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Fusion gene ID: 20440 |
FusionGeneSummary for LYAR_CORO1B |
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Fusion gene information | Fusion gene name: LYAR_CORO1B | Fusion gene ID: 20440 | Hgene | Tgene | Gene symbol | LYAR | CORO1B | Gene ID | 55646 | 57175 |
Gene name | Ly1 antibody reactive | coronin 1B | |
Synonyms | ZC2HC2|ZLYAR | CORONIN-2 | |
Cytomap | 4p16.3 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | cell growth-regulating nucleolar proteinLy1 antibody reactive homolog | coronin-1Bcoronin, actin binding protein, 1B | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q9NX58 | Q9BR76 | |
Ensembl transtripts involved in fusion gene | ENST00000343470, ENST00000452476, | ENST00000393893, ENST00000341356, ENST00000539724, ENST00000453768, ENST00000545016, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: LYAR [Title/Abstract] AND CORO1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CORO1B | GO:0016477 | cell migration | 16027158 |
Tgene | CORO1B | GO:0030036 | actin cytoskeleton organization | 18775315 |
Tgene | CORO1B | GO:0031529 | ruffle organization | 16027158 |
Tgene | CORO1B | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation | 17350576|18775315 |
Tgene | CORO1B | GO:0035767 | endothelial cell chemotaxis | 23667561 |
Tgene | CORO1B | GO:0042060 | wound healing | 23667561 |
Tgene | CORO1B | GO:0051017 | actin filament bundle assembly | 17456547 |
Tgene | CORO1B | GO:0090135 | actin filament branching | 18775315 |
Tgene | CORO1B | GO:1902463 | protein localization to cell leading edge | 17350576 |
Tgene | CORO1B | GO:2000394 | positive regulation of lamellipodium morphogenesis | 17350576 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-13-1403-01A | LYAR | chr4 | 4291763 | - | CORO1B | chr11 | 67208985 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000343470 | ENST00000393893 | LYAR | chr4 | 4291763 | - | CORO1B | chr11 | 67208985 | - |
5UTR-3CDS | ENST00000343470 | ENST00000341356 | LYAR | chr4 | 4291763 | - | CORO1B | chr11 | 67208985 | - |
5UTR-intron | ENST00000343470 | ENST00000539724 | LYAR | chr4 | 4291763 | - | CORO1B | chr11 | 67208985 | - |
5UTR-intron | ENST00000343470 | ENST00000453768 | LYAR | chr4 | 4291763 | - | CORO1B | chr11 | 67208985 | - |
5UTR-3UTR | ENST00000343470 | ENST00000545016 | LYAR | chr4 | 4291763 | - | CORO1B | chr11 | 67208985 | - |
intron-3CDS | ENST00000452476 | ENST00000393893 | LYAR | chr4 | 4291763 | - | CORO1B | chr11 | 67208985 | - |
intron-3CDS | ENST00000452476 | ENST00000341356 | LYAR | chr4 | 4291763 | - | CORO1B | chr11 | 67208985 | - |
intron-intron | ENST00000452476 | ENST00000539724 | LYAR | chr4 | 4291763 | - | CORO1B | chr11 | 67208985 | - |
intron-intron | ENST00000452476 | ENST00000453768 | LYAR | chr4 | 4291763 | - | CORO1B | chr11 | 67208985 | - |
intron-3UTR | ENST00000452476 | ENST00000545016 | LYAR | chr4 | 4291763 | - | CORO1B | chr11 | 67208985 | - |
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FusionProtFeatures for LYAR_CORO1B |
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Hgene | Tgene |
LYAR | CORO1B |
Plays a role in the maintenance of the appropriateprocessing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and theirsubsequent processing to produce 18S and 28S rRNAs(PubMed:24495227). Also acts at the level of transcriptionregulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2)promoter and represses its expression (PubMed:25092918). Inneuroblastoma cells, may also repress the expression of oxidativestress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41that encodes a small nucleolar RNA (PubMed:28686580).Preferentially binds to a DNA motif containing 5'-GGTTAT-3'(PubMed:25092918). Stimulates phagocytosis of photoreceptor outersegments by retinal pigment epithelial cells (By similarity).Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stemcells (ESCs), which in turn is essential for ESC self-renewal (Bysimilarity). {ECO:0000250|UniProtKB:Q08288,ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:25092918,ECO:0000269|PubMed:28686580}. | Regulates leading edge dynamics and cell motility infibroblasts. May be involved in cytokinesis and signaltransduction (By similarity). {ECO:0000250,ECO:0000269|PubMed:16027158}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LYAR_CORO1B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LYAR_CORO1B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LYAR | RPL23A, MYBBP1A, TWF2, KRT85, DHX57, RPL3, TSR1, BRIX1, KRT31, RPS9, GTPBP4, RPL18A, DHX9, RPS3A, RPL21, NAT10, NPM1, GNL2, DDX27, EIF3I, KRT82, EBNA1BP2, RPL31, KPNA1, SRP14, DDX21, ZHX1, ZBTB16, NOP56, OAS3, EIF2AK2, HDGF, TERF1, TERF2, CUL3, CUL1, COPS5, CAND1, GRK5, ESR1, MDC1, PAXIP1, VCP, FGF18, CD2, PHF20L1, ADSSL1, PRKRA, SDCBP2, BEND7, PHF6, RNF2, PRR11, ILF2, EPB41L3, ERCC4, IFI16, CEP152, HNRNPU, NCBP1, RPL10, RFWD3, FAM83H, RNF138, ZNF746, RPL37A, MAGEB10, RPL30, NCL, BRD1 | CORO1B | TERF1, SAFB, NUP107, TPM2, EPPK1, ATP6V1F, CTTN, TELO2, FN1, SOX2, POLR1C, KPNA2, CORO1C, CRMP1, OSBP, OTUD6B, TARS, VPS26A, ZRANB2, ETF1, NUDC, PAPOLA, PARVA, SWAP70, TBC1D17, ZYX, SIRT6, LUZP4, CEP170, IFT57, CORO1A, ACTB, ACTG1, ACTR2, ACTR3, ASPDH, DDB1, MRPL1, NFYB, NFYC, NHP2L1, PHKB, RAD23A, RAD23B, SFTPA2, TXNL1, LSM2, RUVBL2, SPTBN2, TIPRL, CAPZA2, FLNA, MYH9, PPP1CB, IQGAP1, SYNPO, COPS7A, LIMA1, ANLN, MYO5C, MYO19, MYO18A, TRIM15, CDH1, MTMR7, CORO6, G3BP1, TES |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LYAR_CORO1B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LYAR_CORO1B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |