	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 20548

FusionGeneSummary for MAEA_MAEA

Fusion gene summary

Fusion gene information	Fusion gene name: MAEA_MAEA
	Fusion gene ID: 20548
		Hgene	Tgene
	Gene symbol	MAEA	MAEA
	Gene ID	10296	10296
	Gene name	macrophage erythroblast attacher	macrophage erythroblast attacher
	Synonyms	EMLP\|EMP\|GID9\|HLC-10\|PIG5	EMLP\|EMP\|GID9\|HLC-10\|PIG5
	Cytomap	4p16.3	4p16.3
	Type of gene	protein-coding	protein-coding
	Description	macrophage erythroblast attacherGID complex subunit 9, FYV10 homologcell proliferation-inducing gene 5 proteinerythroblast macrophage proteinhuman lung cancer oncogene 10 proteinlung cancer-related protein 10	macrophage erythroblast attacherGID complex subunit 9, FYV10 homologcell proliferation-inducing gene 5 proteinerythroblast macrophage proteinhuman lung cancer oncogene 10 proteinlung cancer-related protein 10
	Modification date	20180523	20180523
	UniProtAcc	Q7L5Y9	Q7L5Y9
	Ensembl transtripts involved in fusion gene	ENST00000303400, ENST00000505177, ENST00000264750, ENST00000452175, ENST00000514708, ENST00000510794, ENST00000505839, ENST00000512289,	ENST00000303400, ENST00000505177, ENST00000264750, ENST00000452175, ENST00000514708, ENST00000510794, ENST00000505839, ENST00000512289,
Fusion gene scores	* DoF score	3 X 6 X 4=72	2 X 4 X 1=8
	# samples	6	4
	** MAII score	log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/8*10)=2.32192809488736
Context	PubMed: MAEA [Title/Abstract] AND MAEA [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAEA	GO:0007155	cell adhesion	9763581
Hgene	MAEA	GO:0033033	negative regulation of myeloid cell apoptotic process	9763581
Tgene	MAEA	GO:0007155	cell adhesion	9763581
Tgene	MAEA	GO:0033033	negative regulation of myeloid cell apoptotic process	9763581

