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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 20498

FusionGeneSummary for MACF1_BRAF

check button Fusion gene summary
Fusion gene informationFusion gene name: MACF1_BRAF
Fusion gene ID: 20498
HgeneTgene
Gene symbol

MACF1

BRAF

Gene ID

23499

673

Gene namemicrotubule-actin crosslinking factor 1B-Raf proto-oncogene, serine/threonine kinase
SynonymsABP620|ACF7|MACF|OFC4B-RAF1|B-raf|BRAF1|NS7|RAFB1
Cytomap

1p34.3

7q34

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-actin cross-linking factor 1620 kDa actin binding proteinactin cross-linking family protein 7macrophin 1 isoformtrabeculin-alphaserine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene
Modification date2018052320180527
UniProtAcc

Q9UPN3

P15056

Ensembl transtripts involved in fusion geneENST00000545844, ENST00000567887, 
ENST00000372915, ENST00000361689, 
ENST00000539005, ENST00000317713, 
ENST00000564288, ENST00000289893, 
ENST00000536367, ENST00000484793, 
ENST00000602421, ENST00000476350, 
ENST00000288602, 
Fusion gene scores* DoF score21 X 18 X 11=415824 X 11 X 10=2640
# samples 2135
** MAII scorelog2(21/4158*10)=-4.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(35/2640*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MACF1 [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMACF1

GO:0030334

regulation of cell migration

27693509

HgeneMACF1

GO:0043001

Golgi to plasma membrane protein transport

15265687

HgeneMACF1

GO:0045773

positive regulation of axon extension

22705394

HgeneMACF1

GO:0051893

regulation of focal adhesion assembly

27693509

TgeneBRAF

GO:0006468

protein phosphorylation

17563371

TgeneBRAF

GO:0010828

positive regulation of glucose transmembrane transport

23010278

TgeneBRAF

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

TgeneBRAF

GO:0043066

negative regulation of apoptotic process

19667065

TgeneBRAF

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

TgeneBRAF

GO:0071277

cellular response to calcium ion

18567582

TgeneBRAF

GO:0090150

establishment of protein localization to membrane

23010278


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHCATCGA-DE-A0Y2-01AMACF1chr1

39896580

+BRAFchr7

140487384

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000545844ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000567887ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000372915ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000361689ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000539005ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000317713ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000564288ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000289893ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
intron-3CDSENST00000536367ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
intron-3CDSENST00000484793ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
intron-3CDSENST00000602421ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
intron-3CDSENST00000476350ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-

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FusionProtFeatures for MACF1_BRAF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MACF1

Q9UPN3

BRAF

P15056


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641122_112742195939Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641414_141742195939Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641986_198942195939Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064698_70342195939Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931122_112737175431Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931414_141737175431Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931986_198937175431Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093698_70337175431Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971122_112756757389Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971414_141756757389Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971986_198956757389Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497698_70356757389Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941122_112737175431Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941414_141737175431Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941986_198937175431Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194698_70337175431Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064194_29842195939DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+306478_18142195939DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064868_92542195939DomainSH3
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093194_29837175431DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+609378_18137175431DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093868_92537175431DomainSH3
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497194_29856757389DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+649778_18156757389DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497868_92556757389DomainSH3
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194194_29837175431DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+619478_18137175431DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194868_92537175431DomainSH3
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641_29542195939RegionNote=Actin-binding
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931_29537175431RegionNote=Actin-binding
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971_29556757389RegionNote=Actin-binding
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941_29537175431RegionNote=Actin-binding
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641050_107342195939RepeatNote=LRR 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641128_115442195939RepeatNote=LRR 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641187_121042195939RepeatNote=LRR 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641257_128242195939RepeatNote=LRR 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064148_17142195939RepeatNote=LRR 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641577_162142195939RepeatNote=Plectin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641654_169642195939RepeatNote=Plectin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641769_180942195939RepeatNote=Plectin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641811_184842195939RepeatNote=Plectin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641855_188642195939RepeatNote=Plectin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30642290_233242195939RepeatNote=Plectin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30642367_241042195939RepeatNote=Plectin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064240_26442195939RepeatNote=LRR 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30642411_243742195939RepeatNote=Plectin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30642501_254342195939RepeatNote=Plectin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30642581_261242195939RepeatNote=Plectin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30642686_273042195939RepeatNote=Plectin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30643239_326242195939RepeatNote=LRR 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30643264_328342195939RepeatNote=LRR 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30643646_366942195939RepeatNote=LRR 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30643696_372042195939RepeatNote=LRR 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064377_39942195939RepeatNote=LRR 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30643883_395742195939RepeatNote=Spectrin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30643936_395842195939RepeatNote=LRR 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644000_410842195939RepeatNote=Spectrin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644125_415042195939RepeatNote=LRR 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064441_46442195939RepeatNote=LRR 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931050_107337175431RepeatNote=LRR 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931128_115437175431RepeatNote=LRR 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931187_121037175431RepeatNote=LRR 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931257_128237175431RepeatNote=LRR 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093148_17137175431RepeatNote=LRR 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931577_162137175431RepeatNote=Plectin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931654_169637175431RepeatNote=Plectin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931769_180937175431RepeatNote=Plectin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931811_184837175431RepeatNote=Plectin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931855_188637175431RepeatNote=Plectin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60932290_233237175431RepeatNote=Plectin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60932367_241037175431RepeatNote=Plectin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093240_26437175431RepeatNote=LRR 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60932411_243737175431RepeatNote=Plectin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60932501_254337175431RepeatNote=Plectin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60932581_261237175431RepeatNote=Plectin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60932686_273037175431RepeatNote=Plectin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60933239_326237175431RepeatNote=LRR 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60933264_328337175431RepeatNote=LRR 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60933646_366937175431RepeatNote=LRR 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60933696_372037175431RepeatNote=LRR 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093377_39937175431RepeatNote=LRR 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093441_46437175431RepeatNote=LRR 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971050_107356757389RepeatNote=LRR 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971128_115456757389RepeatNote=LRR 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971187_121056757389RepeatNote=LRR 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971257_128256757389RepeatNote=LRR 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497148_17156757389RepeatNote=LRR 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971577_162156757389RepeatNote=Plectin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971654_169656757389RepeatNote=Plectin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971769_180956757389RepeatNote=Plectin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971811_184856757389RepeatNote=Plectin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971855_188656757389RepeatNote=Plectin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64972290_233256757389RepeatNote=Plectin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64972367_241056757389RepeatNote=Plectin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497240_26456757389RepeatNote=LRR 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64972411_243756757389RepeatNote=Plectin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64972501_254356757389RepeatNote=Plectin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64972581_261256757389RepeatNote=Plectin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64972686_273056757389RepeatNote=Plectin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64973239_326256757389RepeatNote=LRR 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64973264_328356757389RepeatNote=LRR 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64973646_366956757389RepeatNote=LRR 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64973696_372056757389RepeatNote=LRR 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497377_39956757389RepeatNote=LRR 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64973883_395756757389RepeatNote=Spectrin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64973936_395856757389RepeatNote=LRR 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974000_410856757389RepeatNote=Spectrin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974125_415056757389RepeatNote=LRR 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974261_428756757389RepeatNote=LRR 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497441_46456757389RepeatNote=LRR 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974466_457456757389RepeatNote=Spectrin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974511_453456757389RepeatNote=LRR 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974601_462456757389RepeatNote=LRR 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974769_479256757389RepeatNote=LRR 18
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974800_490456757389RepeatNote=Spectrin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974909_501256757389RepeatNote=Spectrin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975051_507656757389RepeatNote=LRR 19
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975172_519456757389RepeatNote=LRR 20
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975236_534156757389RepeatNote=Spectrin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975281_530456757389RepeatNote=LRR 21
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975348_545056757389RepeatNote=Spectrin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975455_555756757389RepeatNote=Spectrin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941050_107337175431RepeatNote=LRR 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941128_115437175431RepeatNote=LRR 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941187_121037175431RepeatNote=LRR 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941257_128237175431RepeatNote=LRR 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194148_17137175431RepeatNote=LRR 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941577_162137175431RepeatNote=Plectin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941654_169637175431RepeatNote=Plectin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941769_180937175431RepeatNote=Plectin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941811_184837175431RepeatNote=Plectin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941855_188637175431RepeatNote=Plectin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61942290_233237175431RepeatNote=Plectin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61942367_241037175431RepeatNote=Plectin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194240_26437175431RepeatNote=LRR 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61942411_243737175431RepeatNote=Plectin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61942501_254337175431RepeatNote=Plectin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61942581_261237175431RepeatNote=Plectin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61942686_273037175431RepeatNote=Plectin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61943239_326237175431RepeatNote=LRR 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61943264_328337175431RepeatNote=LRR 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61943646_366937175431RepeatNote=LRR 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61943696_372037175431RepeatNote=LRR 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194377_39937175431RepeatNote=LRR 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194441_46437175431RepeatNote=LRR 4
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602-718428_432380767Compositional biasNote=Poly-Ser
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602-718457_717380767DomainProtein kinase
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602-718463_471380767Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647054_706542195939Calcium binding1
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647090_710142195939Calcium binding2
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937054_706537175431Calcium binding1
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937090_710137175431Calcium binding2
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977054_706556757389Calcium binding1
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977090_710156757389Calcium binding2
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947054_706537175431Calcium binding1
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947090_710137175431Calcium binding2
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647222_735142195939Compositional biasNote=Ser-rich
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937222_735137175431Compositional biasNote=Ser-rich
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977222_735156757389Compositional biasNote=Ser-rich
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947222_735137175431Compositional biasNote=Ser-rich
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647041_707642195939DomainEF-hand 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647077_711242195939DomainEF-hand 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647117_718942195939DomainGAR
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937041_707637175431DomainEF-hand 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937077_711237175431DomainEF-hand 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937117_718937175431DomainGAR
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977041_707656757389DomainEF-hand 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977077_711256757389DomainEF-hand 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977117_718956757389DomainGAR
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947041_707637175431DomainEF-hand 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947077_711237175431DomainEF-hand 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947117_718937175431DomainGAR
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647117_738842195939RegionC-terminal tail
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647313_732842195939RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937117_738837175431RegionC-terminal tail
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937313_732837175431RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977117_738856757389RegionC-terminal tail
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977313_732856757389RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947117_738837175431RegionC-terminal tail
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947313_732837175431RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644261_428742195939RepeatNote=LRR 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644466_457442195939RepeatNote=Spectrin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644511_453442195939RepeatNote=LRR 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644601_462442195939RepeatNote=LRR 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644769_479242195939RepeatNote=LRR 18
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644800_490442195939RepeatNote=Spectrin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644909_501242195939RepeatNote=Spectrin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645051_507642195939RepeatNote=LRR 19
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645172_519442195939RepeatNote=LRR 20
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645236_534142195939RepeatNote=Spectrin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645281_530442195939RepeatNote=LRR 21
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645348_545042195939RepeatNote=Spectrin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645455_555742195939RepeatNote=Spectrin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645695_571942195939RepeatNote=LRR 22
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645783_588542195939RepeatNote=Spectrin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645804_582842195939RepeatNote=LRR 23
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646005_611042195939RepeatNote=Spectrin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646115_621942195939RepeatNote=Spectrin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646225_632842195939RepeatNote=Spectrin 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646333_643942195939RepeatNote=Spectrin 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646443_654742195939RepeatNote=Spectrin 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646496_651942195939RepeatNote=LRR 24
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646552_665842195939RepeatNote=Spectrin 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646665_676642195939RepeatNote=Spectrin 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646771_687442195939RepeatNote=Spectrin 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60933883_395737175431RepeatNote=Spectrin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60933936_395837175431RepeatNote=LRR 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934000_410837175431RepeatNote=Spectrin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934125_415037175431RepeatNote=LRR 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934261_428737175431RepeatNote=LRR 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934466_457437175431RepeatNote=Spectrin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934511_453437175431RepeatNote=LRR 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934601_462437175431RepeatNote=LRR 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934769_479237175431RepeatNote=LRR 18
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934800_490437175431RepeatNote=Spectrin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934909_501237175431RepeatNote=Spectrin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935051_507637175431RepeatNote=LRR 19
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935172_519437175431RepeatNote=LRR 20
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935236_534137175431RepeatNote=Spectrin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935281_530437175431RepeatNote=LRR 21
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935348_545037175431RepeatNote=Spectrin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935455_555737175431RepeatNote=Spectrin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935695_571937175431RepeatNote=LRR 22
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935783_588537175431RepeatNote=Spectrin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935804_582837175431RepeatNote=LRR 23
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936005_611037175431RepeatNote=Spectrin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936115_621937175431RepeatNote=Spectrin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936225_632837175431RepeatNote=Spectrin 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936333_643937175431RepeatNote=Spectrin 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936443_654737175431RepeatNote=Spectrin 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936496_651937175431RepeatNote=LRR 24
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936552_665837175431RepeatNote=Spectrin 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936665_676637175431RepeatNote=Spectrin 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936771_687437175431RepeatNote=Spectrin 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975695_571956757389RepeatNote=LRR 22
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975783_588556757389RepeatNote=Spectrin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975804_582856757389RepeatNote=LRR 23
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976005_611056757389RepeatNote=Spectrin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976115_621956757389RepeatNote=Spectrin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976225_632856757389RepeatNote=Spectrin 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976333_643956757389RepeatNote=Spectrin 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976443_654756757389RepeatNote=Spectrin 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976496_651956757389RepeatNote=LRR 24
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976552_665856757389RepeatNote=Spectrin 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976665_676656757389RepeatNote=Spectrin 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976771_687456757389RepeatNote=Spectrin 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61943883_395737175431RepeatNote=Spectrin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61943936_395837175431RepeatNote=LRR 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944000_410837175431RepeatNote=Spectrin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944125_415037175431RepeatNote=LRR 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944261_428737175431RepeatNote=LRR 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944466_457437175431RepeatNote=Spectrin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944511_453437175431RepeatNote=LRR 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944601_462437175431RepeatNote=LRR 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944769_479237175431RepeatNote=LRR 18
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944800_490437175431RepeatNote=Spectrin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944909_501237175431RepeatNote=Spectrin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945051_507637175431RepeatNote=LRR 19
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945172_519437175431RepeatNote=LRR 20
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945236_534137175431RepeatNote=Spectrin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945281_530437175431RepeatNote=LRR 21
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945348_545037175431RepeatNote=Spectrin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945455_555737175431RepeatNote=Spectrin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945695_571937175431RepeatNote=LRR 22
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945783_588537175431RepeatNote=Spectrin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945804_582837175431RepeatNote=LRR 23
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946005_611037175431RepeatNote=Spectrin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946115_621937175431RepeatNote=Spectrin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946225_632837175431RepeatNote=Spectrin 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946333_643937175431RepeatNote=Spectrin 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946443_654737175431RepeatNote=Spectrin 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946496_651937175431RepeatNote=LRR 24
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946552_665837175431RepeatNote=Spectrin 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946665_676637175431RepeatNote=Spectrin 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946771_687437175431RepeatNote=Spectrin 17
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602-718122_129380767Compositional biasNote=Poly-Ser
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602-7186_11380767Compositional biasNote=Poly-Gly
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602-718155_227380767DomainRBD
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602-718234_280380767Zinc fingerPhorbol-ester/DAG-type


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FusionGeneSequence for MACF1_BRAF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MACF1_ENST00000545844_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_4104aa
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME
QLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFK
EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG
KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE
REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP
TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES
QLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLN
SRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE
LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEV
IVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL
LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ
LEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIG
QFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL
TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK
DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDR
KATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA
KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW
LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE
QARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDA
NEQYKLVSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGR
RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCE
GSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE
VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS

