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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20470

FusionGeneSummary for LYZ_AFF1

check button Fusion gene summary
Fusion gene informationFusion gene name: LYZ_AFF1
Fusion gene ID: 20470
HgeneTgene
Gene symbol

LYZ

AFF1

Gene ID

4069

4299

Gene namelysozymeAF4/FMR2 family member 1
SynonymsLYZF1|LZMAF4|MLLT2|PBM1
Cytomap

12q15

4q21.3-q22.1

Type of geneprotein-codingprotein-coding
Descriptionlysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1AF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4
Modification date2018052320180523
UniProtAcc

P61626

P51825

Ensembl transtripts involved in fusion geneENST00000261267, ENST00000549690, 
ENST00000548839, 
ENST00000395146, 
ENST00000307808, ENST00000544085, 
ENST00000511996, 
Fusion gene scores* DoF score19 X 13 X 6=148210 X 25 X 4=1000
# samples 2331
** MAII scorelog2(23/1482*10)=-2.68783968136146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(31/1000*10)=-1.68965987938785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LYZ [Title/Abstract] AND AFF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLYZ

GO:0031640

killing of cells of other organism

9727055

HgeneLYZ

GO:0042742

defense response to bacterium

21093056

HgeneLYZ

GO:0050830

defense response to Gram-positive bacterium

21093056


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB348190LYZchr12

69747549

-AFF1chr4

87890349

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000261267ENST00000395146LYZchr12

69747549

-AFF1chr4

87890349

-
3UTR-intronENST00000261267ENST00000307808LYZchr12

69747549

-AFF1chr4

87890349

-
3UTR-intronENST00000261267ENST00000544085LYZchr12

69747549

-AFF1chr4

87890349

-
3UTR-intronENST00000261267ENST00000511996LYZchr12

69747549

-AFF1chr4

87890349

-
intron-intronENST00000549690ENST00000395146LYZchr12

69747549

-AFF1chr4

87890349

-
intron-intronENST00000549690ENST00000307808LYZchr12

69747549

-AFF1chr4

87890349

-
intron-intronENST00000549690ENST00000544085LYZchr12

69747549

-AFF1chr4

87890349

-
intron-intronENST00000549690ENST00000511996LYZchr12

69747549

-AFF1chr4

87890349

-
intron-intronENST00000548839ENST00000395146LYZchr12

69747549

-AFF1chr4

87890349

-
intron-intronENST00000548839ENST00000307808LYZchr12

69747549

-AFF1chr4

87890349

-
intron-intronENST00000548839ENST00000544085LYZchr12

69747549

-AFF1chr4

87890349

-
intron-intronENST00000548839ENST00000511996LYZchr12

69747549

-AFF1chr4

87890349

-

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FusionProtFeatures for LYZ_AFF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LYZ

P61626

AFF1

P51825

Lysozymes have primarily a bacteriolytic function; thosein tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LYZ_AFF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LYZ_AFF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LYZ_AFF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LYZ_AFF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLYZC0268389Amyloidosis, familial visceral1CTD_human;UNIPROT