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Fusion gene ID: 20470 |
FusionGeneSummary for LYZ_AFF1 |
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Fusion gene information | Fusion gene name: LYZ_AFF1 | Fusion gene ID: 20470 | Hgene | Tgene | Gene symbol | LYZ | AFF1 | Gene ID | 4069 | 4299 |
Gene name | lysozyme | AF4/FMR2 family member 1 | |
Synonyms | LYZF1|LZM | AF4|MLLT2|PBM1 | |
Cytomap | 12q15 | 4q21.3-q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | lysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1 | AF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P61626 | P51825 | |
Ensembl transtripts involved in fusion gene | ENST00000261267, ENST00000549690, ENST00000548839, | ENST00000395146, ENST00000307808, ENST00000544085, ENST00000511996, | |
Fusion gene scores | * DoF score | 19 X 13 X 6=1482 | 10 X 25 X 4=1000 |
# samples | 23 | 31 | |
** MAII score | log2(23/1482*10)=-2.68783968136146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(31/1000*10)=-1.68965987938785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LYZ [Title/Abstract] AND AFF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LYZ | GO:0031640 | killing of cells of other organism | 9727055 |
Hgene | LYZ | GO:0042742 | defense response to bacterium | 21093056 |
Hgene | LYZ | GO:0050830 | defense response to Gram-positive bacterium | 21093056 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DB348190 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000261267 | ENST00000395146 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
3UTR-intron | ENST00000261267 | ENST00000307808 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
3UTR-intron | ENST00000261267 | ENST00000544085 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
3UTR-intron | ENST00000261267 | ENST00000511996 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
intron-intron | ENST00000549690 | ENST00000395146 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
intron-intron | ENST00000549690 | ENST00000307808 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
intron-intron | ENST00000549690 | ENST00000544085 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
intron-intron | ENST00000549690 | ENST00000511996 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
intron-intron | ENST00000548839 | ENST00000395146 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
intron-intron | ENST00000548839 | ENST00000307808 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
intron-intron | ENST00000548839 | ENST00000544085 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
intron-intron | ENST00000548839 | ENST00000511996 | LYZ | chr12 | 69747549 | - | AFF1 | chr4 | 87890349 | - |
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FusionProtFeatures for LYZ_AFF1 |
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Hgene | Tgene |
LYZ | AFF1 |
Lysozymes have primarily a bacteriolytic function; thosein tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LYZ_AFF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LYZ_AFF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LYZ_AFF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LYZ_AFF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LYZ | C0268389 | Amyloidosis, familial visceral | 1 | CTD_human;UNIPROT |