>In-frame_MACF1_ENST00000567887_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_6203aa
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLEPAGLKTLRLVSMPSWCHTNNEEQAEEDDDDVPREKGRMRFHRLQNVQIALDFLKQ
RQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRP
DLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIP
WIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKS
LRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFR
VMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEE
MQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSR
ATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCV
EQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLK
NTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLI
SWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKM
YISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLL
VEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVA
EQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQ
QTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISD
ALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHK
LSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSG
LIAPETGENLSLEEGIARNLINPQMYQQLRELQDALALISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLE
EAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTV
RLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLW
PESGEILPITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGA
AVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQRLLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSS
GWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETEDSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVR
ENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLEL
KSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTG
QKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLL
DKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQS
IDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKRE
IQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKV
LTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISP
ELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLGKDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREIS
LKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQVSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSE
EIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSS
EKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDALTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLH
YQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLE
FSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIIS
PTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMR
TKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAV
EIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQN
RQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD
LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN
KKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD
QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSF
SEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC
EANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQ
KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV
SQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSC
GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWAS
KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRME
EVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW
ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP
GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL
EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPIS
AKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVE
DLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTG
SLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQA
EVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAEC
RHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKM
FQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA
NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF
HETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQD
RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV
LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVL
DTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVK
ALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGV
LRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGD
FGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSN

>In-frame_MACF1_ENST00000372915_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_6062aa
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLREL
QDALALISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTA
EKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLI
DQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQH
IKALFLPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINV
QNGQRLLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKT
TVETEDSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVET
PKKEHQPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQE
AQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGF
FDSQTCESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLA
STLGLVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMR
LSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLT
NEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIID
TATGKRLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQ
NEFLGKDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKG
KSLGQVSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQ
PMNARVKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISV
KHLDALTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETN
YQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELT
GEKFLEMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRE
SPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLT
TLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLIL
NSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHL
QQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTK
LSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLS
GASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQS
EAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGK
EPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEE
LAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQV
SSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS
GKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK
DASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG
SILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKT
ETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLR
PWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRS
SQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK
RLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVA
EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS
KAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI
FDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFH
CRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTER
GKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCD
VQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT
VDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQ
QQIIRHKALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLRE
VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI
QRSQQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGS
GSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLID
IARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIV
LYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNR

>In-frame_MACF1_ENST00000361689_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_4104aa
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME
QLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFK
EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG
KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE
REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP
TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES
QLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLN
SRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE
LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEV
IVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL
LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ
LEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIG
QFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL
TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK
DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDR
KATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA
KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW
LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE
QARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDA
NEQYKLVSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGR
RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCE
GSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE
VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS

>In-frame_MACF1_ENST00000539005_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_3974aa
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME
QLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFK
EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG
KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE
REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
KTDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE
QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI
DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ
DLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAAD
RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTL
QNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILN
SAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLR
AQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD
GMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDF
YRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTL
NKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA
DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALNEEIVNRKK
NVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQI
PQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGDGG
STTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVK
MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSII
HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKT

>In-frame_MACF1_ENST00000317713_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_4104aa
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME
QLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFK
EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG
KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE
REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP
TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES
QLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLN
SRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE
LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEV
IVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL
LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ
LEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIG
QFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL
TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK
DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDR
KATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA
KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW
LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE
QARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDA
NEQYKLVSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGR
RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCE
GSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE
VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS

>In-frame_MACF1_ENST00000564288_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_6166aa
MPLLDSSYLPPTIFILTHVLGVAGVLYWKRHARGRADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLEPA
GLKTLRLVSMPSWCHTNNEEQAEEDDDDVPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI
YISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAED
VDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEIL
AKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQ
ADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTT
THLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSS
VKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSEL
TMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSC
DHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKV
ISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA
HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ
DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG
YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI
RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM
TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT
QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ
LAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA
LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGL
LDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMA
CAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALF
LPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQR
LLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETE
DSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEH
QPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIA
GGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQT
CESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGL
VDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDN
AFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVL
SPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGK
RLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLG
KDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQ
VSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNAR
VKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDA
LTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSW
VTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFL
EMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSE
QTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQ
ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGS
NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQ
EALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE
LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE
KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK
QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI
GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQ
VPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS
GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQ
FMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC
QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPS
VGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA
QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME
KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ
AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV
ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL
LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN
EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG
SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE
MFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ
EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE
HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ
AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR
HKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL
SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK
FQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVS
DTIGQRVDEIDAAIQRSQQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWE
IPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHL
HIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKN
PYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL

>In-frame_MACF1_ENST00000289893_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_4606aa
MQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALALISRLTESRGPLSVVEAIEKRIISETVGLK
ILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSL
KSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSN
DLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSI
CIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQRLLLLDKELMETLTSRDEYQTSPPKVVEIGH
QRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETEDSSVENPEQDLFVEQKERNPNIDALKVINK
VKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTCQNEQAHTLETEYIHDETGGS
HIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELL
EEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNVLMADKAI
SGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLI
SLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPE
TKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDI
ESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRIIASHQVLNGG
IVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLGKDMLIACNQTAEMSCNKVEESERLFQVENQ
SAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQVSLTHPYSECDFKLKEVARNNMGNDTNEEQ
EKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVIVEESIRTCKPAFLSEEKLY
QETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDALTLFSSKQANEGKVNNLSLCLTLKPEENLS
REIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDP
ARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANPNVAGLEAGSIEDIVTQRGSRVLGSF
LPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFTR
QLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKN
LQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQL
DALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAER
ALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE
EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR
HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL
ENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLN
MLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET
TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREM
VTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELN
LEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTET
SMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK
YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLL
VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLK
EFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQS
AISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ
MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK
TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI
RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR
NFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE
DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA
EALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH
CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWT
ELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS
PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNR
KKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGE
QIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGD
GGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVA
VKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS
IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN
RDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MACF1_ENST00000545844_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_12312nt
ATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTCATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGG
TCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTTGCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCG
GTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGCTGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAG
CACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCA
GGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAG
GTGAAACTAGTGAATATTCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTC
CAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGT
TACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTA
GTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTG
CTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTT
CCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATC
AAACAGCATACAATACTGATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAA
GAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATT
AAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGG
CCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCT
AAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGT
GAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATG
CGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCC
TCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACT
CGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAG
ATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAA
GAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAG
CTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACA
GCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAAT
TACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAAC
CACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAG
CATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAA
CGAAAATATTCCTGTGACCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAG
TCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACC
ATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGG
ACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATT
GAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGG
AACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATG
AAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAG
GAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATT
TCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGAC
AGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCA
GTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAG
AAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAA
CTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTA
CGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAG
ATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATT
GCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGG
ATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACG
GCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTAT
GAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCC
ATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTC
CGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACC
CTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTG
TCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCA
GAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAG
CAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGC
AGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGT
GACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAAT
CAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACA
CGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAG
AACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAG
CAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAG
CAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTG
GATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTG
GCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGG
TTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGC
TTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAG
GAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGT
ACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCT
TGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTG
CAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCA
GACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTG
CAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGG
AAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGC
AGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAG
GTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAA
CACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTC
TTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCT
TGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAG
AGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAA
GGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCA
AGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGC
AAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGT
GACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATG
GAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCA
ACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTA
AAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGA
TGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCC
CAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAG
CAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGC
CCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAAC
TCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTT
GGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGAC
TTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAA
CTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTT
GCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATT
TCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTG
ATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAAC
CATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTG
GAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTC
CTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCT
TCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACA
GGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAA
CTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTA
GAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAA
GCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGC
CAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACT
GATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAG
TGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTG
ACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGAC
GCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAA
ATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAA
GACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCA
CAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATA
GCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGA
AAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTG
GAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAG
TTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCC
AAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGG
CAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAA
GACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGG
CTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCT
TTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAG
GTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAG
CAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGT
GGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTG
TTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCT
AACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATT
AGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTG
AAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGA
CGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAG
GGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGA
GTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAG
GGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGC
ATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGT
GATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAA
GTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAG
TTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGT
AACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCT
ATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTT

>In-frame_MACF1_ENST00000567887_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_18609nt
ATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTCATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGG
TCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTTGCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCG
GTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGCTGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAG
CACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCA
GGCATCAAACTGGAGCCAGCAGGGCTGAAGACCCTCCGTCTGGTGAGCATGCCCTCCTGGTGCCATACAAACAACGAGGAGCAGGCGGAG
GAAGATGATGATGATGTACCCCGGGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAG
CGACAGGTGAAACTAGTGAATATTCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTG
CATTTCCAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACA
GCTGGTTACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCC
GATCTAGTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACT
CGCCTGCTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCT
AAAGTTCCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCC
TGGATCAAACAGCATACAATACTGATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACAC
TTCAAAGAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGC
CGAATTAAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCA
CTTCGGCCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACA
CTAGCTAAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAG
GAGTGTGAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGG
GTCATGCGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTT
CCACCCTCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCT
ATGACTCGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAG
ATGCAGATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGT
GTAGAAGAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTT
GGAAAGCTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGA
GCTACAGCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAG
AGAAATTACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTT
GAGAACCACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTT
GAGCAGCATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCC
ATTAAACGAAAATATTCCTGTGACCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTT
ATACAGTCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAG
AACACCATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCT
CAGCGGACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGAT
GCCATTGAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATC
TCTTGGAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAG
ATTATGAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTG
GAAGAGGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATG
TACATTTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGG
ACTGACAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTG
GATGCAGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTG
GTGGAGAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGAT
GCTGAACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCG
ACATTACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCA
GAGCAGATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGA
GTCATTGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATC
AAGTGGATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAG
CAGACGGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAG
GACTATGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCA
GATGCCATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGAT
GCACTCCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTG
TCTACCCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAG
GTTCTGTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAG
CTCTCAGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAG
CTTCAGCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGGAATGCAGAGCAGTTGCTGGGGTGATTGACCTAGGCACAGTGGAG
ATATTTCCCATCTTCAAAGCCATGCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGC
CTCATTGCCCCTGAGACGGGTGAAAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCCAGATGTACCAGCAGCTCCGG
GAGCTACAGGATGCCCTGGCCTTAATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATC
AGTGAGACAGTTGGACTGAAAATCTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAA
GAGGCTTTTCATCAAGGCCTCATTTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCAAGAATTTGATAGACCCTAAC
ACAGCTGAGAAAATTGGTTTGCTGGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAATTACTGCCTGTCAAACAATTG
GCAGGGGGGATGGTGAGCTTGAAATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTC
CGGTTGCTGGAAGCTCAGCTTTTTGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGGAAGAGGCTGTAAGACATAAT
CTGATTGACCAAGATATGGCCTGTGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTGTCACGGGGCAAAGGCTAACA
ATAGATGAAGCAGTGAGCAATGATCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGG
CCTGAATCTGGAGAGATCCTCCCAATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCACATAAAATCCTTAGTAACCGA
CAGCATATTAAGGCTCTGTTTCTACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTT
GCCAATAACTTAAAATCGATTTGTATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAACAAAATATTAATCCTGGAGCA
GCAGTTCTACCGTGCAGCAAGAGCCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGCTGATGACTCACAGCTATATT
AATGTGCAAAATGGACAGAGGCTGCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATGAGTATCAAACAAGTCCTCCA
AAAGTGGTTGAAATTGGGCATCAAAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGT
GGGTGGACTGTGAGGCTGCCTGAGTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAA
AAGACCACTGTAGAAACAGAAGATTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAGAGAGAAATCCAAACATTGAT
GCTTTGAAGGTAATAAATAAAGTCAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGA
GAAAATGCCAGCAGGGGACACCTCCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTT
GAAACACCAAAGAAAGAACATCAACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACACTCTTGAGACTGAATATATT
CATGATGAAACTGGAGGATCTCACATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTA
AAGTCTGAAACTGATGGGAATGTTCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTAAGGATGACCATAAAGAAAGT
CAAGAAGCACAGAACATCGCAGGTGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGC
AGTCATCCATTAGAATTGCTTGAAGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTATCTTTCATGAACAAACAGGT
CAAAAGCTCTTACTAAATGAAGCAATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAG
GGGTTCTTTGACTCTCAGACTTGTGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATGAGAAATTATTACATAATGTC
CTCATGGCAGACAAAGCTATAAGTGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTT
GACAAGGAAACAGCCACCAGAATTTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACT
TTGGCCTCAACTCTTGGCTTGGTGGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAA
ACAGTTAGGGAGAGATTAATTAGTTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCC
ATTGACAGAGGTCTTTTGGAGAGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTATCATTCACCATATATCTGGG
ATGAGACTTTCTGTTGATAATGCCTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATC
CATCAGATTTTTAATCCTGAAACGAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTACCTCAGACCTGAAAAGAGAA
ATCCAGGAGGTTCAGGCCTTTACTGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTG
TTAACTAATGAAGCAGTATTGTCTCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTC
AAGAAATGTAAGATTGATATTGAATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTG
CTTACATTGTCTCAAGCAATTCAGCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATC
ATAGATACTGCTACTGGAAAAAGACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACATGGTCAGAATTATTGCATCT
CATCAGGTGTTAAATGGAGGAATTGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCT
GAACTGGCAAATATGATCCAAATAGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCA
TTACAAAATGAATTTCTAGGAAAGGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGA
TTATTTCAAGTTGAAAATCAGTCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCC
TTAAAGGAATTTGGGTGCAAGGATCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTATCATAAATCCTCATAATCTT
AAAGGTAAATCCTTGGGCCAAGTGTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGA
AATGATACAAATGAAGAGCAGGAAAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTACCTCATGTCTAGATTCTGAA
GAAATAAGAGAAAATCAAGGGGAAGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTG
CAGCAACCAATGAATGCTCGGGTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCAGAACATGCAAACCAGCATTT
CTTTCTGAAGAAAAGTTGTATCAGGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAACCTAGGGAAATGACCTCAAGT
GAAAAAGGGAAAGAAGCTGATACAGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATT
TCTGTAAAACATTTAGATGCTTTAACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTA
AAACCAGAAGAAAACTTATCTCGAGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCCCAAGACCTGAAGGATTGCAC
TACCAGGAATCAGATGGAAAAGCCCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAG
ACCAACTATCAAGATTCCTGGGTTACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATGAATGTAAAGAAAAGTCATAC
CAAGAAGTATCTTTTGACCCAGCAAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAA
TTCTCAGACAGAAAAGACCTTCATCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAATCTGAAATAGCAACACAGGAA
CTAACTGGAGAGAAATTTCTAGAAATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGGACATAGTGACTCAGAGAGGT
TCCAGAGTCTTGGGATCCTTTCTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGCAACAGAATGCCATCATTAGT
CCTACTGTTCTAGAGACCAGTGAAGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTC
AGAGAAAGCCCTGGCAGTGAACAAACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCA
ACTCAGAATGTATTTACCCGGCAACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGTTACGGAACATTGAAATGAGG
ACCAAACAGATTCAACCTTTGGAGCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGAT
CTGACCACCTTGGTCAGTCAGGAGCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCT
CTAGAGAAAGATGCCAAGAATCTTCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTG
GAAATAGAAAAGACTAAAGTGTTAAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTT
ATTCTGAACAGCAAGGGATCTAACAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATGAGGATTTGAAACAGCCCATG
GCTGAAAGGAAAGCTCAGCTGGATGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAAT
CGACAGATGCTGAGGCTTCTGAATGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGC
CATCTTCAACAAATGGAGCAGGAAGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGT
TGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGAC
TTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAG
ACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGT
GTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAAC
AAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAG
CTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAA
TGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGAT
CAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCC
CAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTG
GAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTC
TCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAA
GGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACA
CGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGT
GAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAG
GAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGAC
CACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAG
AAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAG
CAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGC
TTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTG
AGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACAC
CTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTC
CAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGT
GGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGA
GAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGG
AGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGT
AAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAG
ACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGAC
ATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAG
GAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACC
AAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAG
GAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGG
GAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAG
CTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAA
CAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCT
GGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCC
CGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGA
CAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTG
GAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTG
AAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCC
AGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCT
GCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATT
GTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCAT
TGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAA
GACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTA
AGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCA
GAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGG
TCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTT
GAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAG
CCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCT
GAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAG
TTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGAT
AGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGT
CGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACA
GAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCG
ACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATG
TTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGAC
TGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAG
CTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCC
AATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAG
GCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAG
AGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTC
CATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAA
ATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAG
TCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAAGAC
CGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTG
GCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTA
AATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTG
TTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAA
GCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGA
GGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTG
GACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAAC
GAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATTAGA
GACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAA
GCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGG
GACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGA
AAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTA
CTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGC
TCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATG
GATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGAT
TTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTC
ATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTA
CCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAAC
TGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATT
GAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGT

