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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20447

FusionGeneSummary for LYPD6B_LRBA

check button Fusion gene summary
Fusion gene informationFusion gene name: LYPD6B_LRBA
Fusion gene ID: 20447
HgeneTgene
Gene symbol

LYPD6B

LRBA

Gene ID

130576

987

Gene nameLY6/PLAUR domain containing 6BLPS responsive beige-like anchor protein
SynonymsCT116|LYPD7BGL|CDC4L|CVID8|LAB300|LBA
Cytomap

2q23.2

4q31.3

Type of geneprotein-codingprotein-coding
Descriptionly6/PLAUR domain-containing protein 6Bcancer/testis antigen 116lipopolysaccharide-responsive and beige-like anchor proteinCDC4-like proteinLPS-responsive vesicle trafficking, beach and anchor containingvesicle trafficking, beach and anchor containing
Modification date2018052220180519
UniProtAcc

Q8NI32

P50851

Ensembl transtripts involved in fusion geneENST00000409642, ENST00000409876, 
ENST00000409029, ENST00000450639, 
ENST00000498249, ENST00000280115, 
ENST00000535741, ENST00000510413, 
ENST00000503716, ENST00000357115, 
ENST00000507224, 
Fusion gene scores* DoF score2 X 2 X 2=815 X 15 X 7=1575
# samples 218
** MAII scorelog2(2/8*10)=1.32192809488736log2(18/1575*10)=-3.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LYPD6B [Title/Abstract] AND LRBA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-7782-01ALYPD6Bchr2

149975677

+LRBAchr4

151719294

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000409642ENST00000535741LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-3CDSENST00000409642ENST00000510413LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-intronENST00000409642ENST00000503716LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-intronENST00000409642ENST00000357115LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-intronENST00000409642ENST00000507224LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-3CDSENST00000409876ENST00000535741LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-3CDSENST00000409876ENST00000510413LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-intronENST00000409876ENST00000503716LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-intronENST00000409876ENST00000357115LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-intronENST00000409876ENST00000507224LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
5UTR-3CDSENST00000409029ENST00000535741LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
5UTR-3CDSENST00000409029ENST00000510413LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
5UTR-intronENST00000409029ENST00000503716LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
5UTR-intronENST00000409029ENST00000357115LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
5UTR-intronENST00000409029ENST00000507224LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
5UTR-3CDSENST00000450639ENST00000535741LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
5UTR-3CDSENST00000450639ENST00000510413LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
5UTR-intronENST00000450639ENST00000503716LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
5UTR-intronENST00000450639ENST00000357115LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
5UTR-intronENST00000450639ENST00000507224LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-3CDSENST00000498249ENST00000535741LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-3CDSENST00000498249ENST00000510413LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-intronENST00000498249ENST00000503716LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-intronENST00000498249ENST00000357115LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-intronENST00000498249ENST00000507224LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-3CDSENST00000280115ENST00000535741LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-3CDSENST00000280115ENST00000510413LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-intronENST00000280115ENST00000503716LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-intronENST00000280115ENST00000357115LYPD6Bchr2

149975677

+LRBAchr4

151719294

-
intron-intronENST00000280115ENST00000507224LYPD6Bchr2

149975677

+LRBAchr4

151719294

-

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FusionProtFeatures for LYPD6B_LRBA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LYPD6B

Q8NI32

LRBA

P50851

Believed to act as a modulator of nicotinicacetylcholine receptors (nAChRs) activity. In vitro acts on nAChRsin a subtype- and stoichiometry-dependent manner. Modulatesspecifically alpha-3(3):beta-4(2) nAChRs by enhancing thesensitivity to ACh, decreasing ACh-induced maximal currentresponse and increasing the rate of desensitization to ACh; has noeffect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence. {ECO:0000269|PubMed:26586467}. May be involved in coupling signal transduction andvesicle trafficking to enable polarized secretion and/or membranedeposition of immune effector molecules. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LYPD6B_LRBA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LYPD6B_LRBA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LYPD6BCDK5RAP3LRBATUSC2, NOTCH1, FN1, BAG3, CAST, KIF15, DCAF11, INPPL1, MLF2, VCP, MOV10, RIC3, CT55, PARP16, RD3, TMEM52B, MED4, TMEM17, TMEM216, NCR3LG1, PVR, FAM196A, EPHA1, GYPB, DLK2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LYPD6B_LRBA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LYPD6B_LRBA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLRBAC3553512IMMUNODEFICIENCY, COMMON VARIABLE, 8, WITH AUTOIMMUNITY1ORPHANET;UNIPROT