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Fusion gene ID: 20439 |
FusionGeneSummary for LYAR_COL6A3 |
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Fusion gene information | Fusion gene name: LYAR_COL6A3 | Fusion gene ID: 20439 | Hgene | Tgene | Gene symbol | LYAR | COL6A3 | Gene ID | 55646 | 1293 |
Gene name | Ly1 antibody reactive | collagen type VI alpha 3 chain | |
Synonyms | ZC2HC2|ZLYAR | BTHLM1|DYT27|UCMD1 | |
Cytomap | 4p16.3 | 2q37.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cell growth-regulating nucleolar proteinLy1 antibody reactive homolog | collagen alpha-3(VI) chaincollagen VI, alpha-3 polypeptidecollagen, type VI, alpha 3 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NX58 | P12111 | |
Ensembl transtripts involved in fusion gene | ENST00000343470, ENST00000452476, | ENST00000347401, ENST00000353578, ENST00000295550, ENST00000472056, ENST00000409809, ENST00000346358, ENST00000392004, ENST00000392003, ENST00000473258, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 8 X 8 X 2=128 |
# samples | 4 | 8 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/128*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LYAR [Title/Abstract] AND COL6A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU616556 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000343470 | ENST00000347401 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-3CDS | ENST00000343470 | ENST00000353578 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-3CDS | ENST00000343470 | ENST00000295550 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-3CDS | ENST00000343470 | ENST00000472056 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-3CDS | ENST00000343470 | ENST00000409809 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-3CDS | ENST00000343470 | ENST00000346358 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-intron | ENST00000343470 | ENST00000392004 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-intron | ENST00000343470 | ENST00000392003 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-intron | ENST00000343470 | ENST00000473258 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-3CDS | ENST00000452476 | ENST00000347401 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-3CDS | ENST00000452476 | ENST00000353578 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-3CDS | ENST00000452476 | ENST00000295550 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-3CDS | ENST00000452476 | ENST00000472056 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-3CDS | ENST00000452476 | ENST00000409809 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-3CDS | ENST00000452476 | ENST00000346358 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-intron | ENST00000452476 | ENST00000392004 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-intron | ENST00000452476 | ENST00000392003 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
intron-intron | ENST00000452476 | ENST00000473258 | LYAR | chr4 | 4283622 | + | COL6A3 | chr2 | 238275370 | + |
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FusionProtFeatures for LYAR_COL6A3 |
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Hgene | Tgene |
LYAR | COL6A3 |
Plays a role in the maintenance of the appropriateprocessing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and theirsubsequent processing to produce 18S and 28S rRNAs(PubMed:24495227). Also acts at the level of transcriptionregulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2)promoter and represses its expression (PubMed:25092918). Inneuroblastoma cells, may also repress the expression of oxidativestress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41that encodes a small nucleolar RNA (PubMed:28686580).Preferentially binds to a DNA motif containing 5'-GGTTAT-3'(PubMed:25092918). Stimulates phagocytosis of photoreceptor outersegments by retinal pigment epithelial cells (By similarity).Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stemcells (ESCs), which in turn is essential for ESC self-renewal (Bysimilarity). {ECO:0000250|UniProtKB:Q08288,ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:25092918,ECO:0000269|PubMed:28686580}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LYAR_COL6A3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LYAR_COL6A3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LYAR_COL6A3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LYAR_COL6A3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | COL6A3 | C1834674 | Bethlem myopathy | 4 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL6A3 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | COL6A3 | C0410179 | Scleroatonic muscular dystrophy | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL6A3 | C4225336 | DYSTONIA 27 | 1 | ORPHANET;UNIPROT |