>In-frame_MACF1_ENST00000372915_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_18186nt
ATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTCATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGG
TCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTTGCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCG
GTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGCTGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAG
CACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCA
GGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAG
GTGAAACTAGTGAATATTCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTC
CAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGT
TACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTA
GTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTG
CTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTT
CCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATC
AAACAGCATACAATACTGATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAA
GAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATT
AAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGG
CCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCT
AAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGT
GAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATG
CGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCC
TCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACT
CGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAG
ATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAA
GAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAG
CTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACA
GCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAAT
TACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAAC
CACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAG
CATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAA
CGAAAATATTCCTGTGACCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAG
TCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACC
ATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGG
ACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATT
GAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGG
AACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATG
AAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAG
GAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATT
TCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGAC
AGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCA
GTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAG
AAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAA
CTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTA
CGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAG
ATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATT
GCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGG
ATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACG
GCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTAT
GAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCC
ATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTC
CGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACC
CTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTG
TCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCA
GAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAG
CAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGGAATGCAGAGCAGTTGCTGGGGTGATTGACCTAGGCACAGTGGAGATATTT
CCCATCTTCAAAGCCATGCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGCCTCATT
GCCCCTGAGACGGGTGAAAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCCAGATGTACCAGCAGCTCCGGGAGCTA
CAGGATGCCCTGGCCTTAATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATCAGTGAG
ACAGTTGGACTGAAAATCTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAAGAGGCT
TTTCATCAAGGCCTCATTTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCAAGAATTTGATAGACCCTAACACAGCT
GAGAAAATTGGTTTGCTGGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAATTACTGCCTGTCAAACAATTGGCAGGG
GGGATGGTGAGCTTGAAATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTCCGGTTG
CTGGAAGCTCAGCTTTTTGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGGAAGAGGCTGTAAGACATAATCTGATT
GACCAAGATATGGCCTGTGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTGTCACGGGGCAAAGGCTAACAATAGAT
GAAGCAGTGAGCAATGATCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGGCCTGAA
TCTGGAGAGATCCTCCCAATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCACATAAAATCCTTAGTAACCGACAGCAT
ATTAAGGCTCTGTTTCTACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTTGCCAAT
AACTTAAAATCGATTTGTATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAACAAAATATTAATCCTGGAGCAGCAGTT
CTACCGTGCAGCAAGAGCCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGCTGATGACTCACAGCTATATTAATGTG
CAAAATGGACAGAGGCTGCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATGAGTATCAAACAAGTCCTCCAAAAGTG
GTTGAAATTGGGCATCAAAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGTGGGTGG
ACTGTGAGGCTGCCTGAGTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAAAAGACC
ACTGTAGAAACAGAAGATTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAGAGAGAAATCCAAACATTGATGCTTTG
AAGGTAATAAATAAAGTCAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGAGAAAAT
GCCAGCAGGGGACACCTCCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTTGAAACA
CCAAAGAAAGAACATCAACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACACTCTTGAGACTGAATATATTCATGAT
GAAACTGGAGGATCTCACATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTAAAGTCT
GAAACTGATGGGAATGTTCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTAAGGATGACCATAAAGAAAGTCAAGAA
GCACAGAACATCGCAGGTGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGCAGTCAT
CCATTAGAATTGCTTGAAGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTATCTTTCATGAACAAACAGGTCAAAAG
CTCTTACTAAATGAAGCAATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAGGGGTTC
TTTGACTCTCAGACTTGTGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATGAGAAATTATTACATAATGTCCTCATG
GCAGACAAAGCTATAAGTGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTTGACAAG
GAAACAGCCACCAGAATTTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACTTTGGCC
TCAACTCTTGGCTTGGTGGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAAACAGTT
AGGGAGAGATTAATTAGTTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCCATTGAC
AGAGGTCTTTTGGAGAGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTATCATTCACCATATATCTGGGATGAGA
CTTTCTGTTGATAATGCCTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATCCATCAG
ATTTTTAATCCTGAAACGAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTACCTCAGACCTGAAAAGAGAAATCCAG
GAGGTTCAGGCCTTTACTGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTGTTAACT
AATGAAGCAGTATTGTCTCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTCAAGAAA
TGTAAGATTGATATTGAATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTGCTTACA
TTGTCTCAAGCAATTCAGCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATCATAGAT
ACTGCTACTGGAAAAAGACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACATGGTCAGAATTATTGCATCTCATCAG
GTGTTAAATGGAGGAATTGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCTGAACTG
GCAAATATGATCCAAATAGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCATTACAA
AATGAATTTCTAGGAAAGGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGATTATTT
CAAGTTGAAAATCAGTCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCCTTAAAG
GAATTTGGGTGCAAGGATCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTATCATAAATCCTCATAATCTTAAAGGT
AAATCCTTGGGCCAAGTGTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGAAATGAT
ACAAATGAAGAGCAGGAAAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTACCTCATGTCTAGATTCTGAAGAAATA
AGAGAAAATCAAGGGGAAGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTGCAGCAA
CCAATGAATGCTCGGGTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCAGAACATGCAAACCAGCATTTCTTTCT
GAAGAAAAGTTGTATCAGGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAACCTAGGGAAATGACCTCAAGTGAAAAA
GGGAAAGAAGCTGATACAGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATTTCTGTA
AAACATTTAGATGCTTTAACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTAAAACCA
GAAGAAAACTTATCTCGAGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCCCAAGACCTGAAGGATTGCACTACCAG
GAATCAGATGGAAAAGCCCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAGACCAAC
TATCAAGATTCCTGGGTTACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATGAATGTAAAGAAAAGTCATACCAAGAA
GTATCTTTTGACCCAGCAAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAATTCTCA
GACAGAAAAGACCTTCATCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAATCTGAAATAGCAACACAGGAACTAACT
GGAGAGAAATTTCTAGAAATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGGACATAGTGACTCAGAGAGGTTCCAGA
GTCTTGGGATCCTTTCTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGCAACAGAATGCCATCATTAGTCCTACT
GTTCTAGAGACCAGTGAAGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTCAGAGAA
AGCCCTGGCAGTGAACAAACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCAACTCAG
AATGTATTTACCCGGCAACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGTTACGGAACATTGAAATGAGGACCAAA
CAGATTCAACCTTTGGAGCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGATCTGACC
ACCTTGGTCAGTCAGGAGCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCTCTAGAG
AAAGATGCCAAGAATCTTCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTGGAAATA
GAAAAGACTAAAGTGTTAAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTTATTCTG
AACAGCAAGGGATCTAACAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATGAGGATTTGAAACAGCCCATGGCTGAA
AGGAAAGCTCAGCTGGATGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAATCGACAG
ATGCTGAGGCTTCTGAATGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGCCATCTT
CAACAAATGGAGCAGGAAGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTA
GGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAG
GATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAG
CTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCC
CAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAG
AAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCG
GGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAG
ATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCAT
GGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCA
GAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGA
TCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAG
GATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAA
GAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTA
GGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCC
AACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAA
TTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGG
CATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCA
ATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTG
TCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAG
GCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAG
CGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCT
GGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAG
ATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTT
GCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAA
GATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATT
CCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGA
ACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGT
TCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCA
GATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTT
CACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACA
GAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCC
CTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGG
GCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGG
CCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTC
CAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGAT
GTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCC
AGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGG
CTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAG
TTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAG
CGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACC
CAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAA
TTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCT
GAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAA
GAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTT
GTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCA
AAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCA
GATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTC
GAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATC
TTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAG
GTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTC
GCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCAC
TGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTC
CAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACAT
ATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGG
GGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACA
GCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAG
AAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGAT
GTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAG
GAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAG
AAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACA
GTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTT
GAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAG
ACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAG
CAGCAGATCATTCGGCACAAGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTT
CTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGC
TCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAG
GTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAG
GAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGG
CTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATT
CAGAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCA
TTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGG
AATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCT
GGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTA
CAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTG
GCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGAT
ATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCAT
GAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGA
TCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTT
CTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCT
CCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCA
CTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGG
GCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTC

>In-frame_MACF1_ENST00000361689_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_12312nt
ATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTCATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGG
TCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTTGCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCG
GTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGCTGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAG
CACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCA
GGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAG
GTGAAACTAGTGAATATTCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTC
CAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGT
TACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTA
GTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTG
CTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTT
CCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATC
AAACAGCATACAATACTGATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAA
GAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATT
AAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGG
CCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCT
AAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGT
GAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATG
CGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCC
TCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACT
CGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAG
ATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAA
GAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAG
CTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACA
GCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAAT
TACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAAC
CACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAG
CATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAA
CGAAAATATTCCTGTGACCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAG
TCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACC
ATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGG
ACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATT
GAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGG
AACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATG
AAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAG
GAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATT
TCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGAC
AGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCA
GTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAG
AAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAA
CTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTA
CGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAG
ATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATT
GCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGG
ATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACG
GCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTAT
GAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCC
ATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTC
CGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACC
CTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTG
TCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCA
GAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAG
CAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGC
AGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGT
GACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAAT
CAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACA
CGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAG
AACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAG
CAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAG
CAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTG
GATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTG
GCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGG
TTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGC
TTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAG
GAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGT
ACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCT
TGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTG
CAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCA
GACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTG
CAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGG
AAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGC
AGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAG
GTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAA
CACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTC
TTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCT
TGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAG
AGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAA
GGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCA
AGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGC
AAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGT
GACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATG
GAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCA
ACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTA
AAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGA
TGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCC
CAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAG
CAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGC
CCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAAC
TCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTT
GGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGAC
TTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAA
CTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTT
GCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATT
TCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTG
ATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAAC
CATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTG
GAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTC
CTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCT
TCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACA
GGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAA
CTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTA
GAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAA
GCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGC
CAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACT
GATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAG
TGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTG
ACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGAC
GCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAA
ATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAA
GACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCA
CAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATA
GCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGA
AAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTG
GAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAG
TTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCC
AAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGG
CAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAA
GACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGG
CTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCT
TTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAG
GTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAG
CAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGT
GGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTG
TTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCT
AACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATT
AGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTG
AAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGA
CGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAG
GGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGA
GTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAG
GGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGC
ATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGT
GATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAA
GTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAG
TTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGT
AACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCT
ATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTT

>In-frame_MACF1_ENST00000539005_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_11922nt
ATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTCATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGG
TCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTTGCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCG
GTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGCTGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAG
CACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCA
GGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAG
GTGAAACTAGTGAATATTCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTC
CAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGT
TACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTA
GTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTG
CTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTT
CCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATC
AAACAGCATACAATACTGATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAA
GAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATT
AAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGG
CCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCT
AAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGT
GAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATG
CGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCC
TCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACT
CGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAG
ATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAA
GAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAG
CTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACA
GCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAAT
TACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAAC
CACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAG
CATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAA
CGAAAATATTCCTGTGACCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAG
TCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACC
ATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGG
ACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATT
GAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGG
AACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATG
AAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAG
GAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATT
TCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGAC
AGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCA
GTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAG
AAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAA
CTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTA
CGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAG
ATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATT
GCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGG
ATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACG
GCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTAT
GAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCC
ATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTC
CGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACC
CTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTG
TCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCA
GAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAG
CAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGC
AGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGT
GACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAAT
CAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACA
CGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAG
AACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAG
CAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAG
CAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTG
GATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTG
GCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGG
TTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGC
TTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAG
GAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGT
ACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCT
TGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTG
CAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCA
GACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTG
CAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGG
AAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGC
AGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAG
GTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAA
CACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTC
TTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCT
TGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAG
AGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAA
GGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCA
AGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGC
AAGACAGATCTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAA
AGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTG
AAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAA
CAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAG
AAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCAT
CTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATT
GACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAAT
GAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAA
TGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAG
GACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTG
GAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTC
ATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGAT
CGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAA
AGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTT
AATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTA
CAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAG
AAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTG
GATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAAT
AGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCT
GTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAA
AAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGA
GCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGA
TCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATG
ATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGAT
GGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAA
TTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAA
GCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTC
TACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATC
ATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGC
CAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTG
AATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGC
TGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAG
TTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCT
GATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTG
GAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAAC
TCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCACAAGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAG
AATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGT
ATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAG
TCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATA
CCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCT
CTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACT
ATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGA
TCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAG
CGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCT
GATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAA
ATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATC
CTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATC
ATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATC
CACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGA
TGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATAC
AGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGAC
CAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATG
GCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAA
ATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACA

>In-frame_MACF1_ENST00000317713_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_12312nt
ATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTCATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGG
TCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTTGCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCG
GTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGCTGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAG
CACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCA
GGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAG
GTGAAACTAGTGAATATTCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTC
CAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGT
TACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTA
GTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTG
CTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTT
CCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATC
AAACAGCATACAATACTGATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAA
GAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATT
AAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGG
CCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCT
AAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGT
GAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATG
CGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCC
TCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACT
CGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAG
ATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAA
GAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAG
CTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACA
GCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAAT
TACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAAC
CACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAG
CATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAA
CGAAAATATTCCTGTGACCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAG
TCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACC
ATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGG
ACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATT
GAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGG
AACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATG
AAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAG
GAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATT
TCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGAC
AGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCA
GTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAG
AAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAA
CTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTA
CGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAG
ATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATT
GCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGG
ATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACG
GCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTAT
GAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCC
ATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTC
CGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACC
CTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTG
TCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCA
GAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAG
CAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGC
AGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGT
GACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAAT
CAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACA
CGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAG
AACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAG
CAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAG
CAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTG
GATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTG
GCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGG
TTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGC
TTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAG
GAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGT
ACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCT
TGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTG
CAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCA
GACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTG
CAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGG
AAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGC
AGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAG
GTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAA
CACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTC
TTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCT
TGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAG
AGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAA
GGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCA
AGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGC
AAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGT
GACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATG
GAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCA
ACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTA
AAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGA
TGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCC
CAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAG
CAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGC
CCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAAC
TCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTT
GGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGAC
TTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAA
CTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTT
GCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATT
TCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTG
ATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAAC
CATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTG
GAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTC
CTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCT
TCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACA
GGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAA
CTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTA
GAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAA
GCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGC
CAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACT
GATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAG
TGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTG
ACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGAC
GCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAA
ATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAA
GACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCA
CAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATA
GCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGA
AAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTG
GAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAG
TTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCC
AAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGG
CAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAA
GACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGG
CTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCT
TTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAG
GTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAG
CAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGT
GGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTG
TTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCT
AACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATT
AGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTG
AAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGA
CGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAG
GGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGA
GTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAG
GGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGC
ATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGT
GATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAA
GTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAG
TTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGT
AACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCT
ATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTT

>In-frame_MACF1_ENST00000564288_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_18498nt
ATGCCCCTCTTAGATTCATCTTATTTACCACCAACCATCTTTATTTTGACTCACGTTCTTGGAGTTGCTGGTGTTCTATACTGGAAGAGG
CATGCCAGAGGTAGAGCAGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAG
CACATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGCATCAAACTGGAGCCAGCA
GGGCTGAAGACCCTCCGTCTGGTGAGCATGCCCTCCTGGTGCCATACAAACAACGAGGAGCAGGCGGAGGAAGATGATGATGATGTACCC
CGGGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTGAAACTAGTGAAT
ATTCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAGATCTCTGACATC
TACATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTACACAGGAATCAAA
TGCACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTAGACATGGAGAGG
GTGCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTGGATGCAGAAGAT
GTGGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAA
GGGATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAACAGCATACAATA
CTGATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAAACAGAAATTCTG
GCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAACTGCCTCAAGGT
TATCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCGGCTGTGGAGAGG
CTGGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAGAATACACTGCAG
GCTGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAAGGTCTCATCAGG
CAGCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGTCTTCAGGATGAG
CTGGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCTACTTTAACCACC
ACTCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGGGCTGAACTTGTG
GCCATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATGAAACTGGAGCGA
GCAGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAGCTGGGCTCAAGT
GTCAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTGGAGACACAGTAT
TGTAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCTGAGTTGATCTGG
TTGAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTACTTCTCTGAGTTG
ACAATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCACCCAGCCAAGCAG
ACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCATGTGAAAGAGAAT
ACTGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGAAAATATTCCTGT
GACCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCCAAGAGTTCCGTT
GCCAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATTTCTGTCAAGGCT
GTCTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACCAAATGGAAAGTG
ATCAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAGATGGCCAGCAGG
GTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAACTATCTGCGTAAA
GACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAGAACCTTCAGGCC
CACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGT
AAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCAGAGTTGAAGAAC
ATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGAGATGCCTGGCAG
GACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTTTCTATGAAATGT
GACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAGATGGACCATGTC
TATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTCTTGGTCAAAGGT
TATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGGCACTGGCTTAGT
GATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATGAGTCGTCTGACA
CCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCCCAGCTCGAGATT
CGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATTGAGGAAACCACT
GCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCCCTATTTGCAGAA
ATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAATTGCAACTGATG
ACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATCACTCAAGAGTTC
ATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGGCGTCTGGAGGAG
GAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTAGCGAGGAATACA
CAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCAGAAGAGCTGACA
ACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAAAAAGAGAAGAAA
CAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAG
TTGGCTCACCAGACAGAACAAAAGGAATGCAGAGCAGTTGCTGGGGTGATTGACCTAGGCACAGTGGAGATATTTCCCATCTTCAAAGCC
ATGCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGCCTCATTGCCCCTGAGACGGGT
GAAAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCCAGATGTACCAGCAGCTCCGGGAGCTACAGGATGCCCTGGCC
TTAATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATCAGTGAGACAGTTGGACTGAAA
ATCTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAAGAGGCTTTTCATCAAGGCCTC
ATTTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCAAGAATTTGATAGACCCTAACACAGCTGAGAAAATTGGTTTG
CTGGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAATTACTGCCTGTCAAACAATTGGCAGGGGGGATGGTGAGCTTG
AAATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTCCGGTTGCTGGAAGCTCAGCTT
TTTGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGGAAGAGGCTGTAAGACATAATCTGATTGACCAAGATATGGCC
TGTGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTGTCACGGGGCAAAGGCTAACAATAGATGAAGCAGTGAGCAAT
GATCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGGCCTGAATCTGGAGAGATCCTC
CCAATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCACATAAAATCCTTAGTAACCGACAGCATATTAAGGCTCTGTTT
CTACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTTGCCAATAACTTAAAATCGATT
TGTATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAACAAAATATTAATCCTGGAGCAGCAGTTCTACCGTGCAGCAAG
AGCCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGCTGATGACTCACAGCTATATTAATGTGCAAAATGGACAGAGG
CTGCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATGAGTATCAAACAAGTCCTCCAAAAGTGGTTGAAATTGGGCAT
CAAAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGTGGGTGGACTGTGAGGCTGCCT
GAGTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAAAAGACCACTGTAGAAACAGAA
GATTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAGAGAGAAATCCAAACATTGATGCTTTGAAGGTAATAAATAAA
GTCAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGAGAAAATGCCAGCAGGGGACAC
CTCCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTTGAAACACCAAAGAAAGAACAT
CAACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACACTCTTGAGACTGAATATATTCATGATGAAACTGGAGGATCT
CACATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTAAAGTCTGAAACTGATGGGAAT
GTTCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTAAGGATGACCATAAAGAAAGTCAAGAAGCACAGAACATCGCA
GGTGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGCAGTCATCCATTAGAATTGCTT
GAAGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTATCTTTCATGAACAAACAGGTCAAAAGCTCTTACTAAATGAA
GCAATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAGGGGTTCTTTGACTCTCAGACT
TGTGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATGAGAAATTATTACATAATGTCCTCATGGCAGACAAAGCTATA
AGTGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTTGACAAGGAAACAGCCACCAGA
ATTTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACTTTGGCCTCAACTCTTGGCTTG
GTGGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAAACAGTTAGGGAGAGATTAATT
AGTTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCCATTGACAGAGGTCTTTTGGAG
AGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTATCATTCACCATATATCTGGGATGAGACTTTCTGTTGATAAT
GCCTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATCCATCAGATTTTTAATCCTGAA
ACGAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTACCTCAGACCTGAAAAGAGAAATCCAGGAGGTTCAGGCCTTT
ACTGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTGTTAACTAATGAAGCAGTATTG
TCTCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTCAAGAAATGTAAGATTGATATT
GAATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTGCTTACATTGTCTCAAGCAATT
CAGCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATCATAGATACTGCTACTGGAAAA
AGACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACATGGTCAGAATTATTGCATCTCATCAGGTGTTAAATGGAGGA
ATTGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCTGAACTGGCAAATATGATCCAA
ATAGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCATTACAAAATGAATTTCTAGGA
AAGGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGATTATTTCAAGTTGAAAATCAG
TCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCCTTAAAGGAATTTGGGTGCAAG
GATCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTATCATAAATCCTCATAATCTTAAAGGTAAATCCTTGGGCCAA
GTGTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGAAATGATACAAATGAAGAGCAG
GAAAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTACCTCATGTCTAGATTCTGAAGAAATAAGAGAAAATCAAGGG
GAAGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTGCAGCAACCAATGAATGCTCGG
GTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCAGAACATGCAAACCAGCATTTCTTTCTGAAGAAAAGTTGTAT
CAGGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAACCTAGGGAAATGACCTCAAGTGAAAAAGGGAAAGAAGCTGAT
ACAGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATTTCTGTAAAACATTTAGATGCT
TTAACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTAAAACCAGAAGAAAACTTATCT
CGAGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCCCAAGACCTGAAGGATTGCACTACCAGGAATCAGATGGAAAA
GCCCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAGACCAACTATCAAGATTCCTGG
GTTACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATGAATGTAAAGAAAAGTCATACCAAGAAGTATCTTTTGACCCA
GCAAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAATTCTCAGACAGAAAAGACCTT
CATCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAATCTGAAATAGCAACACAGGAACTAACTGGAGAGAAATTTCTA
GAAATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGGACATAGTGACTCAGAGAGGTTCCAGAGTCTTGGGATCCTTT
CTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGCAACAGAATGCCATCATTAGTCCTACTGTTCTAGAGACCAGT
GAAGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTCAGAGAAAGCCCTGGCAGTGAA
CAAACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCAACTCAGAATGTATTTACCCGG
CAACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGTTACGGAACATTGAAATGAGGACCAAACAGATTCAACCTTTG
GAGCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGATCTGACCACCTTGGTCAGTCAG
GAGCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCTCTAGAGAAAGATGCCAAGAAT
CTTCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTGGAAATAGAAAAGACTAAAGTG
TTAAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTTATTCTGAACAGCAAGGGATCT
AACAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATGAGGATTTGAAACAGCCCATGGCTGAAAGGAAAGCTCAGCTG
GATGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAATCGACAGATGCTGAGGCTTCTG
AATGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGCCATCTTCAACAAATGGAGCAG
GAAGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGA
GCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGAC
ATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAG
TTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAG
GAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTC
CTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAG
AAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGT
CACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACA
CCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAG
CAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTG
GAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCAC
AAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATT
GGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAAT
ATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTC
CTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAA
GTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACT
ACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAG
AGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCA
GGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATG
GTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTC
TGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAG
TTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAAT
TTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGC
CAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGC
CAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACT
TCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAA
ATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCT
GTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAG
TATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAAC
TCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCC
CAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTG
GTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACT
GTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAG
AAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAG
GAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACC
AGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAA
GCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCA
GCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTT
AAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTT
GCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAA
ATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAG
TCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTA
CTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAA
ACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAA
GATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAAT
GAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATC
CGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAG
AGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGT
TCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGG
AACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTC
CTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAG
ATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAG
GATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAG
GGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAG
GAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCA
GAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGAT
CCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAA
CATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCAT
TGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCT
GAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAA
GCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACT
GAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATT
TCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGG
CACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCT
CCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCC
CTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTC
AGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGA
AAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTA
GATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAG
TTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAA
CAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGC
CGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGT
GACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGAT
GGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGA
CCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAG
ATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCA
GTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTG
AATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTC
CATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCA
ATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAA
TCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAAT
CCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAAC
AGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGA
TTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTG
CCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCA

