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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20547

FusionGeneSummary for MAEA_CTBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAEA_CTBP1
Fusion gene ID: 20547
HgeneTgene
Gene symbol

MAEA

CTBP1

Gene ID

10296

1487

Gene namemacrophage erythroblast attacherC-terminal binding protein 1
SynonymsEMLP|EMP|GID9|HLC-10|PIG5BARS|HADDTS
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionmacrophage erythroblast attacherGID complex subunit 9, FYV10 homologcell proliferation-inducing gene 5 proteinerythroblast macrophage proteinhuman lung cancer oncogene 10 proteinlung cancer-related protein 10C-terminal-binding protein 1brefeldin A-ribosylated substrate
Modification date2018052320180522
UniProtAcc

Q7L5Y9

Q13363

Ensembl transtripts involved in fusion geneENST00000303400, ENST00000505177, 
ENST00000264750, ENST00000452175, 
ENST00000514708, ENST00000510794, 
ENST00000505839, ENST00000512289, 
ENST00000382952, ENST00000290921, 
ENST00000510568, ENST00000515690, 
Fusion gene scores* DoF score3 X 6 X 4=728 X 7 X 8=448
# samples 612
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/448*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAEA [Title/Abstract] AND CTBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAEA

GO:0007155

cell adhesion

9763581

HgeneMAEA

GO:0033033

negative regulation of myeloid cell apoptotic process

9763581


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCOADTCGA-D5-6531-01AMAEAchr4

1283770

+CTBP1chr4

1235307

-
TCGARVLAMLTCGA-AB-2811-03BMAEAchr4

1316291

+CTBP1chr4

1235307

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000303400ENST00000382952MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-intronENST00000303400ENST00000290921MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000303400ENST00000510568MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-intronENST00000303400ENST00000515690MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000505177ENST00000382952MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-intronENST00000505177ENST00000290921MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000505177ENST00000510568MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-intronENST00000505177ENST00000515690MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000264750ENST00000382952MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-intronENST00000264750ENST00000290921MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000264750ENST00000510568MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-intronENST00000264750ENST00000515690MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000452175ENST00000382952MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-intronENST00000452175ENST00000290921MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000452175ENST00000510568MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-intronENST00000452175ENST00000515690MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000514708ENST00000382952MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-intronENST00000514708ENST00000290921MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000514708ENST00000510568MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-intronENST00000514708ENST00000515690MAEAchr4

1283770

+CTBP1chr4

1235307

-
intron-5UTRENST00000510794ENST00000382952MAEAchr4

1283770

+CTBP1chr4

1235307

-
intron-intronENST00000510794ENST00000290921MAEAchr4

1283770

+CTBP1chr4

1235307

-
intron-5UTRENST00000510794ENST00000510568MAEAchr4

1283770

+CTBP1chr4

1235307

-
intron-intronENST00000510794ENST00000515690MAEAchr4

1283770

+CTBP1chr4

1235307

-
intron-5UTRENST00000505839ENST00000382952MAEAchr4

1283770

+CTBP1chr4

1235307

-
intron-intronENST00000505839ENST00000290921MAEAchr4

1283770

+CTBP1chr4

1235307

-
intron-5UTRENST00000505839ENST00000510568MAEAchr4

1283770

+CTBP1chr4

1235307

-
intron-intronENST00000505839ENST00000515690MAEAchr4

1283770

+CTBP1chr4

1235307

-
intron-5UTRENST00000512289ENST00000382952MAEAchr4

1283770

+CTBP1chr4

1235307

-
intron-intronENST00000512289ENST00000290921MAEAchr4

1283770

+CTBP1chr4

1235307

-
intron-5UTRENST00000512289ENST00000510568MAEAchr4

1283770

+CTBP1chr4

1235307

-
intron-intronENST00000512289ENST00000515690MAEAchr4

1283770

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000303400ENST00000382952MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-intronENST00000303400ENST00000290921MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000303400ENST00000510568MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-intronENST00000303400ENST00000515690MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000505177ENST00000382952MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-intronENST00000505177ENST00000290921MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000505177ENST00000510568MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-intronENST00000505177ENST00000515690MAEAchr4

1316291

+CTBP1chr4

1235307

-
intron-5UTRENST00000264750ENST00000382952MAEAchr4

1316291

+CTBP1chr4

1235307

-
intron-intronENST00000264750ENST00000290921MAEAchr4

1316291

+CTBP1chr4

1235307

-
intron-5UTRENST00000264750ENST00000510568MAEAchr4

1316291

+CTBP1chr4

1235307

-
intron-intronENST00000264750ENST00000515690MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000452175ENST00000382952MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-intronENST00000452175ENST00000290921MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000452175ENST00000510568MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-intronENST00000452175ENST00000515690MAEAchr4