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			CN428118	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
ChiTaRS3.1			CB241800	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
ChiTaRS3.1			T70597	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3UTR	ENST00000303400	ENST00000303400	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000303400	ENST00000505177	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000303400	ENST00000264750	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000303400	ENST00000452175	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000303400	ENST00000514708	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000303400	ENST00000510794	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000303400	ENST00000505839	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000303400	ENST00000512289	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000505177	ENST00000303400	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000505177	ENST00000505177	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000505177	ENST00000264750	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000505177	ENST00000452175	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000505177	ENST00000514708	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000505177	ENST00000510794	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000505177	ENST00000505839	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000505177	ENST00000512289	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000264750	ENST00000303400	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000264750	ENST00000505177	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000264750	ENST00000264750	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000264750	ENST00000452175	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000264750	ENST00000514708	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000264750	ENST00000510794	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000264750	ENST00000505839	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000264750	ENST00000512289	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000452175	ENST00000303400	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000452175	ENST00000505177	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000452175	ENST00000264750	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000452175	ENST00000452175	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000452175	ENST00000514708	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000452175	ENST00000510794	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000452175	ENST00000505839	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000452175	ENST00000512289	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000514708	ENST00000303400	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000514708	ENST00000505177	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000514708	ENST00000264750	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000514708	ENST00000452175	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000514708	ENST00000514708	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000514708	ENST00000510794	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000514708	ENST00000505839	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000514708	ENST00000512289	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000510794	ENST00000303400	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000510794	ENST00000505177	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000510794	ENST00000264750	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000510794	ENST00000452175	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000510794	ENST00000514708	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000510794	ENST00000510794	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000510794	ENST00000505839	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000510794	ENST00000512289	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000505839	ENST00000303400	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000505839	ENST00000505177	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000505839	ENST00000264750	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000505839	ENST00000452175	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000505839	ENST00000514708	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000505839	ENST00000510794	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-intron	ENST00000505839	ENST00000505839	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
intron-3UTR	ENST00000505839	ENST00000512289	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000512289	ENST00000303400	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000512289	ENST00000505177	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000512289	ENST00000264750	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000512289	ENST00000452175	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000512289	ENST00000514708	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000512289	ENST00000510794	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-intron	ENST00000512289	ENST00000505839	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000512289	ENST00000512289	MAEA	chr4	1333703	-	MAEA	chr4	1333796	+
3UTR-3UTR	ENST00000303400	ENST00000303400	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000303400	ENST00000505177	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000303400	ENST00000264750	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000303400	ENST00000452175	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000303400	ENST00000514708	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000303400	ENST00000510794	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000303400	ENST00000505839	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000303400	ENST00000512289	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000505177	ENST00000303400	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000505177	ENST00000505177	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000505177	ENST00000264750	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000505177	ENST00000452175	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000505177	ENST00000514708	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000505177	ENST00000510794	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000505177	ENST00000505839	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000505177	ENST00000512289	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000264750	ENST00000303400	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000264750	ENST00000505177	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000264750	ENST00000264750	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000264750	ENST00000452175	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000264750	ENST00000514708	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000264750	ENST00000510794	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000264750	ENST00000505839	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000264750	ENST00000512289	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000452175	ENST00000303400	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000452175	ENST00000505177	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000452175	ENST00000264750	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000452175	ENST00000452175	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000452175	ENST00000514708	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000452175	ENST00000510794	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000452175	ENST00000505839	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000452175	ENST00000512289	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000514708	ENST00000303400	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000514708	ENST00000505177	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000514708	ENST00000264750	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000514708	ENST00000452175	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000514708	ENST00000514708	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000514708	ENST00000510794	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000514708	ENST00000505839	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000514708	ENST00000512289	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000510794	ENST00000303400	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000510794	ENST00000505177	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000510794	ENST00000264750	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000510794	ENST00000452175	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000510794	ENST00000514708	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000510794	ENST00000510794	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000510794	ENST00000505839	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000510794	ENST00000512289	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000505839	ENST00000303400	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000505839	ENST00000505177	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000505839	ENST00000264750	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000505839	ENST00000452175	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000505839	ENST00000514708	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000505839	ENST00000510794	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000505839	ENST00000505839	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-3UTR	ENST00000505839	ENST00000512289	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000512289	ENST00000303400	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000512289	ENST00000505177	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000512289	ENST00000264750	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000512289	ENST00000452175	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000512289	ENST00000514708	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000512289	ENST00000510794	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-intron	ENST00000512289	ENST00000505839	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
3UTR-3UTR	ENST00000512289	ENST00000512289	MAEA	chr4	1333744	-	MAEA	chr4	1333683	+
intron-intron	ENST00000303400	ENST00000303400	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000303400	ENST00000505177	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000303400	ENST00000264750	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000303400	ENST00000452175	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000303400	ENST00000514708	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000303400	ENST00000510794	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000303400	ENST00000505839	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000303400	ENST00000512289	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505177	ENST00000303400	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505177	ENST00000505177	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505177	ENST00000264750	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505177	ENST00000452175	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505177	ENST00000514708	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505177	ENST00000510794	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505177	ENST00000505839	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505177	ENST00000512289	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000264750	ENST00000303400	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000264750	ENST00000505177	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000264750	ENST00000264750	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000264750	ENST00000452175	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000264750	ENST00000514708	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000264750	ENST00000510794	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000264750	ENST00000505839	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000264750	ENST00000512289	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000452175	ENST00000303400	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000452175	ENST00000505177	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000452175	ENST00000264750	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000452175	ENST00000452175	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000452175	ENST00000514708	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000452175	ENST00000510794	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000452175	ENST00000505839	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000452175	ENST00000512289	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000514708	ENST00000303400	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000514708	ENST00000505177	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000514708	ENST00000264750	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000514708	ENST00000452175	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000514708	ENST00000514708	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000514708	ENST00000510794	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000514708	ENST00000505839	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000514708	ENST00000512289	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000510794	ENST00000303400	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000510794	ENST00000505177	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000510794	ENST00000264750	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000510794	ENST00000452175	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000510794	ENST00000514708	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000510794	ENST00000510794	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000510794	ENST00000505839	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000510794	ENST00000512289	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505839	ENST00000303400	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505839	ENST00000505177	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505839	ENST00000264750	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505839	ENST00000452175	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505839	ENST00000514708	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505839	ENST00000510794	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505839	ENST00000505839	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000505839	ENST00000512289	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000512289	ENST00000303400	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000512289	ENST00000505177	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000512289	ENST00000264750	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000512289	ENST00000452175	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000512289	ENST00000514708	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000512289	ENST00000510794	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000512289	ENST00000505839	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+
intron-intron	ENST00000512289	ENST00000512289	MAEA	chr4	1320557	+	MAEA	chr4	1319809	+

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FusionProtFeatures for MAEA_MAEA

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAEA Q7L5Y9	MAEA Q7L5Y9
Plays a role in erythroblast enucleation and in thedevelopment of the mature macrophages. Mediates the attachment oferythroid cell to mature macrophages, in correlation with thepresence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participatesin erythroblastic island formation, which is the functional unitof definitive erythropoiesis. Associates with F-actin to regulateactin distribution in erythroblasts and macrophages. Maycontribute to nuclear architecture and cells division events.{ECO:0000269\|PubMed:16510120, ECO:0000269\|PubMed:9763581}.	Plays a role in erythroblast enucleation and in thedevelopment of the mature macrophages. Mediates the attachment oferythroid cell to mature macrophages, in correlation with thepresence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participatesin erythroblastic island formation, which is the functional unitof definitive erythropoiesis. Associates with F-actin to regulateactin distribution in erythroblasts and macrophages. Maycontribute to nuclear architecture and cells division events.{ECO:0000269\|PubMed:16510120, ECO:0000269\|PubMed:9763581}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for MAEA_MAEA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAEA_MAEA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for MAEA_MAEA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MAEA_MAEA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	MAEA	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Tgene	MAEA	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human

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Fusion gene ID: 20548

FusionGeneSummary for MAEA_MAEA

FusionProtFeatures for MAEA_MAEA

FusionGeneSequence for MAEA_MAEA

FusionGenePPI for MAEA_MAEA

RelatedDrugs for MAEA_MAEA

RelatedDiseases for MAEA_MAEA