorder) | 1 | ORPHANET;UNIPROT |