1316291

+CTBP1chr4

1235307

-
intron-5UTRENST00000514708ENST00000382952MAEAchr4

1316291

+CTBP1chr4

1235307

-
intron-intronENST00000514708ENST00000290921MAEAchr4

1316291

+CTBP1chr4

1235307

-
intron-5UTRENST00000514708ENST00000510568MAEAchr4

1316291

+CTBP1chr4

1235307

-
intron-intronENST00000514708ENST00000515690MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000510794ENST00000382952MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-intronENST00000510794ENST00000290921MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000510794ENST00000510568MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-intronENST00000510794ENST00000515690MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000505839ENST00000382952MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-intronENST00000505839ENST00000290921MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-5UTRENST00000505839ENST00000510568MAEAchr4

1316291

+CTBP1chr4

1235307

-
5CDS-intronENST00000505839ENST00000515690MAEAchr4

1316291

+CTBP1chr4

1235307

-
intron-5UTRENST00000512289ENST00000382952MAEAchr4

1316291

+CTBP1chr4

1235307

-
intron-intronENST00000512289ENST00000290921MAEAchr4

1316291

+CTBP1chr4

1235307

-
intron-5UTRENST00000512289ENST00000510568MAEAchr4

1316291

+CTBP1chr4

1235307

-
intron-intronENST00000512289ENST00000515690MAEAchr4

1316291

+CTBP1chr4

1235307

-

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FusionProtFeatures for MAEA_CTBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAEA

Q7L5Y9

CTBP1

Q13363

Plays a role in erythroblast enucleation and in thedevelopment of the mature macrophages. Mediates the attachment oferythroid cell to mature macrophages, in correlation with thepresence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participatesin erythroblastic island formation, which is the functional unitof definitive erythropoiesis. Associates with F-actin to regulateactin distribution in erythroblasts and macrophages. Maycontribute to nuclear architecture and cells division events.{ECO:0000269|PubMed:16510120, ECO:0000269|PubMed:9763581}. Corepressor targeting diverse transcription regulatorssuch as GLIS2 or BCL6. Has dehydrogenase activity. Involved incontrolling the equilibrium between tubular and stacked structuresin the Golgi complex. Functions in brown adipose tissue (BAT)differentiation. {ECO:0000269|PubMed:12419229,ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAEA_CTBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAEA_CTBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAEAUBC, MYOC, GRK5, RANBP9, MKLN1, GID8, RMND5A, FLOT1, SOX2, CLIP1, GDNF, GLIPR1L2, MMP7, SFRP2, TDGF1, MRPL4, GPS2, PRG2, BMP1, CCDC120, INSL6, PRICKLE3, PIGT, MRPL38, JPH4, PRG3, PDGFD, TMEM70, TIGD5, PTPN14, RANBP10, RMND5B, ARMC8, WDR26, HTRA2, GID4, DDX5, CCDC51, YPEL5, RAB8A, EFHC2, WWC1CTBP1PNN, IKZF1, SMAD6, RBBP8, TGIF1, NRIP1, MDM2, HDAC1, HDAC3, HDAC4, HDAC5, HDAC9, BRCA1, HDAC2, KAT2B, GEMIN2, TBP, GTF2B, FOXP1, FOXP2, KMT2A, CBX4, MECOM, IKZF4, CTBP2, ZEB1, ACTL6B, HTT, TBL1X, ZNF217, RCOR1, SATB1, CTBP1, TCF4, LCOR, TP53, HIC1, EHMT2, EHMT1, WIZ, APC, PLK1, TUBG1, HSD11B2, TCF7L2, KDM1A, CREBBP, EP300, KAT2A, SP1, RREB1, CDYL, UBE2I, BCORL1, SERPINH1, BCL3, AKT1, HIST3H3, SPEN, ZBP1, SOBP, ZNF219, LCORL, CHD3, RBBP5, CTNNA1, SOX2, ELAVL1, ZEB2, TERF2IP, TERF2, TFAP4, ATXN1L, BCL6, NCOR2, ECT2, CTNNB1, KLF4, DNMT1, RUNX1, BAG3, THAP11, HEMGN, NME2, ORC4, ARNT2, NOL4L, KLF12, MARCH10, CDC23, FUNDC1, IKZF2, KLF3, LNX1, PIAS2, RAI2, RNF111, ZBTB18, CEP68, NOL4, DGCR6, SNRPN, CRY2, HOXB5, PRKAA1, MAPK9, PLCB1, BCAS3, TSHZ3, DMRTB1, EGFR, HIC2, PRDM2, ZNF516, DYRK1A, TRPS1, C10orf12, BCOR, FBXO11, RCOR2, RCOR3, C2orf44, RBL1, INA, RB1, E2F7, TRMT61B, FOXK1, C15orf39, AMPD2, TOR2A, ADSS, ATIC, CARM1, CTH, ECHS1, FKBP1A, GAPDH, DUT, HYI, SSNA1, WDR1, NTRK1, MED23, OFD1, FBF1, KCNIP3, KLF8, NFATC1, NFATC2, MTMR7, RBM14-RBM4, IGFBP1, CHD4, NISCH, KIAA0430, HELZ, PCGF5, SOWAHA, PAN2, EIF4ENIF1, FANCC, FANCA, FANCF, FANCG, FANCL, FANCE, FANCD2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAEA_CTBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAEA_CTBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAEAC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneCTBP1C0009404Colorectal Neoplasms1CTD_human