>In-frame_MACF1_ENST00000289893_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_13818nt
ATGCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGCCTCATTGCCCCTGAGACGGGT
GAAAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCCAGATGTACCAGCAGCTCCGGGAGCTACAGGATGCCCTGGCC
TTAATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATCAGTGAGACAGTTGGACTGAAA
ATCTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAAGAGGCTTTTCATCAAGGCCTC
ATTTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCAAGAATTTGATAGACCCTAACACAGCTGAGAAAATTGGTTTG
CTGGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAATTACTGCCTGTCAAACAATTGGCAGGGGGGATGGTGAGCTTG
AAATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTCCGGTTGCTGGAAGCTCAGCTT
TTTGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGGAAGAGGCTGTAAGACATAATCTGATTGACCAAGATATGGCC
TGTGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTGTCACGGGGCAAAGGCTAACAATAGATGAAGCAGTGAGCAAT
GATCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGGCCTGAATCTGGAGAGATCCTC
CCAATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCACATAAAATCCTTAGTAACCGACAGCATATTAAGGCTCTGTTT
CTACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTTGCCAATAACTTAAAATCGATT
TGTATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAACAAAATATTAATCCTGGAGCAGCAGTTCTACCGTGCAGCAAG
AGCCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGCTGATGACTCACAGCTATATTAATGTGCAAAATGGACAGAGG
CTGCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATGAGTATCAAACAAGTCCTCCAAAAGTGGTTGAAATTGGGCAT
CAAAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGTGGGTGGACTGTGAGGCTGCCT
GAGTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAAAAGACCACTGTAGAAACAGAA
GATTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAGAGAGAAATCCAAACATTGATGCTTTGAAGGTAATAAATAAA
GTCAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGAGAAAATGCCAGCAGGGGACAC
CTCCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTTGAAACACCAAAGAAAGAACAT
CAACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACACTCTTGAGACTGAATATATTCATGATGAAACTGGAGGATCT
CACATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTAAAGTCTGAAACTGATGGGAAT
GTTCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTAAGGATGACCATAAAGAAAGTCAAGAAGCACAGAACATCGCA
GGTGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGCAGTCATCCATTAGAATTGCTT
GAAGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTATCTTTCATGAACAAACAGGTCAAAAGCTCTTACTAAATGAA
GCAATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAGGGGTTCTTTGACTCTCAGACT
TGTGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATGAGAAATTATTACATAATGTCCTCATGGCAGACAAAGCTATA
AGTGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTTGACAAGGAAACAGCCACCAGA
ATTTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACTTTGGCCTCAACTCTTGGCTTG
GTGGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAAACAGTTAGGGAGAGATTAATT
AGTTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCCATTGACAGAGGTCTTTTGGAG
AGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTATCATTCACCATATATCTGGGATGAGACTTTCTGTTGATAAT
GCCTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATCCATCAGATTTTTAATCCTGAA
ACGAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTACCTCAGACCTGAAAAGAGAAATCCAGGAGGTTCAGGCCTTT
ACTGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTGTTAACTAATGAAGCAGTATTG
TCTCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTCAAGAAATGTAAGATTGATATT
GAATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTGCTTACATTGTCTCAAGCAATT
CAGCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATCATAGATACTGCTACTGGAAAA
AGACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACATGGTCAGAATTATTGCATCTCATCAGGTGTTAAATGGAGGA
ATTGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCTGAACTGGCAAATATGATCCAA
ATAGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCATTACAAAATGAATTTCTAGGA
AAGGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGATTATTTCAAGTTGAAAATCAG
TCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCCTTAAAGGAATTTGGGTGCAAG
GATCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTATCATAAATCCTCATAATCTTAAAGGTAAATCCTTGGGCCAA
GTGTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGAAATGATACAAATGAAGAGCAG
GAAAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTACCTCATGTCTAGATTCTGAAGAAATAAGAGAAAATCAAGGG
GAAGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTGCAGCAACCAATGAATGCTCGG
GTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCAGAACATGCAAACCAGCATTTCTTTCTGAAGAAAAGTTGTAT
CAGGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAACCTAGGGAAATGACCTCAAGTGAAAAAGGGAAAGAAGCTGAT
ACAGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATTTCTGTAAAACATTTAGATGCT
TTAACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTAAAACCAGAAGAAAACTTATCT
CGAGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCCCAAGACCTGAAGGATTGCACTACCAGGAATCAGATGGAAAA
GCCCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAGACCAACTATCAAGATTCCTGG
GTTACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATGAATGTAAAGAAAAGTCATACCAAGAAGTATCTTTTGACCCA
GCAAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAATTCTCAGACAGAAAAGACCTT
CATCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAATCTGAAATAGCAACACAGGAACTAACTGGAGAGAAATTTCTA
GAAATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGGACATAGTGACTCAGAGAGGTTCCAGAGTCTTGGGATCCTTT
CTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGCAACAGAATGCCATCATTAGTCCTACTGTTCTAGAGACCAGT
GAAGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTCAGAGAAAGCCCTGGCAGTGAA
CAAACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCAACTCAGAATGTATTTACCCGG
CAACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGTTACGGAACATTGAAATGAGGACCAAACAGATTCAACCTTTG
GAGCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGATCTGACCACCTTGGTCAGTCAG
GAGCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCTCTAGAGAAAGATGCCAAGAAT
CTTCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTGGAAATAGAAAAGACTAAAGTG
TTAAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTTATTCTGAACAGCAAGGGATCT
AACAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATGAGGATTTGAAACAGCCCATGGCTGAAAGGAAAGCTCAGCTG
GATGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAATCGACAGATGCTGAGGCTTCTG
AATGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGCCATCTTCAACAAATGGAGCAG
GAAGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGA
GCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGAC
ATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAG
TTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAG
GAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTC
CTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAG
AAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGT
CACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACA
CCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAG
CAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTG
GAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCAC
AAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATT
GGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAAT
ATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTC
CTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAA
GTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACT
ACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAG
AGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCA
GGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATG
GTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTC
TGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAG
TTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAAT
TTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGC
CAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGC
CAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACT
TCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAA
ATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCT
GTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAG
TATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAAC
TCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCC
CAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTG
GTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACT
GTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAG
AAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAG
GAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACC
AGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAA
GCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCA
GCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTT
AAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTT
GCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAA
ATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAG
TCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTA
CTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAA
ACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAA
GATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAAT
GAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATC
CGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAG
AGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGT
TCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGG
AACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTC
CTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAG
ATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAG
GATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAG
GGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAG
GAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCA
GAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGAT
CCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAA
CATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCAT
TGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCT
GAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAA
GCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACT
GAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATT
TCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGG
CACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCT
CCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCC
CTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTC
AGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGA
AAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTA
GATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAG
TTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAA
CAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGC
CGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGT
GACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGAT
GGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGA
CCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAG
ATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCA
GTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTG
AATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTC
CATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCA
ATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAA
TCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAAT
CCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAAC
AGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGA
TTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTG
CCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_MACF1_ENST00000545844_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_12538nt
GATGAAGAAACTGAGTCTCAGAGAGGTGAAGTGACTTGCCCAAGATCACAGCAATTATCACTTCTCCCTGGGCTCCCAGGCCCTCCTGCA
GCAGCCCCCGCCTGGGCCATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTCATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGA
TCTTACAGGAGCGAGCGGTCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTTGCCCTGGAACCTGCCACTGCATGAGCAGAAAAAG
CGGAAAAGCCAGGATTCGGTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGCTGATGAACGGGACCGGGTTCAGAAGAAAACGTTC
ACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCT
CTGTTGGAGGTCCTCTCAGGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGAC
TTCCTAAAGCAGCGACAGGTGAAACTAGTGAATATTCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGG
ACCATTATTTTGCATTTCCAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACC
CAGAAGGTGACAGCTGGTTACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCAC
CGATACCGACCCGATCTAGTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGA
CTGGGGGTCACTCGCCTGCTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTAT
GATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGAC
TCCCTCATTCCCTGGATCAAACAGCATACAATACTGATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAAC
CAATATATACACTTCAAAGAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGG
ATTGAATTTGGCCGAATTAAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAA
CGAGAGAAATCACTTCGGCCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAA
GAAAAACTGACACTAGCTAAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATT
ATGTACATTCAGGAGTGTGAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAG
CTGGCTTTTAGGGTCATGCGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCA
CTTGAATTGGTTCCACCCTCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGG
TTCCGAAAGCCTATGACTCGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCT
TGGGTAGAAGAGATGCAGATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCAC
ATCCATACGAGTGTAGAAGAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTAT
GCTGAAACTCTTGGAAAGCTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAA
TTTGTTTCCAGAGCTACAGCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAAT
ATCTCAGCCAAGAGAAATTACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAA
CTACTTTCACTTGAGAACCACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTG
TGCCTGTGTGTTGAGCAGCATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAAC
CTCCAAGATTCCATTAAACGAAAATATTCCTGTGACCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAA
AAGGAGCAGCTTATACAGTCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGAC
CATGTGTTAAAGAACACCATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTA
GAAGATAATTCTCAGCGGACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCA
CCCAATAAGGATGCCATTGAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACC
AAAAGCCTTATCTCTTGGAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGG
GAGTGCCATCAGATTATGAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGAT
CGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACT
GTGGCCAAGATGTACATTTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTA
GCCAGCTCTAGGACTGACAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTG
AGGTCAGACTTGGATGCAGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAA
CTGAATCTGCTGGTGGAGAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGT
AGCATACAGGATGCTGAACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAG
GCCCATTGGTCGACATTACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCC
AAGGTAGTGGCAGAGCAGATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAG
CGTTGGCACCGAGTCATTGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCAT
GGAACTCTCATCAAGTGGATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAG
CAGCTCAGCCAGCAGACGGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCT
ACTATTGTAAAGGACTATGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATG
CTTTCCTCTTCAGATGCCATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAA
TACATCAGTGATGCACTCCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTT
TTGGGCTGGGTGTCTACCCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATT
TTGGAACAGCAGGTTCTGTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAG
CATGGTCATAAGCTCTCAGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGT
TCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGACCCTGCAGAAACAACAAAATACCTGTCACCAG
CAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCT
TTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAG
GGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAG
GCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCA
GCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACC
AACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCC
CCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAG
TCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAA
CAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCAT
AAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTG
CTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGAC
ATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACT
GCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTG
CAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTT
GCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATT
GAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCT
GAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTT
GAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGAC
ATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTG
CAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCC
CAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGAT
CAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTG
GTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTA
CAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAA
TGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGT
CTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACA
GCACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGAT
CTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAG
GCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATG
GATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCT
CCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAG
GAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGC
TTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAAC
ATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCT
CAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAG
CTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCA
GAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACC
AGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAG
CAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAAC
AGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAA
GCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACAC
AGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAG
TTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAG
AAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTG
CAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCT
GACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAA
GAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTT
GAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAG
GAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCT
TCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAAC
AAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGT
GCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATA
GAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAAC
AAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAA
TTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAA
CAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTA
ATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAG
GTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCA
GATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAG
CGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAG
AAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATC
CTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCT
GTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCAC
CAGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCC
CGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAG
GTGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAG
CATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAA
CAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAG
GCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAG
GAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTC
ATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGAT
AAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGA
TCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCT
GGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGA
ATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCA
TTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCC
TTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATT
GTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCA
CGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGAC
CTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATT
TTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTAT
GAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGAT
CTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTT
CCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGT
TTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGA
AACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACT

>In-frame_MACF1_ENST00000567887_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_18884nt
GAAACTGAGGTACAGATAGGCAGGACTAGAACCTCTGCTTCCCAAGTCCCAGTGTTCCTTATGGGACCCCTTTTGTCTGCTCACATTCAC
CCCTTTCTCCTTCAGATCACTTCTCCCTGGGCTCCCAGGCCCTCCTGCAGCAGCCCCCGCCTGGGCCATGTCTTCCTCAGATGAAGAGAC
GCTCAGTGAGCGGTCATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGGTCGGGGAGCCTGTCTCCCTGTCC
CCCAGGGGACACCTTGCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCGGTGCTGGACCCTGCAGAGCGTGC
TGTGGTCAGAGTCGCTGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAGCA
CATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGCATCAAACTGGAGCCAGCAGG
GCTGAAGACCCTCCGTCTGGTGAGCATGCCCTCCTGGTGCCATACAAACAACGAGGAGCAGGCGGAGGAAGATGATGATGATGTACCCCG
GGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTGAAACTAGTGAATAT
TCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAGATCTCTGACATCTA
CATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTACACAGGAATCAAATG
CACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTAGACATGGAGAGGGT
GCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTGGATGCAGAAGATGT
GGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAAGG
GATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAACAGCATACAATACT
GATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAAACAGAAATTCTGGC
CAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAACTGCCTCAAGGTTA
TCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCGGCTGTGGAGAGGCT
GGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAGAATACACTGCAGGC
TGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAAGGTCTCATCAGGCA
GCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGTCTTCAGGATGAGCT
GGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCTACTTTAACCACCAC
TCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGGGCTGAACTTGTGGC
CATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATGAAACTGGAGCGAGC
AGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAGCTGGGCTCAAGTGT
CAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTGGAGACACAGTATTG
TAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCTGAGTTGATCTGGTT
GAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTACTTCTCTGAGTTGAC
AATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCACCCAGCCAAGCAGAC
AGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCATGTGAAAGAGAATAC
TGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGAAAATATTCCTGTGA
CCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCCAAGAGTTCCGTTGC
CAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATTTCTGTCAAGGCTGT
CTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACCAAATGGAAAGTGAT
CAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAGATGGCCAGCAGGGT
CGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAACTATCTGCGTAAAGA
CCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAGAACCTTCAGGCCCA
CTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGTAA
AGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCAGAGTTGAAGAACAT
CCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGAGATGCCTGGCAGGA
CAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTTTCTATGAAATGTGA
CAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAGATGGACCATGTCTA
TGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTCTTGGTCAAAGGTTA
TGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGGCACTGGCTTAGTGA
TGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATGAGTCGTCTGACACC
AGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCCCAGCTCGAGATTCG
CCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATTGAGGAAACCACTGC
CCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCCCTATTTGCAGAAAT
TGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAATTGCAACTGATGAC
ATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATCACTCAAGAGTTCAT
GGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGGCGTCTGGAGGAGGA
GGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTAGCGAGGAATACACA
AGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCAGAAGAGCTGACAAC
AAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAAAAAGAGAAGAAACA
AATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAGTT
GGCTCACCAGACAGAACAAAAGGAATGCAGAGCAGTTGCTGGGGTGATTGACCTAGGCACAGTGGAGATATTTCCCATCTTCAAAGCCAT
GCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGCCTCATTGCCCCTGAGACGGGTGA
AAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCCAGATGTACCAGCAGCTCCGGGAGCTACAGGATGCCCTGGCCTT
AATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATCAGTGAGACAGTTGGACTGAAAAT
CTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAAGAGGCTTTTCATCAAGGCCTCAT
TTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCAAGAATTTGATAGACCCTAACACAGCTGAGAAAATTGGTTTGCT
GGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAATTACTGCCTGTCAAACAATTGGCAGGGGGGATGGTGAGCTTGAA
ATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTCCGGTTGCTGGAAGCTCAGCTTTT
TGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGGAAGAGGCTGTAAGACATAATCTGATTGACCAAGATATGGCCTG
TGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTGTCACGGGGCAAAGGCTAACAATAGATGAAGCAGTGAGCAATGA
TCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGGCCTGAATCTGGAGAGATCCTCCC
AATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCACATAAAATCCTTAGTAACCGACAGCATATTAAGGCTCTGTTTCT
ACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTTGCCAATAACTTAAAATCGATTTG
TATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAACAAAATATTAATCCTGGAGCAGCAGTTCTACCGTGCAGCAAGAG
CCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGCTGATGACTCACAGCTATATTAATGTGCAAAATGGACAGAGGCT
GCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATGAGTATCAAACAAGTCCTCCAAAAGTGGTTGAAATTGGGCATCA
AAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGTGGGTGGACTGTGAGGCTGCCTGA
GTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAAAAGACCACTGTAGAAACAGAAGA
TTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAGAGAGAAATCCAAACATTGATGCTTTGAAGGTAATAAATAAAGT
CAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGAGAAAATGCCAGCAGGGGACACCT
CCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTTGAAACACCAAAGAAAGAACATCA
ACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACACTCTTGAGACTGAATATATTCATGATGAAACTGGAGGATCTCA
CATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTAAAGTCTGAAACTGATGGGAATGT
TCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTAAGGATGACCATAAAGAAAGTCAAGAAGCACAGAACATCGCAGG
TGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGCAGTCATCCATTAGAATTGCTTGA
AGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTATCTTTCATGAACAAACAGGTCAAAAGCTCTTACTAAATGAAGC
AATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAGGGGTTCTTTGACTCTCAGACTTG
TGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATGAGAAATTATTACATAATGTCCTCATGGCAGACAAAGCTATAAG
TGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTTGACAAGGAAACAGCCACCAGAAT
TTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACTTTGGCCTCAACTCTTGGCTTGGT
GGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAAACAGTTAGGGAGAGATTAATTAG
TTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCCATTGACAGAGGTCTTTTGGAGAG
AGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTATCATTCACCATATATCTGGGATGAGACTTTCTGTTGATAATGC
CTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATCCATCAGATTTTTAATCCTGAAAC
GAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTACCTCAGACCTGAAAAGAGAAATCCAGGAGGTTCAGGCCTTTAC
TGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTGTTAACTAATGAAGCAGTATTGTC
TCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTCAAGAAATGTAAGATTGATATTGA
ATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTGCTTACATTGTCTCAAGCAATTCA
GCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATCATAGATACTGCTACTGGAAAAAG
ACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACATGGTCAGAATTATTGCATCTCATCAGGTGTTAAATGGAGGAAT
TGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCTGAACTGGCAAATATGATCCAAAT
AGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCATTACAAAATGAATTTCTAGGAAA
GGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGATTATTTCAAGTTGAAAATCAGTC
TGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCCTTAAAGGAATTTGGGTGCAAGGA
TCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTATCATAAATCCTCATAATCTTAAAGGTAAATCCTTGGGCCAAGT
GTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGAAATGATACAAATGAAGAGCAGGA
AAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTACCTCATGTCTAGATTCTGAAGAAATAAGAGAAAATCAAGGGGA
AGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTGCAGCAACCAATGAATGCTCGGGT
GAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCAGAACATGCAAACCAGCATTTCTTTCTGAAGAAAAGTTGTATCA
GGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAACCTAGGGAAATGACCTCAAGTGAAAAAGGGAAAGAAGCTGATAC
AGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATTTCTGTAAAACATTTAGATGCTTT
AACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTAAAACCAGAAGAAAACTTATCTCG
AGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCCCAAGACCTGAAGGATTGCACTACCAGGAATCAGATGGAAAAGC
CCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAGACCAACTATCAAGATTCCTGGGT
TACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATGAATGTAAAGAAAAGTCATACCAAGAAGTATCTTTTGACCCAGC
AAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAATTCTCAGACAGAAAAGACCTTCA
TCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAATCTGAAATAGCAACACAGGAACTAACTGGAGAGAAATTTCTAGA
AATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGGACATAGTGACTCAGAGAGGTTCCAGAGTCTTGGGATCCTTTCT
TCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGCAACAGAATGCCATCATTAGTCCTACTGTTCTAGAGACCAGTGA
AGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTCAGAGAAAGCCCTGGCAGTGAACA
AACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCAACTCAGAATGTATTTACCCGGCA
ACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGTTACGGAACATTGAAATGAGGACCAAACAGATTCAACCTTTGGA
GCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGATCTGACCACCTTGGTCAGTCAGGA
GCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCTCTAGAGAAAGATGCCAAGAATCT
TCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTGGAAATAGAAAAGACTAAAGTGTT
AAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTTATTCTGAACAGCAAGGGATCTAA
CAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATGAGGATTTGAAACAGCCCATGGCTGAAAGGAAAGCTCAGCTGGA
TGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAATCGACAGATGCTGAGGCTTCTGAA
TGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGCCATCTTCAACAAATGGAGCAGGA
AGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGC
ACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACAT
TCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTT
GACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGA
AGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCT
GGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAA
AGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCA
CCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACC
TGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCA
GGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGA
GAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAA
AGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGG
AAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATAT
GCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCT
CTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGT
ACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTAC
AGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAG
TGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGG
AGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGT
GACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTG
TCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTT
CATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTT
GGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCA
GCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCA
GGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTC
TATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAAT
CAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCTGT
AGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTA
TGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTC
TGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCA
AGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGT
GACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGT
GGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAA
AGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGA
ATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAG
CCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGC
TATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGC
TATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAA
GGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGC
CCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAAT
GTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTC
TCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACT
TCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAAC
TGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGA
TTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGA
GGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCG
GGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAG
GCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTC
TCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAA
CTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCT
CGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGAT
GTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGA
TGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGG
GACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGA
ACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGA
GGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCC
TCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACA
TGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTG
TGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGA
GTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGC
AGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGA
ACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTC
TGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCA
CAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCTCC
TGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCCCT
ACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAG
TTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGAAA
GAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGA
TGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTT
CCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACA
GATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCG
TGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGA
CACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGG
AGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACC
TCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGAT
TCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGT
GAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAA
TATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCA
TATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAAT
CATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATC
TCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCC
ATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAG
GGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATT
AATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCC
AAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAA
AACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAA

>In-frame_MACF1_ENST00000372915_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_18391nt
TTTTGTCTGCTCACATTCACCCCTTTCTCCTTCAGATCACTTCTCCCTGGGCTCCCAGGCCCTCCTGCAGCAGCCCCCGCCTGGGCCATG
TCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTCATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGGTCG
GGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTTGCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCGGTG
CTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGCTGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCAC
TTAATGAAGGTCCGCAAGCACATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGC
ATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTG
AAACTAGTGAATATTCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAG
ATCTCTGACATCTACATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTAC
ACAGGAATCAAATGCACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTA
GACATGGAGAGGGTGCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTG
GATGCAGAAGATGTGGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCT
GAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAA
CAGCATACAATACTGATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAA
ACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAA
CTGCCTCAAGGTTATCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCG
GCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAG
AATACACTGCAGGCTGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAA
GGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGT
CTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCT
ACTTTAACCACCACTCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGG
GCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATG
AAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAG
CTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTG
GAGACACAGTATTGTAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCT
GAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTAC
TTCTCTGAGTTGACAATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCAC
CCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCAT
GTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGA
AAATATTCCTGTGACCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCC
AAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATT
TCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACC
AAATGGAAAGTGATCAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAG
ATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAAC
TATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAG
AACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAG
GTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCA
GAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGA
GATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTT
TCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAG
ATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTC
TTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGG
CACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATG
AGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCC
CAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATT
GAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCC
CTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAA
TTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATC
ACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGG
CGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTA
GCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCA
GAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAA
AAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAG
CTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGGAATGCAGAGCAGTTGCTGGGGTGATTGACCTAGGCACAGTGGAGATATTTCCC
ATCTTCAAAGCCATGCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGCCTCATTGCC
CCTGAGACGGGTGAAAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCCAGATGTACCAGCAGCTCCGGGAGCTACAG
GATGCCCTGGCCTTAATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATCAGTGAGACA
GTTGGACTGAAAATCTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAAGAGGCTTTT
CATCAAGGCCTCATTTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCAAGAATTTGATAGACCCTAACACAGCTGAG
AAAATTGGTTTGCTGGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAATTACTGCCTGTCAAACAATTGGCAGGGGGG
ATGGTGAGCTTGAAATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTCCGGTTGCTG
GAAGCTCAGCTTTTTGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGGAAGAGGCTGTAAGACATAATCTGATTGAC
CAAGATATGGCCTGTGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTGTCACGGGGCAAAGGCTAACAATAGATGAA
GCAGTGAGCAATGATCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGGCCTGAATCT
GGAGAGATCCTCCCAATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCACATAAAATCCTTAGTAACCGACAGCATATT
AAGGCTCTGTTTCTACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTTGCCAATAAC
TTAAAATCGATTTGTATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAACAAAATATTAATCCTGGAGCAGCAGTTCTA
CCGTGCAGCAAGAGCCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGCTGATGACTCACAGCTATATTAATGTGCAA
AATGGACAGAGGCTGCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATGAGTATCAAACAAGTCCTCCAAAAGTGGTT
GAAATTGGGCATCAAAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGTGGGTGGACT
GTGAGGCTGCCTGAGTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAAAAGACCACT
GTAGAAACAGAAGATTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAGAGAGAAATCCAAACATTGATGCTTTGAAG
GTAATAAATAAAGTCAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGAGAAAATGCC
AGCAGGGGACACCTCCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTTGAAACACCA
AAGAAAGAACATCAACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACACTCTTGAGACTGAATATATTCATGATGAA
ACTGGAGGATCTCACATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTAAAGTCTGAA
ACTGATGGGAATGTTCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTAAGGATGACCATAAAGAAAGTCAAGAAGCA
CAGAACATCGCAGGTGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGCAGTCATCCA
TTAGAATTGCTTGAAGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTATCTTTCATGAACAAACAGGTCAAAAGCTC
TTACTAAATGAAGCAATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAGGGGTTCTTT
GACTCTCAGACTTGTGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATGAGAAATTATTACATAATGTCCTCATGGCA
GACAAAGCTATAAGTGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTTGACAAGGAA
ACAGCCACCAGAATTTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACTTTGGCCTCA
ACTCTTGGCTTGGTGGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAAACAGTTAGG
GAGAGATTAATTAGTTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCCATTGACAGA
GGTCTTTTGGAGAGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTATCATTCACCATATATCTGGGATGAGACTT
TCTGTTGATAATGCCTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATCCATCAGATT
TTTAATCCTGAAACGAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTACCTCAGACCTGAAAAGAGAAATCCAGGAG
GTTCAGGCCTTTACTGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTGTTAACTAAT
GAAGCAGTATTGTCTCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTCAAGAAATGT
AAGATTGATATTGAATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTGCTTACATTG
TCTCAAGCAATTCAGCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATCATAGATACT
GCTACTGGAAAAAGACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACATGGTCAGAATTATTGCATCTCATCAGGTG
TTAAATGGAGGAATTGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCTGAACTGGCA
AATATGATCCAAATAGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCATTACAAAAT
GAATTTCTAGGAAAGGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGATTATTTCAA
GTTGAAAATCAGTCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCCTTAAAGGAA
TTTGGGTGCAAGGATCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTATCATAAATCCTCATAATCTTAAAGGTAAA
TCCTTGGGCCAAGTGTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGAAATGATACA
AATGAAGAGCAGGAAAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTACCTCATGTCTAGATTCTGAAGAAATAAGA
GAAAATCAAGGGGAAGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTGCAGCAACCA
ATGAATGCTCGGGTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCAGAACATGCAAACCAGCATTTCTTTCTGAA
GAAAAGTTGTATCAGGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAACCTAGGGAAATGACCTCAAGTGAAAAAGGG
AAAGAAGCTGATACAGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATTTCTGTAAAA
CATTTAGATGCTTTAACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTAAAACCAGAA
GAAAACTTATCTCGAGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCCCAAGACCTGAAGGATTGCACTACCAGGAA
TCAGATGGAAAAGCCCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAGACCAACTAT
CAAGATTCCTGGGTTACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATGAATGTAAAGAAAAGTCATACCAAGAAGTA
TCTTTTGACCCAGCAAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAATTCTCAGAC
AGAAAAGACCTTCATCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAATCTGAAATAGCAACACAGGAACTAACTGGA
GAGAAATTTCTAGAAATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGGACATAGTGACTCAGAGAGGTTCCAGAGTC
TTGGGATCCTTTCTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGCAACAGAATGCCATCATTAGTCCTACTGTT
CTAGAGACCAGTGAAGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTCAGAGAAAGC
CCTGGCAGTGAACAAACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCAACTCAGAAT
GTATTTACCCGGCAACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGTTACGGAACATTGAAATGAGGACCAAACAG
ATTCAACCTTTGGAGCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGATCTGACCACC
TTGGTCAGTCAGGAGCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCTCTAGAGAAA
GATGCCAAGAATCTTCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTGGAAATAGAA
AAGACTAAAGTGTTAAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTTATTCTGAAC
AGCAAGGGATCTAACAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATGAGGATTTGAAACAGCCCATGGCTGAAAGG
AAAGCTCAGCTGGATGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAATCGACAGATG
CTGAGGCTTCTGAATGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGCCATCTTCAA
CAAATGGAGCAGGAAGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGA
CAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGAT
TTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTG
AGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAG
AAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAG
ATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGA
GCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATG
ATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGC
CACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAG
GCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCC
GAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGAT
GTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAA
CCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGA
TCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAAC
GTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTG
GCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCAT
GTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATT
GCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCA
TCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCC
ACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGG
TTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGT
AAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATC
CAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCG
CTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGAT
GCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCA
CCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACT
CTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGTTCC
ATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCAGAT
GTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCAC
AAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAA
ACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTG
GCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCC
ACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCG
TGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAG
TTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTC
TCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGC
CAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTG
AGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTA
GACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGT
TTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAG
CAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTG
GAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAA
GGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAG
CTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTG
CCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAG
GCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGAT
GAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAA
GAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTT
GATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTA
GACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCC
CAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGC
CGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAG
TCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATG
CTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGG
AAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCA
GCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAA
GAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTA
CAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAA
GCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAA
CCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTA
GACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAA
AGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACA
GCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAG
CAGATCATTCGGCACAAGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTA
AAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCC
AAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTG
GAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAG
GTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTG
GATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAG
AGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTA
CCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAAT
CGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGA
TCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAA
GCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCT
ATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATT
GCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAA
GACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCC
ATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTG
TATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCA
GATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTC
TTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCT
GGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCAC
TGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAAT

>In-frame_MACF1_ENST00000361689_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_12482nt
ATCACTTCTCCCTGGGCTCCCAGGCCCTCCTGCAGCAGCCCCCGCCTGGGCCATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTC
ATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGGTCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTT
GCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCGGTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGC
TGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTA
TGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTT
TCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTGAAACTAGTGAATATTCGCAATGATGACATCACAGA
TGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGA
TATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTG
GAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGA
GAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGA
AAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGA
CTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAACAGCATACAATACTGATGTCAGATAAAACTTTTCC
CCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAG
AATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGA
AGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGC
AAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATC
AGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGAT
CCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTG
TACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTT
AACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGA
AGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCC
TAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGA
GGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAG
CTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGA
ACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACA
GGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGC
TGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAG
TGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGAAAATATTCCTGTGACCACAACACCAGCTTATCCCG
CCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAA
AACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGA
GATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGC
AATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGT
TATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTG
GAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGA
TAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGAT
GAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTA
TGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGA
GCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCC
ATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCT
GAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGA
AGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGT
GTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGA
GCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTAT
CCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCC
AGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACT
GGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATC
GCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACAC
GGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGA
GAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGA
GACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGA
AGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGC
CCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAA
GACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCA
CCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGC
CACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCG
GGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTC
CGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAAC
TTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGA
CACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCT
GTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACA
GATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACT
TCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAA
GGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAG
ATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAA
GGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCA
GTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGT
TGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAA
ACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTACAGATTCCATACT
CAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAG
CCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGA
AGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCAT
GGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCA
AGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAA
AAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGA
CCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAG
GGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGA
TGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAA
AGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGG
TACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGT
AGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGG
GGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTG
GCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAA
CAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAA
CTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAG
GCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGAT
GGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACG
CAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAA
AGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAG
CACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCA
ACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGAC
ACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCA
AGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTT
GAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGA
GAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACC
TCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACA
ATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAA
GATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCG
CCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGC
TGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTT
CCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAG
CAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGG
TCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCA
AAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATT
GGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATT
CCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTT
GTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACT
GACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTG
GGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAA
ATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGA
GATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCA
AGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGT
GAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAG
AATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAA
GGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATC
TGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGA
AGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGG
TGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGC
TCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGT
AAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGA
TCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGAC
TCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTA
TGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTT
TCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGA
GCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACA
AAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCAC
AGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAG
GAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCA
GATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAA
TGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTT
CATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGAC
CAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGA
CCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGG
GTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCA
GTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAAT
TTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTG
CCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCG
CAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCA
GGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACAT

>In-frame_MACF1_ENST00000539005_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_12092nt
ATCACTTCTCCCTGGGCTCCCAGGCCCTCCTGCAGCAGCCCCCGCCTGGGCCATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTC
ATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGGTCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTT
GCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCGGTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGC
TGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTA
TGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTT
TCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTGAAACTAGTGAATATTCGCAATGATGACATCACAGA
TGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGA
TATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTG
GAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGA
GAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGA
AAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGA
CTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAACAGCATACAATACTGATGTCAGATAAAACTTTTCC
CCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAG
AATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGA
AGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGC
AAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATC
AGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGAT
CCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTG
TACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTT
AACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGA
AGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCC
TAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGA
GGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAG
CTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGA
ACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACA
GGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGC
TGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAG
TGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGAAAATATTCCTGTGACCACAACACCAGCTTATCCCG
CCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAA
AACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGA
GATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGC
AATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGT
TATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTG
GAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGA
TAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGAT
GAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTA
TGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGA
GCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCC
ATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCT
GAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGA
AGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGT
GTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGA
GCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTAT
CCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCC
AGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACT
GGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATC
GCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACAC
GGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGA
GAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGA
GACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGA
AGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGC
CCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAA
GACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCA
CCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGC
CACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCG
GGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTC
CGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAAC
TTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGA
CACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCT
GTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACA
GATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACT
TCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAA
GGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAG
ATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAA
GGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCA
GTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGT
TGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAA
ACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTACAGATTCCATACT
CAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAG
CCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGA
AGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCAT
GGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCA
AGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAA
AAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGA
CCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAG
GGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGA
TGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAA
AGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGG
TACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGATCTGACGGAGATCCAGTGTGACATGTCAGA
TGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCA
CAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGA
AACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCT
GGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGC
CACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCC
GTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCA
GTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGT
CTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAG
CCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCT
GAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTT
AGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCG
TTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCA
GCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATT
GGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGA
AGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGA
GCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGT
GCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAA
GGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGA
TGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGA
AGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTT
TGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGT
AGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGC
CCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTG
CCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCA
GTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATAT
GCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGG
GAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGC
AGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAA
AGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGT
ACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGA
AGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAA
ACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGT
AGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGA
AAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGAC
AGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCA
GCAGATCATTCGGCACAAGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCT
AAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTC
CAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGT
GGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGA
GGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCT
GGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCA
GAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATT
ACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAA
TCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGG
ATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACA
AGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGC
TATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATAT
TGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGA
AGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATC
CATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCT
GTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCC
AGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACT
CTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGC
TGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCA
CTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAA

>In-frame_MACF1_ENST00000317713_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_12482nt
ATCACTTCTCCCTGGGCTCCCAGGCCCTCCTGCAGCAGCCCCCGCCTGGGCCATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTC
ATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGGTCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTT
GCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCGGTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGC
TGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTA
TGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTT
TCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTGAAACTAGTGAATATTCGCAATGATGACATCACAGA
TGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGA
TATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTG
GAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGA
GAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGA
AAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGA
CTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAACAGCATACAATACTGATGTCAGATAAAACTTTTCC
CCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAG
AATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGA
AGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGC
AAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATC
AGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGAT
CCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTG
TACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTT
AACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGA
AGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCC
TAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGA
GGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAG
CTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGA
ACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACA
GGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGC
TGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAG
TGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGAAAATATTCCTGTGACCACAACACCAGCTTATCCCG
CCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAA
AACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGA
GATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGC
AATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGT
TATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTG
GAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGA
TAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGAT
GAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTA
TGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGA
GCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCC
ATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCT
GAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGA
AGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGT
GTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGA
GCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTAT
CCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCC
AGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACT
GGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATC
GCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACAC
GGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGA
GAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGA
GACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGA
AGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGC
CCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAA
GACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCA
CCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGC
CACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCG
GGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTC
CGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAAC
TTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGA
CACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCT
GTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACA
GATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACT
TCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAA
GGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAG
ATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAA
GGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCA
GTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGT
TGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAA
ACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTACAGATTCCATACT
CAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAG
CCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGA
AGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCAT
GGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCA
AGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAA
AAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGA
CCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAG
GGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGA
TGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAA
AGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGG
TACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGT
AGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGG
GGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTG
GCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAA
CAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAA
CTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAG
GCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGAT
GGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACG
CAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAA
AGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAG
CACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCA
ACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGAC
ACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCA
AGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTT
GAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGA
GAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACC
TCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACA
ATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAA
GATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCG
CCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGC
TGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTT
CCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAG
CAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGG
TCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCA
AAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATT
GGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATT
CCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTT
GTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACT
GACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTG
GGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAA
ATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGA
GATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCA
AGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGT
GAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAG
AATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAA
GGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATC
TGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGA
AGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGG
TGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGC
TCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGT
AAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGA
TCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGAC
TCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTA
TGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTT
TCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGA
GCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACA
AAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCAC
AGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAG
GAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCA
GATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAA
TGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTT
CATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGAC
CAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGA
CCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGG
GTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCA
GTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAAT
TTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTG
CCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCG
CAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCA
GGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACAT

>In-frame_MACF1_ENST00000564288_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_19393nt
GGGATTACAGCCATGAACCACTGCGCCCAGCCAGACGGATTTTTTTAACCCTTGAGAAGTACCCCCTAAATGAGCAGTTTGCTCTCCTCG
CTGATCTTCATCACACCTAGATGTCAGGTCTGCTTCATGGGAGCTTGCTCTGTATGTATCCTCCCTGGACTGATGTTCAGGCTCCTTGCT
TCTCCTCCCGGGTTGTGGGTATGGAGGGTTTGCCCTCTGACAACTCCAGGGTACTTGTGGTGCTCATACATCCTCATGTACTTTGCTTTC
TCCCCGCAAGAGGTTCCCTAATGCTTCTGTGACTTTTTTCTTCTGGCTACATCCTGAAGTCTGGCCTTGCAGGCAGGCTGGGAATGGAAA
GTTAAGAGTGTGACGTCCTCTGACACCCTCCCTTCTTGTAGAAGGGTCTGAGGTTTGTTTATTTAAGCTGAGCAGAGGATGCCAAAGATA
GAGGTTTGAGTCAGCTTGACACTGGCTTAGGCGCTCCTTTTCACTCTCCTTGTTCCTTCTTCCCTTTCCCCTCCCCCGCTGGCCAGTTGT
TTCCTGGGCTTTGTCTGAGATACACTGTACAGTTTTAGTCCCAGTCTACTAGCGCCTGCTGAAAAACAGTCAGAAGTGAGATGGAGGAGA
AGCTGCCAGGAAGTTTCTGACAACACTAAGCTCCGGCCTCTGCCTCTGCTGATAGTACAGGACAACAGTAACCTCAGGAGAAAGGCATCC
AGAGGCCTGCGCTGAGCTTGTGGCTAACTCAAGGGAGGAGAAAGGACGGGCCTGGAAATGCCCCTCTTAGATTCATCTTATTTACCACCA
ACCATCTTTATTTTGACTCACGTTCTTGGAGTTGCTGGTGTTCTATACTGGAAGAGGCATGCCAGAGGTAGAGCAGATGAACGGGACCGG
GTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTATGAAGATCTGCGGGAT
GGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGCATCAAACTGGAGCCAGCAGGGCTGAAGACCCTCCGTCTGGTGAGCATGCCC
TCCTGGTGCCATACAAACAACGAGGAGCAGGCGGAGGAAGATGATGATGATGTACCCCGGGAGAAGGGCAGGATGCGTTTTCATAGGCTG
CAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTGAAACTAGTGAATATTCGCAATGATGACATCACAGATGGCAACCCC
AAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGATATGTCAGCC
AAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTGGAGTGATGGG
AAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGAGAATCTGGAA
CAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGAAAAGTCTGTA
ATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGACTCCAGGTGG
CAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAACAGCATACAATACTGATGTCAGATAAAACTTTTCCCCAAAACCCT
GTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAA
TTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGAAGAGTGGGGA
AAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGCAAACAAAATC
CAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATCAGGACAACCG
GTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGATCCTGCGGGAT
GAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTGTACAAACCTG
TACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTTAACCAAGGCA
ACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGAAGGCAATCTC
CGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCCTAGTGTGGAG
TTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGAGGGAAAGATG
TCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAGCTTCCGGATG
AGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGAACTAGCATAT
GACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACAGGATGTGTTT
CGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCC
CAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAGTGATGCACGA
GAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGAAAATATTCCTGTGACCACAACACCAGCTTATCCCGCCTTGAAGAC
CTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAAAACCATCGTT
CAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGAGATTACTATT
TGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGCAATGGTGCCG
TCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGTTATGGCCCTT
TGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAA
AAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGAC
TCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATG
GAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGG
GTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCAC
ACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCA
AGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTA
AAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTA
CTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTC
CTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAG
GAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTT
CTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCA
GAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGT
CAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAA
TCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTG
ACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAA
CATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAA
TCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAA
ACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAG
GCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGGAATGCAGA
GCAGTTGCTGGGGTGATTGACCTAGGCACAGTGGAGATATTTCCCATCTTCAAAGCCATGCAAAAGGGCCTCCTTGACCAAGACACAGGC
CTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGCCTCATTGCCCCTGAGACGGGTGAAAACCTCTCTTTGGAGGAGGGCATAGCCAGA
AACCTCATTAATCCCCAGATGTACCAGCAGCTCCGGGAGCTACAGGATGCCCTGGCCTTAATAAGCAGGCTTACTGAGAGCAGAGGCCCT
CTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATCAGTGAGACAGTTGGACTGAAAATCTTAGAAGCTCACCTGGCAACTGGAGGTTTC
AGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAAGAGGCTTTTCATCAAGGCCTCATTTCTGCATGGCTTCATTCAGTATTAGAGTCT
TATCTTAGAACATCCAAGAATTTGATAGACCCTAACACAGCTGAGAAAATTGGTTTGCTGGATCTGATGCAGCGATGTATTGTCCACCAG
GAATCAGGATTCAAATTACTGCCTGTCAAACAATTGGCAGGGGGGATGGTGAGCTTGAAATCAGGCCGGAAGGTTAGCATTTTCCGTGCA
GTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTCCGGTTGCTGGAAGCTCAGCTTTTTGCTGGTGGCATAGTAGATCCAAGAACAGGA
CACAGACTTACAGTGGAAGAGGCTGTAAGACATAATCTGATTGACCAAGATATGGCCTGTGCTATCCTCATAAGGCAGCTTCAGACAGGA
GGCATCATAGACACTGTCACGGGGCAAAGGCTAACAATAGATGAAGCAGTGAGCAATGATCTAGTAGCTGCTAAGATCGCCCTTGTGATT
CTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGGCCTGAATCTGGAGAGATCCTCCCAATTACAGATGCCCTAGAACAAGGTATTGTG
TCTACTGAACTAGCACATAAAATCCTTAGTAACCGACAGCATATTAAGGCTCTGTTTCTACCAGCAACCACAGAGATTTTGTCCTGGAAG
AAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTTGCCAATAACTTAAAATCGATTTGTATACCTGATGTGATGCCCCACATGCAACTA
GCAGACTCTGCAGAACAAAATATTAATCCTGGAGCAGCAGTTCTACCGTGCAGCAAGAGCCACCCTAAGGCCACAGCAAGCCAGAGTGAG
AATCTGTTGTTCCAGCTGATGACTCACAGCTATATTAATGTGCAAAATGGACAGAGGCTGCTTCTGTTAGATAAAGAGCTGATGGAGACA
CTAACATCCAGAGATGAGTATCAAACAAGTCCTCCAAAAGTGGTTGAAATTGGGCATCAAAGGCAAAAAACTCCTGAGGGATTGCAAGAA
TCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGTGGGTGGACTGTGAGGCTGCCTGAGTTCCAGTTTTCTTCTCAGAACAAAGAATAT
CCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAAAAGACCACTGTAGAAACAGAAGATTCTTCTGTAGAGAACCCTGAACAGGATCTG
TTTGTAGAACAAAAAGAGAGAAATCCAAACATTGATGCTTTGAAGGTAATAAATAAAGTCAAATTAGAGGTACAAAGGCAGTTGATAGGT
ACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGAGAAAATGCCAGCAGGGGACACCTCCTGACCATACCTCCTGCTGAGGCGGAAGGT
GTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTTGAAACACCAAAGAAAGAACATCAACCTCTAAGAAACACTTCCTTTACATGTCAG
AATGAACAAGCACACACTCTTGAGACTGAATATATTCATGATGAAACTGGAGGATCTCACATAAAACCCCAAAGCAAAAAGTTACAAGTT
CAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTAAAGTCTGAAACTGATGGGAATGTTCATCCTCTGGACAAAAAGGAAATGTTAAAG
AAAACATTTCTGGCTAAGGATGACCATAAAGAAAGTCAAGAAGCACAGAACATCGCAGGTGGTAGTATGATGATGTCAGAAAAGACCGAT
GAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGCAGTCATCCATTAGAATTGCTTGAAGAAGCTACCTTAAATGTATTATCTGCACAG
TTACTAGATGGTGGTATCTTTCATGAACAAACAGGTCAAAAGCTCTTACTAAATGAAGCAATATCCCGAGGCATTGTGCCAAGTCACACT
GCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAGGGGTTCTTTGACTCTCAGACTTGTGAGTCTTTGACAACTGAAGAAGTCATTAAT
GAAGGTCTGATGGATGAGAAATTATTACATAATGTCCTCATGGCAGACAAAGCTATAAGTGGTGTCTTAGACCCCCGTACCCAGACACTG
TGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTTGACAAGGAAACAGCCACCAGAATTTTAGAGAGGCAGGTGGTGACTGGTGGAATT
ATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACTTTGGCCTCAACTCTTGGCTTGGTGGACGTTGCTGACCAGCCAGAACTTATAAAT
CTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAAACAGTTAGGGAGAGATTAATTAGTTTACAAATGGAAACAACAGGACTTATAGAC
CCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCCATTGACAGAGGTCTTTTGGAGAGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAA
GTGGTAGATGGAGGTATCATTCACCATATATCTGGGATGAGACTTTCTGTTGATAATGCCTTCAGACATGGCTTAATTGGTGAAGATTTA
GCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATCCATCAGATTTTTAATCCTGAAACGAAGGAAAATATTTCCCTCCCTAAAGCCATA
AAATTAGATCTTATTACCTCAGACCTGAAAAGAGAAATCCAGGAGGTTCAGGCCTTTACTGGAAACTTTGTGGATCTCATTTCTGGTCAG
AGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTGTTAACTAATGAAGCAGTATTGTCTCCAGGAATGATGCATGGCATTGTAGATCCC
GAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTCAAGAAATGTAAGATTGATATTGAATCTGGACAGAGATATCTAGAAGTAATTCCC
TTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTGCTTACATTGTCTCAAGCAATTCAGCTTGGAAAAGTAGACTTTGCATCTACGCTG
AAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATCATAGATACTGCTACTGGAAAAAGACTGACATTGGCATCAGCTTTGGAAGAGAAA
CTGGTGGATGAAAACATGGTCAGAATTATTGCATCTCATCAGGTGTTAAATGGAGGAATTGTTGACATATTTAGTGATCAGAGAGTGACT
TTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCTGAACTGGCAAATATGATCCAAATAGATAGTTCAGAGTTCAGCGATCACAGGGCT
CAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCATTACAAAATGAATTTCTAGGAAAGGATATGTTAATTGCTTGTAATCAGACTGCT
GAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGATTATTTCAAGTTGAAAATCAGTCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCT
GATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCCTTAAAGGAATTTGGGTGCAAGGATCAACGTAAGCCAAGAATGTCTTCAGATGCT
AAAGAATTTATCAGTATCATAAATCCTCATAATCTTAAAGGTAAATCCTTGGGCCAAGTGTCATTGACACACCCTTACTCTGAATGTGAT
TTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGAAATGATACAAATGAAGAGCAGGAAAAAGCAGTGACAAAAATAGAAATTATTTCT
CATATGAAGCAGTCTACCTCATGTCTAGATTCTGAAGAAATAAGAGAAAATCAAGGGGAAGTGATTTTGGAAGTACAAGAAACATATTGT
GAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTGCAGCAACCAATGAATGCTCGGGTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATT
GTAGAAGAAAGTATCAGAACATGCAAACCAGCATTTCTTTCTGAAGAAAAGTTGTATCAGGAAACTGCCATTAGAGATGAGCATGACTCC
CATATAAAGAGCCAACCTAGGGAAATGACCTCAAGTGAAAAAGGGAAAGAAGCTGATACAGAAATGGGATTTTCTATTACTTTTAAAATT
GAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATTTCTGTAAAACATTTAGATGCTTTAACACTCTTCAGCTCTAAACAGGCCAATGAA
GGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTAAAACCAGAAGAAAACTTATCTCGAGAAATTGCCTGTGGGGCCCAGAGTGAACCA
TTCCCTTGTATGACCCCAAGACCTGAAGGATTGCACTACCAGGAATCAGATGGAAAAGCCCAAGTGACAGGCCCATCCCAAATTTCCAAA
ACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAGACCAACTATCAAGATTCCTGGGTTACTTCGAAAACTAAGGAAACCAAACATCAA
ATTTCCTCATCTAATGAATGTAAAGAAAAGTCATACCAAGAAGTATCTTTTGACCCAGCAAGAGGTCTTAAATTGGAAGAAATCACAGTT
TCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAATTCTCAGACAGAAAAGACCTTCATCATCAGGGCAGCAAAAGTGATGATAAACTT
TGTGGAACTCTCAAATCTGAAATAGCAACACAGGAACTAACTGGAGAGAAATTTCTAGAAATGGCAAACCCTAATGTTGCAGGTCTAGAA
GCAGGATCCATTGAGGACATAGTGACTCAGAGAGGTTCCAGAGTCTTGGGATCCTTTCTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAA
AAAGAGAATACAGGGCAACAGAATGCCATCATTAGTCCTACTGTTCTAGAGACCAGTGAAGAAAAGACAGTGTCCCTAACAGTATGCTCT
GCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTCAGAGAAAGCCCTGGCAGTGAACAAACTCCCTTCATGACTGCACCTGAAGGAAAG
GGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCAACTCAGAATGTATTTACCCGGCAACTCTGTTTAGAACATGATGAAAAGCTAGTA
TCCTATCTGTCTCTGTTACGGAACATTGAAATGAGGACCAAACAGATTCAACCTTTGGAGCTAAACCTGGCAGAACTACAGGATCTGCTG
TGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGATCTGACCACCTTGGTCAGTCAGGAGCTGGAGTGTGTGAATCAGATTATCATCAGC
CAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCTCTAGAGAAAGATGCCAAGAATCTTCAGAAGTCTCTCAGCTCTGTGAGTGACACT
TGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTGGAAATAGAAAAGACTAAAGTGTTAAATCAGCACACACAGCTAGAAGGCCGACTT
CAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTTATTCTGAACAGCAAGGGATCTAACAGTGAAATAGATGTTGACAGCCTGAACCTC
TGCCTCCAACAGTATGAGGATTTGAAACAGCCCATGGCTGAAAGGAAAGCTCAGCTGGATGCTCTTGCTTTTGATATTCAGTTCTTTATC
TCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAATCGACAGATGCTGAGGCTTCTGAATGAACTGCAGAGGTCCTTCCAGGACATTTTG
GAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGCCATCTTCAACAAATGGAGCAGGAAGCCCTGGTGAAGACCCTGCAGAAACAACAA
AATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAG
CAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTT
GTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCT
AAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACT
GAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGT
GGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATG
GGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTC
ATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTG
GGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAA
TTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAG
ACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGA
CAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCA
ACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAAC
AGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTT
CTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGT
GACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTC
TCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAG
TCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATG
AAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACT
ACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTA
AAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCT
GGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGAT
ACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAA
GACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTC
AGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATT
GAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTC
ATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATAC
CACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGC
CAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAA
GTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAG
TTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAAT
TGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCA
AGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTG
TCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAA
CTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAAT
CAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTG
CTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAG
CAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCA
GTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCA
GCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGAT
AAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAA
AGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGG
ACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGT
ATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTC
ACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATA
TTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATG
GATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAAT
ATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAG
CTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCA
GATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGT
GTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAG
CTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTC
CTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAG
CTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAG
GACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTG
GAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGA
CTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAAT
ACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTG
CTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAA
CAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAG
CTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAA
CAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTT
GCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCAT
GCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATA
GACTCATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTG
TTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGAT
GTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGT
CAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACA
GTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGG
CTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAA
TTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCC
AGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGAT
GCTGCTATTCAGAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCC
CCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCA
GAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGA
ATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCT
CAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAG
CCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAA
CTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATA
TTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAG
TTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTT
GGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGA
TACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGAT
GAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCC
TTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCG
TTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAA

>In-frame_MACF1_ENST00000289893_chr1_39896580_+_BRAF_ENST00000288602_chr7_140487384_-_14067nt
GGCTCTGATTCAGTTTTCTTTTTCTTCTCTTTTCCTTTTTTTTTTTTTTTTTTTTTTTTTTTTAGGAATGCAGAGCAGTTGCTGGGGTGA
TTGACCTAGGCACAGTGGAGATATTTCCCATCTTCAAAGCCATGCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAAT
CTCAGGTTATCATGTCTGGCCTCATTGCCCCTGAGACGGGTGAAAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCC
AGATGTACCAGCAGCTCCGGGAGCTACAGGATGCCCTGGCCTTAATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAG
CAATTGAAAAGAGAATAATCAGTGAGACAGTTGGACTGAAAATCTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTG
AGAACTGTATTAACCTGGAAGAGGCTTTTCATCAAGGCCTCATTTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCA
AGAATTTGATAGACCCTAACACAGCTGAGAAAATTGGTTTGCTGGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAAT
TACTGCCTGTCAAACAATTGGCAGGGGGGATGGTGAGCTTGAAATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAA
TAGATAGGCAGGTCACTGTCCGGTTGCTGGAAGCTCAGCTTTTTGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGG
AAGAGGCTGTAAGACATAATCTGATTGACCAAGATATGGCCTGTGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTG
TCACGGGGCAAAGGCTAACAATAGATGAAGCAGTGAGCAATGATCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGT
CATTCATGGGGTTGCTGTGGCCTGAATCTGGAGAGATCCTCCCAATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCAC
ATAAAATCCTTAGTAACCGACAGCATATTAAGGCTCTGTTTCTACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTG
GTATCCTGGATAGAGATCTTGCCAATAACTTAAAATCGATTTGTATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAAC
AAAATATTAATCCTGGAGCAGCAGTTCTACCGTGCAGCAAGAGCCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGC
TGATGACTCACAGCTATATTAATGTGCAAAATGGACAGAGGCTGCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATG
AGTATCAAACAAGTCCTCCAAAAGTGGTTGAAATTGGGCATCAAAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAA
TCTCAGGAACTTTCAGCAGTGGGTGGACTGTGAGGCTGCCTGAGTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATT
GCACTACAGAAAAAGGCAAAAAGACCACTGTAGAAACAGAAGATTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAG
AGAGAAATCCAAACATTGATGCTTTGAAGGTAATAAATAAAGTCAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACC
AAACAGCAGTGTCTGTCAGAGAAAATGCCAGCAGGGGACACCTCCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTG
ACAAAGATGTTTTTTCTGTTGAAACACCAAAGAAAGAACATCAACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACA
CTCTTGAGACTGAATATATTCATGATGAAACTGGAGGATCTCACATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTC
TAGGTATAAAGTTAGAACTAAAGTCTGAAACTGATGGGAATGTTCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTA
AGGATGACCATAAAGAAAGTCAAGAAGCACAGAACATCGCAGGTGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCA
GGGAAATTTTTCTGTCATGCAGTCATCCATTAGAATTGCTTGAAGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTA
TCTTTCATGAACAAACAGGTCAAAAGCTCTTACTAAATGAAGCAATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGG
AGAAGCTGAACATGTTTCAGGGGTTCTTTGACTCTCAGACTTGTGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATG
AGAAATTATTACATAATGTCCTCATGGCAGACAAAGCTATAAGTGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATG
CAGTTACAGTTGGACTTCTTGACAAGGAAACAGCCACCAGAATTTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAG
GCAAAAAAGTTTCAGTAACTTTGGCCTCAACTCTTGGCTTGGTGGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCA
AAGGTAGAGATGCTGAAAAAACAGTTAGGGAGAGATTAATTAGTTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCAC
CTTTAACAGTTGTGCAGTCCATTGACAGAGGTCTTTTGGAGAGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTA
TCATTCACCATATATCTGGGATGAGACTTTCTGTTGATAATGCCTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAA
GAGTTGAGAACTTAAACATCCATCAGATTTTTAATCCTGAAACGAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTA
CCTCAGACCTGAAAAGAGAAATCCAGGAGGTTCAGGCCTTTACTGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAG
AAGCTAAAAAAGAAGGACTGTTAACTAATGAAGCAGTATTGTCTCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTG
TCCCCTACTCAGAATTAGTCAAGAAATGTAAGATTGATATTGAATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAG
ATGGGGTGAGCGACAAAGTGCTTACATTGTCTCAAGCAATTCAGCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCC
AGGCAAATACTGGTGGAATCATAGATACTGCTACTGGAAAAAGACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACA
TGGTCAGAATTATTGCATCTCATCAGGTGTTAAATGGAGGAATTGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTG
AGAAAAGACTGATCAGCCCTGAACTGGCAAATATGATCCAAATAGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAG
AAGGGATTGAAGTGTGTGCATTACAAAATGAATTTCTAGGAAAGGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATA
AAGTAGAAGAGAGTGAGAGATTATTTCAAGTTGAAAATCAGTCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAA
AAAAGAGCAGGGAAATTTCCTTAAAGGAATTTGGGTGCAAGGATCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTA
TCATAAATCCTCATAATCTTAAAGGTAAATCCTTGGGCCAAGTGTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAG
TGGCTAGAAATAACATGGGAAATGATACAAATGAAGAGCAGGAAAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTA
CCTCATGTCTAGATTCTGAAGAAATAAGAGAAAATCAAGGGGAAGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAAT
TGCCGAGTGAGCAGGTTTTGCAGCAACCAATGAATGCTCGGGTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCA
GAACATGCAAACCAGCATTTCTTTCTGAAGAAAAGTTGTATCAGGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAAC
CTAGGGAAATGACCTCAAGTGAAAAAGGGAAAGAAGCTGATACAGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCC
AAGTGGTACCTCAAGGAATTTCTGTAAAACATTTAGATGCTTTAACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATT
TAAGTCTCTGCTTGACTTTAAAACCAGAAGAAAACTTATCTCGAGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCC
CAAGACCTGAAGGATTGCACTACCAGGAATCAGATGGAAAAGCCCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCC
AAGGAACCACCAGACAGGAGACCAACTATCAAGATTCCTGGGTTACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATG
AATGTAAAGAAAAGTCATACCAAGAAGTATCTTTTGACCCAGCAAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAA
AAGAAGTCAGGTATCTAGAATTCTCAGACAGAAAAGACCTTCATCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAAT
CTGAAATAGCAACACAGGAACTAACTGGAGAGAAATTTCTAGAAATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGG
ACATAGTGACTCAGAGAGGTTCCAGAGTCTTGGGATCCTTTCTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGC
AACAGAATGCCATCATTAGTCCTACTGTTCTAGAGACCAGTGAAGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGA
AGACACCACAGGAAAAGCTCAGAGAAAGCCCTGGCAGTGAACAAACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAA
ACCCAGAGCCCTTCAGAGCAACTCAGAATGTATTTACCCGGCAACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGT
TACGGAACATTGAAATGAGGACCAAACAGATTCAACCTTTGGAGCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTAT
TAGAAAGGGAGTTAAAGGATCTGACCACCTTGGTCAGTCAGGAGCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTC
CTGCTCAACTGTTGAAGGCTCTAGAGAAAGATGCCAAGAATCTTCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTAC
TCCACTTCCAGAATGCTGTGGAAATAGAAAAGACTAAAGTGTTAAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCT
GGGTTGGCAATAAAAATCTTATTCTGAACAGCAAGGGATCTAACAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATG
AGGATTTGAAACAGCCCATGGCTGAAAGGAAAGCTCAGCTGGATGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGG
ACTTGTCCCCTCAGCAGAATCGACAGATGCTGAGGCTTCTGAATGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTC
AGGTGGATGCCTTGCAGGGCCATCTTCAACAAATGGAGCAGGAAGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGC
AACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTT
TGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGG
GGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGG
CGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAG
CAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCA
ACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCC
CAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGT
CAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAAC
AATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATA
AAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGC
TAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACA
TGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTG
CTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGC
AGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTG
CAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTG
AAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTG
AGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTG
AACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACA
TTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGC
AGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCC
AGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATC
AAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGG
TCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTAC
AGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAAT
GGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTC
TACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAG
CACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATC
TGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGG
CTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGG
ATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTC
CAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGG
AAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCT
TCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACA
TGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTC
AGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGC
TGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAG
AGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCA
GTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGC
AGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACA
GACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAG
CAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACA
GTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGT
TGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGA
AATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGC
AGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTG
ACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAG
AGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTG
AAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGG
AAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTT
CTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACA
AGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTG
CTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAG
AGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACA
AACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAAT
TGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAAC
AATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAA
TTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGG
TCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAG
ATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGC
GGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGA
AAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCC
TGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTG
TTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACC
AGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCC
GATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGG
TGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGC
ATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAAC
AAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGG
CCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGG
AGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCA
TGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATA
AACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGAT
CACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTG
GCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAA
TGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCAT
TTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCT
TCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTG
TTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCAC
GACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACC
TCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTT
TGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATG
AATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATC
TCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTC
CCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTT
TCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAA
ACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTC


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FusionGenePPI for MACF1_BRAF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MACF1MAPK9, JUN, APC, TERF2, ESRRA, CDC5L, DISC1, DTNBP1, CEP63, TRAF3IP1, EXOC1, TNIK, NRCAM, NRXN1, PLXND1, CNTNAP2, NRXN2, TANGO6, CNTNAP4, CEBPA, SIRT7, CUL3, HUWE1, EIF5A, PSMD5, PDIA6, VCAM1, FN1, SKIL, SOX2, HECW2, YBX3, CSRP1, PRKCD, MAPRE1, CUL7, OBSL1, CCDC8, ABCE1, SNAP29, AMMECR1L, TTC29, CDKL5, USP7, YWHAE, SRPK2, CAPZA2, DAXX, MAD2L1, MYH9, SYNCRIP, KIAA1107, BAG6, MCM2, ATOH1, CDH1, ID2, ALX3, MTUS2, UBC, MTNR1B, G3BP1, TESBRAFYWHAB, YWHAG, YWHAQ, YWHAZ, SFN, HRAS, AKT1, MAPK3, RAP1GAP, RAF1, MRAS, RAP1A, PAK2, TERF1, CCDC88A, NEDD4L, MAP2K1, RNF149, KSR1, BRAP, PRKCE, RPS6KB2, HSP90AA1, BRAF, YWHAE, HSPA5, MAP2K2, HSPA1A, HSPA8, YWHAH, HSPA9, ARAF, CDC37, HSP90AB1, PHKB, LIMK1, IQGAP1, MAPK1, BAD, LIPF, MUS81, FBXW7, FGFR2, BRCA2, VHL, FNTA, HDAC2, PIK3CA, EGFR, PTEN, FNIP1, FNIP2, RAB3GAP1, KRAS, KIAA0141, FKBPL, ARMCX3, KCNC4, RPTOR, CYLD, NRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MACF1_BRAF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneBRAFP15056DB08881VemurafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved
TgeneBRAFP15056DB08896RegorafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved
TgeneBRAFP15056DB00398SorafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved|investigational
TgeneBRAFP15056DB08912DabrafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved|investigational

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RelatedDiseases for MACF1_BRAF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBRAFC0025202melanoma21CTD_human
TgeneBRAFC1527249Colorectal Cancer8UNIPROT
TgeneBRAFC1275081Cardio-facio-cutaneous syndrome6CTD_human;ORPHANET;UNIPROT
TgeneBRAFC0009404Colorectal Neoplasms4CTD_human
TgeneBRAFC0040136Thyroid Neoplasm4CTD_human
TgeneBRAFC0024305Lymphoma, Non-Hodgkin3UNIPROT
TgeneBRAFC0684249Carcinoma of lung3UNIPROT
TgeneBRAFC3150970NOONAN SYNDROME 73CTD_human;UNIPROT
TgeneBRAFC0152013Adenocarcinoma of lung (disorder)2CTD_human
TgeneBRAFC0002448Ameloblastoma1CTD_human
TgeneBRAFC0004114Astrocytoma1CTD_human
TgeneBRAFC0010276Craniopharyngioma1CTD_human;ORPHANET
TgeneBRAFC0017638Glioma1CTD_human
TgeneBRAFC0022665Kidney Neoplasm1CTD_human
TgeneBRAFC0023903Liver neoplasms1CTD_human
TgeneBRAFC0024694Mandibular Neoplasms1CTD_human
TgeneBRAFC0028326Noonan Syndrome1CTD_human;ORPHANET
TgeneBRAFC0033578Prostatic Neoplasms1CTD_human
TgeneBRAFC0036920Sezary Syndrome1CTD_human
TgeneBRAFC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneBRAFC0206686Adrenocortical carcinoma1CTD_human
TgeneBRAFC0206754Neuroendocrine Tumors1CTD_human
TgeneBRAFC0238463Papillary thyroid carcinoma1CTD_human;ORPHANET
TgeneBRAFC0587248Costello syndrome (disorder)1CTD_human
TgeneBRAFC0596263Carcinogenesis1CTD_human
TgeneBRAFC0920269Microsatellite Instability1CTD_human
TgeneBRAFC2239176Liver carcinoma1CTD_human